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Elsevier

Books in Life sciences

  • Guide to Plant Transcription Factors

    • 1st Edition
    • Aryadeep Roychoudhury
    • English
    Guide to Plant Transcription Factors is the first comprehensive resource on the dynamics of transcription factor function in plants, covering their roles in process regulation, stress management, post-translational modification, and epigenetic control. The book explores how transcription factors can be manipulated or engineered for crop improvement, offering insights into their regulatory mechanisms and practical applications.Transcr... factors bind to upstream regions of target genes and recruit additional proteins, often facilitating chromatin remodeling to enable further binding. They play critical roles in diverse physiological processes, including seedling development, shoot and root growth, flowering, fruit ripening, seed maturation, nitrogen fixation, and photosynthesis. Plant transcription factors belong to numerous families, each with distinct mechanisms and functions. They also govern plant responses to pathogens and tolerance to abiotic stresses through complex gene regulatory networks.This volume provides a systematic overview of recent advances in transcription factor research, their relationship with stress tolerance, and the roles of individual transcription factors in plant systems. Featuring contributions from leading scientists worldwide, Guide to Plant Transcription Factors is an essential reference for researchers, academics, and advanced students in plant biology and biotechnology.

  • Innovations and Human Factors Challenges in Healthcare Product Design

    • 1st Edition
    • Kamalpreet Sandhu + 3 more
    • English
    Innovations and Human Factors Challenges in Healthcare Product Design covers best practices and advanced design methods to capture, document, and validate various challenges at the early stage of the design process, also delving into how to mitigate design strategies to address those challenges without compromising the cost, effort, safety, and quality of the device. The book provides a comprehensive collection of technical notes, research designs, design methods and processes, case studies, comprehensive literature on the industrial impact of design methods and processes, and applications of digital technologies for design, analysis, manufacturing, testing, and deployment. Readers will find multidisciplinary coverage of the application of technology and science for product design in healthcare sectors.

  • miRNA in Human Disease

    From Biomarkers to Therapeutics
    • 1st Edition
    • Parul Gupta + 6 more
    • English
    miRNA in Human Disease: From Biomarkers to Therapeutics explores the critical role of microRNAs (miRNAs) in the development and progression of various diseases, emphasizing their significance as biomarkers and therapeutic targets. Sections provide a comprehensive overview of the biogenesis, function, and regulation of miRNAs, offering insights into how these small noncoding RNA molecules influence gene expression and contribute to disease development and progression. The book covers traditional and advanced methods for miRNA extraction, the role of miRNAs in infectious diseases, cancer, neurological disorders, cardiovascular disease, hemoglobinopathies, pregnancy complications, and metabolic disorders.Sections also discuss the latest research on miRNA-based therapies, including the design and delivery of miRNA mimics and inhibitors and their potential applications in personalized medicine. With a strong focus on practical implementation, the book includes detailed case studies and real-world examples that demonstrate the clinical relevance of miRNA research. It addresses the challenges and future directions in the field, providing a roadmap for researchers, clinicians, and industry professionals to harness the potential of miRNAs for disease diagnosis, treatment, and prevention.

  • Enzymology for Biotechnologists

    • 1st Edition
    • Timir Tripathi + 1 more
    • English
    Enzymology for Biotechnologists provides a comprehensive introduction to enzymology with a strong focus on its applications in biotechnology. Chapters cover the fundamental principles of enzyme structure, function, kinetics, and assays, and extends into advanced topics such as enzyme production, immobilization, reactor design, process intensification, and the use of enzymes in low-water and green solvent systems. Special attention is given to industrial applications, grey and white biotechnology, and the integration of processes that highlight sustainability and innovation. The book presents enzymology from a perspective of biotechnology, and focuses on scale-up, process design, and industrial applications. This targeted approach makes sure that BTech, MTech, MSc, and PhD students, as well as researchers and professionals, gain not only a solid understanding of enzyme science but also its translation into real-world biotechnological processes.

  • Biomedical Basis of Human Disease

    From Research to Clinic
    • 1st Edition
    • Ahmed El-Hashash + 3 more
    • English
    Biomedical Basis of Human Disease: From Research to Clinic provides information on pathophysiology/mech... of organ system disease and selected disorders and diseases that cause the most deaths worldwide, including but not limited to cardiovascular, respiratory, gastrointestinal and nervous systems. This information is placed within the structural context of tissue/organ, molecular and cellular biology, pathophysiology, diagnostic and treatment methods, and disease models in sections that also describe recent research examples, such as recently developed cutting-edge in vitro and in vivo biomedical science methods to bridge the bench and bedside. This text is suitable for students, researchers and practitioners in biomedicine and basic medicine.

  • Pulse Breeding, Processing, Functionality, and Products

    • 1st Edition
    • Fatma Boukid + 3 more
    • English
    Pulse Breeding, Processing, Functionality, and Products reflects the shift from animal- to plant-based foods, addressing increased interest in pulses due to their higher protein contents when compared to most cereals. The book provides comprehensive coverage of a wide range of knowledge related to pulses, from breeding approaches and market landscapes to extraction and fractionization, post- treatments for improved ingredients, their nutritional and compositional qualities, advances in testing methods, and their potential industrial applications in food and pet food. With its inclusion of problems/solutions and issues-focused insights, the book's content is valuable for immediate application and for inspiring additional research. The book offers the food industry and researchers the necessary insights to know the latest developments and emerging uses of pulse ingredients. As pulses have high adaptability, versatility, and offer potentially significant contributions to the human diet and pulse ingredient flours, proteins, fibers, and starches, they are increasingly being used in food formulations, hence this book covers the topic with a wide breadth of knowledge. Challenges, including taste, color, bite, mouthfeel, and texture are also covered for innovative products.

  • Principles of Antiviral Drug Development

    Rapid Discovery Technologies and Practical Applications
    • 1st Edition
    • Ailin Liu
    • English
    Principles of Antiviral Drug Development: Rapid Discovery Technologies and Practical Applications systematically integrates the major experimental techniques and virtual drug screening methods involved in the discovery of antiviral drugs, and provides a detailed discussion of their applications: among them, the combination of virtual drug screening technologies coupled with experimental methods offers strong potential for the rapid discovery of antiviral agents. The book also discusses activity-guided extraction, isolation, and activity evaluation of active components in order to reveal the material basis of antiviral activity and preliminary mechanisms of action. The book also discusses: drug repurposing of approved medicines; and an analysis of the discovery and mechanistic studies of a series of antiviral natural products which offer important information on the needs of future research, development, together with the clinical application of new antiviral drugs.

  • Body-on-a-Chip

    Design, Technology, and Applications
    • 1st Edition
    • Anthony Atala + 1 more
    • English
    Body-on-a-Chip: Essentials and Applications provides the reader high-quality information, in a single resource, that is necessary to explore the use of BOC systems from design and development to testing and personalized medicine, to medical research and diagnostics. BOC systems can recapitulate native tissue/ organ architecture, diffusion kinetics of drugs physiological flow conditions etc., similar to what would happen in the body, they are particularly powerful in predicting human efficacy prior to clinical testing of a drug, determining potential toxicity, or in clinical studies to test underlying mechanisms or action or adverse effects. With recent advancements in high-throughput analysis systems and artificial intelligence, it has also become possible to screen several drugs at a time.

  • Marine Mammals of the World

    A Comprehensive Guide to Their Identification
    • 3rd Edition
    • Marc A. Webber + 2 more
    • English
    Marine Mammals of the World, Third Edition describes and illustrates newly discovered and rarely photographed species, making it the most comprehensive and up-to-date identification guide to all marine global mammal species. This latest edition meets the research-focused needs of marine biologists, conservation biologists, and students, as well as weekend whale-watchers and community scientists by providing an unmatched collection of new illustrations and photos brought about by related advances in digital and drone photography. This guide describes the identification features, global distribution, and basic biology of all the extant and recently extinct marine mammal species, including cetaceans, sirenians, pinnipeds, and other marine carnivores.This a vital resource for marine biologists and ecologists, as well as wildlife managers, conservation and comparative biologists, and physiologists.

