Books in Life sciences

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

1st Edition
August 22, 2009
F. Javier Alvarez-Leefmans + 1 more
English
Hardback
9 7 8 0 1 2 3 7 4 3 7 3 2
eBook
9 7 8 0 0 8 0 9 2 2 0 3 4

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction... neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.

Molecular Diagnostics

2nd Edition
August 21, 2009
George P. Patrinos + 1 more
English
eBook
9 7 8 0 0 8 0 9 2 3 1 8 5

The 2e of Molecular Diagnostics, the only book dealing with diagnosis on a molecular level, discusses current molecular biological techniques used to identify the underlying molecular defects in inherited disease. The book delves further into the principle and brief description of the technique, followed by examples from the authors' own expertise. Contributors to the 2e are well-known experts in their field, and derive from a variety of disciplines, to ensure breadth and depth of coverage. Molecular Diagnostics, 2e , is a needed resource for graduate students, researchers, physicians and practicing scientists in molecular genetics and professionals from similar backgrounds working in diagnostic laboratories in academia or industry, as well as academic institutions and hospital libraries.

Bone Cancer

1st Edition
August 20, 2009
Dominique Heymann
English
eBook
9 7 8 0 0 8 0 9 5 3 8 8 5

The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches.Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.

Advances in Virus Research

1st Edition
Volume 74
August 19, 2009
Karl Maramorosch + 2 more
English
Hardback
9 7 8 0 1 2 3 7 8 5 8 7 9
eBook
9 7 8 0 1 2 3 7 8 5 8 8 6

Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. The impact factor for 2008 is 4.886, placing it 4th in the highly competitive category of virology.

Advances in Parasitology

1st Edition
Volume 69
August 18, 2009
David Rollinson + 1 more
English
Hardback
9 7 8 0 1 2 3 7 4 7 9 5 2
eBook
9 7 8 0 0 8 0 9 5 0 9 6 9

First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies on parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. Eclectic volumes are supplemented by thematic volumes on various topics, including control of human parasitic diseases and global mapping of infectious diseases.

Advances in Quaternary Entomology

1st Edition
Volume 12
August 18, 2009
Scott A. Elias
English
Hardback
9 7 8 0 4 4 4 5 3 4 2 4 8
eBook
9 7 8 0 0 8 0 9 5 8 4 9 1

Advances in Quaternary Entomology addresses the science of fossil insects by demonstrating their immense contribution to our knowledge of the paleoenvironmental and climatological record of the past 2.6 million years. In this comprehensive survey of the field, Scott A. Elias recounts development of scholarship, reviews the fossil insect record from Quaternary deposits throughout the world, and points to rewarding areas for future research. The study of Quaternary entomology is becoming an important tool in understanding past environmental changes. Most insects are quite specific as to habitat requirements, and those in non-island environments have undergone almost no evolutionary change in the Quaternary period. We therefore can use their modern ecological requirements as a basis for interpreting what past environments must have been like.

Advances in Virus Research

1st Edition
Volume 73
August 17, 2009
Karl Maramorosch + 2 more
English
Hardback
9 7 8 0 1 2 3 7 4 7 8 6 0
eBook
9 7 8 0 0 8 0 9 5 0 8 7 7

Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. The impact factor for 2007 is 3.120, placing it 9th in the highly competitive category of virology.

Foundations of Regenerative Medicine

1st Edition
August 14, 2009
Anthony Atala
English
eBook
9 7 8 0 1 2 3 7 8 5 6 2 6

The interdisciplinary field of regenerative medicine holds the promise of repairing and replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Derived from the fields of tissue engineering, cell and developmental biology, biomaterials science, nanotechnology, physics, chemistry, physiology, molecular biology, biochemistry, bioengineering, and surgery, regenerative medicine is one of the most influential topics of biological research today.Derived from the successful Principles of Regenerative Medicine, this volume brings together the latest information on the advances in technology and medicine and the replacement of tissues and organs damaged by disease. Chapters focus on the fundamental principles of regenerative therapies that have crossover with a broad range of disciplines. From the molecular basis to therapeutic applications, this volume is an essential source for students, researchers, and technicians in tissue engineering, stem cells, nuclear transfer (therapeutic cloning), cell, tissue, and organ transplantation, nanotechnology, bioengineering, and medicine to gain a comprehensive understanding of the nature and prospects for this important field.

Fundamentals of Osteoporosis

1st Edition
August 14, 2009
Robert Marcus + 3 more
English
eBook
9 7 8 0 1 2 3 7 5 1 0 8 9

Fundamentals of Osteoporosis offers a concise yet comprehensive source of all the latest basic research related to osteoporosis in one reference work. Experts from all areas of osteoporosis research expose readers to genomic and proteomic analysis, and histopathology and imaging, as well cellular and molecular mechanisms relevant to assay development and drug discovery.

Insect Development

1st Edition
August 13, 2009
Lawrence I. Gilbert
English
eBook
9 7 8 0 1 2 3 7 5 1 3 7 9

The publication of the extensive 7-volume work Comprehensive Molecular Insect Science has provided library customers and their end-users with a complete reference encompassing important developments and achievements in modern insect science including reviews on the ecdysone receptor, lipocalins, and bacterial toxins. This derivative from the major reference work, Insect Development: Metamorphosis, Molting and Morphogenesis, presents a new opportunity for the end user who desires to purchase a comprehensive yet affordable work on these important aspects of insect development. Timeless articles by a host of respected contributors in the field cover such topics as embryonic development, hormonal control of form and function of the nervous system, programmed cell death, organization of the endocrine system, and much more.

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Books in Life sciences

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Molecular Diagnostics

Bone Cancer

Advances in Virus Research

Advances in Parasitology

Advances in Quaternary Entomology

Advances in Virus Research

Foundations of Regenerative Medicine

Fundamentals of Osteoporosis

Insect Development

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