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Books in Life sciences

  • Database Directory and Master Indices

    Nucleotide Sequences 1986/1987, Vol. 8
    • 1st Edition
    • Edwin J. Atencio + 2 more
    • English
    Nucleotide Sequences 1986/1987, Volume VIII: Database Directory and Master Indices presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into 13 sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main emphasis in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • Enzymology in the Practice of Laboratory Medicine

    Proceedings of a Continuation Course Held at the University of Minnesota, Minneapolis, Minnesota, 10-12 May 1972
    • 1st Edition
    • Philip Blume + 1 more
    • English
    Enzymology in the Practice of Laboratory Medicine focuses on disease processes, enzymatic reactions and activities, and diagnosis and management of diseases. The selection first offers information on developments in the search for mechanisms of enzymic catalysis; application of the spin labeling technique to biological membranes; and the properties of membrane bound enzymes involved in energy transduction processes. Discussions focus on possible clinical interrelationships of membrane function, mitochondrial membrane transactions, mechanical details of chymotryptic catalysis, and physical nature of globular proteins. The text then elaborates on metalloenzymes, enzyme measurement, and enzymology, clinical chemistry, and development of fast analyzers. The publication examines the analytical uses of immobilized enzymes; origin of serum enzymes and the basis for their variation; and the screening methods for glycolytic enzyme deficiencies in red blood cells. Topics include factors contributing to normal variation of enzyme activity, catabolism of enzymes, mechanism of release from cells to plasma, and determination of urea in blood and urine. The selection is a dependable reference for researchers interested in the application of enzymology in laboratory medicine.

  • The Receptors

    Volume IV
    • 1st Edition
    • P. Michael Conn
    • English
    The Receptors, Volume IV deals with receptors for intracellular hormones, estrogen, and sex steroids as well as for dopamine, cholecystokinin, and corticotropin. The role of surface recognition receptors in disease is also discussed, along with receptors for plant auxin action and auxin transport. Comprised of 11 chapters, this volume begins with a detailed account of the ?-adrenergic receptor-coupled adenylate cyclase and the reconstitution of the functional interactions of its various purified components. The discussion then turns to the mechanism of action of steroid and thyroid hormones and how abnormalities in their receptors lead to disease; nuclear location of estrogen receptors; and the biochemistry of the fungal sex steroid receptors as well as the use of Achlya as a model system for the study of the mechanism of action of steroid hormones in general. Subsequent chapters focus on dopamine receptors; cholecystokinin receptor; corticotropin receptors; and the search for receptors that mediate sweetness. The book concludes with an analysis of endocrine receptors on lymphocytes and the integration of endocrine and immune systems, with emphasis on large granular lymphocytes. This monograph will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

  • The Cell

    Biochemistry, Physiology, Morphology
    • 1st Edition
    • Jean Brachet + 1 more
    • English
    The Cell: Biochemistry, Physiology, Morphology, Volume I focuses on the advancements of processes, techniques, and approaches used in studies on the structure and functions of cells. The selection first offers information on the optical methods in cytology, fixation and staining, and autoradiography. Discussions focus on microscopical analysis, techniques related to autoradiography, staining for electron microscopy and light microscopy, fixation, electron microscope in cytology, and X-ray microscopy of cells. The text then takes a look at the quantitative microscopical techniques for single cells and quantitative microchemical techniques of histo- and cytochemistry. The manuscript ponders on micrurgical studies on living cells, isolation of subcellular components, and "tissue culture," cellular autonomy, and cellular interrelations. Topics include standardization procedures, factors influencing the choice of isolation procedure, future applications and extensions of micrurgy, and applications of micrurgy to the study of living cells. The effects of radiations on cells, acquisition of biological specificity, and nucleocytoplasmic interactions in eggs and embryos are also discussed. The selection is a dependable reference for researchers interested in pursuing further studies on the biochemistry, physiology, and morphology of cells.

  • Agglutination, Complement, Neutralization, and Inhibition

    Methods in Immunology and Immunochemistry, Vol. 4
    • 1st Edition
    • Curtis A. Williams + 1 more
    • English
    Methods in Immunology and Immunochemistry, Volume IV: Agglutination, Complement, Neutralization, and Inhibition provides information pertinent to direct and indirect agglutination reactions. This book covers a variety of topics, including complement-fixation procedures, isolation of complement components, hemolytic intermediates, complement-related proteins, and neutralization reactions. Organized into three chapters, this volume begins with an overview of test-tube agglutinations that are preferred for blood grouping with saline agglutinins that require more than a few minutes for agglutination. This text then describes blood group antibodies that agglutinate red blood cells suspended in saline. Other chapters consider the classical pathway of complement utilization. This book discusses as well the complexity of events leading to hemolysis of erythrocytes by complement. The final chapter deals with the ability of antitoxin to neutralize diphtheria toxin and explains the quantitative relationships between antigen and antibody. This book is a valuable resource for immunologists, scientists, and research workers.

  • Major Methods of Peptide Bond Formation

    The Peptides Analysis, Synthesis, Biology, Vol. 1
    • 1st Edition
    • Erhard Gross + 1 more
    • English
    The Peptides: Analysis, Synthesis, Biology, Volume 1: Major Methods of Peptide Bond Formation provides comprehensive and critical reviews of important developments in three major areas of peptide research—analysis, synthesis, and biology. This book discusses the nature of the peptide bond, coupling between amino acid residues, and catalysis of active ester reactions. The formation of hydrazides, reactions of carbodiimides with amines, and mixed carbonic anhydride method of peptide synthesis are also elaborated. This publication likewise covers the control of racemization during peptide synthesis, strategies for minimizing racemization during amide-forming steps, and assays for chiral purity. This volume is suitable for students, specialists, and scientists from a broad range of disciplines concerned with peptides.

  • Hepatic Plasma Proteins

    Mechanisms of Function and Regulation
    • 1st Edition
    • Barbara H. Bowman
    • English
    Hepatic Plasma Proteins: Mechanisms of Function and Regulation covers the mechanisms of function, inherited variation, and regulation of genes encoding the plasma proteins synthesized in the liver. The book discusses the physiological and clinical implications of human plasma protein abnormalities; the acute-phase reactants; and the variety of human plasma proteinase inhibitors. The text also describes the plasma protein vehicles (transferrin, ceruloplasmin, transthyretin, haptoglobin, hemopexin, and the vitamin D binding protein), as well as cytokines and transcription factors involved in the regulatory process. The protein and gene anatomies are discussed in terms of evolutionary relationships and genetic variations, especially those with mutations causing clinical manifestations. The book also encompasses the mechanisms responsible for tissue specific and developmental expression of plasma protein genes. Geneticists, biochemists, molecular biologists, physicians, and other students of biology will find the book invaluable.

  • Biochemical and Molecular Aspects of Selected Cancers

    • 1st Edition
    • Thomas G. Pretlow + 1 more
    • English
    Biochemical and Molecular Aspects of Selected Cancers, Volume I provides an overview of important topics and prototypes in cancer research. The book consists of papers provided by outstanding investigators in diverse disciplines in different areas of cancer research. This volume focuses on topics relevant to cancers in humans. It covers such topics as tumor-suppressor genes and human neoplasia; protein kinase C in neoplastic cells; and extracellular matrix interactions with tumor-progressing cells: tumor versus cell type-specific mechanisms. Structural and functional characteristics of human melanoma; steroid hormones and hormone receptors in neoplastic diseases; and patterns and significance of genetic changes in neuroblastomas are expounded as well. Oncologists, biochemists, cytologists, and other researchers in allied fields will find the book invaluable.

  • Molecular Aspects of Animal Development

    • 1st Edition
    • Rudolf Weber
    • English
    The Biochemistry of Animal Development, Volume III: Molecular Aspects of Animal Development provides an account of the developments in the molecular approach to vertebrate development with particular emphasis on the functions of nucleic acids. The book discusses topics on oocyte maturation, transcriptional patterns in early development, the post-transcriptional control of gene expression, and the significance of gene amplification. Morphogenetic substances, growth-promoting proteins, and the functional differentiation of mitochondria in embryonic systems are covered as well. Biochemists, biologists, and zoologists will find the book invaluable.

  • Monoclonal Antibodies Against Bacteria

    Volume III
    • 1st Edition
    • Alberto J. L. Macario + 1 more
    • English
    Monoclonal Antibodies Against Bacteria, Volume III covers the basis for understanding developments of practical importance in the health sciences within the area of microbiology and infectious diseases, focusing on advances made possible by monoclonal antibodies. This 12-chapter volume specifically considers the basic principles of hybridoma technology. The introductory chapters deal with treponemal antigens of significance for understanding syphilis, yaws, pinta, salmonellosis, and other gastroenteropathies. The subsequent chapters highlight pediatric infections and the strategies for molecular analyses of bacterial antigens, focusing on cell walls, S layers, and sheaths. The remaining chapters examine the bacterial toxins involved in gaseous gangrene and other forms of cell damage, such as diphtheria, caries and periodontal diseases, and bacteria relevant to animal sciences. This book will prove useful to internists, pediatricians, surgeons, dentists, veterinarians, clinical pathologists, and laboratory technologists.

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