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Elsevier

Books in Life sciences

  • Mineral Nutrients to Mitigate Abiotic Stress in Crops

    • 1st Edition
    • Azamal Husen
    • English
    Mineral Nutrients to Mitigate Abiotic Stress in Crops offers a clear and timely examination of the physiological and biochemical dynamics that govern how plants endure increasingly unpredictable growing conditions. The volume begins by outlining the fundamental principles that shape a crop’s capacity to acquire, distribute, and utilize nutrients, and then considers how these processes influence its survival and productivity when confronting drought, salinity, heat, or nutrient-induced stress. Across the chapters, contributors show how nutrient availability guides defense mechanisms—from maintaining cellular stability and enzymatic function to modulating antioxidant potential, osmotic adjustment, and stress-related signaling—and how intensifying environmental pressures reorder metabolic priorities, redirect root behaviour, and reallocate resources at the whole-plant level.Building on this foundation and proceeding in an intentionally structured sequence, this book integrates applied approaches encompassing soil and fertilizer systems, nutrient biofortification, and the breeding of nutrient-efficient cultivars. By integrating established science with emerging insights, it delivers a coherent, forward-looking framework for interpreting plant resilience and for implementing adaptive strategies that underpin effective responses in diverse cultivation contexts, thereby strategically equipping researchers and practitioners to navigate the increasingly complex challenges facing modern agriculture.

  • Dairy 4.0

    Revolutionizing the Dairy Sector Through Industry 4.0 Technologies
    • 1st Edition
    • Abderrahmane Aït Kaddour + 1 more
    • English
    Dairy 4.0: Revolutionizing the Dairy Sector Through Industry 4.0 Technologies explores how cutting-edge technologies like artificial intelligence, big data, smart sensors, 3D printing, blockchain, and digital twins can drive the future of dairy. The book provides a thorough understanding of Industry 4.0 technologies and their applications, promoting sustainability through improved resource efficiency, waste reduction, and environmental impact. The book also offers practical insights and case studies demonstrating the impact of technology on dairy quality, safety, and traceability. Challenges such as high initial costs, data security concerns, technological integration complexities, regulatory and ethical issues, and resistance to change are addressed.Users will find this to be a resource that stimulates innovation by showcasing the latest research and developments, thus fostering a culture of continuous improvement. The book explores opportunities and hurdles, providing insights to drive the industry's transformation and helping to create conducive regulatory environments for technological adoption.

  • Cellular Senescence and Cardiac Aging

    Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases
    • 1st Edition
    • Gaurav Gupta + 4 more
    • English
    Cellular Senescence and Cardiac Aging: Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases offers a comprehensive and up-to-date exploration of the molecular and cellular processes driving cardiac aging, with a special focus on cellular senescence. This authoritative volume bridges cutting-edge, basic science with clinical applications, detailing how senescent cells contribute to age-related cardiovascular diseases and highlighting innovative therapeutic approaches such as senolytics and regenerative medicine. Ideal for graduate students, researchers, and clinicians in biomedical sciences, cardiology, pharmacology, and regenerative medicine, this book provides essential insights into biomarkers, epigenetics, autophagy, and emerging treatments.With contributions from global experts, it also addresses gender and ethnic disparities, ensuring a broad and inclusive perspective. This indispensable resource equips readers with the knowledge needed to advance research and improve patient care in the rapidly evolving field of cardiac aging.

  • Starches in Smart Packaging

    • 1st Edition
    • Swarup Roy + 1 more
    • English
    Starches in Smart Packaging explores the innovative use of biodegradable, starch-based polymers in developing sustainable packaging solutions. Derived from natural resources such as maize, rice, and tubers, starch is a non-toxic, eco-friendly material with great potential to replace conventional plastics. This book addresses the growing need for environmentally responsible packaging by covering research from laboratory studies to industrial applications, focusing on smart packaging for food preservation, quality monitoring, and active packaging functionalities. Content includes discussions on starch extraction processes, fabrication techniques, and methods to enhance properties like barrier, thermal, and mechanical performance.It also examines the incorporation of bioactives, nanomaterials, natural colorants, and cross-linkers to create advanced packaging materials. Finally, the book highlights applications in extending shelf life, monitoring food freshness, and ensuring safety, alongside considerations for large-scale production, biodegradability, and sustainability. Regulatory frameworks, consumer acceptance, and future challenges in the field round out the content.

  • Extrusion Cooking for Food and Feed

    Biochemistry, Technology, and Applications
    • 1st Edition
    • Amit Baran Das + 2 more
    • English
    Extrusion Cooking for Food and Feed: Biochemistry, Technology, and Applications offers a comprehensive updated knowledge on extruded food products (for human, pet, and aquaculture) and the associated processing technologies and machinery requirements. Comprised of 18 chapters, the book covers every possible application of the food extrusion, explaining the biochemical changes of food ingredients during extrusion cooking, the design aspect of the extruder, besides also covering cold and hybrid extrusion, the role of carbohydrates, proteins, fat and lipid in extrusion, and the pet feed and aqua feed. A concise book on extrusion cooking benefits the readers to understand the present status of snacks foods, and it also allows industries take on meeting the growing demand for pet food.

  • Genetic Breeding and Aquaculture of Shellfish

    • 1st Edition
    • Shi Wang + 1 more
    • English
    Genetic Breeding and Aquaculture of Shellfish covers the global status, research advancements, and future trends in shellfish genetic breeding. Addressing the challenges and solutions related to shellfish genetic breeding and aquaculture, this book is structured into two main sections, genetic breeding and aquaculture. Early chapters summarize the basic biology and ecology of shellfish before delving into the theory and research of genetic breeding practices. Latter chapters apply theory to practice, offering practical guidance on mature and novel cultivation models and technical directions for stakeholders and technicians working in shellfish cultivation industries.Readers will find this to be a resource that bridges scientific innovation with practical application to navigate the progress of shellfish aquaculture in the 21st century and contribute to the sustainable development of global aquaculture. It is an essential resource for students, academic researchers, industry scientists, and aquaculture technicians spanning shellfish research and aquaculture sectors.

  • Aging and the Kidney

    Mechanisms, Consequences, and Management Strategies
    • 1st Edition
    • Stephen Fadem + 2 more
    • English
    Aging and the Kidney: Possible Mechanisms, Consequences, and Management Strategies explores the connection between kidney health and overall well-being with increasing age and longevity. The first part examines histological, structural, physiological, and functional changes that contribute to age-related declines in kidney function. The role of nutrition and proteomics is also discussed. The second part examines the functional decline in elderly patients and includes subparts on impaired quality of life, sleep quality, fall risk, frailty, depression, and sarcopenia. It also considers unique features of hypertension, diabetes, glomerulonephritis, and peripheral vascular disease.The final part focuses on diagnostic, management, and prevention strategies. Common myths about chronic kidney disease in the elderly are addressed, with particular attention to how a solitary kidney in living donors ages over time. In addition, kidney function and its relationship to neurologic complications, cancers, and cardiovascular disease are explained, along with current treatment approaches, medications, and future directions in the care of elderly patients.

  • Advances in Biosystems

    • 1st Edition
    • Xiaoli Li + 2 more
    • English
    Advances in Biosystems investigates the latest techniques for evaluating, detecting, measuring, and enhancing the functional bioactivities, chemical composition, and physicochemical characteristics of animal, plant, and environmental biosystems. This comprehensive, interdisciplinary handbook provides detailed explanations for tracking functional molecules during various biological processes, along with practical methodologies for both laboratory and industrial applications. Sections cover cellular biosystems advances, including single-cell microsystems and tissue system biology of plants and animals, alongside biomass microsystems and agricultural biosystems advances, exploring innovations in animal, plant, and crop biosystems, as well as food hydrocolloids and biotechnological advancements.Additio... content addresses environmental biosystems, discussing colloidal biosystems, nano and micro-biosystems, chemical toxicology, eco-friendly biosystems, and green chemistry, pharmaceutical biosystems, highlighting medical biosystems, human cellular metabolomics, nutrigenomics, and precision medicine applications. A final section presents in-depth analytical methods for tracking these various biosystems, including high-throughput technologies, deep learning, machine learning, bioinformatics models, and spectroscopic and sensor-based techniques.

  • Advancements in Personalized Cellular Immunotherapy

    A Comprehensive Guide to Cancer Treatment
    • 1st Edition
    • Arun Kumar Singh + 3 more
    • English
    Advancements in Personalized Cellular Immunotherapy: A Comprehensive Guide to Cancer Treatment is an authoritative guide that delves into the foundational principles, recent advancements, and clinical applications of this innovative treatment approach, aiming to bridge the gap between research and clinical practice. It offers a thorough analysis of the mechanisms of action, therapeutic efficacy, and safety profiles of various cellular immunotherapy modalities, enabling clinicians to make well-informed treatment decisions and optimize patient outcomes. The book promotes interdisciplinary collaboration by bringing together experts from oncology, immunology, molecular biology, and translational medicine. Through detailed case studies, clinical guidelines, and practical insights, it provides healthcare professionals with the knowledge and tools needed to effectively incorporate cellular immunotherapy into standard oncology practice. Additionally, the book addresses key challenges and future directions in the field, such as strategies to enhance treatment efficacy, overcome resistance mechanisms, and broaden the accessibility of cellular immunotherapy to more patients. Advancements in Personalized Cellular Immunotherapy: A Comprehensive Guide to Cancer Treatment aims to educate and empower healthcare professionals, fostering continued innovation and collaboration to improve cancer care and patient outcomes.

  • Microbiome in Head and Neck Cancer: Pathogenesis, Diagnosis and Therapeutic Implications

    Part B
    • 1st Edition
    • Volume 170
    • English
    Advances in Immunology, Volume 170 presents current developments and comprehensive reviews in immunology. This volume focuses on mechanisms of gasdermin activation and pyroptosis, providing insights into inflammatory cell death and immune signaling, and serving as a valuable reference for researchers in the field.

  • Cell Free Synthesis of Biologics

    A Comprehensive Guide
    • 1st Edition
    • Sarfaraz Niazi
    • English
    Cell Free Synthesis of Biologics: A Comprehensive Guide addresses the need for efficient production methods in biopharmaceutical manufacturing. As the demand for biologics continues to rise, traditional cell-based production systems often fall short due to high costs and complexity. This book offers a detailed exploration of cell-free protein synthesis (CFPS), providing researchers and professionals with the latest methodologies, best practices, and troubleshooting strategies necessary for successful implementation. The content is structured into comprehensive chapters that cover the historical development, technical foundations, optimization strategies, advanced technologies, and the regulatory landscape surrounding CFPS.Each section is designed to guide users through the complexities of establishing and scaling up cell-free systems, ensuring a clear understanding of the processes involved and the potential applications in therapeutic development, diagnostics, and industrial biotechnology. This book provides pharmaceutical scientists and pharma manufacturing professionals with practical insights and innovative strategies to enhance efficiency and reduce costs in biopharmaceutical production.

  • Advances in Parasitology

    • 1st Edition
    • Volume 133
    • English
    This volume brings together critical insights into the biology, epidemiology, and diagnostics of major parasitic threats to both veterinary and human health. Chapter One explores the complex world of equine cyathostomins, addressing their lifecycle, clinical manifestations such as acute larval cyathostominosis, immune interactions, and the challenges posed by widespread anthelmintic resistance. Building upon the necessity for precise diagnostic tools, Chapter Two shifts the focus to human health, re-evaluating soil-transmitted helminth diagnostics in the genomic era. The authors highlight how unaddressed genetic diversity in diagnostic target regions can compromise traditional and molecular tools like qPCR, risking "diagnostic escape," and advocate for integrating whole-genome sequencing and nemabiome approaches into public health surveillance. Finally, Chapter Three provides a comprehensive, One Health-driven synthesis on zoonotic sarcocystosis, addressing how Sarcocystis species cross ecological boundaries between wildlife, livestock, companion animals, and humans.

  • Sustainable Agriculture

    Technologies, Application, and Practices
    • 1st Edition
    • Wasswa Shafik
    • English
    Sustainable Agriculture: Technologies, Application, and Practices provides readers with a foundational understanding of sustainable agriculture principles alongside the cutting-edge capabilities of artificial intelligence. Structured into six well-organized sections, the book begins with foundational concepts of sustainability and the enabling technologies that support them. This includes in-depth discussions on the principles of sustainability, the role of technology in enhancing agricultural practices, and the socioeconomic impacts of sustainable farming. Subsequent chapters look into practical applications, showcasing how smart irrigation, crop monitoring, and supply chain optimization can significantly bolster sustainable operations.Each chapter provides case studies and practical strategies to ensure a thorough understanding of how artificial intelligence can revolutionize sustainable agriculture. This book serves as an essential resource for upper-level undergraduate and graduate students studying sustainable agriculture, agricultural technology, and environmental science.

