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Elsevier

Books in Life sciences

  • Tabata Training

    The Science and History of HIIT
    • 1st Edition
    • Izumi Tabata
    • English
    Tabata Training: The Science and History of HIIT provides evidence and mechanism(s) that explain the beneficial effects Tabata training has on diseases like diabetes, cardiovascular diseases and colon cancer. The book also includes coverage of maximal oxygen uptake as an essential parameter of both sport and health-oriented fitness for researchers and exercisers. HIIT was first prepared for young adults, but nowadays, evidence has been accumulated to prescribe it to adult men and women. For kids, several papers have reported beneficial effects of Tabata training on normal and obese pupils of elementary to high school students as well as for physical education classes. Recent studies showed that not only improving sport performance, Tabata training contributes to good health outcomes in adults.

  • Single-Port Robotic Surgery in Urology

    The New Beginning After the Advent of Dedicated Platforms
    • 1st Edition
    • Riccardo Bertolo + 1 more
    • English
    **Selected for Doody’s Core Titles® 2024 in Urology**Single-Port Robotic Surgery in Urology: The New Beginning After the Advent of Dedicated Platforms describes the novel field of robotic single-port urologic surgery. Recent advances in surgical robotics combined with the pursuit to reduce the invasiveness of laparoscopic surgery have led to the development of novel robotic platforms specifically designed for single-port surgery. This reference summarizes the state-of-the-art of robotic single-port urologic surgery. Coverage takes a three-part approach, providing a description of the technological evolution which led to the advent of novel platforms specifically designed for single-port surgery, describing the urological procedures that can be performed, and outcomes and potential drawbacks.

  • The Vasculome

    From Many, One
    • 1st Edition
    • Zorina S. Galis
    • English
    The Vasculome: From Many, One introduces the fundamental bases of the “unity in diversity” of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney. Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section. Zorina Galis' The Vasculome was named a finalist in the Clinical Medicine category of the American Association of Publishers’ 2023 PROSE Awards.

  • Methods of Mathematical Modelling

    Infectious Diseases
    • 1st Edition
    • Harendra Singh + 2 more
    • English
    Methods of Mathematical Modeling: Infectious Diseases presents computational methods related to biological systems and their numerical treatment via mathematical tools and techniques. Edited by renowned experts in the field, Dr. Hari Mohan Srivastava, Dr. Dumitru Baleanu, and Dr. Harendra Singh, the book examines advanced numerical methods to provide global solutions for biological models. These results are important for medical professionals, biomedical engineers, mathematicians, scientists and researchers working on biological models with real-life applications. The authors deal with methods as well as applications, including stability analysis of biological models, bifurcation scenarios, chaotic dynamics, and non-linear differential equations arising in biology. The book focuses primarily on infectious disease modeling and computational modeling of other real-world medical issues, including COVID-19, smoking, cancer and diabetes. The book provides the solution of these models so as to provide actual remedies.

  • Genomic Medicine Skills and Competencies

    • 1st Edition
    • Dhavendra Kumar
    • English
    Genomic Medicine Skills and Competencies discusses core and practical aspects of genetic and genomic education and training for medical field. Many aspects of genomic applications in science, biotechnology, clinical medicine and healthcare require core and specialist knowledge, skills development and competencies for carrying out diverse tasks. Several knowledge-based courses and opportunities for skills and competencies development and assessment are now available and the main required subjects are discussed in this volume. The book focuses on all major aspects of genetic and genomic education training that are currently offered and evaluated and is a valuable resource for researchers, clinicians, physicians, nurses, genetic counselors, bioinformatics technicians, and other professionals who are interested in learning more about such promising field.

  • Applied Environmental Metabolomics

    Community Insights and Guidance from the Field
    • 1st Edition
    • David J. Beale + 3 more
    • English
    Applied Environmental Metabolomics: Community Insights and Guidance from the Field brings together contributions from global experts who have helped to define and develop the exciting and rapid advances that are taking place in the field of environmental metabolomics. This book is aimed at expert users, students, researchers, and academics in metabolomics and systems biology. It not only demonstrates the best practice in experimental design but also provides insight into state-of-the-art instrumentation and the depth of analysis one can expect to get by using various sampling, chromatographic, mass spectrometric, and nuclear magnetic resonance (NMR) techniques. Common experimental and technical pitfalls are also highlighted. This book provides a unique insight into the world of environmental metabolomics and will help the practicing scientist avoid repeating similar costly mistakes, steering them efficiently toward the generation of high-quality data and high-impact publications.

  • Macrophages in the Human Body

    A Tissue Level Approach
    • 1st Edition
    • Niels Olson Saraiva Camara + 1 more
    • English
    Through recent research, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators which ultimately altered the behavior of other cells. Moreover, environment signals modify and induce metabolic reprograming that it alters phenotype and functions.Macrophage... in the Human Body: A Tissue Level Approach presents a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics. It covers translational aspects where there is research support to indicate the therapeutic potential.

