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Books in Life sciences

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    • Drug Design and Discovery in Alzheimer’s Disease

      • 1st Edition
      • June 2, 2015
      • Atta-ur Rahman + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 0 3 9 5 9 5
      • eBook
        9 7 8 0 1 2 8 0 3 9 6 0 1
      Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of β-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery.

    • Food and Drug Regulation in an Era of Globalized Markets

      • 1st Edition
      • August 31, 2015
      • Sam F Halabi
      • English
      • Paperback
        9 7 8 0 1 2 8 0 2 3 1 1 2
      • eBook
        9 7 8 0 1 2 8 0 2 5 5 0 5
      Food and Drug Regulation in an Era of Globalized Markets provides a synthesized look at the pressures that are impacting today’s markets, including trade liberalization, harmonization initiatives between governments, increased aid activities to low-and middle-income countries, and developing pharmaceutical sectors in China and India. From the changing nature of packaged and processed food supply chains, to the reorientation of pharmaceutical research and funding coalesced to confront firms, regulators, and consumers are now faced with previously unknown challenges. Based on the 2014 O’Neill Institute Summer program, this book provides an international, cross-disciplinary look at the changing world of regulations and offers insights into requirements for successful implementation.

    • Medicinal Chemistry of Anticancer Drugs

      • 2nd Edition
      • April 28, 2015
      • Carmen Avendaño + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 4 6 2 6 4 9 3
      • eBook
        9 7 8 0 4 4 4 6 2 6 6 7 7
      Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design.

    • Omic Studies of Neurodegenerative Disease - Part A

      • 1st Edition
      • Volume 121
      • August 25, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 4 8 0 6
      • eBook
        9 7 8 0 1 2 8 0 1 6 2 1 3
      Omic Studies of Neurodegenerative Disease: Part A is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields. The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research.

    • Neuroscience of Pain, Stress, and Emotion

      • 1st Edition
      • December 28, 2015
      • Magne Arve Flaten + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 0 5 3 8 5
      • eBook
        9 7 8 0 1 2 8 0 0 6 6 6 5
      Neuroscience of Pain, Stress, and Emotion: Psychological and Clinical Implications presents updated research on stress, pain, and emotion, all key research areas within both basic and clinical neuroscience. Improved research understanding of their interaction is ultimately necessary if clinicians and those working in the field of psychosomatic medicine are to alleviate patient suffering. This volume offers broad coverage of that interaction, with chapters written by major researchers in the field. After reviewing the neuroscience of pain and stress, the contents go on to address the interaction between stress and chronic/acute pain, the role of different emotions in pain, neurobiological mechanisms mediating these various interactions, individual differences in both stress and pain, the role of patient expectations during treatment (placebo and nocebo responses), and how those relate to stress modulation. While there are books on the market which discuss pain, stress, and emotion separately, this volume is the first to tackle their nexus, thus appealing to both researchers and clinicians.

    • Introductory Experiments on Biomolecules and their Interactions

      • 1st Edition
      • March 6, 2015
      • Robert K. Delong + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 0 0 9 6 9 7
      • eBook
        9 7 8 0 1 2 8 0 1 0 1 2 9
      Introductory Experiments on Biomolecules and their Interactions provides a novel approach to teaching biomolecules in the lab. While featuring the requisite fundamentals, it also captures the author’s experience in industry, thus providing unique, up-to-date experiments which take the learning experience one-step further. The text parallels lectures using a standard biochemistry undergraduate text. Unlike most current lab manuals available in the market which simply emphasize an introduction of techniques, this lab manual provides students with opportunities to demonstrate and prove the knowledge and theories they learn from class.

    • Plant Nematode Interactions

      • 1st Edition
      • Volume 73
      • March 25, 2015
      • English
      • Hardback
        9 7 8 0 1 2 4 1 7 1 6 1 9
      • eBook
        9 7 8 0 1 2 4 1 7 1 8 0 0
      Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 73rd volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume features reviews on molecular and developmental aspects of the compatible plant-nematode interaction. The contributors all actively work in the field of molecular genetics and genomics of plant parasitic nematodes and nematode feeding sites. Reviews focus on molecular and physiological aspects of nematode feeding site development and includes specific chapters on nematode effectors as well as plant responses.

    • Hydrogen Sulfide in Redox Biology Part A

      • 1st Edition
      • Volume 554
      • February 23, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 5 1 2 4
      • eBook
        9 7 8 0 1 2 8 0 1 6 2 3 7
      These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes of Methods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, such as cardiovascular and nervous system as well as its function in inflammatory responses. Two chapters are also devoted to hydrogen sulfide in plants and a newcomer, molecular hydrogen, its function as a novel antioxidant.

    • Glycosylation and Cancer

      • 1st Edition
      • Volume 126
      • February 26, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 3 8 1 6
      • eBook
        9 7 8 0 1 2 8 0 1 6 1 4 5
      Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

    • Metabolic Analysis Using Stable Isotopes

      • 1st Edition
      • Volume 561
      • September 8, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 2 9 3 1
      • eBook
        9 7 8 0 1 2 8 0 2 5 3 4 5
      Metabolic Analysis Using Stable Isotopes, the newest volume in Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in metabolic analysis using stable isotopes.

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