  • The Immunology of Horses and Donkeys

    • 1st Edition
    • Ian R. Tizard
    • English
    The Immunology of Horses and Donkeys offers a comprehensive overview of the immune systems of equids, bridging a critical gap by combining current research with foundational concepts and emphasizing both mechanisms and practical applications. The book covers immune development, disease resistance, vaccination, and immune disorders, supporting improved health management in horses and donkeys. Organized logically, it begins with the evolutionary history and domestication of equids and then explores immune ontogeny, innate and adaptive responses, and lymphoid tissue structure. Chapters detail the major histocompatibility complex, cytokine signaling, antigen-presenting cells, and mucosal immunity.Additional sections address the microbiota, vaccine strategies, and immune responses to bacterial, viral, and parasitic infections, providing a holistic view of equine immune health. Users will find content that advances understanding in immunology, biomedical research, and veterinary medicine, supporting the development of better diagnostics, vaccines, and therapies. The book's clear, thorough approach benefits both scientific discovery and clinical application, ultimately improving equine health and informing broader mammalian immunology studies.

  • Nano Drug Delivery Systems for Colon Cancer

    Innovations, Challenges, and Applications
    • 1st Edition
    • Arun Kumar Singh + 4 more
    • English
    Nano Drug Delivery Systems for Colon Cancer: Innovations, Challenges, and Applications is a breakthrough exploration that delves into the latest advancements in colon cancer diagnosis and treatment. This comprehensive guide, composed of 15 detailed chapters, focuses on the design, synthesis, and application of various nanodrug delivery systems, showcasing how nanoparticulate drug carriers can significantly enhance therapeutic efficacy through strategic design. Aimed at graduates, clinical researchers, and scientists, this book addresses the complexities and challenges in drug and gene delivery. Beyond its technical insights, this book highlights the global health impact of colon cancer and offers a roadmap for developing more efficient and targeted treatments.It serves as a vital resource, fostering interdisciplinary knowledge and advancements that have the potential to revolutionize colon cancer therapeutics. This book’s interdisciplinary approach ensures it is a beacon of knowledge for those seeking to navigate and innovate within this critical field.

  • Aggressive Behavior of People with Autism and other Intellectual and Developmental Disability

    • 1st Edition
    • Lauren Charlot + 1 more
    • English
    Aggressive Behavior of People with Autism and other Intellectual and Developmental Disability explores the primary factors influencing the occurrence of aggression in autistic people, offering practical suggestions for improving outcomes. Topics covered include understanding the effects of neurodevelopmental disorders, multiple factors that frequently impact the risk for aggression, common medical and neurological influences, and the effects of trauma. The book will also introduce a new model for integrating multiple influences into a contextual, functional behavior assessment.While people with autism and other intellectual and developmental disabilities receive extensive services for their behavioral health needs, many continue to struggle and lack a positive quality of life. This book covers these occurrences and the primary factors governing aggression and other externalizing behaviors.

  • Metabolic Memory

    Past, Present and Future Implications
    • 1st Edition
    • Jeena Gupta
    • English
    Metabolic Memory: Past, Present and Future Implications delves into the emerging concept of metabolic memory, exploring how our body's metabolic processes retain a 'memory' of past experiences and how this impacts our current and future health. Drawing on the latest scientific research this book aims to bridge the gap between complex scientific concepts and their practical implications for everyday health and wellness. Metabolic memory has profound implications for understanding chronic diseases, particularly diabetes, cardiovascular diseases, and obesity. Despite its significance, there is a lack of comprehensive resource that make this information accessible to both professionals and the general public. This book fills that gap, providing a detailed yet understandable exploration of how past metabolic states influence present and future health outcomes.

  • Mpox

    • 1st Edition
    • Volume 59
    • English
    Monkeypox, Volume 59 covers the diagnosis of Mpox from clinical specimens and wastewater, while also discussing the neurological, dermatological, reproductive, and structural biology of Mpox. Specific chapters cover Tracking Mpox through Wastewater: Advances in Environmental Surveillance and Analytical Methodologies, Community-Based Monitoring of Mpox and Co-occurring Sexually Transmitted Infections (STIs), Clade-Level Differentiation of Mpox Virus: Molecular Diagnostic Strategies for Routine Testing in Low-Resource Settings, Comparative Analysis of Mathematical and Stochastic Modelling of MPOX in Human and Rodent Populations, Genomic Sequencing Methods for mpox Detection and Genotyping, and The gastrointestinal manifestations of mpox.Additional sections explore the Neurological complications of Mpox, Dermatological complications of Mpox infections, Reproductive complications of Mpox, and the Structural Biology of Mpox: Advanced Imaging Illuminate Viral Mechanisms.

  • Molecular Tools and Infectious Disease Epidemiology

    • 2nd Edition
    • Betsy Foxman + 1 more
    • English
    Molecular Tools and Infectious Disease Epidemiology, Second Edition examines the opportunities and methodologic challenges in the application of modern molecular genetic and biologic techniques to infectious disease epidemiology. The application of these techniques dramatically improves the measurement of disease and putative risk factors, increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. This book presents the key points of consideration when integrating molecular biology and epidemiology.Section... discuss how using molecular tools in epidemiologic research affects program design and conduct, consider the ethical concerns that arise in molecular epidemiologic studies, and provide a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory, and in the field. The book is recommended for graduate and advanced undergraduate students studying infectious disease epidemiology and molecular epidemiology; and for the epidemiologist wishing to integrate molecular techniques into their studies.

  • Procedural Medicine for Spaceflight

    • 1st Edition
    • Dana Levin + 2 more
    • English
    Procedural Medicine for Spaceflight is a collection of research and experiential data on procedural medicine and the needs of those involved in Space Medicine. Procedural medicine is a core competency for the specialty of Space Medicine, but there is no single reference available which addresses the unique spaceflight environment or the medical techniques required to ensure success.This book is divided into six sections. Starting with the Introduction, then moving to Procedural Considerations, Anesthesia and Pain Management; Post Procedure Care; Other Considerations; and concluding with The Future of Procedural Medicine in Space. Each chapter is written by experienced subject matter experts in relevant disciplines. This book is intended for physicians, medical students, engineers, mission planners, and medical researchers interested in and/or training in Space Medicine.

  • Fish Feed Formulation with Agroindustrial Wastes and Byproducts

    • 1st Edition
    • Hrudayanath Thatoi + 3 more
    • English
    Fish Feed Formulation with Agroindustrial Wastes and Byproducts provides a comprehensive examination of various agrodindustrial wastes and byproducts, detailing their nutritional composition, processing techniques, and potential applications in fish feed formulation. Sections delve into future perspectives and research directions in the field of fish feed formulation with agroindustrial byproducts, offering readers a glimpse into emerging trends, technological advancements, and opportunities for innovation. This book will assist readers in staying abreast of the latest developments, anticipating future challenges and opportunities in aquafeed production, and positioning themselves to adapt and thrive in an ever-evolving industry landscape.Readers will gain valuable insights into the diverse range of alternative feed ingredients available, allowing them to make informed decisions regarding ingredient selection and formulation strategies. Written and edited by a diverse team of aquaculture specialists, this book includes practical case studies to provide readers with concrete illustrations of how agroindustrial wastes can be effectively utilized in commercial aquafeed production.

  • Vertebrate Carbonic Anhydrases

    • 1st Edition
    • Volume 59
    • English
    Vertebrate Carbonic Anhydrases, Volume 59 in The Enzymes series, explores recent advances in the study of carbonic anhydrases (CAs) in vertebrate systems. This volume presents a comprehensive collection of chapters examining the diversity, structure, function, and physiological roles of vertebrate CA isoforms across multiple tissues and cellular compartments. Chapters include discussions on the phylogenetic relationships of vertebrate carbonic anhydrases and detailed examinations of several important isoforms, including carbonic anhydrases I, II, and III, as well as membrane-associated enzymes such as CA IV and XV. Additional contributions explore mitochondrial carbonic anhydrases (CA VA and VB), secreted isoforms such as CA VI, and more.The volume also examines acatalytic carbonic anhydrases and tumor-associated isoforms, providing insights into their structural characteristics and biological significance. A concluding chapter addresses current challenges and opportunities in the development of selective inhibitors and activators targeting vertebrate carbonic anhydrase isoforms, highlighting their potential therapeutic applications.

  • Advances in Agronomy

    • 1st Edition
    • Volume 199
    • English
    Advances in Agronomy, Volume 199, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors.

  • Nutrition and Neurotoxicology - Part B

    • 1st Edition
    • Volume 16
    • English
    Nutrition and Neurotoxicity: Part B, Volume Sixteen highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Chemicals in cow milk and soy beverages: neurotoxicity and neuroprotection, Decoding the diet-inflammation axis: modulating neuroinflammation through nutritional interventions, Phytochemicals and neuroprotection: early strategies to prevent neurodegenerative diseases, Influence of non-caloric sweeteners on neural health: The current state of knowledge, Nutraceuticals and obsessive-compulsive disorder therapy: An update, The nexus between the catabolism of tryptophan and neurotoxicity, Neuroprotective phytonutrients: mechanisms of action and evidence in neurotoxic and degenerative conditions, and more.Additional chapters delve into Nutritive agents ameliorating neurodegeneration, Nutraceuticals and Neurotoxicity, and Neurotoxicity of heavy metals across the lifespan: The beneficial role of nutrition from fetus to the elderly.

  • Healing Botanicals

    From Tradition to Therapeutics
    • 1st Edition
    • Awanish Kumar + 4 more
    • English
    Healing Botanicals: From Tradition to Therapeutics explores the connection between traditional herbal wisdom and modern medical science, examining herbaceuticals—plant... compounds with therapeutic potential—through the lens of clinical evidence, pharmacology, and global healthcare practices. Organized into five parts, the book begins by tracing the evolution of herbal medicine and delving into the phytochemical and pharmacological foundations of healing botanicals. Subsequent sections focus on botanicals for stress, immunity, digestion, chronic pain, mental health, and cardiovascular support, highlighting their applications in disease management.Special emphasis is placed on the integration of adaptogens, immune-boosting herbs, and neuroprotective botanicals in contemporary therapeutic strategies. In addition to therapeutic uses, the book addresses critical concerns such as safety, clinical validation, regulatory frameworks, and quality control. It concludes by forecasting the future of herbal medicine, exploring innovations, global trends, and the potential of plant-based therapies in preventive and personalized healthcare.

  • Current Approaches to Cryo-electron Microscopy

    • 1st Edition
    • Volume 223
    • English
    Current Approaches to Cryo-electron Microscopy, Volume 223 provides a comprehensive overview of the field, tracing its evolution from early structural studies to modern pipelines powered by deep-learning algorithms for helical reconstruction. The book addresses the persistent bottleneck of sample preparation, detailing the physical challenges of fibril clumping and interfacial adsorption, alongside emerging solutions to these problems. Chapters in this new release include Advancing biological understanding of the poxvirus scaffold through breakthroughs in cryo-electron microscopy, Pursuing the physics of cryoEM image formation, AI Tools for Cryo-EM: Protein Particle Picking, Density Map Enhancement, and Atomic Model Building, and much more.Additional chapters cover Cryo-EM of Amyloid Fibrils: Advances, Challenges, and Translational Applications, Computational Approaches for Protein Complex Modeling for Intermediate Resolution Cryo-EM Maps, Calcium-sensing receptor, involved in the oral perception of the kokumi substances, Insights into the Structure and Diversity of the Bacterial Flagellum from cryo-EM studies, Overview and future potential in structural studies of bacteriophages by cryo-electron microscopy, and more.

  • Innovative Nanocarriers for Stimulated Drug Delivery

    A Comprehensive Guide to Stimuli-responsive Nanoparticles
    • 1st Edition
    • Prashant Kesharwani
    • English
    Innovative Nanocarriers for Stimulated Drug Delivery: A Comprehensive Guide to Stimuli-responsive Nanoparticles summarizes recent advances and achievements in nanocarriers responsive to external or internal stimuli. The book presents different stimuli-sensitive strategies and their applications in drug delivery, therapy, and theranostics. Sections provide fundamental knowledge on the experiential and experimental aspects of stimuli-responsive nanocarriers, discuss external-responsive nanocarriers for biomedical applications, such as ultrasound, thermal, magnetic, light, and electric field-response systems, and describe internal stimuli-responsive nanocarriers for biomedical applications, including pH, hypoxia, redox potential, enzyme, glucose, and microRNA-responsive nanocarriers. Additionally, the book covers dual and multimodal-responsiv... nanocarriers and the therapeutic aspects of stimuli-responsive nanocarriers, such as metallic and non-metallic stimuli-responsive nanocarriers in the treatment of various cancer and noncancerous diseases. Finally, recent advances and regulatory aspects of stimuli-responsive nanocarriers, including clinical translation, challenges, biological toxicity, safety issues, clinical trials, and future perspectives are covered.

  • Statistical Bioinformatics with R

    • 2nd Edition
    • Sunil K. Mathur
    • English
    Statistical Bioinformatics with R, Second Edition offers a balanced treatment of statistical theory within the context of bioinformatics applications. The book goes beyond gene expression and sequence analysis to include a careful integration of statistical theory in bioinformatics. The inclusion of R codes, along with the development of advanced methodologies such as Bayesian and Markov models, equips students with a solid foundation for conducting bioinformatics research. Sections incorporate the latest advancements in bioinformatics and statistical methodologies, including new chapters on cutting-edge topics such as high-throughput sequencing data analysis, AI/machine learning applications in bioinformatics, and advanced statistical methods.From new and updated practical examples and case studies that illustrate real-world applications of statistical techniques to bioinformatic problems to enhanced end-of-chapter exercises, detailed code annotations, and an improved companion website with supplementary materials, including datasets and R scripts, this book is a valuable resource for both self-study and formal coursework, fostering a deeper understanding of statistical bioinformatics and equipping readers with the skills needed to tackle complex biological data analysis challenges.

  • Basal Ganglia Dynamics

    From Motor Units to Networked Chaotic Oscillators
    • 1st Edition
    • Erwin B. Montgomery Jr.
    • English
    Basal Ganglia Dynamics: From Motor Units to Networked Chaotic Oscillators addresses the critical need for new theoretical frameworks in understanding the basal ganglia–thalamic cortical system, particularly in the context of movement disorders such as Parkinson’s disease. Despite significant therapeutic advances, current dopamine replacement and Deep Brain Stimulation therapies remain limited due to incomplete and oversimplified prevailing theories. This reference provides a comprehensive alternative approach grounded in complexity science, nonlinear dynamics, and Chaotic Systems theory. The contents span foundational concepts, including motor unit orchestration, networked nonlinear oscillators, information theory, and methodological considerations. Detailed chapters cover the shortcomings of current models, the application of Chaotic System mathematics to basal ganglia physiology, and the implications for pathophysiology and treatment. The book also includes extensive simulations, operational hypotheses, and a rigorous critique of existing paradigms, supported by principles such as Causational and Informational Synonymy.

  • Cell Death Part D

    • 1st Edition
    • Volume 209
    • English
    Cell Death, Part D, Volume 209 explores the latest advances in the mechanisms, regulation, and significance of cell death in health and disease. Covering diverse topics such as apoptosis, necrosis, autophagy, and emerging pathways, this volume presents chapters on Utilizing FLAMBE to study the structure-function relationship and regulation of monomeric BAX activation in solution, Sensitive detection of Lysosomal Membrane Permeabilization using the Galectin Puncta Assay, Assessing the activity of caspase-activated pannexin-1 channels by flow cytometry, In vitro culture of intestinal organoids for cell death assessments, Optimized Strategies for Necroptosis Induction and Evaluation, and more.Additional sections cover Ferroptosis induction via genetic approaches - CRISPR/Cas9-based disruption on key anti-ferroptotic genes, Reprogramming T cell fate through antibody-mediated galectin-1 blockade, 3D bioluminescence imaging assays for measuring in vitro CAR T cell cytotoxicity, The heat-ramp method to study regulated cell death in the pathogenic yeast Cryptococcus neoformans, High throughput assessment of cellular viability, and High-Throughput Screening for Cell Death Inducers and Inhibitors. This book will serve as a valuable resource for researchers, clinicians, and students interested in understanding cellular processes and their implications for therapy and diagnostics.

  • Applications of Artificial Intelligence in Healthcare

    The Changing Landscape
    • 1st Edition
    • Debasis Bagchi + 3 more
    • English
    Applications of Artificial Intelligence in Healthcare: The Changing Landscape takes a systematic approach, discussing the benefits and achievements of AI while also exploring the questions and challenges of AI as it relates to health and medicine. The first section provides historical context, introducing the reader to the fundamentals of AI in health care. The second section addresses the primary applications of AI in healthcare, including chatbots for tele-counseling, telemedicine, and AI assisted prediction tools. The third section focuses on the use of robotics and AI driven precision instruments to carry out complex surgical procedures.The fourth section highlights emerging AI assisted technologies for the management of diseases and disorders. The fifth section covers emerging applications of AI in medical science and holistic health management, for example ChatGPT and Natural Language Processing algorithms. Finally, the sixth section concludes with chapters dedicated to federal and regulatory issues of adopting AI as it relates to human health, along with the ethical issues and limitations.

  • Molecular Targets and Therapeutic Design

    • 1st Edition
    • Volume 153
    • English
    Molecular Targets and Therapeutic Design, Volume 152 provides a comprehensive overview of the current landscape and future directions in the identification and exploitation of molecular targets for the development of new therapeutics. This volume brings together leading experts to discuss the fundamental principles of target discovery, validation, and the strategies used to design molecules that modulate biological pathways in disease. Topics covered in this new release include Recent Strategies and Approaches for the Development of Molecularly Targeted Nanomedicine, Transcriptomic Profiling for Therapeutic Target Discovery in Neuropsychiatric Conditions, Transcriptomic Insights into Hormone-Driven Malignancies: Toward Targeted Therapeutic Strategies, and much more.Additional chapters cover Targeting Kinases in Neurodegenerative Diseases and Cancer: Structural Insights and Therapeutic Strategies, Small molecular therapeutic targets for neurodegenerative diseases, Signaling cascades of Tau protein, Understanding molecular role of lipids for Alzheimer's disease, Clinical Challenges and Therapeutic Strategies in Chordoma, Molecular Characterization and Experimental Models of Chordoma, Disordered Proteins as Fuzzy Viral Drug Targets, amongst other timely topics.