  • Comprehensive Pharmacology

    • 1st Edition
    • Terry P. Kenakin
    • English
    Comprehensive Pharmacology, Seven Volume Set is organized into twelve sections that explore therapeutic areas, with a total of 320 comprehensive articles and 6,800 pages of important findings. Sections contain highly detailed coverage of information that has been overseen by an editorial board made up of well-respected, field leading experts. The content in this book offers readers an in-depth and easily accessible reference work on every aspect of pharmacological research surrounding the pharmacology of all therapeutic applications of drugs, their mechanism of action and their therapeutic values. These elements are essential as drugs are almost never tested and developed in the actual therapeutic system, but rather in test systems from which parameters must be determined to predict activity in systems of varying ambient physiology. As different technologies rapidly evolve, there is an ever-increasing level of knowledge about the pharmacology of known drugs, along with increasing capability to utilize pharmacological systems to predict new drug activity, all of which must be communicated to professionals in varying fields.

  • The ERAS® Society Handbook for Obstetrics & Gynecology

    • 1st Edition
    • Gregg Nelson + 4 more
    • English
    The ERAS® Society Handbook for Obstetrics & Gynecology covers all aspects of enhanced recovery care for disciplines of general gynecology, gynecologic oncology, urogynecology and obstetrical surgery. Written by renowned experts in the field, chapters discuss foundational knowledge on ERAS and provide specific worked examples, ERAS order sets, and practical implementation tools. This book is an indispensable resource to researchers interested in ERAS, but it is also ideal for anesthesiologists, gynecologists and obstetricians interested in initiating an ERAS program. Enhanced Recovery After Surgery (ERAS) is a global surgical quality improvement initiative that originated in colorectal surgery and has now spread to numerous other disciplines, including gynecology (benign and malignant) and obstetrics (caesarean delivery). ERAS is associated with improvements in clinical outcomes (reduction in length of hospital stay, complications, readmissions), cost savings for the healthcare system, and patient satisfaction, hence the addition of this comprehensive resource on the topics is a welcomed addition to the available literature.

  • Sustainable Crop Productivity and Quality under Climate Change

    Responses of Crop Plants to Climate Change
    • 1st Edition
    • Fulai Liu + 5 more
    • English
    Sustainable Crop Productivity and Quality under Climate Change: Responses of Crop Plants to Climate Change explores the physiological, biochemical, and molecular basis of the responses of major crop plants to a range of climate change scenarios. From the development of climate-resilient crop varieties which lead to enhanced crop productivity and quality to better utilization of natural resources to ensure food security through modern breeding techniques, it presents insights into improving yield while securing the environment. Understanding the impact of climate on crop quality and production is a key challenge of crop science. Predicted increases in climate variability necessitate crop varieties with intrinsic resilience to cooccurring abiotic stresses such as heat, drought, and flooding in a future climate of elevated CO2. This book presents a much-needed mechanistic understanding of the interactions between multiple stress responses of plants that is required to identify and take advantage of acclimation traits in major crop species as a prerequisite for securing robust yield and good quality. This book is an excellent reference for crop and agricultural scientists, plant scientists, and researchers working on crop plant ecophysiology/stress physiology and future crop production.

  • Cancer Biomarkers: Clinical Aspects and Laboratory Determination

    • 1st Edition
    • Lakshmi V. Ramanathan + 2 more
    • English
    Cancer Biomarkers: Clinical Aspects and Laboratory Determination provides a comprehensive overview of current biomarkers for cancer detection, monitoring and recurrence, focusing on emerging technologies, impacts on the field, and selected biomarkers currently used in clinical practice. The content highlights current laboratory tests used in the management of adult and pediatric cancer patients. In addition, it investigates the role of Circulating Tumor Cells and circulating tumor DNA as biomarkers in cancer management as well as cytokines in monitoring response to CAR T therapies. This title is a perfect reference for clinical pathologists, laboratory scientists, medical technologists, physicians specializing in oncology, internal medicine, family practice and transplant medicine, resident physicians, medical students, nurse practitioners and clinical chemists.

  • Advances in Cardiovascular Technology

    New Devices and Concepts
    • 1st Edition
    • Jamshid Karimov + 2 more
    • English
    Advances in Cardiovascular Technology: New Devices and Concepts is a comprehensive reference for cardiovascular devices of all types. For engineers, this book provides a basic understanding of underlying pathologies and their prevalence/incidence... It also covers what devices are available, how they are clinically used, and their impact on pathophysiology. In addition, the book presents the constraints imposed on device design and manufacture by the environment in which it is used (e.g., exposure to tissues within the body, blood in particular) and the primary requirements for each specific type of device, including its durability and resistance to fatigue. For clinicians, this book contains information on primary engineering challenges, the types of devices available, their advantages and disadvantages, and the (current and emerging) tools and materials available to device designers.

  • Biology of Mycobacterial Lipids

    • 1st Edition
    • Zeeshan Fatima + 1 more
    • English
    Biology of Mycobacterial Lipids covers various topics pertaining to the advancements and current research in the field of mycobacterial lipids, and on the significant progress in lipidomics, in recent times. The chapters present comprehensive, yet systematic cutting-edge research, comprising mycobacterial lipid terminologies, classifications, biosynthetic pathways, tools and techniques, and functional burgeoning. This unique reference book has contributions from pioneer researchers, experts, and eminent veterans from around the globe. It covers ground-breaking work that will bridge the gap between understanding biochemical patterns related to virulence, pathogenesis, and resistance and elucidating new targets for drug design, identifying biomarkers for predicting risk, early diagnosis, and therapeutic outcome.

  • Updates in Thyroidology, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 51-2
    • Megan R. Haymart + 1 more
    • English
    In this issue of Endocrinology and Metabolism Clinics of North America, guest editors Drs. Megan R. Haymart and Maria Papaleontiou bring their considerable expertise to the topic of Thyroidology. Top experts in the field cover recent advances in the diagnosis and management of thyroid conditions, providing a contemporary view of updates in this challenging field.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 108
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 108, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release focusing on Nephrinuria and podocytopathies, Extracellular vesicles in respiratory disease, Diabetes and cognitive decline, Testosterone analysis in prostate cancer, Mono/polyclonal free light chains as challenging biomarkers for immunological abnormalities, and more.

  • Advances in Food and Nutrition Research

    • 1st Edition
    • Volume 100
    • Fidel Toldra
    • English
    Advances in Food and Nutrition Research, Volume 100 provides the latest advances on emerging bioactive compounds with putative health benefits and their controlled release and application in foods and nutraceuticals, as well as up-to-date information on recent developments in food technology, including 3D printing, safety of raw materials and viruses in foods, and new low energy food processing.

  • Food Proteomics

    Technological Advances, Current Applications and Future Perspectives
    • 1st Edition
    • Maria Lopez Pedrouso + 2 more
    • English
    Food Proteomics: Technological Advances, Current Applications and Future Perspectives addresses many of the food proteomic issues in the industry today. Food proteomics continues to be an emerging field, becoming increasingly important in product innovation, food safety, food quality and health. The book is divided into sections describing the role of proteomics in the field of food science, conceptual background methodological aspects, and bioinformatic tools employed in the field. The book describes proteomic studies collected from the most relevant animal and vegetables species in food production and discusses important food challenges from a proteomic point-of-view. This is an essential and practical reference that provides analytical tools to help introduce technical innovations in the food industry with the latest scientific information useful and accessible to new researchers in the field as well as advanced.

  • New Insights on the Development of the Vascular System

    • 1st Edition
    • Domenico Ribatti
    • English
    New Insights on the Development of the Vascular System examines the most recent literature and data on the development of the vascular system, along with advice on new laboratory techniques and approaches to data analysis. This volume is a comprehensive handbook to the state-of-the-art in vascular system development. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system, and there is extensive literature on the genetic background and molecular mechanisms responsible for blood vessel formation. Yet new data and techniques have been developed in recent years. Although scientific literature covers the descriptive aspects of embryonic vascular system development, modern techniques such as the technology of cell fusion, cell sorting and image analysis give new insight into the mechanisms by which vessels form and regress and how blood flow changes directions in the same vessels.

  • New Targets for the Treatment of Hypertension and Associated Diseases

    • 1st Edition
    • Volume 94
    • English
    New Targets for the Treatment of Hypertension and Associated Diseases, Volume 94 in the Advances in Pharmacology serial, highlights new advances in the field, with this new volume presenting interesting chapters on Cytochrome P450, 20-hydroxyeicosatetr... acid and GPR75 pathway in hypertension, Treatment of hypertension with soluble epoxide hydrolase inhibitors, Effects of allosteric modifiers of adenosine receptors in the heart, Orally active epoxyeicosatrienoic acid analogs in hypertension and renal injury, Drugs affecting the nitric oxide- cyclic GMP pathway in hypertension, Relaxin-2 and Serelaxin in renal and cardiac dysfunction in hypertension, and more.

  • Loneliness in Older Adults

    Effects, Prevention, and Treatment
    • 1st Edition
    • Luis Miguel Rondon Garcia
    • English
    Loneliness in Older Adults: Effects, Prevention, and Treatment analyzes loneliness as a complex phenomenon, taking into account the most recent contributions from neuroscience, psychology, medicine and sociology. This volume describes this phenomenon from an interdisciplinary point of view, with special emphasis on older people from a plural and heterogeneous perspective: older people in general, older immigrants, older women, older LGTBI, etc. Faced with the impact of this emerging issue, this book provides a comprehensive knowledge of loneliness, contributing scientific knowledge to the practice of evidence. Tools are also provided for professionals, providing intervention protocols with debates and proposals, and effective digital resources to combat it. Tables, images, and tools guide students, academics, and professionals step-by-step in solving the cases raised, through an integrated practice. There is no work that develops this theme from such a plural and pragmatic perspective, covering all the dimensions of loneliness in each of the thematic axes: psychological, neurological, social, and health. Readers are provided feedback for all the knowledge for a comprehensive scientific knowledge based on evidence and given the necessary instrumental skills related to being social and the functioning of our brain. This book is aimed at a very plural audience of researchers, academics and professionals in the social and behavioral sciences including psychologists, sociologists, social workers, anthropologists, and also professionals in the health sciences, among others.

  • Mathematical Analysis of Infectious Diseases

    • 1st Edition
    • Praveen Agarwal + 2 more
    • English
    Mathematical Analysis of Infectious Diseases updates on the mathematical and epidemiological analysis of infectious diseases. Epidemic mathematical modeling and analysis is important, not only to understand disease progression, but also to provide predictions about the evolution of disease. One of the main focuses of the book is the transmission dynamics of the infectious diseases like COVID-19 and the intervention strategies. It also discusses optimal control strategies like vaccination and plasma transfusion and their potential effectiveness on infections using compartmental and mathematical models in epidemiology like SI, SIR, SICA, and SEIR. The book also covers topics like: biodynamic hypothesis and its application for the mathematical modeling of biological growth and the analysis of infectious diseases, mathematical modeling and analysis of diagnosis rate effects and prediction of viruses, data-driven graphical analysis of epidemic trends, dynamic simulation and scenario analysis of the spread of diseases, and the systematic review of the mathematical modeling of infectious disease like coronaviruses.

  • Mitochondria as a Key Intracellular Target of Thallium Toxicity

    • 1st Edition
    • Sergey Korotkov
    • English
    Approx.264 pages

  • Cyanobacterial Physiology

    From Fundamentals to Biotechnology
    • 1st Edition
    • Hakuto Kageyama + 1 more
    • English
    Cyanobacteria are ancient, primordial oxygenic phototrophs, and probably the progenitor of oxygen-evolving photosynthesis. They are a prolific source of natural products and metabolites and vitally important for environmental biology and biotechnology. Cyanobacterial Physiology presents foundational knowledge alongside the most recent advances in cyanobacterial biology. The title examines the challenges of industrial application through an understanding of the basic molecular machinery of cyanobacteria. Sixteen chapters are organized into three sections. The first part covers basic cyanobacterial biology, emphasizing environmental biology such as photosynthesis, nitrogen fixation, circadian rhythm, and programmed cell death. The second part includes the chapters that discuss cyanobacterial extremophiles, adaptations, secondary metabolites, osmoprotectants, and toxins. The third part covers aspects of cyanobacterial application that are based on environmental biology. Leading scientists contribute chapters on cyanobacteria. Cyanobacterial Physiology presents a comprehensive and vibrant solution for researchers and engineers in biotechnology interested in cyanobacteria and their applications. Topics include the cyanobacterial cell and fundamental physiological processes; the biotechnological potential of cyanobacteria with their versatile metabolism; and advanced applications of cyanobacterial products. At each stage the book is informed by basic and applied research.

  • Microbial Xylanolytic Enzymes

    • 1st Edition
    • Pratima Bajpai
    • English
    Microbial Xylanolytic Enzymes describes the enzyme structure and its interaction with plant cell walls, the properties and production of different enzymes and their applications, and the knowledge gathered on the hydrolysis mechanism of hemicellulose. The knowledge gathered about the hydrolysis mechanism of the hemicelluloses, especially xylans, has greatly promoted the rapid application of these enzymes in new areas. In recent years, there has been a spurt of interest in xylan degrading enzymes due to their applications in several industrial processes, including paper and pulp industries, food and feed industries, biofuel industry, textile industry, chemical and pharmaceutical industry, brewing industry, and more. Xylan is the principal type of hemicellulose. An enzymatic complex is responsible for the hydrolysis of xylan, but the main enzymes involved are enzymes produced by fungi, bacteria, yeast, algae, protozoans, and more.

  • The Vascular Endothelium

    A Holistic Approach for Oncology
    • 1st Edition
    • Domenico Ribatti + 1 more
    • English
    The Vascular Endothelium: A Holistic Approach for Oncology provides novel and integrated knowledge on the endothelial cells as a crucial component involved in the growth of different organs in both physiological and pathological conditions. By covering diverse aspects of anatomy, embryology, molecular biology and pathology, it details the important role of the endothelium for the pathogenesis of cancer and how this knowledge can improve the outcome of cancer research.The content is split in six parts: appearance and evolution of the endothelial cell, which discusses for instance comparative anatomy of the endothelium in relation to the vascular system; endothelial cell in embryology and organogenesis, covering the interaction between endothelial and hematopoietic cells; the lymphatic system, which brings information on lymphatic endothelial cell markers and molecular regulation of lymphangiogenesis; the anatomy of the endothelium in adults, showing the differences in the mature endothelial cells through the body; the physiology of the endothelial cells, with organ specific physiological activity of the endothelium; and the endothelial cells in cancer, discussing the use of endothelium as target for treatment and current therapeutic approaches.This book is a valuable resource for cancer researchers, oncologists and other members of biomedical field who are interested to learn more about the complexity of vascular endothelium and its impact on cancer and other related diseases.

  • Feed and Feeding Practices in Aquaculture

    • 2nd Edition
    • D. Allen Davis
    • English
    Feed and Feeding Practices in Aquaculture, Second Edition continues to play an important role in the successful production of fish and other seafood for human consumption. This is an excellent resource for understanding the key properties of feeds for aquaculture, advances in feed formulation and manufacturing techniques, and the practicalities of feeding systems and strategies. Many new updates have been integrated to reflect recent advances within the market, including special emphasis on up-and-coming trends and new technologies on monitoring fish feeding patterns, making this book useful for anyone working in R&D in the production of feed, as well as nutritionists, farm owners and technicians, and academics/postgradua... students with a research interest in the area.

  • Essential Human Virology

    • 2nd Edition
    • Jennifer Louten
    • English
    *Textbook and Academic Authors Association (TAA) Textbook Excellence Award Winner, 2024*Essential Human Virology, Second Edition focuses on the structure and classification of viruses, virus transmission and virus replication strategies based upon type of viral nucleic acid. Several chapters focus on notable and recognizable viruses and the diseases caused by them, including influenza, HIV, hepatitis viruses, poliovirus, herpesviruses and emerging and dangerous viruses. Additionally, how viruses cause disease (pathogenesis) is highlighted, along with discussions on immune response to viruses, vaccines, anti-viral drugs, gene therapy, the beneficial uses of viruses, research laboratory assays and viral diagnosis assays.Fully revised and updated with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses, the book provides students with a solid foundation in virology.

  • Geminivirus: Detection, Diagnosis and Management

    • 1st Edition
    • R.K. Gaur + 2 more
    • English
    Geminivirus: Detection, Diagnosis and Management focuses on the latest techniques for managing diseases caused by these circular, single-stranded (ss) DNA genomes. The most significant impact of plant diseases in host populations is often caused by emerging diseases, whose incidence in a plant host is increasing as a result of long-term changes in their underlying epidemiology. Genetic changes in pathogen and host populations, as well as changes in host ecology and environment, are major factors contributing to disease emergence. Understanding plant virus evolution is crucial for modeling the within-host and between-host dynamics and genetics of virus populations. The book presents a comprehensive review of how these viruses develop, including contributing factors such as population bottlenecks during cell-to-cell movement, systemic colonization, or between-host transmission by different procedures. Presented in five sections—Detection and Diagnosis, Emergence and Diversity, Vector and Transmission, Virus–Host Interaction, and Disease Management, the book includes host range determinant and virulence factors involved in pathogenesis, virus–vector interactions during acquisition, retention, and transmission and evaluating management strategies to control Geminivirus. The book is an essential reference for students and researchers interested in plant virology, particularly begomoviruses, geminiviruses, and vector transmission biology. Introduces identification and characterization of geminiviruses that infect agricultural crops, their wild relatives, and weed hosts Discusses recombination and reassortment mechanisms influencing viral genetic diversity, virulence, and vector transmission Explores the origin, evolution, and bottlenecks of Geminiviruses

  • Advances in Plant Tissue Culture

    Current Developments and Future Trends
    • 1st Edition
    • Avinash Chandra Rai + 3 more
    • English
    Advances in Plant Tissue Culture: Current Developments and Future Trends provides a complete and up-to-date text on all basic and applied aspects of plant tissue cultures and their latest application implications. It will be beneficial for students and early-career researchers of plant sciences and plant/agricultural biotechnology. Plant tissue culture has emerged as a sustainable way to meet the requirements of fresh produces, horticultural crops, medicinal or ornamental plants. Nowadays, plant tissue culture is an emerging filed applied in various aspects, including sustainable agriculture, plant breeding, horticulture and forestry. This book covers the latest technology, broadly applied for crop improvement, clonal propagation, Somatic hybridization Embryo rescue, Germplasm conservation, genetic conservation, or for the preservation of endangered species. However, these technologies also play a vital role in breaking seed dormancy over conventional methods of conservation.

  • Biochemistry of Drug Metabolizing Enzymes

    Trends and Challenges
    • 1st Edition
    • Muhammad Sajid Hamid Akash + 1 more
    • English
    Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsible for their deactivation, and their malfunction. Chapters explain the biochemistry of DMEs, including biochemical activation, functions, computational approaches, different contaminants on the action and function of DMEs, and describe the importance of DMEs in the drug development process. Conditions covered include metabolic diseases, cardiovascular diseases, neurological diseases, physiological diseases, xenobiotics and inflammatory responses, and their contribution in the malfunctioning of drug metabolizing enzymes. This book is the perfect resource for pharmacology and biochemistry researchers to understand the principles of DMEs. Researchers in the corporate environment will also benefit from the comprehensive list of diseases associated with malfunction of DMEs.

  • Environmental, Physiological and Chemical Controls of Adventitious Rooting in Cuttings

    • 1st Edition
    • Azamal Husen
    • English
    Environmental, Physiological and Chemical Controls of Adventitious Rooting in Cuttings provides a review of the environmental, physiological and chemical controls of adventitious rooting in cuttings obtained from plants. In plants, adventitious roots, which are highly useful for vegetative propagation (or clonal propagation) are produced mainly from leaves, hypocotyls, stems or shoots. Vegetative propagation may occur naturally by using propagules such as roots, underground and aerial stems, leaves, buds and bulbils. It may also be done artificially through regenerative organs (rhizomes, bulbs, and corms) and by utilizing specialized methods, like cutting, grafting and layering. This book covers the latest tactics surrounding these processes. As a plethora of factors affect the adventitious rooting of cuttings, adding to the complexity of the phenomenon. The main factors which control adventitious root formation are types of cuttings, presence of leaf area on cuttings, types of hormones and their concentration, duration of hormonal treatment (quick dip, long soak, dry dip, spray dip, or total immerse method), maturation (juvenile or mature), genotype, explant position, and more, all of which are discussed here.

  • Coenzyme B12 Enzymes Part B

    • 1st Edition
    • Volume 669
    • English
    Coenzyme B12 Enzymes, Part B, Volume 169 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on Structural characterization of cobalamin-dependent radical SAM methylases, Purification and characterization of sequential cobalamin-dependent radical SAM methylases ThnK and TokK in -lactam antibiotic biosynthesis, Characterization of the cobalamin-dependent radical S-adenosyl-L-methion... enzyme C-methyltransferase Fom3 in fosfomycin biosynthesis, Studies of OxsB and GenK, two B12-dependent radical SAM enzymes involved in natural product biosynthesis, Purification and structural elucidation of the cobalamin-dependent radical SAM enzyme OxsB, and more. Other chapters discuss Methods for studying the mechanisms of B12 enzymes, Computational investigations of B12 dependent enzymatic reactions, Using kinetic isotope effects to probe the mechanisms of adenosylcobalamin-de... enzymes, Steady-state and pre-steady state kinetic analysis of ornithine 4,5-aminomutase, and more.

  • Plant Nematode Biopesticides

    • 1st Edition
    • Anwar L. Bilgrami + 1 more
    • English
    Plant Nematode Biopesticides presents the most current knowledge on various categories of biopesticides used in the management of nematode pests of crops or those that have significant potential as biological control agents. This book presents an exploratory and investigatory compilation and explanation of the actions and potentials of predatory nematodes, microbial agents, plant and other organic products, nanobiopesticides, and predatory invertebrates as biopesticides of nematode pests of agricultural crops. It is of unique importance and value as the only currently available single-volume resource focusing on plant parasitic nematodes as the pests and biopesticides. In addition, the book addresses common reservations in using biopesticides, either alone or in integrated pest management programs, providing advanced insights on various biopesticidal agents and products. Biopesticides may be microbial (nematodes, bacteria, fungi, virus, herbs etc.), plant-incorporated protectants (PIPs), plant products (citronella oil, neem oil, capsaicin, pyrethrin etc.), synthetic biochemical molecules, pheromones, semio-chemicals, plant extracts, or nanobiopesticides.

  • Essential Tremor: Current Concepts and Controversies

    • 1st Edition
    • Volume 163
    • Sheng-Han Kuo + 1 more
    • English
    Tremors, Volume 163 in the International Review in Neurobiology serial highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Neurosurgical Management of Psychiatric Disorders, Part B

    • 1st Edition
    • Volume 272
    • English
    Neurosurgical Management of Psychiatric Disorders, Part B, Volume 267 in the Progress in Brain Research serial highlights new advances in the field with this new volume presenting interesting chapters on topics such as the Neurosurgical Management of Tourette Syndrome, Stereotactic Surgeries for Opioid Addiction: Patient Selection and Results, Psychiatric Disorders as Indication for Surgical Management of Drug-Resistant Temporal Epilepsy, Surgery of Autism: Is it Possible?, Psychogenic Pain: Diagnosis and Management, Stereotactic Cingulotomy and Capsulotomy for Obsessive-Compulsive Disorders: Indications and Comparative Results, and much more.

  • Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-oncology

    From Basic Research to Advanced Study
    • 1st Edition
    • Imteyaz Qamar + 1 more
    • English
    Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-Oncology: From Basic Research to Advanced Study analyzes the emerging the field of cardio-oncology, reviewing recent advancements in the field, discussing how to monitor and treat cancer survivors for cardiotoxicity, and identifying potential cardiac side effects in novel cancer therapies. By adopting a translational approach, the book first comprehensively covers the basic science, mechanisms and concepts, which is followed by advanced state-of-art of cardio-oncology. Other sections cover tyrosine kinase inhibitors, Anthracyclines, and biomarkers in cardiotoxicity induced by chemotherapeutic drugs, noninvasive cardiovascular imaging techniques, radiotherapy induced cardiovascular, and more. Anti-cancer treatment is associated with serious cardiovascular adverse events, including arterial and pulmonary hypertension, supraventricular and ventricular arrhythmias, systolic and diastolic cardiac dysfunction and coronary artery disease. Progress in cancer therapy over the past decades improved long-term survival but increased cancer therapy-related cardiotoxicity. Both traditional chemotherapeutic agents and newer therapies have demonstrated profound cardiovascular toxicities. It is important to understand the mechanisms of these toxicities to establish strategies for the prevention and management of complications—arrhyt... heart failure, and even death.

  • Redox Chemistry and Biology of Thiols

    • 1st Edition
    • Beatriz Alvarez + 3 more
    • English
    Redox Chemistry and Biology of Thiols offers an applied, comprehensive overview of redox chemistry and biology of thiol-dependent processes. Running from basic biology and chemistry of redox phenomena to research methods and highlighting recently identified roles of thiols across cellular and bodily systems, this book draws upon a range of disciplines to illuminate new research directions, new applications of thiol studies, and clinical translation. Sections cover thiol oxidizing species, thiol reactivity and modifications, thioredoxin, glutaredoxin, glutathione, peroxidases, thiol repair enzymes, thiol oxidative signaling, disulfide bond formation, thiol-based redox biosensors, cysteine and hydrogen sulfide metabolism, iron-sulfur cluster biogenesis, thiols in chloroplasts, blood thiols, sugar and polyamine thiols in pathogenic organisms, redox medicine (therapeutic applications of thiols and drug development), as well as methods and bioinformatics tools.

