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Books in Life sciences

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    • ODE/PDE α-synuclein Models for Parkinson’s Disease

      • 1st Edition
      • February 13, 2018
      • William E. Schiesser
      • English
      • Paperback
        9 7 8 0 1 2 8 1 4 6 1 4 9
      • eBook
        9 7 8 0 1 2 8 1 4 8 0 2 0
      ODE/PDE Alpha-Synuclein Models for Parkinson’s Disease discusses a mechanism for the evolution of Parkinson’s Disease (PD) based on the dynamics of the protein α-synuclein, a monomer that has been implicated in this disease. Specifically, α-synuclein morphs and aggregates into a polymer that can interfere with functioning neurons and lead to neurodegenerative pathology. This book first demonstrates computer-based implementation of a prototype ODE/PDE model for the dynamics of the α-synuclein monomer and polymer, and then details the methodology for the numerical integration of ODE/PDE systems which can be applied to computer-based analyses of alternative models based on the reader's interest. This book facilitates immediate computer use for research without the necessity to first learn the basic concepts of numerical analysis for ODE/PDEs and programming algorithms

    • Analytical Methods for Food Safety by Mass Spectrometry

      • 1st Edition
      • June 21, 2018
      • Guo-Fang Pang
      • English
      Analytical Methods for Food Safety by Mass Spectrometry, Volume One: Pesticides systematically introduces the Pesticide and Veterinary Drug Multiresidues Analytical Methods. Volume One includes discussions on 20 pesticide multiresidues chromatic-MS (GC-MS and LC-MS/MS) analytical techniques that have the capability of detecting over 800 pesticides and chemicals in 10 categories of agricultural products, including fruits, vegetables, grains, teas, Chinese medicinal herbs, edible fungus mushrooms, fruit and vegetable juices, animal tissues, aquatic products, raw milk and milk powders, and drinkable water. This book also includes chromatic-MS analytical parameters, linear equations and GPC chromatic behavior parameters for over 800 pesticides. This valuable book can be used as reference for not only university students, but also technical personnel of different specialties who are engaged with study and applications, such as food safety, agricultural environment protection, pesticide development, and utilization in scientific research units, institutions and quality inspection organizations.

    • Stress and Inflammation in Disorders

      • 1st Edition
      • Volume 108
      • April 17, 2017
      • English
      • Hardback
        9 7 8 0 1 2 8 1 2 3 8 8 1
      • eBook
        9 7 8 0 1 2 8 1 2 3 8 9 8
      Stress and Inflammation in Disorders, Volume 108, the newest volume in this ongoing series, brings forth new information on protocols and analysis of proteins. This volume covers the latest on Oxidative Stress: Love and Hate History in the Central Nervous System, Neuroinflammation in Alzheimer's Disease: The Preventive and Therapeutic Potential of Polyphenolic Nutraceuticals, Inflammation in Epileptic Encephalopathies, A Computational Approach to Identify the Biophysical and Structural Aspect of Methylenetetrahydrof... Reductase (MTHFR) Mutations (A222V, E429A and R594Q) Leading to Schizophrenia, and Analyzing the Effect of V66M Mutation in BDNF in Causing MOOD Disorders- A Computational Approach. Each release in the Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

    • Early Stage Protein Misfolding and Amyloid Aggregation

      • 1st Edition
      • Volume 329
      • January 18, 2017
      • English
      • Hardback
        9 7 8 0 1 2 8 1 2 2 5 1 8
      • eBook
        9 7 8 0 1 2 8 1 2 2 5 2 5
      Early Stage Protein Misfolding and Amyloid Aggregation, Volume 329, the latest in the International Review of Cell and Molecular Biology series presents comprehensive reviews and current advances in cell and molecular biology, including articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a worldwide readership and maintains a high standard by publishing invited articles on important and timely topics as authored by prominent cell and molecular biologists.

    • International Review of Cell and Molecular Biology

      • 1st Edition
      • Volume 328
      • January 5, 2017
      • English
      • Hardback
        9 7 8 0 1 2 8 1 2 2 2 0 4
      • eBook
        9 7 8 0 1 2 8 1 2 2 2 1 1
      International Review of Cell and Molecular Biology, Volume 328 is the latest release in this series that publishes comprehensive and detailed reviews on current advances in cell and molecular biology. The IRCMB series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. IRCMB ranks high amongst scientific journals dealing with Cell Biology.

    • Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics

      • 1st Edition
      • May 3, 2017
      • Alexandru Mihai Grumezescu
      • English
      • Paperback
        9 7 8 0 3 2 3 5 2 7 2 5 5
      • eBook
        9 7 8 0 3 2 3 5 2 7 2 6 2
      Multifunctional Systems for Combined Delivery, Biosensing, and Diagnostics explores how multifunctional nanocarriers are being used in combined delivery and diagnostics in contemporary medicine. Particular attention is given to efforts to i) reduce the side effects of therapeutic agents, ii) increase the pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. The chapters focus on applications of nanostructured materials and nanocarriers, highlighting how these can be used effectively in both diagnosis and delivery. This applied focus makes the book an important reference source for those wanting to learn more about how specific nanomaterials and nanotechnology systems can help to solve drug delivery and diagnostics problems. This book is a valuable resource for materials scientists, bioengineers, and medical researchers who are looking for an applications-oriente... guide on how nanotechnology and nanomaterials can be used effectively throughout the medical treatment process, from diagnosis to treatment.

    • Nanomaterials for Biosensors

      • 1st Edition
      • October 16, 2017
      • Bansi D. Malhotra + 1 more
      • English
      • Hardback
        9 7 8 0 3 2 3 4 4 9 2 3 6
      • eBook
        9 7 8 0 1 2 8 1 3 5 1 5 0
      Nanomaterials for Biosensors: Fundamentals and Applications provides a detailed summary of the main nanomaterials used in biosensing and their application. It covers recent developments in nanomaterials for the fabrication of biosensor devices for healthcare diagnostics, food freshness and bioprocessing. The various processes used for synthesis and characterization of nanostructured materials are examined, along with the design and fabrication of bioelectronic devices using nanostructured materials as building blocks. Users will find the fundamentals of the main nanomaterials used in biosensing, helping them visualize a systematic and coherent picture of how nanomaterials are used in biosensors. The book also addresses the role of bio-conjugation of nanomaterials in the construction of nano-biointerfaces for application in biosensors. Such applications, including metal nanoparticles, metal oxide nanoparticles, nanocomposites, carbon nanotubes, conducting polymers and plasmonic nanostructures in biosensing are discussed relative to each nanomaterial concerned. Finally, recent advancements in protein functionalized nanomaterials for cancer diagnostics and bio-imaging are also included.

    • Microbiorobotics

      • 2nd Edition
      • February 20, 2017
      • Minjun Kim + 2 more
      • English
      • Hardback
        9 7 8 0 3 2 3 4 2 9 9 3 1
      • eBook
        9 7 8 0 3 2 3 4 3 0 1 9 7
      Microbiorobotics: Biologically Inspired Microscale Robotic Systems, Second Edition presents information on a new engineering discipline that takes a multidisciplinary approach to accomplish precise manipulation of microscale spaces. Microorganisms have evolved various mechanisms to thrive in microscale environments and are therefore a useful tool for use in many applications, ranging from micromanufacturing techniques, to cellular manipulation. In the context of microrobotics, biological microrobots can directly harness the microorganisms for propulsive and sensing power and synthetic microrobots can mimic the microorganisms’ motions for effective locomotion. This second edition covers new advances and insights that have emerged in recent years. Several new chapters have been added on important new research areas, with existing chapters thoroughly revised. In particular, increased coverage is given to fluid dynamics of microswimmers in nature.

    • FDA's Drug Review Process and the Package Label

      • 1st Edition
      • December 1, 2017
      • Tom Brody
      • English
      • Paperback
        9 7 8 0 1 2 8 1 4 6 4 7 7
      • eBook
        9 7 8 0 1 2 8 1 4 6 4 8 4
      FDA's Drug Review Process and the Package Label provides guidance to pharmaceutical companies for writing FDA-submissions, such as the NDA, BLA, Clinical Study Reports, and Investigator's Brochures. The book provides guidance to medical writers for drafting FDA-submissions in a way more likely to persuade FDA reviewers to grant approval of the drug. In detail, the book reproduces data on efficacy and safety from one hundred different FDA-submissions (NDAs, BLAs). The book reproduces comments and complaints from FDA reviewers regarding data that are fragmentary, ambiguous, or that detract from the drug's approvability, and the book reveals how sponsors overcame FDA's concerns and how sponsors succeeded in persuading FDA to grant approval of the drug. The book uses the most reliable and comprehensive source of information available for writing FDA-submissions, namely text and data from NDAs and BLAs, as published on FDA's website. The source material for writing this book included about 80,000 pages from FDA's Medical Reviews, FDA's Clinical Pharmacology Reviews, and FDA's Pharmacology Reviews, from one hundred different NDAs or BLAs for one hundred different drugs. Each chapter focuses on a different section of the package label, e.g., the Dosage and Administration section or the Drug Interactions section, and demonstrates how the sponsor's data supported that section of the package label.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology