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    • Infections of the Nervous System

      • 1st Edition
      • October 22, 2013
      • Peter G. E. Kennedy + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 7 6 3 1 4
      • eBook
        9 7 8 1 4 8 3 1 9 2 1 2 3
      Infections of the Nervous System aims to continue the legacy of its predecessor, Modern Trends in Neurology. Its goal is to produce annually a monograph on a topic in clinical neurology in which progress through research has brought about new concepts of patient management. This book is organized into 13 chapters. It highlights the areas or subjects in which significant advances have been made which also have relevance to the treatment of patients. It covers a number of important aspects of different infectious diseases of the nervous system including acute bacterial meningitis, tuberculosis of the nervous system, spirochaetal infections of the nervous system, and fungal diseases of the central nervous system. This book is intended for use by physicians who deal with the problems of neurological disorder on a daily basis, whether they are neurologists, neurologists in training, or those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

    • Cooperative Phenomena in Biology

      • 1st Edition
      • October 22, 2013
      • George Karreman
      • English
      • Paperback
        9 7 8 1 4 8 3 1 1 6 2 5 9
      • eBook
        9 7 8 1 4 8 3 1 4 8 6 7 0
      Cooperative Phenomena in Biology deals with cooperation in biology and covers topics such as cooperative specific adsorption; the kinetics of oxygen binding to hemoglobin; allosteric control of cooperative adsorption and conformation changes; and cooperativity in biological surfaces responding to topical treatment. The use of Monte Carlo methods to investigate the behavior of cooperative Ising models is also described. This book is comprised of five chapters and opens with a discussion on the phenomenon of cooperative specific adsorption and its importance for the understanding of fundamental biological phenomena. The derivation of the cooperative specific adsorption isotherm both stochastically and on the basis of statistical mechanics is explained. The next chapter reviews the theory of the allosteric control of cooperative adsorption and conformation changes and outlines a molecular model for physiological activities according to the association-inductio... hypothesis. The reader is also introduced to a kinetic equation for hemoglobin oxygenation based on the infinite chain; the use of bioelectrometric methods to study solute interactions with biocolloidal surfaces responding to topical treatment; and the use of Monte Carlo computations to determine the behavior of cooperative Ising models. This monograph is intended for biologists, physicists, chemists, and mathematicians.

    • Enzymes Dependent on Pyridoxal Phosphate and Other Carbonyl Compounds as Cofactors

      • 1st Edition
      • October 22, 2013
      • T. Fukui
      • English
      • eBook
        9 7 8 1 4 8 3 2 8 7 5 6 0
      This volume is a summary of the proceedings of the 8th International Symposium on Vitamin B6 and Carbonyl Catalysis, held in Osaka, Japan, 15-19 October 1990. The development of molecular biology and x-ray crystallography techniques have contributed greatly to the knowledge and understanding of PLP-dependent enzymes. The structural, mechanistic and functional aspects of the PLP-dependent enzymes have been studied for over 40 years by many active researchers. Recent evidence indicates that the coenzyme is substituted by the pyruvoyl group which is a reactive carbonyl in some amino acid decarboxylases, and the presence of pyrroloquinoline quinone (PQQ), another carbonyl coenzyme, in other enzymes. The contents of this volume attest to the exciting progress in elucidating structure, mechanism of action, and the function of enzymes dependent on coenzymes containing the carbonyl group.