  • Covid-19: Biomedical Perspectives

    • 1st Edition
    • Volume 50
    • English
    Covid-19: Biomedical Perspectives, Volume 50 in the Methods in Microbiology series highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Individual chapters in this new release include Sensitive methods for detection of SARS-CoV-2 RNA, Treatment of COVID-19 using Chinese herbal medicine, Understanding how SARS-CoV-2 is evolving and its impact on COVID-19 animal models and vaccine evaluation, Methods in machine learning to identify COVID-19 literature, COVID-19 seasonal behavior and the mutational landscape of the SARS-CoV-2 virus, CRISPR use in Diagnosis and Therapy for COVID-19, and much more.

  • Braconidae of the Middle East (Hymenoptera)

    Taxonomy, Distribution, Biology, and Biocontrol Benefits of Parasitoid Wasps
    • 1st Edition
    • Neveen S. Gadallah + 2 more
    • English
    Braconidae of the Middle East (Hymenoptera): Taxonomy, Distribution, Biology, and Biocontrol Benefits of Parasitoid Wasps provides the latest and most comprehensive knowledge of parasitoid wasp species. The highest concentration of these species is native to, or found in, the Middle East. This book covers the distribution of these species across the Palearctic region and their widespread global benefits as natural biocontrol agents. Each chapter covers a braconid subfamily, providing introductory information on its biology and phylogeny, total number of species, global distribution, and how they can be used to control pests and invasive insect species. In addition, this book discusses the importance of integrated pest management, specifically how Braconidae can be used for one-time or repeated introduction to natural enemies in suppressing pest populations. Finally, each chapter offers an illustrative key for readers to visualize and identify each species.

  • Carbon Dots in Agricultural Systems

    Strategies to Enhance Plant Productivity
    • 1st Edition
    • Raju Khan + 2 more
    • English
    Carbon Dots in Agricultural Systems integrates and crystallizes the emerging knowledge and application strategies of carbon dots as a powerful tool in agriculture systems. The book includes practical insights into the synthesis of carbon dots from indigenous raw materials and how to employ them in agriculture systems to increase crop productivity and provide renewable and cost-effective strategies that meet agricultural needs. Presented by an international team of experts, this resource updates on the latest in synthesis, physical, chemical and optical properties, along with the effects and mechanisms of carbon dots, all further explained in real-world studies. Finally, the book highlights emerging innovative topics which are of great relevance to scientists, academicians and innovators in agriculture (soil science, agricultural chemistry and agronomy) and biotechnology for further research and development.

  • Nanotheranostics for Treatment and Diagnosis of Infectious Diseases

    • 1st Edition
    • Keerti Jain + 1 more
    • English
    Nanotheranostics for Treatment and Diagnosis of Infectious Diseases comprises the latest information on the technological advancements made in the field of nanotechnology for application in therapeutics with diagnostic applications. The book focuses on the theranostic applications of nanomaterials in infectious diseases, highlighting that rapid diagnosis, safe and effective treatment and strong preventive measures like vaccines are urgently needed. It compiles all relevant information to help scientists, researchers and students understand the role of nanomaterials, how nanomaterials could be explored simultaneously for therapeutic and diagnostic applications, and how to ensure safety and efficacy of these nanomaterials. Sections cover fundamental concepts, emerging concerns and challenges to combat infectious diseases, the characterization of nanomaterials for theranostic applications, and the toxicity, biocompatibility and regulatory perspectives in the diagnosis and treatment of infectious diseases.

  • Sex and Gender Bias in Technology and Artificial Intelligence

    Biomedicine and Healthcare Applications
    • 1st Edition
    • Davide Cirillo + 2 more
    • English
    Sex and Gender Bias in Technology and Artificial Intelligence: Biomedicine and Healthcare Applications details the integration of sex and gender as critical factors in innovative technologies (artificial intelligence, digital medicine, natural language processing, robotics) for biomedicine and healthcare applications. By systematically reviewing existing scientific literature, a multidisciplinary group of international experts analyze diverse aspects of the complex relationship between sex and gender, health and technology, providing a perspective overview of the pressing need of an ethically-informed science. The reader is guided through the latest implementations and insights in technological areas of accelerated growth, putting forward the neglected and overlooked aspects of sex and gender in biomedical research and healthcare solutions that leverage artificial intelligence, biosensors, and personalized medicine approaches to predict and prevent disease outcomes. The reader comes away with a critical understanding of this fundamental issue for the sake of better future technologies and more effective clinical approaches.

  • Principles and Practice of Ovarian Tissue Cryopreservation and Transplantation

    • 1st Edition
    • Kutluk Oktay
    • English
    Principles and Practice of Ovarian Tissue Cryopreservation and Transplantation provides methods and techniques of ovarian tissue harvesting and cryopreservation, including instructional videos. This book will benefit a wide audience, guiding infertility specialists, fellows, residents, reproductive surgeons, reproductive endocrinologists, pediatric surgeons, embryologists, infertility nurses and gynecologists. Ovarian cryopreservation and transplantation is rapidly gaining acceptance as a successful and established fertility preservation strategy in cancer patients and beyond. Unlike other fertility preservation strategies, it can be performed in children as well as adults, and can be helpful in restoring natural ovarian function and fertility, hence this is a welcomed resource on the topic.