  • Omega-3 and Omega-6 Polyunsaturated Fatty Acids in Food Systems

    Advances and Opportunities in Product Formulation, Technology, and Delivery
    • 1st Edition
    • Pothiyappan Karthik + 3 more
    • English
    Omega-3 and Omega-6 Polyunsaturated Fatty Acids in Food Systems: Advances and Opportunities in Product Formulation, Technology and Delivery introduces readers to the health and nutritional benefits for DHA and EPA in inflammation regulation, advances in new delivery systems, commercialization strategies, and the use of PUFAs in functional foods and new product development. The book not only provides practical guidance for formulating PUFA-enriched products for maximum health benefits, but also explores emerging trends and opportunities, including the development of novel functional foods, nutraceuticals, the role of microorganisms as a promising source of microbial oils, and personalized nutrition solutions.With detailed information on how PUFAs can be effectively and sustainably sourced, processed, formulated, and marketed in the food industry, readers will better understand and learn how to overcome the challenges of scaling up PUFA production for industrial use and maximum nutritional value. Researchers, grad students working in the fields of nutrition, food science, and biochemistry, and industry professionals in the food and pharmaceutical industries involved in product development, functional foods, and formulation will benefit from this book.

  • ​​Cannabinoids for Chronic Pain

    From Research to Clinical Applications​
    • 1st Edition
    • Alaa Abd-Elsayed
    • English
    Cannabinoids for Chronic Pain: From Research to Clinical Applications provides an in-depth exploration of cannabinoids and their applications in modern medicine. The book begins with an historical overview, followed by a detailed examination of the endocannabinoid system and cannabinoid receptors. Next, sections cover various phytocannabinoids, including CBD and THC, as well as synthetic cannabinoids like dronabinol and nabilone. Each chapter delves into the pharmacokinetics, pharmacodynamics, actions, and side effects. The content is meticulously organized to address the medical uses of cannabinoids, including in pain management, perioperative care, and their applications in specific populations such as children, pregnant women, and the elderly.Sections also discuss the medicolegal considerations surrounding cannabinoid use. Contributions from leading experts provide evidence-based recommendations and practical guidelines for clinical practice, ensuring a comprehensive understanding of the subject. This book is an invaluable resource for healthcare professionals, researchers, and students. It bridges the gap between research and clinical practice, offering practical insights and up-to-date information. Readers will benefit from its thorough coverage, multidisciplinary perspectives, and detailed discussions, making it an essential guide for anyone involved in the medical use of cannabinoids.

  • Psychology of Obesity

    • 1st Edition
    • Samapika Das Biswas
    • English
    Psychology of Obesity offers a comprehensive exploration of various psychological research and clinical experiences from both a foundation in research and practical applications. From understanding the impact of stigmatization and coping mechanisms to examining the relationships between self-esteem, anxiety, depression, and obesity, this book will be beneficial to both researchers as well as clinicians.

  • Diagnosis and Analysis of Glaucoma using AI and ML for Medical Imaging

    • 1st Edition
    • Mohammad Sufian Badar
    • English
    Diagnosis and Analysis of Glaucoma Using AI and ML for Medical Imaging highlights the importance of early detection while also discussing and updating on current treatment options to slow disease progression, emphasizing the role of artificial intelligence (AI) and machine learning (ML) in improving diagnosis and management. Sections explore causes, symptoms, diagnostic challenges, and treatment strategies for glaucoma, integrating insights on how AI and ML models can enhance healthcare delivery. Practical case studies and discussions on how accessible AI tools can be utilized by healthcare workers, NGOs, students, and researchers to address diagnostic barriers prevalent in resource-limited settings are included.This targeted resource is aimed at increasing understanding of this often asymptomatic, progressive eye disease, particularly in developing countries. Healthcare professionals, students, and policymakers will find this resource valuable with its straightforward, easy-to-understand, curriculum-aligned content. Its emphasis on practical applications and awareness-building makes it a valuable tool for advancing glaucoma care and fostering interdisciplinary collaboration in eye health.

  • Gene and Cell Therapies

    Principles of Pharmaceutical Development
    • 1st Edition
    • Chris Van Der Walle
    • English
    Gene and Cell Therapies: Principles of Pharmaceutical Development explores increasing interest in gene and cell therapies following powerful demonstrations of their capability to treat rare genetic disorders, advanced cancers, and regenerate or repair tissues. Sections cover the design of viral vectors, oncolytic viruses, ribonucleic acid cancer vaccines, and autologous and allogeneic cell therapies, along with impacts on their pharmaceutical development. Advances in molecular and cell biology that have led to efficacious and safe gene and cell therapies are also covered, including their relationship to the process and analytical developments that ensure quality.Gene and Cell Therapies: Principles of Pharmaceutical Development scope and style, along with included case studies, learning points, and lecture slides will allow non-specialists to develop a foundational understanding, while new concepts urge further advancements. Although these new, advanced medicines are continually being improved upon, their complex manufacture remains a key obstacle to increasing patient access.

  • Advances in Parasitology

    • 1st Edition
    • Volume 132
    • English
    The discipline of parasitology is undergoing a profound paradigm shift as anthropogenic pressures dissolve the boundaries separating wildlife, domestic animals, and human populations. This Volume brings together three foundational chapters on vector-borne parasite transmission, wildlife reservoirs, and the ecological frameworks necessary to combat global zoonoses. In the opening Chapter, Sarah N. Farrell and colleagues propose that treating the mosquito vector rather than the human host with antimalarial compounds may represent a suitable and sustainable strategy for malaria control. By attacking the Plasmodium parasite at its bottleneck oocyst stage within the vector, this approach exploits a lower parasite population size to drastically minimize the evolutionary selection pressure for drug resistance. Transitioning from micro-level vector dynamics to macro-level landscape epidemiology, Andrea Springer and colleagues document how conservation successes and urban adaptation have shifted the distribution of zoonotic pathogens. Focusing on the red fox as primary sentinel, the authors illustrate how wild reservoirs dynamically interact with domestic animals and humans, highlighting the importance of the health triangle connecting wild carnivores to urban public health. Finally, Alicia Rojas and Alberto Solano-Barquero dissect the micro- and macroevolutionary events, such as host-switching and hybridization, that allow multi-host parasites to overcome human physiological defenses, and propose instead a balanced "One Health pentad" that gives equal weight to wildlife reservoirs, intermediate bridge hosts, vectors, and complex environmental stages.