    • Pharmaceutical and Biomedical Applications of Liquid Chromatography

      • 1st Edition
      • Volume 1
      • October 22, 2013
      • W.J. Lough + 2 more
      • English
      • Paperback
        9 7 8 0 0 8 0 9 7 8 6 4 2
      • eBook
        9 7 8 0 0 8 0 9 8 4 5 4 4
      This volume reflects the changes that have taken place in the pharmaceutical industry over the last ten years, most notably the increased importance attached to the question of chirality, the growing influence of biotechnology and the need for more rigorous documentation and validation of analytical methods and procedures.The first part of this book deals with the application of new technology to pharmaceutical and biomedical analysis, reflecting the present needs for increased speed, sensitivity and selectivity in the analysis of drugs. The second chapter provides an overview of capillary electophoresis, which represents one of the most inportant analytical developments to impact directly on pharmaceutical development in recent years. Although not a chromatographic technique, capillary electrophoresis was considered too important to be ignored.Over the last 25 years, liquid chromatography has grown into a mature analytical technique and many of the fundamental issues concerned with retention and separation are well defined. The practitioners of modern liquid chromatography spend as much time in the development of techniques for sampling handling and automation as they do in the development of the separation. Therefore, Part Two of this book describes some of the recent advances in the areas of sample handling and the isolation of compounds from biological samples, including solid phase extraction, restricted access media for direct injection, coupled column technology and microdialysis. Similarily, Part Three contains two chapters concerned with liquid chromatographic methods for the isolation of drug substances, peptides and proteins from other complex media.The pharmaceutical industry and the process of drug development are highly regulated and the increasing importance that the regulatory authorities attach to validation has had a significant impact on the analytical techniques used for the analysis of drugs. Although this has increased the workload of analysts in the pharmaceutical industry, it has also improved the quality of analytical methods used in the support of investigational and new drug applications as well as the quality of methods published more recently in the literature. Consequently, Part Four of this volume describes approaches to the optimization and validation of liquid chromatography methods for the analysis of drugs in the bulk form, in pharmaceutical formulations and biological fluids.

    • An Introduction to Gastro-Enterology

      • 1st Edition
      • October 22, 2013
      • James Dunlop Lickley
      • English
      • Paperback
        9 7 8 1 4 8 3 1 7 8 2 3 3
      • eBook
        9 7 8 1 4 8 3 1 9 4 0 4 2
      An Introduction to Gastro-Enterology: A Clinical Study of the Structure and Functions of the Human Alimentary Tube covers the diagnosis and treatment of alimentary tube disorders. This book is organized into four parts encompassing 19 chapters that evaluate the basic structure, divisions, and vascular arrangements of alimentary tube. Some of the topics covered in the book are the vascular and nervous functions of the alimentary tube; its lining membrane and the disposition of its abdominal part; mechanism of the preparatory, final digestive, and absorptive segments. Other chapters deal with the operations of the expulsive segments, the important features of the controlling nervous mechanism, and the implications of alimentary pain. The defense mechanisms unique to the alimentary tube are described. The last chapters are devoted to the useful clinical applications of the expulsive segments. The book can provide useful information to doctors, students, and researchers.

    • Coastal Environments

      • 1st Edition
      • October 22, 2013
      • R. W.G. Carter
      • English
      • Paperback
        9 7 8 0 1 2 1 6 1 8 5 6 8
      • eBook
        9 7 8 0 0 8 0 5 0 2 1 4 4
      This original volume draws on the author's own research experiences in Ireland, Britain, France, Canada, and the United States to present a guide of coastal environments for applications of shoreline and environmental management. Topics include: long-term development of coasts, water supply and waste disposal, energy resources and coastal water management, coastal water management for recreation, coastal management of storm hazards, and managing world sea-level rise.

    • Hormones and the Fetus

      • 1st Edition
      • October 22, 2013
      • J. R. Pasqualini + 2 more
      • English
      • eBook
        9 7 8 1 4 8 3 2 8 6 6 8 6
      Volume One of Hormones and the Fetus contained a generalization of the role of hormones during fetal life. In this second volume, the main topics focus on hormonal binding to fetal and maternal plasma proteins, amniotic fluid and placenta; the presence of hormone receptors in the fetal compartment; and the mechanism of action of various hormones in different target tissues of the fetus and placenta. This up-to-date information is of major importance in the study of hormonal activity in fetal life, and the biological effect of hormones through the receptor. The mechanism of fetal sexual differentiation, in which hormones play an important role, is extensively covered.

