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Metabolic Phenotyping in Personalized and Public Healthcare
1st Edition - February 11, 2016
Editors: Jeremy Nicholson, Ara Darzi, Elaine Holmes, John C. Lindon
Hardback ISBN:9780128003442
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eBook ISBN:9780128004142
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Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may… Read more
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Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches.In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream.
Translates the conjunction of new surgical tools for intraoperative, real-time, metabolite evaluation and direct analysis of biofluid samples into novel options for augmented clinical decision-making
Discusses longitudinal sampling from individual patients for stratified medicine
Covers high resolution analytical spectroscopy and sophisticated computational modelling for prediction of adverse reactions in critical care scenarios, prognostic evaluation of cancer from biofluidism, and prognostic prediction of metabolism or response of patients to pharmaceutical interventions
Encapsulates recent technology options for broader population profiling considerations, in particular, the metabolome-wide association studies (MWAS) that aid the translational researcher in identifying metabolic patterns associated with disease
Foreword written by Professor Dame Sally Davies who is the Chief Medical Officer for England
Principally genomics and metabolomics researchers, translational biologists, bioanalytical chemists, biochemists, related clinicians, and anyone more broadly interested in systems-level approaches, whether in systems biology, biotechnology, toxicology or pharmaceutical sciences
Foreword Preface List of Contributors
1. Unmet Medical Needs Abstract
1.1 A Historical Perspective
1.2 Unmet Medical Needs
1.3 Addressing the Problems
1.4 Personalized Medicine
1.5 Personalized Medicine: The Role of Metabolic Phenotyping References
2. The Development of Metabolic Phenotyping—A Historical Perspective Abstract
2.1 Introduction
2.2 The 20th Century
2.3 The COMET Project for Drug Toxicity
2.4 Attempts to Define Biofluid Composition and Standardize Procedures
2.5 Early Efforts at Integrating Metabolic Phenotyping Data With Other “-Omics” Data
2.6 Population Scale Studies and Biomarkers of Disease Risk
2.7 Predictive Metabolic Phenotyping and its Application to Stratified Medicine
2.8 Monitoring the Patient Journey
2.9 Phenome Center Concept
2.10 Concluding Remarks Acknowledgment References
3. Phenotyping the Patient Journey Abstract
3.1 Bottlenecks in the Patient Journey
3.2 What Does a Good Patient Journey Look Like?
3.3 The Role of Metabolic Profiling in the Patient Journey
3.4 Stratified and Personalized Health Care
3.5 Data Visualization for the Physician
3.6 Communication With the Patient and Family: Improving the Patient Experience
3.7 Implementing Clinical Metabolic Phenotyping in the Patient Journey: The Clinical Phenome Center Concept References
4. Precision Surgery and Surgical Spectroscopy Abstract
4.1 Introduction
4.2 Surgery as a Model for Studying Metabolism
4.3 Molecular Phenotyping and Sample Phenotyping
4.4 Current Challenges in Surgical Cancer Biomarker Discovery