  • Phytotoxicity of Organic Pollutants

    Impacts and Management
    • 1st Edition
    • Golam Jalal Ahammed + 1 more
    • English
    Phytotoxicity of Organic Pollutants: Impacts and Management provides a comprehensive and up‑to‑date overview of how diverse organic pollutants affect plant physiology, growth, and development. Bringing together contributions from leading experts, the book examines the sources, environmental behavior, and biological impacts of major classes of organic pollutants. The volume highlights recent advances in understanding the physiological, biochemical, and molecular mechanisms underlying plant responses to organic pollutant exposure. It also explores plant‑ and microbe‑based remediation strategies, emphasizing their potential to safeguard food quality and ecosystem health. Phytotoxicity of Organic Pollutants: Impacts and Management serves as an interdisciplinary resource for researchers, academics, graduate students, environmental professionals, and industry practitioners working in plant science, ecotoxicology, environmental chemistry, and sustainable remediation.

  • Brain Energy Metabolism in Alzheimers Disease - Part B

    • 1st Edition
    • Volume 187
    • English
    Brain Energy Metabolism in Alzheimer’s Disease – Part B, Volume 187 in the International Review of Neurobiology series, presents current advances and comprehensive reviews on metabolic dysfunction in neurodegenerative diseases. This volume brings together contributions from an international panel of experts, focusing on the molecular and cellular mechanisms underlying energy imbalance in Alzheimer’s disease and related disorders.Chapters in this release explore key processes such as autophagy and ESCRT pathways, tau modifications, insulin resistance, and mitochondrial dysfunction. Additional sections examine neurovascular–glial interactions, genetic and epigenetic factors in neurodegeneration, and the roles of metallospecies, noncoding RNAs, and phase separation in disease progression.Further contributions address neuroprotective signaling pathways, metabolic impairments in glucose and lipid homeostasis, and emerging diagnostic and therapeutic approaches, including liquid biopsy markers and targeted metabolic interventions. Together, these chapters provide an integrated overview of the mechanisms, biomarkers, and therapeutic opportunities associated with brain energy metabolism in neurodegenerative diseases, making this volume an essential reference for researchers and clinicians in neuroscience and neurobiology.

  • MEX Das Mündliche Examen - Neurologie

    mit Bilderquiz
    • 3rd Edition
    • Andreas Bender
    • German
    Bestens gewappnet, um in der Prüfung Rede und Antwort zu stehen!Die mündlich-praktische Prüfung des Staatsexamens naht, du musst viel Wissen in kürzester Zeit abrufen, absolute Sicherheit auf allen Themengebieten besitzen und souverän auftreten – zahlreiche Absolventen bestätigen seit über einem Jahrzehnt: mit MEX ist das möglich!MEX – Das Mündliche Examen heißt, die „Mündliche“ im Fach Neurologie in der Tasche zu haben – ganz ohne unnötigen Ballast. MEX erspart dir Redundanzen sowie lästiges Blättern in anderen Werken und gestaltet Lernen und Wiederholen enorm effizient. Hier bekommst du wirklich alles, was du für die letzte Hürde vor deinem Abschluss wissen musst!Deine Garantie für einen professionellen Auftritt am 1. und 2. Prüfungstag!MEX bietet …zahlreiche Tipps und Fakten zu Vorbereitung und Ablauf der mündlich-praktischen PrüfungDiagnostik Schritt für Schritt erklärt – von der Anamnese und den wichtigsten Untersuchungsmethode... bis zu den relevanten Krankheitsbildernsys... differenzialdiagnost... Vorgehen dank 16 anschaulicher Flussdiagramme zu den häufigsten Leitsymptomendie optimale Fallpräsentation, von Analyse bis Vorstellung, mit 24 alltags- und prüfungsrelevanten Fällendas ideale Training der realen Prüfungssituation nach dem Frage-Antwort-Prinzi... mit einer strengen Auswahl der wichtigsten und aktuellen Prüfungsprotokollfra... Bilderquiz zum Selbsttest mit typischen CT- und MRT-Aufnahmen, wie in der PrüfungNeu in der 3. Auflage:Alle Kapitel wurden überarbeitet mit besonderem Fokus auf die Aktualität der Fälle, häufig geprüfte Themen und neueste medizinische Erkenntnisse, einschließlich neuer LeitlinienMEX – DU LIEST ES, DU VERSTEHST ES, DU WEISST ES!

  • Cardiometabolic Dynamics

    A Deep Dive into Health and Disease
    • 1st Edition
    • Yihua Bei + 1 more
    • English
    Cardiometabolic Dynamics: A Deep Dive into Health and Disease explores the intricate relationship between metabolic health and cardiovascular diseases, illuminating how cellular and molecular mechanisms contribute to metabolic dysregulation. The book delves into the ways metabolic pathologies act as precursors to cardiovascular conditions, including hypertension, atherosclerosis, cardiomyopathy, and heart failure. With a focus on healthy cardiometabolic dynamics, it underscores the crucial role they play in sustaining cardiovascular wellness, offering a comprehensive perspective on the intersection of metabolism and heart health.The book further examines the influence of lifestyle factors, such as diet and exercise on cardiovascular metabolism and highlights emerging technologies like omics, genetic engineering, and wearable devices to advance research, diagnosis, and treatment.

  • Ion Channels in Cellular Pathophysiology Part B

    • 1st Edition
    • Volume 98
    • English
    Ion Channels in Cellular Pathophysiology Part B, Volume 98 covers a variety of timely topics, including Nerve electrophysiological alterations in experimental diabetic neuropathy, Possible therapeutic effects of essential oils on Na channels in experimental diabetic neuropathy, Breast cancer and voltage gated ion channels, Cardioprotective effect of natural products on doxorubicin-induced acute cardiotoxicity and cardiac ischemia-reperfusion injury,and Modulation of ion channels by Group I metabotropic glutamate receptors.