    • Biological and Environmental Effects of Arsenic

      • 1st Edition
      • Volume 6
      • October 22, 2013
      • B.A. Fowler
      • English
      • Hardback
        9 7 8 0 4 4 4 8 0 5 1 3 3
      • eBook
        9 7 8 1 4 8 3 2 9 0 1 9 5
      Topics in Environmental Health, Volume 6: Biological and Environmental Effects of Arsenic focuses on the properties, characteristics, and reactions of arsenic and its effects on the environment. The selection first tackles the mobilization of arsenic by natural and industrial processes and emissions, cycling, and effects of arsenic in soil ecosystems. Discussions focus on the effects of arsenic on plants and soil microorganisms, exposure through consumption, sources of arsenic, and mobilization of arsenic by natural processes and industrial activities. The publication then ponders on environmental reaction and analysis methods and arsenical metabolism and toxicity to freshwater and marine species. The text examines the metabolism of arsenic and epidemiology of human arsenic exposure, including acute and chronic effects by arsenic in man, absorption, tissue distribution and retention, and elimination and biological half-time. The publication then takes a look at the toxicity of arsenic and its compounds, as well as biological transformation of arsenic compounds in soil ecosystems and effects on plants; biotransformation of arsenic compounds and toxicity to freshwater and marine biota; and environmental transformation of arsenic in freshwater/marine ecosystems. The selection is a dependable reference for readers interested in the biological and environmental effects of arsenic.

    • Quantitative and Qualitative Microscopy

      • 1st Edition
      • October 22, 2013
      • P. Michael Conn
      • English
      • Hardback
        9 7 8 0 1 2 1 8 5 2 5 5 9
      • Paperback
        9 7 8 1 4 8 3 2 3 7 6 0 2
      • eBook
        9 7 8 1 4 8 3 2 6 8 1 7 0
      Methods in Neurosciences, Volume 3: Quantitative and Qualitative Microscopy is a collection of papers that deals with microscopic techniques in statistical measures. This volume describes microscopy using sophisticated stains and dyes to advance observation of tests and experiments. Section I describes autoradiography including micro chemical methods, high-resolution autoradiography, and single- or double-label quantitative autoradiography for use in imaging of brain activity patterns or determining cerebral physiology. Section II discusses the quantification of structures through statistical and computational methods including dynamic video imaging technology. Section III explains the use of tracers, toxins, or dyes in tracing neuronal connections. One paper addresses the use of small injections of axonally transported fluorescent tracers. Section IV explains staining technology such as using the silver impregnation method for frozen sections of human nervous tissue that are gathered from tissues preserved in formalin. Section V addresses freezing techniques and those using freeze-fracture methods in neurobiology. The text also discusses cryoprotection and other freezing methods to control ice crystals found in fixed or unfixed brain tissues. Section VI presents the combined and high-resolution methods in polarization microscopy and microscopic investigations. Cellular biologists, micro-chemists, and scientific researchers in the field of micro- and cellular biology will appreciate this book.

    • Human Ecology in the Tropics

      • 1st Edition
      • October 22, 2013
      • J. P. Garlick + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 2 8 2 7 6
      • Hardback
        9 7 8 0 0 8 0 0 6 7 8 6 5
      • eBook
        9 7 8 1 4 8 3 1 6 0 6 9 6
      Symposia of the Society for the Study of Human Biology, Volume 9: Human Ecology in the Tropics covers papers related to the impact of human on the natural ecosystems in tropical countries. The volume presents papers about the operation of typical plant-soil systems in relation to human activity in West Africa; the interrelationships of habitat, economy, and society among three Guiana people; tropical health; and the use and production of tropical food potentials. The book also describes papers about the ecology of African schistosomiasis, as well as the interaction between the trypanosome-tsetse-w... fauna ecosystem and the surrounding human communities of southern Busoga in Uganda. The volume concludes by discussing the development of young children in a West African village. Ecologists and biologists will find the book invaluable.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology