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    • A Comprehensive Guide to Toxicology in Nonclinical Drug Development

      • 2nd Edition
      • November 3, 2016
      • Ali S. Faqi
      • English
      • Hardback
        9 7 8 0 1 2 8 0 3 6 2 0 4
      • eBook
        9 7 8 0 1 2 8 0 3 6 2 1 1
      A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

    • Retrograde Ureteroscopy

      • 1st Edition
      • April 7, 2016
      • Petrisor Aurelian Geavlete
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 4 0 3 4
      • eBook
        9 7 8 0 1 2 8 0 2 6 6 2 5
      Retrograde Ureteroscopy: Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology, with all chapters describing the most recent techniques, reviewing the latest results, and analyzing the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic, minimally-invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides a quick references with over 4000 images that are appropriate for fellows and those teaching in the field.

    • Adult Neurogenesis in the Hippocampus

      • 1st Edition
      • March 23, 2016
      • Juan J. Canales
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 9 7 7 1
      • eBook
        9 7 8 0 1 2 8 0 1 9 9 2 4
      Neurogenesis in the adult brain has emerged as one of the most dynamic and rapidly moving fields in modern neuroscience research. The implications of adult neurogenesis for health and well-being are wide-ranging, with findings in this area having distinct relevance for treatment and rehabilitation in neurology and psychopathology. Adult Neurogenesis in the Hippocampus addresses these implications by providing an up-to-date account on how neurogenesis in the adult hippocampus contributes to critical psychological and physiological processes, such as learning and memory, and how it is modified by life experiences, such as aging, environmental enrichment, exercise, and dieting. The book also provides the most current reviews of how adult hippocampal neurogenesis influences the pathogenesis of mood disorders, addiction, and key neurological disorders. This book is the ideal resource for researchers and advanced graduates seeking focused knowledge on the role of adult neurogenesis in brain health and disease.

    • Dynemicin A, Uncialamycin and Analogues

      • 1st Edition
      • June 14, 2016
      • Daniel Best + 2 more
      • English
      • Hardback
        9 7 8 1 7 8 5 4 8 1 5 0 5
      • eBook
        9 7 8 0 0 8 1 0 1 0 8 6 0
      Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis.Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs.

    • Non-Equilibrium States and Glass Transitions in Foods

      • 1st Edition
      • November 10, 2016
      • Bhesh Bhandari + 1 more
      • English
      • Hardback
        9 7 8 0 0 8 1 0 0 3 0 9 1
      • eBook
        9 7 8 0 0 8 1 0 0 3 3 5 0
      Non-equilibrium States and Glass Transitions in Foods: Processing Effects and Product Specific Implications presents the tactics needed to understand and control non-equilibrium states and glass transitions in food, an essential element in maintaining the shelf-life and quality of foods. After brief introductory chapters introduce the science behind non-equilibrium states and glass transitions in foods, the book details how glass transition temperature is affected by composition and the ways it influences processability and physico-chemical changes during the storage of foods, also exploring how these effects can be controlled. The second section looks at individual foods, highlighting the implications of non-equilibrium states and glass transitions within these foods. Maintaining and improving the quality of food is of upmost importance to food companies who have to ensure that the shelf life of their products is as long as possible. A large amount of research has been performed into glass transitions in food over the last few years, however there has not been a comprehensive review. This book fills that gap.

    • Computational Approaches for Studying Enzyme Mechanism Part A

      • 1st Edition
      • Volume 577
      • August 4, 2016
      • English
      • Hardback
        9 7 8 0 1 2 8 0 5 3 4 7 8
      • eBook
        9 7 8 0 1 2 8 0 5 3 6 3 8
      Computational Approaches for Studying Enzyme Mechanism Part A, is the first of two volumes in the Methods in Enzymology series, focusses on computational approaches for studying enzyme mechanism. The serial achieves the critically acclaimed gold standard of laboratory practices and remains one of the most highly respected publications in the molecular biosciences. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 550 volumes, the series remains a prominent and essential publication for researchers in all fields of life sciences and biotechnology, including biochemistry, chemical biology, microbiology, synthetic biology, cancer research, and genetics to name a few.