  • How Plant-Based Fermented Foods are Shaping the Future of Health and Sustainability

    • 1st Edition
    • Volume 120
    • English
    How Plant-Based Fermented Foods are Shaping the Future of Health and Sustainability, Volume 120 in the Advances in Food and Nutrition Research series, presents interesting chapters on topics such as What is the role of fermented plant foods in sustainable and secure food systems?, Recent trends in plant-based fermented foods: fermentation technologies and their impacts on phytochemicals and health benefits, Beyond dairy: The science and sustainability of plant-based yogurt alternatives, Designing fermentation to enhance oat and faba bean properties, The role of fermentation in digestion of plant-based food, Fermented Plant-Based Diets and Gut Health: A Critical Evaluation, and much more.Additional chapters cover B vitamins bioavailability in plant-based fermented foods: Beyond content to nutritional impact and Legume Fermentation: Nutritional Benefits and Emerging Applications.

  • Explainable AI in Clinical Practice

    Advanced Applications and Future Directions
    • 1st Edition
    • Saurav Mallik + 4 more
    • English
    Explainable AI in Clinical Practice: Advanced Applications and Future Directions builds on foundational concepts to explore the practical implementation and emerging trends of transparent AI in healthcare. Featuring contributions from leading experts, this volume presents advanced methodologies, real-world case studies across various medical specialties, and strategies for overcoming ethical, regulatory, and operational challenges. The book offers comprehensive frameworks for integrating explainable AI into clinical workflows, emphasizing trust, patient understanding, and regulatory compliance. In addition, it examines future technologies such as federated learning, multimodal systems, and human-AI collaboration, providing insights into the evolving landscape of AI in medicine.Essential for healthcare professionals, researchers, and policymakers, this volume aims to accelerate the responsible adoption of explainable AI, ultimately enhancing patient care, clinical decision-making, and healthcare system efficiency.

  • Cadmium Contamination in Soils and Plants

    Mechanisms and Mitigation
    • 1st Edition
    • Fang-Jie Zhao + 2 more
    • English
    Cadmium Contamination in Soils and Plants presents a rigorous, up-to-date account of how this toxic metal enters agricultural landscapes, persists in soils, interacts with living systems, and ultimately affects food safety and human health. The volume synthesizes cutting-edge findings on the processes that drive Cd movement from soil to crops and clarifies the biological pathways by which plants and microorganisms respond. It translates scientific insight into practical solutions for safer agricultural production systems, drawing on recent advances in measurement, modeling, and remediation.This book is intended for researchers, graduate students, and professionals across environmental science, agronomy, and public health who need an authoritative, research-grounded reference to inform decisions in cultivation-related settings.

  • Hormones in Neuroscience

    The Pancreas and Pancreatic Hormones
    • 1st Edition
    • Victor R. Preedy + 3 more
    • English
    Hormones in Neuroscience: The Pancreas and Pancreatic Hormones explores the latest research in neuroendocrinology in relation to the pancreas and pancreatic hormones. This volume aims to cover the deficiencies in existing literature on the link between hormones and neurological tissues. This book offers a translational context and seeks to address the behavioral consequences of altered endocrine gland pathology while also addressing causative and modulating influences.

  • Microbiome in Head and Neck Cancer: Pathogenesis, Diagnosis and Therapeutic Implications

    Part A
    • 1st Edition
    • Volume 169
    • English
    Microbiome in Head and Neck Cancer: Pathogenesis, Diagnosis and Therapeutic Implications, Volume 169 in the Advances in Immunology series, presents an authoritative exploration on how microbial communities contribute to the initiation, progression, and treatment of head and neck cancers. Chapters highlight The Microbiome of the Head and Neck Region, Overview Head and Neck Microbiota and the Factors Influencing the Head and Neck Microbiome, Mechanistic Pathways of Dysbiosis in Cancer Development, Oral Microbiota and OPMDs, Oral Potentially Malignant Disorders (OPMDs): An Overview, Oral Microbiota and Oral Cancer, Oral Squamous Cell Carcinoma (OSCC): An Overview, and much more.Additional chapters cover the Role of the Oral Microbiome in Oral Cancer (OSCC), Microbiome as a Prognostic Indicator in Oral Cancer, Diagnostic and Therapeutic Applications, Microbiome-Based Diagnostic Approaches, Modulating the Head and Neck Microbiome for Cancer Prevention, Microbiome-Targeted Therapeutics in Head and Neck Cancer, Artificial Intelligence in Microbiome Data Analysis: Applications in Head and Neck Cancer, and Challenges and Future Directions in Head & Neck Microbiome Research.

  • Native and Modified Starches for Food Applications

    • 1st Edition
    • Pothiyappan Karthik + 2 more
    • English
    Native and Modified Starches for Food Applications, a volume in the Applications of Starches in Food and Packaging series, provides an in-depth exploration of the diverse types and sources of starches, their functional properties, and their applications in various culinary contexts. Chapters cover the gelatinization process, texture modification, and sustainable utilization of starches in addition to exploring future directions in starch research and applications. As the food industry continues to seek natural, functional ingredients, this resource meets the demand for a comprehensive and up-to-date exploration of the use of starches in food applications.Users will find this to be a great resource for facilitating informed decision-making in recipe development, processing techniques, and the creation of innovative, sustainable, and gluten-free food products.

  • Environmental Microbiology

    • 4th Edition
    • Ian Pepper + 3 more
    • English
    Environmental Microbiology, Fourth Edition is the revised edition of a key, foundational text for the field of environmental microbiology which hits all the pillars of the field and takes into account the tremendous advances in environmental microbiology over past decade. It provides comprehensive information on traditional methodologies utilized to study environmental microbes, as well as state-of-the-art technologies. Emphasis is placed on molecular and bio-informatic approaches to the study of environmental microbes, including nucleic acid and ‘omic methodologies. The book is divided into seven parts that stretch across microbiology concepts, microbial environments, microbial methods and technologies, microbial transport, biogeochemistry, and bioremediation, water and foodborne pathogens, wastewater treatment and distribution, and urban microbiology. 1) “Environmental Microbiology” is the study of microbes within all habitats, and their beneficial and detrimental impacts on human health and welfare. This book illustrates the significance of environmental microbes in our daily lives in terms of not only the overall health of the planet, but also: what infects us; what heals us; what we drink; what we eat; and what we breathe.

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