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Nematode Models of Development and Disease
- 1st Edition, Volume 144 - May 13, 2021
- Editors: Benjamin Podbilewicz, Sophie Jarriault
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 6 1 7 7 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 6 1 7 8 - 4
Nematode Models of Development and Disease, Volume 144 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presentin… Read more
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Request a sales quoteNematode Models of Development and Disease, Volume 144 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters surrounding Transgenerational inheritance, Oscillatory expression and function, Concepts and functions of small RNA pathways in C. elegans, Exploring the nuclear lamina in health and pathology using C. elegans, Cellular Plasticity, Morphogenesis, Tubulogenesis, Organogenesis forces, Programmed cell fusion in development and homeostasis, One template, two outcomes: how does the sex-shared nervous system generate sex-specific behaviors?, Metabolic Cellular Coordination of Gene-Environment Interactions, and much more.
Other chapters cover Chemical and physical cues and micro-evolution in early embryogenesis, Innate immunity, Sex and Death, Dendrites maturation, axonal growth and extracellular glycoproteins, Autophagocytosis, Spermatogenesis, and the developmental and physiological roles of phagocytosis in Caenorhabditis elegans.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Current Topics in Developmental Biology
Clinicians in the fields of endocrinology, rheumatology, orthopedics, pediatrics and dentistry; basic scientists in anatomy, cell and developmental biology; students and postdoctoral fellows who would like to enter these fields and make further discoveries as well as improve the treatment of major bone-related disorders
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Can brain activity transmit transgenerationally?
- Abstract
- 1: Lost in translation
- 2: Molecular memories—Historical perspective
- 3: Modern “molecular memory transfer” experiments
- 4: Transfer of RNA memories between generations in C. elegans
- 5: A role for small RNAs in C. elegans behavior and long-term memory?
- 6: Transgenerational inheritance of neuronal small RNA-based responses in C. elegans
- 7: Discussion
- Acknowledgment
- Chapter Two: Gene expression oscillations in C. elegans underlie a new developmental clock
- Abstract
- 1: Introduction
- 2: Developmental periodicities in other systems
- 3: A developmental clock linked to molting
- 4: Mechanisms of oscillatory gene expression
- 5: Methods to study the C. elegans oscillator
- 6: Implications for gene expression profiling in C. elegans
- 7: Conclusions and outlook
- Acknowledgments
- Chapter Three: Concepts and functions of small RNA pathways in C. elegans
- Abstract
- 1: A general core of small RNA pathways: Argonaute proteins
- 2: The microRNA pathway (or the ALG-1/-2 pathway)
- 3: Other small RNA pathways
- 4: Subcellular organization of small RNA pathways
- 5: Developmental functions of small RNA pathways
- 6: Closing remarks
- Chapter Four: Exploring the nuclear lamina in health and pathology using C. elegans
- Abstract
- 1: Caenorhabditis elegans as a model organism
- 2: The nuclear envelope (NE) structure
- 3: The nuclear lamina (NL)
- 4: Lamin structure
- 5: Lamin binding proteins
- 6: The NL and spatial genomic organization
- 7: Nuclear migration and positioning
- 8: NL during meiosis and mitosis
- 9: NL during aging
- 10: C. elegans models of laminopathies
- 11: Concluding remarks
- Acknowledgments
- Chapter Five: On the origins and conceptual frameworks of natural plasticity—Lessons from single-cell models in C. elegans
- Abstract
- 1: Introduction
- 2: An atlas of cellular plasticity in the worm
- 3: Testing the frontiers of cellular plasticity: Definitions and cellular mechanisms
- 4: Open questions
- 5: Concluding remarks
- Acknowledgments
- Chapter Six: Epithelial morphogenesis, tubulogenesis and forces in organogenesis
- Abstract
- 1: Introduction
- 2: The epidermis
- 3: The alimentary system
- 4: The excretory system
- 5: Summary and open questions
- Acknowledgments
- Chapter Seven: Programmed cell fusion in development and homeostasis
- Abstract
- 1: Introduction
- 2: Cell fusion in embryogenesis
- 3: Cell fusion during larval development
- 4: Fusion in homeostasis
- 5: Why does C. elegans need more than one fusogen?
- 6: Concluding remarks
- Acknowledgments
- Chapter Eight: One template, two outcomes: How does the sex-shared nervous system generate sex-specific behaviors?
- Abstract
- 1: Introduction
- 2: Sex determination in C. elegans
- 3: Sexual dimorphism in sex-shared behavioral states and traits
- 4: Mechanisms that generate a dimorphic sex-shared nervous system: Dimorphic connectivity
- 5: Molecular mechanisms that generate a dimorphic sex-shared nervous system: Dimorphic gene expression/molecular profile
- 6: Developmental aspects of neuronal dimorphism
- 7: Future directions and concluding remarks
- Acknowledgments
- Chapter Nine: The first steps in the life of a worm: Themes and variations in asymmetric division in C. elegans and other nematodes
- Abstract
- 1: Introduction
- 2: Symmetry breaking
- 3: Spindle positioning in response to early zygote polarization
- 4: Cellular asynchrony in response to early zygote polarization
- 5: Perspectives and challenges
- 6: Outlook
- Acknowledgments
- Chapter Ten: Innate immunity in C. elegans
- Abstract
- 1: Natural environment and microbiota
- 2: Surveillance-activated host defence in C. elegans
- 3: Cell-autonomous responses
- 4: Cell non-autonomous response
- 5: Conclusion
- Acknowledgments
- Chapter Eleven: Sex and death
- Abstract
- 1: C. elegans: A good model for studying mating-induced death
- 2: Post-mating physiological changes: Shrinking, glycogen loss, and fat loss
- 3: What causes early death in mated C. elegans?
- 4: Is mating-induced death avoidable?
- 5: Pathways and mechanisms involved in mating-induced lifespan regulation
- 6: Why does mating-induced death occur?
- Chapter Twelve: Roles of glycoconjugates in neural patterning in C. elegans
- Abstract
- 1: Types of glycoconjugates
- 2: Glycoconjugates in axonal and neuronal migrations
- 3: Glycoconjugates in dendrite patterning
- 4: Glycoconjugates in neuronal disease and regeneration
- 5: Concluding remarks and outlook
- Acknowledgments
- Chapter Thirteen: The developmental and physiological roles of phagocytosis in Caenorhabditis elegans
- Abstract
- 1: Introduction to phagocytosis
- 2: Signaling for clearance
- 3: Pseudopod extension to form the phagocytic cup
- 4: Phagosome formation
- 5: Phagosome maturation
- 6: Atg8/LC3 family proteins and the phagosome
- 7: Phagolysosome resolution
- 8: Conclusion
- Acknowledgments
- No. of pages: 450
- Language: English
- Edition: 1
- Volume: 144
- Published: May 13, 2021
- Imprint: Academic Press
- Hardback ISBN: 9780128161777
- eBook ISBN: 9780128161784
BP
Benjamin Podbilewicz
Benjamin Podbilewicz is at Technion – Israel Institute of Technology, Israel
Affiliations and expertise
Technion – Israel Institute of Technology, IsraelSJ
Sophie Jarriault
Sophie Jarriault is at the Université de Strasbourg, France
Affiliations and expertise
Universite de Strasbourg, FranceRead Nematode Models of Development and Disease on ScienceDirect