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Books in Life sciences

Pharmaceutical and Biomedical Applications of Liquid Chromatography
1st Edition
Volume 1
October 22, 2013
W.J. Lough + 2 more
English
This volume reflects the changes that have taken place in the pharmaceutical industry over the last ten years, most notably the increased importance attached to the question of chirality, the growing influence of biotechnology and the need for more rigorous documentation and validation of analytical methods and procedures.The first part of this book deals with the application of new technology to pharmaceutical and biomedical analysis, reflecting the present needs for increased speed, sensitivity and selectivity in the analysis of drugs. The second chapter provides an overview of capillary electophoresis, which represents one of the most inportant analytical developments to impact directly on pharmaceutical development in recent years. Although not a chromatographic technique, capillary electrophoresis was considered too important to be ignored.Over the last 25 years, liquid chromatography has grown into a mature analytical technique and many of the fundamental issues concerned with retention and separation are well defined. The practitioners of modern liquid chromatography spend as much time in the development of techniques for sampling handling and automation as they do in the development of the separation. Therefore, Part Two of this book describes some of the recent advances in the areas of sample handling and the isolation of compounds from biological samples, including solid phase extraction, restricted access media for direct injection, coupled column technology and microdialysis. Similarily, Part Three contains two chapters concerned with liquid chromatographic methods for the isolation of drug substances, peptides and proteins from other complex media.The pharmaceutical industry and the process of drug development are highly regulated and the increasing importance that the regulatory authorities attach to validation has had a significant impact on the analytical techniques used for the analysis of drugs. Although this has increased the workload of analysts in the pharmaceutical industry, it has also improved the quality of analytical methods used in the support of investigational and new drug applications as well as the quality of methods published more recently in the literature. Consequently, Part Four of this volume describes approaches to the optimization and validation of liquid chromatography methods for the analysis of drugs in the bulk form, in pharmaceutical formulations and biological fluids.
Food Legislative System of the UK
1st Edition
October 22, 2013
Stephen J. Fallows
English
Food Legislative System of the UK discusses the principles underlying the country's food laws, the historical context of today's food legislation, and the process for amendments in legislation. The book also reviews the influences on the system such as those arising from interest groups, the changing diet, and health environment. In addressing the Food Legislative System of the United Kingdom, the book tackles various examples of food legislation and numerous food- related advisory bodies. Industry, consumer, or enforcement pressures can initiate changes and modifications of laws. Once ministers are convinced that a prima-facie case exists for amending food legislation, they will seek advice from various authorities; make a draft, and present it for full parliamentary procedure. For example, the "Food and Environment Bill" has passed through Parliament by ministers representing the Ministry of Agriculture, Fisheries and Food, while the "Food Bill" has gone through another route with the chief legal officers and company. The book emphasizes the mechanisms through which change is achieved, as well as the points when opportunities exist for interest groups to make their views known to the decision makers. The book can be helpful for food lobbyists, consumer food groups, nutritionists, political scientists, and heads of food and welfare organizations.
Data Acquisition and Processing in Biology and Medicine
Proceedings of the 1964 Rochester Conference
1st Edition
October 22, 2013
Kurt Enslein + 1 more
English
Data Acquisition and Processing in Biology and Medicine, Volume 4 deals with theories in data acquisition and processing as well as their implementation in biology and medicine. Topics covered range from computer-oriented study of human metabolism to automatic classification of chromosomes; retrieval and processing medical measurement data; data manipulation in investigational new drug applications; and methods of microglossary analysis. Comprised of 20 chapters, this volume begins with a description of the techniques, instrumentation, and analytical procedures for acquiring, storing, and retrieving psychophysiological data on more than 200 subjects. The discussion then turns to the use of computers to study human metabolism, for the reduction of ultracentrifuge data, and in objective content analysis of psychotherapy. Subsequent chapters explore mechanized image systems; cortical auditory response in humans; information processing by electric fishes; and fetal heart rate during cesarean section. This book will be useful for undergraduate students, educators, practitioners, and researchers in computing, biology, and medicine.
Hormone Action in Plant Development — A Critical Appraisal
1st Edition
October 22, 2013
G. V. Hoad + 2 more
English
Hormone Action in Plant Development - A Critical Appraisal documents the proceedings of the Tenth Long Ashton Symposium, September 1986. The symposium was convened to assess the evidence for and against the view that plant hormones are endogenous regulators of plant development. The meeting also aimed to focus on and assess promising strategies for future research. The symposium opened with the Douglas Wills Lecture, given by Professor Carl Leopold. In many respects, progress in research on animal hormones seems greater than in the plant sciences and there may well be merit in following progress in animal hormone research as suggested by Professor Leopold. The symposium was comprised of four sessions. The introductory session considered the coordinating role of hormones in plant growth and development, and focused on hormone action at the molecular level, including their binding to receptors and their control of gene expression. The next two sessions embraced contributions on the experimental manipulation of development by genetic (notably by biochemical mutants), chemical (for example, with gibberellin/biosynth... inhibitors), and environmental (including drought stress) means. All these approaches consolidated the central importance of hormones in plant growth. In the final session, three speakers suggested some promising avenues for future research into the physiology, biochemistry, and molecular biology of plant hormones.
The Hallucinogens
1st Edition
October 22, 2013
A. Hoffer + 1 more
English
The Hallucinogens attempts to provide a detailed description of the hallucinogens in a single volume. Hallucinogens are chemicals which in nontoxic doses produce changes in perception, in thought, and in mood, but which seldom produce mental confusion, memory loss, or disorientation for person, place, and time. These latter changes are characteristic of organic brain reactions following intoxications with alcohol, anesthetics, and other toxic drugs. The book covers the following hallucinogens: plant ß-phenethylamines, d-lysergic acid diethylamide, ololiuqui, indole hallucinogens derived from tryptophan, and taraxein. The discussions include their chemistry, biochemistry, and neurophysiological effects. The final chapter deals with animal studies with hallucinogenic drugs. This work has been written for chemists, biochemists, psychologists, sociologists, and research physicians. While it cannot satisfy each group fully, it is sufficiently comprehensive and well documented so that each group can use it as a springboard for future enquiry into these fascinating chemicals.
A Practical Course in Agricultural Chemistry
The Commonwealth and International Library: Agriculture and Forestry Division
1st Edition
October 22, 2013
D. W. Gilchrist Shirlaw
J. E. Nichols
English
A Practical Course in Agricultural Chemistry provides practical methods in agricultural chemistry. This book discusses the major developments in agricultural analysis, including the atomic absorption technique and gas chromatography. Organized into six chapters, this book starts with an overview of the best instrument to use in soil sampling. This text then discusses a number of various methods for the mechanical analysis of soils. Other chapters consider the methods for the determination of phosphate, nitrogen, and potash in farmyard manure. This book discusses as well the methods for the determination of some of the individual minerals. The final chapter deals with the variation of the color of a solution with a change in the concentration of one of its constituents, which forms the basis of colorimetric analysis. This book is a valuable resource for students taking agricultural chemistry as a subsidiary course as well as for students in farm institutes or agricultural colleges.
Nervous System Theory
An Introductory Study
1st Edition
October 22, 2013
K. N. Leibovic
English
Nervous System Theory: An Introductory Study focuses on the nervous system theory, stressing the means for understanding the nature of the biological system rather than the elaboration of mathematical theories. This book begins with a discussion on single-cell responses, followed by a discussion of sensory information processing that leads into models of perceptual processes and their possible neural bases. This text concludes with some general principles and theoretical investigations relating to units that make up a nervous system, through a sensory pathway and central structures. The peripheral stimuli that explain the operations of the brain are also described. This publication is a good reference for neurologists, medical practitioners, and researchers conducting work on the nervous system theory.
The Physiology and Pharmacology of the Microcirculation
1st Edition
October 22, 2013
Nicholas A. Mortillaro
English
The Physiology and Pharmacology of the Microcirculation, Volume 2, discusses the microcirculatory function of specific organ systems. The first volume of The Physiology and Pharmacology of the Microcirculation presented some general aspects of microcirculatory function and then concentrated on the microcirculation of a specific organ system, namely, brain, eye, heart, and kidneys. This second and final volume continues the presentation of microcirculatory function of specific organ systems. The book begins with a chapter on the microcirculation of the lungs, with a description of its microcirculatory features and current methods of study. This is followed by separate chapters on the microcirculation of the splanchnic organs. These include the stomach, emphasizing hemodynamics, tissue oxygenation, and control of blood flow; the small and large intestine. Subsequent chapters deal with the microcirculatory responses of both the liver and spleen to different physiological and pharmacological challenges; the microcirculation of the skin, with emphasis on human microcirculation; normal and abnormal microcirculatory dynamics in skeletal muscle; microcirculation of bone; and microcirculation of the salivary glands and exocrine pancreas. The final chapter presents a selective review of pathological events involving the microcirculation, with the emphasis directed toward human diseases.
Animal Communication by Pheromones
1st Edition
October 22, 2013
H. H. Shorey
English
Animal Communication by Pheromones describes how the behavior of animals is controlled and influenced by pheromone communication. This book describes the mechanism through which the social animals interact with each other and by which they are organized according to their relative statuses and functions. The text then describes the pheromonal communication system; the mechanisms of movement and orientation to pheromone sources; and recognition, aggregation, and dispersion pheromone behaviors. The sex pheromone behavior; the environmental and physiological control of sex pheromone behavior; and the aspects of pheromones as stimulators or inhibitors of aggression are considered. The book further tackles sex pheromones; reproductive isolation; and the evolution of pheromonal communication. Entomologists and animal scientists will find the book useful.
Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells
1st Edition
October 22, 2013
T.E. Gram
English
Research has shown that the lung is capable of metabolically activating xenobiotics into intermediates that can covalently bind to pulmonary tissue. Further, it has been shown that the lung consists of many distinct cell types with the ability to take up and sequester metabolically unchanged drugs and chemicals that are ultimately toxic in effect. This volume reflects the extent of these developments and provides a state-of-the art reference in a rapidly evolving field incorporating both drug metabolism and pulmonary toxicology research.

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