    • Gaseous Air Pollutants and Plant Metabolism

      • 1st Edition
      • March 5, 2016
      • M. J. KozioÅ‚ + 1 more
      • English
      • Hardback
        9 7 8 0 4 0 8 1 1 1 5 2 2
      • Paperback
        9 7 8 1 4 8 3 1 3 2 9 4 5
      • eBook
        9 7 8 1 4 8 3 1 6 5 3 6 3
      Gaseous Air Pollutants and Plant Metabolism mainly talks about plants and air pollution. The publication of this book is inspired by a symposium on plants and pollution, which generated great interest among the personnel related to the field. The book begins with a brief background on air pollution and continues with a discussion on different types, effects, and solutions to the pollution. The book also features studies about the gaseous air pollution in North America, China, and Japan. The chapters that follow explore the different effects of pollution on chloroplasts, respiration, biochemistry, plant, and plant cells. The text is a valuable reference to undergraduates or postgraduates of chemistry and its related studies.

    • The Teeth of Non-Mammalian Vertebrates

      • 1st Edition
      • October 14, 2016
      • Barry Berkovitz + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 8 5 0 6
      • eBook
        9 7 8 0 1 2 8 0 2 8 8 4 1
      The Teeth of Non-Mammalian Vertebrates is the first comprehensive publication devoted to the teeth and dentitions of living fishes, amphibians and reptiles. The book presents a comprehensive survey of the amazing variety of tooth forms among non-mammalian vertebrates, based on descriptions of approximately 400 species belonging to about 160 families. The text is lavishly illustrated with more than 600 high-quality color and monochrome photographs of specimens gathered from top museums and research workers from around the world, supplemented by radiographs and micro-CT images. This stimulating work discusses the functional morphology of feeding, the attachment of teeth, and the relationship of tooth form to function, with each chapter accompanied by a comprehensive, up-to-date reference list. Following the descriptions of the teeth and dentitions in each class, four chapters review current topics with considerable research activity: tooth development; tooth replacement; and the structure, formation and evolution of the dental hard tissues. This timely book, authored by internationally recognized teachers and researchers in the field, also reflects the resurgence of interest in the dentitions of non-mammalian vertebrates as experimental systems to help understand genetic changes in evolution of teeth and jaws.

    • Chemosensory Transduction

      • 1st Edition
      • February 18, 2016
      • Frank Zufall + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 6 9 4 7
      • eBook
        9 7 8 0 1 2 8 0 1 7 8 6 9
      Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such topics as social odors in mammals, vertebrate and invertebrate olfactory receptors, peptide signaling in taste and gut nutrient sensing. Includes a foreword by preeminent olfactory scientist Stuart Firestein, Chair of Columbia University’s Department of Biological Sciences in New York, NY. Chemosensory Transduction describes state-of-the-art approaches and key findings related to the study of the chemical senses. Thus, it serves as the go-to reference for this subject for practicing scientists and students with backgrounds in sensory biology and/or neurobiology. The volume will also be valuable for industry researchers engaged in the design or testing of flavors, fragrances, foods and/or pharmaceuticals.

    • Sexual Biology and Reproduction in Crustaceans

      • 1st Edition
      • September 22, 2016
      • Thanumalaya Subramoniam
      • English
      • Paperback
        9 7 8 0 1 2 8 0 9 3 3 7 5
      • eBook
        9 7 8 0 1 2 8 0 9 6 0 6 2
      Sexual Biology and Reproduction in Crustaceans covers crustacean reproduction as it deals with the structural morphology of the gamete-producing primary sex organs, such as the testis and ovary, the formation and maturation of gametes, their fusion during fertilization, and embryonic development that lead to the release of larvae. Constituting a diverse assemblage of animals, crustaceans are best known by their common representatives, such as shrimps, lobsters, and crabs, but also include many more less familiar, but biologically important forms. This work covers the variety of ways in which both male and female gametes are produced by evolving different sexual systems in crustaceans, the range of reproductive systems, and the accordingly, and highly diverse, mechanistic modes of sex determination. In addition, the book features such topics as genetic and environmental determinants in sex determination pattern, variability of mechanisms of fertilization among different species, the origin of different mating systems, the associated mating and brooding behaviors, and the adaptive ability to different environmental conditions with discussion on the evolutionary ecology of social and sexual systems in certain species, which have shown eusocial tendencies, similar to social insects. Marine species occupying diversified ecological niches in tropical and temperate zones reproduce under definitive environmental conditions. Therefore, reproductive ecology of different crustaceans inhabiting different ecological niches also constitutes another important aspect of the work, along with yolk utilization and embryogenesis leading to release of different larval forms, which reflect on their aquatic adaptability.

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Toxicology