Books in Life sciences

Diseases of the Nervous System

2nd Edition
May 18, 2021
Harald Sontheimer
English
Hardback
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eBook
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The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations.

Global Emergency of Mental Disorders

1st Edition
May 18, 2021
Jahangir Moini + 2 more
English
Paperback
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eBook
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Global Emergency of Mental Disorders is a comprehensive, yet easy-to-read overview of the neurodevelopmental basis of multiple mental disorders and their accompanying consequences, including addiction, suicide and homelessness. Compared to other references that examine the treatment of psychiatric disorders, this book uniquely focuses on their neurodevelopment. It is designed for neuroscience, psychiatry, psychology students, and various other clinical professions. With chapters on anxiety, depression, schizophrenia and others, this volume provides information about incidence, prevalence and mortality rates in addition to developmental origins. With millions worldwide affected, this book will be an invaluable resource.

Neurologic Emergencies, An Issue of Neurologic Clinics

1st Edition
Volume 39-2
May 16, 2021
Joseph D. Burns + 1 more
English

This issue of Neurologic Clinics, guest edited by Drs. Joseph D. Burns and Anna M. Cervantes-Arslanian, will focus on Neurologic Emergencies. This issue is one of four selected each year by series consulting editor, Dr. Randolph W. Evans. Topics include—but are not limited to—Coma and depressed level of alertness; Post-arrest Neuroprotection; Headache Emergencies; Acute dizziness, vertigo, and unsteadiness; Neuro-ophthalmologic emergencies; Intracerebral hemorrhage; Acute ischemic stroke; Seizures and status epilepticus; Movement disorders emergencies; Neuromuscular respiratory failure; Neuroinfectious disease emergencies; Severe traumatic brain injury; Acute myelopathy; Neuro-oncologic emergencies; Autoimmune neurologic emergencies; Brain herniation and intracranial hypertension; Aneurysmal subarachnoid hemorrhage; Anesthesiology considerations in neurological emergencies; Neurological emergencies during the COVID pandemic; Neurocritical care and the COVID pandemic; and Neurologic Emergencies during Pregnancy.

Drug Discovery and Development

3rd Edition
August 24, 2021
Raymond G Hill + 1 more
English

Essential insight into drug development and the pharmaceutical industry With unprecedented interest in the power that the modern therapeutic armamentarium has to combat disease, the new edition of Drug Discovery and Development is an essential resource for anyone interested in understanding how drugs and other therapeutic interventions are discovered and developed, through to clinical research, registration, and market access. The text has been thoroughly updated, with new information on biopharmaceuticals and vaccines as well as clinical development and target identification. Drug discovery and development continues to evolve rapidly and this new edition reflects important changes in the landscape. Edited by industry experts Raymond Hill and Duncan Richards, this market-leading text is suitable for undergraduates and graduates undertaking degrees in pharmacy, pharmacology, toxicology, and clinical development through to those embarking on a career in the pharmaceutical industry.

Williams. Tratado de endocrinología

14th Edition
May 15, 2021
Shlomo Melmed + 2 more
Spanish

Nueva edición de la obra de referencia en endocrinología durante los últimos 70 años, donde los lectores encontrarán un análisis del espectro completo de los trastornos del sistema endocrino adulto y pediátrico. Contiene nuevos capítulos sobre la tasa global de endocrinopatías, y aborda las directrices de práctica clínica en endocrinologí ay la endocrinología transgénero. Aporta una significativa actualización de los capítulos dedicados a la diabetes, con un nuevo capítulo sobre la fisiología de la secrección de insulina y mayor cobertura de la diabetes de tipo 2. Nuevos capítulos y significativas revisiones, incorporadas a lo largo de toda la obra, ofrecen una perspectiva actualizada de los más recientes avances en áreas como los fármacos, los tratamientos y los ensayos clínicos. Esta obra de referencia es un recurso imprescindible para endocrinólogos, cirujanos, endocrinos, ginecólogos, internistas, pediatras y otros profesionales clínicos que precisan una información completa y actualizada acerca de las múltiples facetas de esta disciplina. Incluye la versión electrónica del libro en ExpertConsult, en inglés, que permite acceder al texto completo, las figuras y las referencias bibliográficas de la obra desde distintos dispositivos.

Chemical Biology of the Genome

1st Edition
May 14, 2021
Siddhartha Roy + 1 more
English
Paperback
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eBook
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Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs.

Stress Tolerance in Horticultural Crops

1st Edition
May 14, 2021
Ajay Kumar + 4 more
English
Paperback
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eBook
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Stress Tolerance in Horticultural Crops: Challenges and Mitigation Strategies explores concepts, strategies and recent advancements in the area of abiotic stress tolerance in horticultural crops, highlighting the latest advances in molecular breeding, genome sequencing and functional genomics approaches. Further sections present specific insights on different aspects of abiotic stress tolerance from classical breeding, hybrid breeding, speed breeding, epigenetics, gene/quantitative trait loci (QTL) mapping, transgenics, physiological and biochemical approaches to OMICS approaches, including functional genomics, proteomics and genomics assisted breeding. Due to constantly changing environmental conditions, abiotic stress such as high temperature, salinity and drought are being understood as an imminent threat to horticultural crops, including their detrimental effects on plant growth, development, reproduction, and ultimately, on yield. This book offers a comprehensive resource on new developments that is ideal for anyone working in the field of abiotic stress management in horticultural crops, including researchers, students and educators.

Nematode Models of Development and Disease

1st Edition
Volume 144
May 13, 2021
Benjamin Podbilewicz + 1 more
English
Hardback
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eBook
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Nematode Models of Development and Disease, Volume 144 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters surrounding Transgenerational inheritance, Oscillatory expression and function, Concepts and functions of small RNA pathways in C. elegans, Exploring the nuclear lamina in health and pathology using C. elegans, Cellular Plasticity, Morphogenesis, Tubulogenesis, Organogenesis forces, Programmed cell fusion in development and homeostasis, One template, two outcomes: how does the sex-shared nervous system generate sex-specific behaviors?, Metabolic Cellular Coordination of Gene-Environment Interactions, and much more. Other chapters cover Chemical and physical cues and micro-evolution in early embryogenesis, Innate immunity, Sex and Death, Dendrites maturation, axonal growth and extracellular glycoproteins, Autophagocytosis, Spermatogenesis, and the developmental and physiological roles of phagocytosis in Caenorhabditis elegans.

Biochemical and Molecular Basis of Pediatric Disease

5th Edition
May 13, 2021
Edward C.C. Wong + 3 more
English
Paperback
9 7 8 0 1 2 8 1 7 9 6 2 8
eBook
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Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases.

Fluorescent Probes

1st Edition
Volume 48
May 13, 2021
Volker Gurtler
English
Hardback
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eBook
9 7 8 0 1 2 8 2 3 5 4 3 0

Fluorescent Probes, Volume 48 in the Methods in Microbiology series, highlights new advances in the field, with this new volume presenting interesting chapters on important topics, including Hydrogel microarray technology as a tool for clinical diagnostics, The use of probes and bacteriophages for bacteria detection, Probes used with point-of-care microfluidic devices for pathogen detection, Methods for combining FIB/SEM with three-dimensional fluorescence microscopy using CLEM approaches, Probes and Microbes, Microbial signatures associated with cancers, Fluorescent Aptamers for Detection and Treatment of Pathogenic Bacteria and Cancer, Labelled and Unlabeled Probes for Pathogen Detection with Molecular Biology Methods and Biosensors, and much more.

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