Life sciences print books and ebooks | Elsevier

Therapeutic Risk Management of Medicines

1st Edition
March 13, 2014
Stephen J. Mayall + 1 more
English
Hardback
9 7 8 1 9 0 7 5 6 8 4 8 0
eBook
9 7 8 1 9 0 8 8 1 8 2 7 0

Therapeutic risk management of medicines is an authoritative and practical guide on developing, implementing and evaluating risk management plans for medicines globally. It explains how to assess risks and benefit-risk balance, design and roll out risk minimisation and pharmacovigilance activities, and interact effectively with key stakeholders.A more systematic approach for managing the risks of medicines arose following a number of high-profile drug safety incidents and a need for better access to effective but potentially risky treatments. Regulatory requirements have evolved rapidly over the past decade. Risk management plans (RMPs) are mandatory for new medicinal products in the EU and a Risk Evaluation and Mitigation Strategy (REMS) is needed for certain drugs in the US.This book is an easy-to-read resource that complements current regulatory guidance, by exploring key areas and practical implications in greater detail. It is structured into chapters encompassing a background to therapeutic risk management, strategies for developing RMPs, implementation of RMPs, and the continuing evolution of the risk management field.The topic is of critical importance not only to the pharmaceutical and biotechnology industries, but also regulators and healthcare policymakers.Some chapters feature contributions from selected industry experts.

Reconstituting the Cytoskeleton

1st Edition
Volume 540
March 11, 2014
Ron Vale
English
Hardback
9 7 8 0 1 2 3 9 7 9 2 4 7
eBook
9 7 8 0 1 2 3 9 8 4 8 0 7

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers cytoskeletal structure, including such topics as rotational movement of formins studied by fluorescence polarization microscopy, in vitro assembly assays for bacterial actin filaments, and modulators of microtubule plus end growth.

Food Plant Safety

1st Edition
March 11, 2014
Tatiana Koutchma
English
eBook
9 7 8 0 1 2 4 1 6 6 6 7 7

Food Plant Safety: UV Applications for Food and Non-Food Surfaces discusses the fundamental principles of ultraviolet (UV) light technology, and gives practical recommendations on UV processes and systems design for specific processing operations, as well as how microbial efficacy of UV light can improve the quality of existing product lines. Innovative research of ultraviolet light for food applications has been growing worldwide. With increased consumer demand for fresher, minimally processed but safe foods, comes the need for novel technologies to meet that demand. Ultraviolet technology has been taking its niche in food production as a non-chemical treatment to control and enhance safety of processing plants and storage facilities. This concise resource covers the fundamentals of this promising technology and its applications; it will benefit a broad audience of professionals in food engineering, processing, and product development, as well as graduate level students.

From an Antagonistic to a Synergistic Predator Prey Perspective

1st Edition
March 11, 2014
Tore Johannessen
English
Paperback
9 7 8 0 1 2 4 1 7 0 1 6 2
eBook
9 7 8 0 1 2 4 2 0 1 1 1 8

From an Antagonistic to a Synergistic Predator Prey Perspective: Bifurcations in Marine Ecosystems is a groundbreaking reference that challenges the widespread perception that predators generally have a negative impact on the abundance of their prey, and it proposes a novel paradigm — Predator-prey Synergism — in which both predator and prey enhance abundance by their co-existence. Using this model, the text explains a number of issues that appear paradoxical in the case of a negative predator-prey relationship, including observed ecosystem bifurcations (regime shifts), ecosystem resilience, red tides in apparently nutrient depleted water, and the dominance of grazed phytoplankton over non-grazed species under high grazing pressure. This novel paradigm can also be used to predict the potential impact of global warming on marine ecosystems, identify how marine ecosystem may respond to gradual environmental changes, and develop possible measures to mitigate the negative impact of increasing temperature in marine ecosystems. This book approaches the long-standing question of what generates recruitment variability in marine fishes and invertebrates in an engaging and unique way that students and researchers in marine ecosystems will understand.

Advances in Agronomy

1st Edition
Volume 125
March 11, 2014
Donald L. Sparks
English
eBook
9 7 8 0 1 2 8 0 0 3 5 9 6

Advances in Agronomy continues to be recognized as a leading reference and a first-rate source for the latest research in agronomy. As always, the subjects covered are varied and exemplary of the myriad of subject matter dealt with by this long-running serial.

Advances in Protein Chemistry and Structural Biology

1st Edition
Volume 94
March 11, 2014
Rossen Donev
English
eBook
9 7 8 0 1 2 8 0 0 3 7 3 2

This eclectic volume features two major topics: applications of mass spectrometry in bioscience; and computational methods for analysis of protein structure and interactions with other macromolecules. Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.

Starch Polymers

1st Edition
March 8, 2014
P. Halley + 1 more
English
eBook
9 7 8 0 4 4 4 5 3 7 3 1 7

This book focuses on starch polymers including starch genetics, biotechnological and chemical modification, nanostructures, processing, characterization, properties and applications. This books topic is in a cutting edge and emerging technology area of biomaterials, nanomaterials and renewable materials, and will involve international experts in diverse fields from genetic engineering to applications.

Erectile Dysfunction as a Cardiovascular Impairment

1st Edition
March 6, 2014
Robert Fried
English
Hardback
9 7 8 0 1 2 4 2 0 0 4 6 3
eBook
9 7 8 0 1 2 4 2 0 0 4 1 8

Erectile Dysfunction as a Cardiovascular Impairment organizes and summarizes the many aspects of biology and metabolism in cardiovascular and sexual function. Coverage includes how blood vessels are discovered to work, their role in hypertension, atherosclerosis, type-2 diabetes, oxidative stress, metabolic syndrome, and erectile dysfunction.

Aging

1st Edition
March 5, 2014
Victor R Preedy
English
Hardback
9 7 8 0 1 2 4 0 5 9 3 3 7
eBook
9 7 8 0 1 2 4 0 5 5 2 3 0

Aging: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in aging and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging.

Pattern Recognition and Signal Analysis in Medical Imaging

2nd Edition
March 5, 2014
Anke Meyer-Baese + 1 more
English
Paperback
9 7 8 0 1 2 8 1 0 1 1 6 2
eBook
9 7 8 0 1 2 4 1 6 6 1 5 8

Medical imaging is one of the heaviest funded biomedical engineering research areas. The second edition of Pattern Recognition and Signal Analysis in Medical Imaging brings sharp focus to the development of integrated systems for use in the clinical sector, enabling both imaging and the automatic assessment of the resultant data. Since the first edition, there has been tremendous development of new, powerful technologies for detecting, storing, transmitting, analyzing, and displaying medical images. Computer-aided analytical techniques, coupled with a continuing need to derive more information from medical images, has led to a growing application of digital processing techniques in cancer detection as well as elsewhere in medicine. This book is an essential tool for students and professionals, compiling and explaining proven and cutting-edge methods in pattern recognition for medical imaging.

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