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Books in Life sciences

  • Cellular Therapies for Cancer Treatment

    Advancements in Drug Delivery Strategies
    • 1st Edition
    • Arun Kumar Singh + 3 more
    • English
    Cellular Therapies for Cancer Treatment: Advancements in Drug Delivery Strategies explores the innovative use of cellular therapy to combat cancer, placing an emphasis on state-of-the-art delivery approaches. By covering a variety of cellular therapies for cancer, such as stem cells, immune cells, and others, this book provides a comprehensive introduction to the field. It describes ways to deliver drugs that target cancer cells more efficiently, decrease off-target effects, and enhance therapy outcomes. In 14 chapters, Cellular Therapies for Cancer Treatment: Advancements in Drug Delivery Strategies provides a brief overview of cancer cell biology, describes the need for advance drug delivery systems in cancer and gives a directive to the challenges and future directions associated with cellular Therapies for cancer treatment. The book also goes into the ideas behind cellular therapies and how they may overcome drug resistance and make existing cancer treatments more effective. By elaborating on the value of diversity and inclusion in cancer research and treatment, the book also emphasizes the importance of all patients having equal access to innovative therapies. All things considered, the book is a great tool for researchers, doctors, and students in the cancer treatment sector.

  • Artificial Intelligence and Food Science

    • 1st Edition
    • Rana Muhammad Aadil + 3 more
    • English
    Artificial Intelligence and Food Science is a wide-ranging and timely textbook that explores the impact of AI and smart technologies on the food industry. It examines a range of applications from pre- and post-harvest management to food packaging, and the dairy industry, providing a thorough overview of how AI is revolutionizing these industries. By addressing the pressing need for innovation and efficiency, this book offers valuable insights into the integration of AI for enhancing food quality, safety, and sustainability across different food industries. The initial chapters introduce the fundamentals of AI and its recent advancements, covering key areas such as Constraint Satisfaction Problems, Adversarial Search, and Statistical Learning Theory. The book then moves on to explore AI applications in pre- and post-harvest management and highlights techniques such as machine vision and spectral imaging for non-destructive analysis of agricultural products. Subsequent chapters probe the use of AI in the processing of fruits, vegetables, dairy, and meat, and detail how technologies like neural networks and Industry 4.0 innovations can drive improvements in product quality. The role of AI in the fat and oil processing industry, specifically the use of bioinformatics predictive methods based on artificial neural network (ANN) is discussed in detail. Later chapters explore AI applications in the baking and confectionery industries, with a focus on automation and 3D printing technologies that are setting new standards for production and product design. This textbook is an essential resource for upper-level undergraduate students in food science, agricultural engineering, and related disciplines. It is also useful for researchers and professionals working in food technology, agricultural automation, and environmental consulting. Artificial Intelligence and Food Science contains PowerPoint slides, and a test bank as additional resources for students and instructors.

  • Aging and Troponin

    Clinical Implications and Uses Beyond Diagnosis
    • 1st Edition
    • Gary Tse + 3 more
    • English
    Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Section I covers the technical aspects of troponin assays, comparing traditional and high-sensitivity assays, and exploring point-of-care testing advancements. It also examines age-related changes and intra- and inter-individual variability in troponin levels. Section II focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity. Section III discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice. Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis is an invaluable resource for researchers, clinicians, and healthcare professionals seeking to understand the impact of aging on troponin levels.

  • Starch and Health

    Nutrition, Metabolism and Medical Applications
    • 1st Edition
    • Monica Trif + 3 more
    • English
    Starch and Health: Nutrition, Metabolism and Medical Applications, a volume in the Applications of Starches in Food and Packaging Series, discusses the use of starch and its role in human health. This volume provides detailed information on the glycemic index of various starches, the role of resistant starch in gut health, and practical starch uses in managing disorders such as diabetes and cardiovascular disease. Through detailed analysis and practical insights, readers gain a deeper understanding of the nutritional and medicinal applications of starch. Chapters deal with digestive metabolism of starch; different types of resistant starches and its health benefits; starch in gut, cardiovascular, and mental health; besides innovations in starch-based medical applications, and its implications in food allergies and intolerances. This comprehensive approach ensures that the volume serves as both an informative guide and a practical tool for those in the field. By compiling the latest research findings, methodologies, and case studies, this book serves as a valuable resource for scientists, researchers, and industry professionals seeking to harness the potential of starch in human health.

  • Drug Targeting Complexity

    Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy
    • 1st Edition
    • Lalit Kumar + 2 more
    • English
    Drug Targeting Complexity: Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy presents a rigorous examination of advanced strategies for the selective targeting of neoplastic cells and their distinct microenvironments. This comprehensive volume elucidates both tissue-specific and tumor-specific molecular targets, clarifying how these methodologies can significantly enhance therapeutic precision while mitigating off-target effects. The initial section of the text provides an in-depth analysis of tissue-specific regulatory targets across various organs, including the liver, lungs, brain, skin, and bones. It delineates the critical mediators and mechanisms that govern tumor immunity, thereby identifying novel therapeutic avenues. Each chapter meticulously evaluates key regulatory molecules such as TGF-β, CTLA-4, and IL-10, exploring their roles in tumorigenesis and the potential for targeted interventions across a spectrum of malignancies. The subsequent sections focus on tumor tissue-specific molecular targets, encompassing immunological checkpoints, growth factors, and signaling pathways pertinent to cancers of the liver, stomach, ovary, prostate, and colon. The text provides insights into the application of monoclonal antibodies and molecular inhibitors as strategies to impede cancer progression and address therapeutic resistance. In its concluding chapters, the volume addresses emerging therapeutic paradigms, including precision medicine and nanotechnology, emphasizing their capacity to refine drug delivery systems and customize therapeutic regimens based on individual genetic and molecular profiles. This academic reference is intended for pharmaceutical scientists, pharmacologists, and oncologists seeking a comprehensive understanding of targeted cancer therapeutics, thereby establishing a foundation for the next generation of oncological treatments aimed at optimizing patient outcomes through personalized, precision-based methodologies.

  • Protein Serine/Threonine Kinases in Neurodegenerative Disorders

    • 1st Edition
    • Heba Mohamed Mansour + 1 more
    • English
    Protein Serine/Threonine Kinases in Neurodegenerative Disorders provides a comprehensive overview of protein serine/threonine kinases (STKs) in health and disease. It also discusses protein kinase inhibitors and their potential role in modulating and treating neurodegenerative diseases. The book begins with an introduction to protein kinases and inhibitors, followed by detailed discussions on different types of kinases, including protein kinase C (PKC), AMP-activated protein kinase (AMPK), Death-associated protein kinase 1 (DAPK1), cyclin-dependent kinases (CDKs), glycogen synthase kinases (GSKs), Rho-associated protein kinase (ROCK), microtubule affinity regulating kinases (MARK), mammalian target of Rapamycin (mTOR), Leucine-rich repeat kinase 2 (LRRK2), PTEN-induced kinase 1 (PINK1), dual-specificity tyrosine phosphorylation-regu... kinase (DYRKs), and their roles in neurodegenerative disease, potential inhibitors, and therapeutic mechanisms.Protein Serine/Threonine Kinases in Neurodegenerative Disorders features 23 chapters written by renowned experts in kinases field. It explores novel targets modulated by protein kinases, including non-coding RNAs (ncRNAs), mitogen-activated protein kinases (MAPKs) activated by tyrosine receptor kinases, and their roles in neurodegeneration. It also discusses the nexus between glycogen synthase kinases (GSKs) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their metabolic regulation role in neurodegeneration. The modulatory effects of protein kinase B (PKB/AKT) pathways in various neurodegenerative disorders, particularly Parkinson’s disease, are also examined. The book sheds light on bioactive compounds from natural products that target kinases. The book explains the role of different kinases in various pathogenic pathways and mechanisms involved in neurodegeneration, including regulated cell death, autophagy, synaptic dysfunction, and neuroinflammation. It also discusses splicing kinases in regulating splicing factor phosphorylation and details how aberrant kinase activity leads to splicing defects that contribute to neurodegenerative pathologies. This book emphasizes bridging laboratory research with clinical applications, focusing on translational opportunities. It includes insights from FDA regulatory experts on therapeutic applications and safety considerations of targeting kinases, highlighting the importance of balancing efficacy and safety, particularly in relation to drug-induced liver injury associated with kinase inhibitors. Finally, the book discusses the obstacles and opportunities for the potential repositioning of protein kinase inhibitors in neurodegenerative disorders.

  • Structural and Functional Dynamics of Nontuberculous Mycobacterium Proteins

    Insights into Pathogenic Mechanisms
    • 1st Edition
    • Parissa Farnia + 3 more
    • English
    Structural and Functional Dynamics of Nontuberculous Mycobacterium Proteins: Insights into Pathogenic Mechanisms explores the structural and functional dynamics of nontuberculous mycobacterium (NTM) proteins, focusing on their roles in pathogenicity, the mechanisms underlying microbial infections, and the potential for developing targeted therapeutic strategies to combat these emerging pathogens. The book begins with a foundation overview of nontuberculous mycobacteria (NTM), distinguishing them from Mycobacterium tuberculosis, their epidemiology, clinical significance, and structural biology. It discusses key structural features of NTM proteins and advanced techniques for protein structure determination, proteomic analyses, and bioinformatics approaches. It also investigates the pathogenic mechanisms and the complexities of the host-pathogen interaction. Concluding with insights into emerging research, interdisciplinary collaboration, future treatment, and prevention strategies, Structural and Functional Dynamics of Nontuberculous Mycobacterium Proteins: Insights into Pathogenic Mechanisms is a helpful resource for researchers and healthcare professionals engaged in the study of infectious diseases.

  • Atlas of Heart and Vascular Pathology

    • 1st Edition
    • E. Rene Rodriguez + 1 more
    • English
    Atlas of Heart and Vascular Pathology presents disease entities through descriptions of gross and microscopic features in featuring images that are well-annotated. The authors illustrate with clarity common aspects of cardiovascular anatomy and pathology useful to medical and non-medical professionals who work on cardiovascular medical, surgical, technical and scientific fields. It is an indispensable reference to understanding the three-dimensional architecture of the heart to further understand how disease or pathologic processes affect its function. The atlas presents detailed knowledge of how the normal heart structure can adapt to physiologic processes and how this adaptation can progress into pathologic states. In modern practice there are many interventions available to address diverse structural components of the heart and vascular systems (coronary arteries, valves, pericardium, the heart muscle itself, and vessels), many such interventions will be demonstrated in the atlas. Complications of such interventions, causing pathologic changes are also illustrated. This resource aids to understand the anatomical features and landmarks of the cardiac structures affected by pathologic process or by interventions and surgical procedures. In addition, it can help cardiovascular imagers and radiologists evaluate anatomic structures and interpret pathologic alterations.

  • Statistical Bioinformatics with R

    • 2nd Edition
    • Sunil K. Mathur
    • English
    Statistical Bioinformatics with R, Second Edition offers a balanced treatment of statistical theory within the context of bioinformatics applications. Designed for a one- or two-semester senior undergraduate or graduate statistical bioinformatics course, this text provides a comprehensive overview of the statistical methods that can be used to analyze bioinformatics data including omics and single cell-RNA seq data. It goes beyond gene expression and sequence analysis to include a careful integration of statistical theory in bioinformatics. The inclusion of R codes, along with the development of advanced methodologies such as Bayesian and Markov models, equips students with a solid foundation for conducting bioinformatics research. Statistical Bioinformatics with R, Second Edition expands upon the original material by incorporating the latest advancements in bioinformatics and statistical methodologies, including new chapters and sections that explore cutting-edge topics such as high-throughput sequencing data analysis, AI/machine learning applications in bioinformatics, and advanced statistical methods. From new and updated practical examples and case studies that illustrate real-world applications of statistical techniques to bioinformatic problems, to enhanced end-of-chapter exercises, detailed code annotations, and an improved companion website with supplementary materials, including datasets and R scripts, this book is a valuable resource for both self-study and formal coursework, fostering a deeper understanding of statistical bioinformatics and equipping readers with the skills needed to tackle complex biological data analysis challenges. Ancillary materials including PowerPoint lectures for both students and instructors and an Instructors Manual provide support for students across upper-level undergraduate and graduate courses in bioinformatics, computational biology, and biostatistics.

  • The Potential of Extracellular Vesicles from Plant and Animal Sources for Improving Human Beauty and Health

    • 1st Edition
    • Khalid Rehman Hakeem + 2 more
    • English
    The Potential of Extracellular Vesicles from Plant and Animal Sources for Improving Human Beauty and Health is a comprehensive resource that consolidates the latest research on the mechanisms of extracellular vesicles (EVs) and their application to the cosmetic industry. The book explores a range of topics, including the latest techniques in isolation and characterization of EVs, safety considerations, methods and challenges associated with large-scale production, and recent advancements in biomedical applications. The therapeutic potential of EVs for age-related neurological conditions and autoimmune skin diseases is investigated, as well as the application of EVs for skincare, hair loss and anti-aging products. The book considers EVs from a variety of sources, including humans, plants, animals and bacteria, highlighting their major differences. It also includes discussion of market trends and global impact for EV products in the cosmetic and anti-aging industries. With growing interest in the role of extracellular vesicles in enhancing health and beauty, this book provides invaluable insights to researchers working in this field, equipping them with the knowledge to leverage EVs for innovative cosmetic applications and natural solutions.

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