  • One, No One, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part B

    • 1st Edition
    • Volume 368
    • English
    One, No One, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part B, Volume 369 provides in-depth reviews on the last progresses on the role of macrophages in health and diseases, with a special focus on the role of macrophages during development. New chapters cover The role of salivary gland macrophages in infection, disease and repair, Reprogramming or replacing brain macrophages to treat neurodegenerative disease, Targeting macrophages for cancer immunotherapy, Heart Macrophages at steady-state and disease: simple bystanders or active players?, Macrophages in the liver, and Developmental programming of macrophages.

  • Algae-Based Biomaterials for Sustainable Development

    Biomedical, Environmental Remediation and Sustainability Assessment
    • 1st Edition
    • Huu Hao Ngo + 4 more
    • English
    Biomass, Biofuels, and Biochemicals: Algae-Based Biomaterials for Sustainable Development, Biomedical, Environmental Remediation and Sustainability Assessment, a new release in the Biomass, Biofuels, and Biochemicals series, covers algae-based biomaterials—the green and renewable material that can be produced from various micro- and macro-algae species and utilized for several applications, including biomedical healthcare and environmental remediation. The book provides assessments of the current development of algae-based biomaterials, delivering information on diverse feedstocks and technologies for biomaterial production with a perspective surrounding sustainable development. In addition, circular bioeconomy aspects are included, giving researchers a comprehensive, sustainable development view. This valuable addition to the series delivers a much-needed reference for today’s applications in biomedical and environmental remediation.

  • The Pituitary

    • 5th Edition
    • Shlomo Melmed
    • English
    The Pituitary, Fifth Edition continues the tradition of a cogent blend of basic science and clinical medicine. The comprehensive text written by expert pituitary scholars is devoted to the pathogenesis, diagnosis and treatment of pituitary disorders. The new fifth edition has been extensively revised to reflect the most recent data on new research advances in tumorigenesis and new therapeutic approaches for pituitary tumors, particularly in acromegaly and Cushing disease. Notably, new chapters devoted to the Pituitary-Immune Interface and Pituitary Radiotherapy have been included, along with a chapter on Aggressive Pituitary Adenomas developed to align with the WHOs Classification of Pituitary Tumors. Furthermore, new authors have been invited, ensuring a fresh perspective on critical issues in the field. This extensive body of knowledge is useful for students, trainees, physicians, and scientists who need to understand critical pituitary functions and how to care for patients with pituitary disorders.

  • Big Data Analytics for Healthcare

    Datasets, Techniques, Life Cycles, Management, and Applications
    • 1st Edition
    • Pantea Keikhosrokiani
    • English
    Big Data Analytics and Medical Information Systems presents the valuable use of artificial intelligence and big data analytics in healthcare and medical sciences. It focuses on theories, methods and approaches in which data analytic techniques can be used to examine medical data to provide a meaningful pattern for classification, diagnosis, treatment, and prediction of diseases. The book discusses topics such as theories and concepts of the field, and how big medical data mining techniques and applications can be applied to classification, diagnosis, treatment, and prediction of diseases. In addition, it covers social, behavioral, and medical fake news analytics to prevent medical misinformation and myths. It is a valuable resource for graduate students, researchers and members of biomedical field who are interested in learning more about analytic tools to support their work.

  • Neurobiology of Brain Disorders

    Biological Basis of Neurological and Psychiatric Disorders
    • 2nd Edition
    • Michael J. Zigmond + 2 more
    • English
    Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegeneration, infectious diseases, and diseases of higher function. Organized by individual disorder, each chapter includes coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. This volume reflects progress in the field since publication of the first edition, with fully updated chapters, and new chapters on isolation, aging, global diseases, vascular diseases, and toxic/metabolic disease. New disorder coverage includes fibromyalgia, chronic fatigue, Restless Legs Syndrome, myasthenia gravis, and more.

  • Protein Kinase Inhibitors

    From Discovery to Therapeutics
    • 1st Edition
    • Md. Imtaiyaz Hassan + 1 more
    • English
    Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in disease modulation and treatment. Here, international experts in the field offer an integrated discussion of kinase inhibitor biology, biomarker discovery, and methods for drug design and development. After a brief overview of kinases and kinase inhibitors, subsequent chapters discuss individual kinases that are representative of the wider kinases and kinase families, including their roles in disease pathogenesis, underlying mechanisms, potential inhibitors and their modes of action for therapeutic modulation. Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development.

  • Headache and Migraine in Practice

    • 1st Edition
    • Mansoureh Togha + 4 more
    • English
    Headache and Migraine in Practice provides practical and precise approaches to the headaches and facial pains commonly encountered in hospitals and clinics. The book pays specific attention to the clinical features of headaches to present treatment solutions, while also recommending ICHD3 differential diagnoses based on diagnostic criteria. Topics covered were developed by colleagues with expertise in Neurology, Nutrition, Psychiatry, Physical Medicine, and Sports Medicine, thus providing a collaborative authorship that adds interdisciplinary value. Sections cover the diagnosis and treatment of various types of headaches in children, the elderly and women during different periods of pregnancy, lactation and hormone-related stages. This book is recommended for general practitioners, internists, neurologists, headache nurse specialists, and all others who would like to contribute to better diagnoses and more effective treatment plans for patients with headaches and facial pains.

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