Life sciences print books and ebooks | Elsevier

Autoimmune Neurology

1st Edition
Volume 133
March 11, 2016
English
Hardback
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eBook
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Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders.

Metabolic Phenotyping in Personalized and Public Healthcare

1st Edition
February 11, 2016
Jeremy Nicholson + 3 more
English
Hardback
9 7 8 0 1 2 8 0 0 3 4 4 2
eBook
9 7 8 0 1 2 8 0 0 4 1 4 2

Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches.In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream.

The Evolution of the Immune System

1st Edition
May 20, 2016
Davide Malagoli
English
Paperback
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eBook
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The Evolution of the Immune System: Conservation and Diversification is the first book of its kind that prompts a new perspective when describing and considering the evolution of the immune system. Its unique approach summarizes, updates, and provides new insights on the different immune receptors, soluble factors, and immune cell effectors.

Chromatin Signaling and Diseases

1st Edition
August 6, 2016
Olivier Binda + 1 more
English
Hardback
9 7 8 0 1 2 8 0 2 3 8 9 1
eBook
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Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored.

Antibiotics and Antibiosis in Agriculture

1st Edition
April 19, 2016
M. Woodbine
English
Hardback
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Paperback
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eBook
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Antibiotics and Antibiosis in Agriculture: With Special Reference to Synergism is a collection of papers dealing with the properties of penicillins, cephalosporins, sulfonamides, as well as the synergistic combinations of these and other antibacterial substances. One paper discusses issues regarding antibiotics such as the sufficiency of supply, the need for more and new antibiotics, and the period of obsolescence of antibiotics. Another paper explains the use of pairs of agents as synergic combinations, for example, novobiocin and tetracycline combined together as albamacyn T. Synergy types in chemotherapy includes those used in antibacterial, penetration, and internal synergies; the paper also notes that possible complications can arise from antibiotic interactions of drug synergies. Some papers discuss applications of antibiotics, antibiosis, stress effects, and food microbiology. These applications include the use of nisin, an antibiotic, as an aid in heat preservation of food. The use of starvation as a stress mechanism in a culture of Enterobacter aerogenes to accelerate exhaustion of glycerol, which the microorganisms need, lead to glycerol-deficiency related deaths. Other papers discuss the relationships of antibiotics and antibiosis to animals and animal feeds. This collection will benefit pharmacologists, bio-chemists, agriculturists, chemotherapists, veterinarians, and medical practitioners.

Studies in Natural Products Chemistry

1st Edition
Volume 51
November 24, 2016
Atta-ur Rahman
English
Hardback
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eBook
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Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. This series covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

Modeling in Food Microbiology

1st Edition
January 22, 2016
Jeanne-Marie Membré + 1 more
English
Hardback
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eBook
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Predictive microbiology primarily deals with the quantitative assessment of microbial responses at a macroscopic or microscopic level, but also involves the estimation of how likely an individual or population is to be exposed to a microbial hazard.This book provides an overview of the major literature in the area of predictive microbiology, with a special focus on food. The authors tackle issues related to modeling approaches and their applications in both microbial spoilage and safety.Food spoilage is presented through applications of best-before-date determination and commercial sterility. Food safety is presented through applications of risk-based safety management. The different modeling aspects are introduced through probabilistic and stochastic approaches, including model and data uncertainty, but also biological variability.

Durum Wheat Chemistry and Technology

2nd Edition
April 27, 2016
Michael Sissons
English
Paperback
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eBook
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The most extensive and comprehensive reference on durum wheat chemistry and technology ever available, this ambitious update to the first edition covers more diverse and interesting topics in a new expanded format. Forty-six contributors, each highly experienced and recognized as world authorities on durum wheat, provide the latest developments in scientific research and technology. All aspects of durum wheat are covered, from agronomy and the chemical composition of the grain, to the latest industrial approaches to processing durum wheat, as well as food safety and quality assurance issues. Expanded to include new topics like functional pasta, grain safety, and biotechnology, along with practical and applied information including a table of uses for specific carbohydrates, descriptions of improved laboratory techniques, and international comparisons of HACCP experiences, Durum Wheat: Chemistry and Technology, Second Edition is a must-have reference for professionals, students, and researchers inside and outside the field who want to learn about durum wheat technology and chemistry. New and Revised Topics Include: Agronomy of durum wheat production Pasta made from non-traditional raw materials: technological and nutritional aspects Grain safety assurance, including impacts on durum wheat trading Origin and distribution of durum wheat genetic diversity in the world Genetics and breeding of durum wheat Insect and mite pests and diseases of durum wheat Kernel components of technological value Vitamins, minerals, and nutritional value of durum wheat Durum wheat milling Manufacture of pasta products Other traditional durum derived products Methods used to assess and predict quality of durum wheat, semolina, and pasta Grading factors impacting on durum wheat and processing quality Grain safety assurance including impacts on durum wheat trading Marketing perspectives in the durum wheat trade Special Features: Detailed figures outlining the processes used to manufacture durum products International comparisons of HACCP experiences Table of uses for specific carbohydrates Descriptions of improved laboratory techniques Extensive bibliography An Essential Reference For: Scientists and researchers in agriculture and plant biology Professionals in the food industry who are processing durum wheat (millers, pasta makers, grain handling companies, and grain buyers) Government regulators Food scientists and technologists developing products using durum wheat Plant breeders University lecturers in agricultural science and plant biology Professionals who market wheat Nutritionists and medical practitioners interested in the impacts of food ingredients on human healthStudents Scientific libraries and their patrons

The Competitiveness of Tropical Agriculture

1st Edition
December 27, 2016
Roger D. Norton
English
Paperback
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eBook
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The Competitiveness of Tropical Agriculture: A Guide to Competitive Potential with Case Studies describes and synthesizes existing methodologies for evaluating competitiveness in agriculture, introduces extensions and refinements, and provides a novel approach based on a combination of quantitative and qualitative methodologies. As exports of tropical fruit, nuts, and other high-value crops have been growing very rapidly from developing countries, but often encounter serious obstacles in their value chains, this book demonstrates how national agricultural policy is oftentimes not guided by considerations of inherent competitiveness. In addition, the book presents case studies that illustrate the application of these approaches using quantitative frameworks. A concluding chapter introduces policy considerations for competitiveness from work in Jordan, Colombia, Estonia, Peru, and elsewhere, also discussing the role of specific policies in raising competitiveness sustainably and its role in reducing rural poverty.

Linked by Blood: Hemophilia and AIDS

1st Edition
May 19, 2016
David Green
English
Paperback
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eBook
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Linked by Blood: Hemophilia and AIDS recounts the factors responsible for the widespread infection of people with hemophilia by Human Immunodeficiency Virus (HIV)-contaminated blood and offers a prescription for addressing the challenges of future viral epidemics. The book describes the impact of AIDS on people with hemophilia, their families, and caregivers. The collection, processing, and distribution of blood in the early years of the HIV epidemic are described, including the failure of regulatory agencies to promulgate effective rules to safeguard the blood supply. The contributions of individuals and organizations that mitigated the epidemic are recognized. Linked by Blood presents recommendations for addressing the myriad medical, social, and economic challenges posed by blood-borne viral infections (AIDS, Ebola, MERS) that periodically sweep through large segments of our population.

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