  • Patient Treatment and Management Following an Osteoporotic Vertebral Compression Fracture

    • 1st Edition
    • Douglas P. Beall
    • English
    Worldwide, vertebral compression fractures (VCFs) continue to be the most common major fragility fracture, affecting patients over the age of 50, and osteoporosis is the most prevalent condition associated with VCFs. Patient Treatment and Management Following an Osteoporotic Vertebral Compression Fracture provides treatment and management guidance of the osteoporosis disease process in patients who have had a VCF. This book opens with a foundation of osteoporosis and VCF and then reviews clinical and radiological assessment approaches, evaluation, treatment, and ongoing management options. Subsequent chapters cover the efficacy of the different vertebral augmentation types on patient outcomes, optimization methods, decisions for osteoporosis treatment in these patients, and recommendations to improve patient outcomes. Special attention is paid to the treatment sequence and objectives following an osteoporotic VCF. This book concludes with coverage of insightful developments in clinical management and current research and features targeted case studies representing common patient characteristics that showcase varying aspects of different VCFs and the underlying osteoporosis that gives rise to these fractures. This title serves as an invaluable resource for any practitioner managing fragility fractures in older patients as well as treating their underlying osteoporosis.

  • Advanced and Integrative Therapeutic Strategies in Parkinson’s Disease Management

    • 1st Edition
    • Wael Mohamed
    • English
    Advanced and Integrative Therapeutic Strategies in Parkinson’s Disease Management offers a comprehensive exploration of the latest innovations and multidisciplinary approaches in Parkinson’s Disease treatment. The volume is organized into sections covering genetic therapies, gut microbiota, artificial intelligence, virtual reality, neuroprotective strategies, polypharmacy, and combination therapies. It addresses the integration of personalized medicine, neuroprotective diets, natural products, cognitive enhancers, and ethical considerations. Additional chapters introduce traditional medicine, music therapy, and the synergy between pharmacotherapy and complementary modalities. The book equips readers with the knowledge to implement innovative therapies, navigate complex ethical landscapes, and integrate multidisciplinary and complementary approaches.This reference is essential for those seeking to advance clinical practice and research in Parkinson’s Disease through the adoption of cutting-edge strategies.

  • Stem Cell Toxicology

    Principles, Models, and Applications
    • 1st Edition
    • Guibin Jiang + 2 more
    • English
    Stem Cell Toxicology: Principles, Models, and Applications is the first comprehensive and practical academic book to systematically present cutting-edge progress of stem cell technologies for toxicological research and applications. This book addresses the current paradigm shift in toxicology by exploring the application value of stem cell models in assessing risks associated with complex exposures, including environmental pollutants, drugs, and food additives. It offers a complete theoretical framework and technical toolkit for professionals engaged in toxicology, stem cell biology, drug safety assessment, and environmental health research.

  • Wood-Water Interactions

    • 1st Edition
    • Samuel L. Zelinka + 3 more
    • English
    Wood-Water Interactions examines the complex relationship between wood and water using an intuitive approach to what has historically been treated as an opaque and demanding field of study. Wood-moisture interactions dominate nearly every facet of wood technology and utilization, yet new findings continue to change our understanding of this topic. Authored by experts in the field, the chapters follow a logical structure and include case studies with vivid illustrations. Readers are motivated to understand updated information about the interaction of water with wood, the effect of changes in moisture content on the properties of wood and wood-based materials as well as the latest research methods used to study wood-water interactions.

  • Artificial Intelligence and the Water-Energy-Food Nexus

    Innovations for Sustainable Resource Management
    • 1st Edition
    • Ali Fares
    • English
    Artificial Intelligence and the Water-Energy-Food Nexus: Innovations for Sustainable Resource Management is a groundbreaking exploration on how AI transforms the management of our planet's most vital resources. Specific topics include enhancing poultry production and the predictions of crop yields and post-harvest processing, while also dealing with FEW security in sub-Saharan Africa. Additionally, the book covers various topics that showcase AI's potential to boost agricultural productivity, mitigate climate change, and promote food security. This book's content covers ethical considerations, interdisciplinary collaboration, and the integration of AI into real-world practices.Readers will find an in-depth analysis of the intersections of AI and the FEW Nexus, including the critical need for sustainable farming practices, water conservation, and energy efficiency. Contributing authors are experts from around the globe who offer practical solutions, case studies, and cutting-edge technologies like digital twins, machine learning, and hyperspectral imaging to optimize resource management.

  • Neuroscience of Social Behavior

    Bridging the Mind and Society
    • 1st Edition
    • Mikhail Votinov
    • English
    Social behavior is fundamental to human experience, yet the neural mechanisms that govern how individuals perceive, interpret, and respond to one another are only beginning to be understood. Neuroscience of Social Behavior: Bridging the Mind and Society offers a rigorous and integrative examination of the biological foundations of social interaction, synthesizing current knowledge from neuroscience, psychology, sociology, and anthropology into a coherent framework.The book addresses the full scope of social neuroscience, from the evolutionary origins of the social brain to the challenges posed by digital communication and artificial intelligence. Core topics include social perception, language and communication, empathy, mentalizing, moral cognition, decision-making, and the neural basis of both prosocial and antisocial behavior. The text further explores how hormones and neurochemistry modulate social bonds, how social reward and pain systems shape motivation, and how clinical conditions disrupt social functioning. Computational and translational perspectives are integrated throughout, connecting laboratory findings to real-world implications.By bridging multiple levels of analysis, from neural circuits and neurochemistry to behavior and societal context, this volume equips readers with a comprehensive understanding of how the brain supports, and sometimes undermines, our capacity for social life.

  • The Renaissance in GPCR Research and Drug Discovery

    Receptor Function, Receptor Structure, New Techniques, and Characterization of Drug Activity
    • 1st Edition
    • Terry P. Kenakin
    • English
    The Renaissance in GPCR Research and Drug Discovery: Receptor Function, Receptor Structure, New Techniques, Characterization of Drug Activity, Drug Discovery is a comprehensive reference for pharmacology researchers. It focuses on utilizing novel aspects of GPCR function for therapeutic advantage and applying new chemical types to modify GPCR behavior. Recent advancements have revitalized GPCR discovery, opening unexplored avenues for new drug development. The book's content is meticulously divided into five distinct parts, covering evolutionary perspectives, novel functions, investigative technologies, therapeutic modalities, and a broad range of GPCR ligands.Beyond these key topics, the book delves into the evolution of GPCRs as drug targets, the mechanisms behind their novel functions, and the latest technologies driving research and discovery. It also highlights new and recently approved therapeutic modalities and provides a broad coverage of GPCR ligands. Edited and authored by leading researchers, this book serves as an essential reference for drug discovery researchers and medicinal chemists, as well as AI researchers exploring this drug discovery space.

  • Pediatric Deep Brain Stimulation

    • 1st Edition
    • George M. Ibrahim + 1 more
    • English
    Pediatric Deep Brain Stimulation offers the first comprehensive, multi-disciplinary exploration of this rapidly advancing field, providing clinicians with an authoritative guide to the science, practice, and future of pediatric neuromodulation.Orga... into four integrated sections, the book begins with the essentials of a pediatric DBS program—including state-of-the-art imaging, peri-operative management, complication avoidance, and ethical considerations unique to the developing brain. Subsequent chapters examine the use of DBS across the spectrum of childhood movement disorders, from monogenic and acquired dystonias to non-dystonic conditions. A dedicated section addresses neuromodulation for pediatric epilepsy, with a focus on emerging technologies. The book concludes with cutting-edge applications of DBS in neurodevelopmental and neuropsychiatric disorders and a view toward the integration of neuroengineering to expand the reach and future potential of circuit-based interventions in children.Edited by a pediatric movement disorders neurologist and a pediatric functional neurosurgeon who together direct an integrative, comprehensive pediatric DBS program, this volume brings a uniquely collaborative perspective and deep clinical expertise. It is an essential resource for neurosurgeons, neurologists, epileptologists, pediatric specialists, and researchers committed to advancing care for children with severe neurological disease.

  • Biopolymer Based Nano Drug Delivery for Cancer Wound Healing

    • 1st Edition
    • Vipan Kumar + 5 more
    • English
    Biopolymer Based Nano Drug Delivery for Cancer Wound Healing explores groundbreaking advancements in nanomedicine's role in treating cancer and promoting wound healing. The book delves into the pathophysiology of cancerous wounds, introduces biopolymer-based nanomedicine, and examines drug delivery systems using biopolymer-based nanoparticles. It concludes with future prospects of biopolymers in antitumor drug delivery systems. This resource is invaluable for researchers, advanced students, and R&D personnel across various fields, including cancer research, polymer science, biomaterials, biomedicine, pharmaceutics, biotechnology, and chemistry. Each chapter bridges theoretical concepts with practical applications, providing examples to illustrate key points.The book covers the pathophysiology of cancer and wounds, biopolymer-based nanomedicine for cancerous wounds, and drug delivery systems for healing. This is an essential reference for scientists and students focusing on pharmacy, drug delivery, and biomedicine.

  • Novel Plant Proteins as Mainstream Ingredients for Future Foods

    • 1st Edition
    • Khetan Shevkani
    • English
    Novel Plant Proteins as Mainstream Ingredients for Future Foods addresses the techno-functionality... health benefits, and sustainability of alternative proteins from familiar plant sources such as quinoa and other pseudocereals, rice bran, and hempseeds, along with more novel sources such as nigella seeds, fenugreek, moringa leaves, and the aquatic plant duckweed. The book provides a concise overview of the techno-functional, nutritional, and nutraceutical properties of these proteins that are essential for their application in functional foods, dietary supplements, and in the creation of healthier foods. Sections discuss advanced processing technologies capable of overcoming the limitations of conventional protein extraction methods and highlight the composition and nutritional value of fruits and vegetable by-products, elaborating on the quality and techno-functionality of fruit and vegetable seed protein isolates to critically examine their adoption by the food industry. The book concludes by analyzing the challenges associated with plant proteins such as allergens, antinutrient presence, compositional inconsistencies, poor nutritional quality compared to animal proteins, and undesirable sensory effects, along with promising solutions to enhance future applications.

  • Protein Kinase Inhibitors

    The Promise of Natural Products in Cancer Therapeutics
    • 1st Edition
    • Md. Imtaiyaz Hassan + 1 more
    • English
    Protein Kinase Inhibitors: The Promise of Natural Products in Cancer Therapeutics explores a novel therapeutic avenue for cancer treatment through nutraceutical-based kinase inhibitors. The book covers their historical background, outlook, mechanistic pathways, and clinical aspects, highlighting their relevance in cancer therapy. It also examines the potential of polyphenolic derivatives and other natural compounds in inhibiting key kinases involved in major cancer signaling pathways, focusing on their application in clinical trials and marketed drugs. Sections explore the implications of polyphenols in cancer management, novel sources of breast cancer inhibitors, the role of natural products in lymphoma therapy, and the multitarget potential of phytochemicals. Each chapter is designed to provide a thorough understanding of how natural products can be harnessed to develop innovative cancer therapeutics. It will serve as a valuable resource for academics, scientists, young researchers, students, and pharmacists working or interested in kinase biology and cancer therapeutics with its unique perspective on using nature's own arsenal to combat cancer.

  • Clinical Neurodynamics

    From Theory to Practice
    • 1st Edition
    • Stefano Serrecchia
    • English
    Clinical Neurodynamics: From Theory to Practice provides a comprehensive, clinically focused synthesis of neurodynamics that bridges foundational science with real-world application. Integrating neural tissue biomechanics, mechanotransduction, intra-neuronal physiology, and contemporary pain science, this book equips clinicians with a clear, evidence-based framework for assessing and treating neurodynamic dysfunctions. Designed to address a persistent gap in musculoskeletal and neurological care, the text translates complex neurophysiological mechanisms into practical clinical reasoning. Readers are guided through standardized neurodynamic testing of the upper and lower limbs—including upper limb neurodynamic tests, straight leg raise, slump test, and femoral nerve tests—with consistent interpretation strategies and reproducible treatment progressions. Manual therapy techniques are seamlessly integrated with exercise-based rehabilitation and patient self-management approaches. Each chapter emphasizes clinical relevance, combining stepwise assessment-to-interv... pathways, decision algorithms, and concise clinical boxes. High-quality anatomical illustrations and QR-linked videos featuring 25 demonstrations enhance skill acquisition, teaching, and clinical confidence. Advanced chapters explore chronic pain, sensitization, and emerging innovations, positioning neurodynamics within modern, multidisciplinary rehabilitation practice. This book serves as an essential reference for clinicians and educators seeking a unified, research-supported approach to neurodynamic evaluation and treatment grounded in contemporary neuroscience.

  • Green Polymeric Materials in Drug Delivery

    Sustainable Solutions for Therapeutic Applications
    • 1st Edition
    • Parteek Prasher + 5 more
    • English
    Green Polymeric Materials in Drug Delivery: Sustainable Solutions for Therapeutic Applications addresses the critical intersection of polymer science, pharmaceutical technology, and environmental sustainability. This reference responds to the urgent need for eco-friendly drug delivery systems that improve therapeutic outcomes while minimizing ecological impact. It offers researchers and professionals a detailed exploration of green polymers derived from renewable sources and their transformative potential in healthcare. The comprehensive contents cover fundamental principles, synthesis, biocompatibility, formulation strategies, and innovative applications including nanomaterials, hydrogels, vesicular systems, and vaccine delivery. Chapters authored by leading experts examine targeted delivery routes such as mucosal, ocular, transdermal, and neural pathways. Regulatory frameworks and clinical trial insights further support translation from research to practice. Emerging technologies like AI-assisted formulation and 3D printing of implants are also discussed. This reference benefits polymer chemists, pharmaceutical scientists, regulatory experts, and clinicians by providing authoritative knowledge on sustainable materials for drug delivery. It equips readers with the scientific foundation and practical case studies necessary to advance green polymeric technologies in therapeutic development, fostering a sustainable future in pharmaceutical innovation and patient care.

  • Prise en charge des troubles somatiques fonctionnels par les TCCE

    • 1st Edition
    • Jeanne Danel + 1 more
    • French
    Les troubles somatiques fonctionnels (ou troubles fonctionnels, troubles à symptomatologie somatique, troubles somatoformes) correspondent à un ensemble de symptômes physiques persistants pour lesquels aucune lésion susceptible de les expliquer ne peut être mise en évidence. Malgré leur fréquence, ces troubles sont mal repérés et rarement pris en charge, en raison de la difficulté à poser un diagnostic et de l’absence de soins spécifiques proposés. Fondé sur l’expérience des auteurs, l’ouvrage propose les éléments nécessaires à la compréhension, au repérage et à la prise en charge des troubles somatiques fonctionnels :le rappel des concepts et des modèles physiopathologiques,... description des différents troubles (troubles neurologiques somatiques, fibromyalgie, syndrome de l’intestinirritable, syndrome de fatigue chronique, acouphènes, vertiges, troubles cardiovasculaires, syndrome post-infectieux, etc.),le diagnostic positif et différentiel de ces troubles,les enjeux de ce diagnostic (parcours de soins, stigmatisation, idées reçues),les modalités de la prise en charge, notamment les TCCE, mais toujours pluridisciplinaire.D... vignettes cliniques, des exemples de programmes et de séances de TCCE, des fiches d’information et des exercices pour les patients sont également proposés dans l’ouvrage et en complément en ligne.Mathilde Horn est psychiatre et PU-PH dans le service de psychiatrie de l’adulte, hôpital Fontan, CHU de Lille, chercheuse à l’université de Lille, équipe Interactions – Centre Lille Neuroscience & Cognition, Lille.Caroline Moumen est psychiatre dans le service de psychiatrie de l’adulte, hôpital Fontan, CHU de Lille, et intervient sur l’EPSM des Flandres, Bailleul.Jeanne Danel est psychologue dans le service de psychiatrie de l’adulte, hôpital Fontan, CHU de Lille.Margot Rousselle est psychologue dans le service de psychiatrie de l’adulte, hôpital Fontan, CHU de Lille.

  • Epigenetic Mechanisms in Brain Physiology and Disorders

    • 1st Edition
    • Volume 219
    • Moshe Szyf + 1 more
    • English
    Epigenetic Mechanisms in Brain Physiology and Disorders provides a comprehensive summary of epigenetic mechanisms in brain development, from embryogenesis to aging, brain physiology and pathology. It discusses the role DNA methylation plays in regulating genomic functions, which in turn guide brain function. The book explores the epigenetic role in cell type differentiation, epigenetic processes in memory, learning, and neuronal functioning, the role of DNA methylation and other epigenetic mechanisms in sleep, feeding and metabolic control, sex, temperature regulation, and cardiovascular and blood pressure regulation. It further explores the role of epigenetic processes in neuropsychiatry disorders, neurological disease and behavioral disorders, as well as epigenetic diagnostics and therapeutics.

  • Radiation Biology

    Molecular Foundations and Clinical Applications
    • 1st Edition
    • Barry S. Rosenstein + 1 more
    • English
    Radiation Biology: Molecular Foundations and Clinical Applications explores the effects of ionizing radiation on a molecular scale, with a focus on radiobiological principles relevant to cancer radiotherapy.The book starts at the subcellular level, elucidating the interactions between radiation and important cellular macromolecules, then gradually moves toward larger scales, demonstrating how the effects of radiation on macromolecules result in changes to the cell, which in turn lead to either cure or control of a cancer, or alternatively injury to normal tissues and organs. Topics covered include radiation-induced DNA damage and repair; effects of radiation on cellular signaling and cell death; quantification of cell kill and the effects of oxygen, linear energy transfer, radiosensitizers, and radioprotectors; models of radiation-induced tissue damage; the role of fractionation and dose rate; radiation-induced mutagenesis; and whole-body effects of radiation. Active areas of current research in radiation biology are discussed, including the use of radiation with immune-modulating agents, bystander effects, novel mechanisms of radiation-induced cell death, FLASH radiotherapy, personalized assays for prediction of radiation effects, nanoparticle delivery of radiosensitizers, and GRID/LATTICE radiotherapy. The last section of the book provides a review of cancer biology, discussing cancer genetics and epigenetics, the role of the tumor microenvironment, tumor metabolism, chemotherapy, and immunotherapy.

  • Digital Transformation in Healthcare

    Innovations in Hospital and Medical Services
    • 1st Edition
    • Patricia Ordonez de Pablos + 1 more
    • English
    Digital Transformation in Healthcare: Innovations in Hospital and Medical Services explores the digital revolution in healthcare, addressing the challenges and opportunities faced by hospitals, medical faculties, and research institutions. The book highlights the role of advanced information technologies in providing innovative solutions for an ageing population's well-being. It covers critical areas such as hospital management, adapting medical education to digital advancements, and emerging IT tools in healthcare. The book features contributions from leading academics and practitioners worldwide, discussing topics like 5G, AI, big data, blockchain, and digital tools for citizen empowerment, supported by real-world case studies. This resource is invaluable for academics, offering new insights to shape innovative policies in healthcare, education, and information technologies. It fosters dialogue among managers, students, policymakers, and healthcare professionals, contributing to the global advancement of digital healthcare practices.

  • Gestational Diabetes Mellitus

    Epidemiology, Clinical Practice and Evidence-Based Guidelines
    • 1st Edition
    • Moshe Hod + 6 more
    • English
    Gestational Diabetes Mellitus: Epidemiology, Clinical Practice and Evidence-Based Guidelines is an invaluable resource for healthcare professionals seeking to understand the latest developments in GDM. Over the past 20 years, significant progress has been made in the study of its epidemiology, mechanisms, diagnosis, management, and prevention. This book delves into these advancements, offering insights that are crucial for both researchers and clinicians. It explores potential therapeutic solutions to enhance patient care, and is essential reading for obstetricians, endocrinologists, diabetes researchers, maternal health specialists, and pediatric endocrinologists, as well as specialty fellows, residents, postdoctoral fellows, and graduate students in these fields.

  • Surgical and Non-Surgical Advances in Stroke Management and Therapeutics

    • 1st Edition
    • Creed M. Stary + 2 more
    • English
    Surgical and Non-Surgical Advances in Stroke Management and Therapeutics offers a comprehensive exploration of contemporary stroke care. This essential resource synthesizes the latest research and clinical innovations, providing in-depth insights into advanced surgical techniques, emerging therapies, and interdisciplinary approaches to stroke treatment. Readers will gain a thorough understanding of both acute and chronic stroke management, enriched by expert commentary from leading clinicians and researchers. Covering everything from pioneering non-invasive interventions to state-of-the-art surgical strategies, this book delivers a critical framework for healthcare professionals dedicated to optimizing patient outcomes and rehabilitation.

  • Acute Myocardial Infarction in Young Women

    Understanding its Mechanisms and Management
    • 1st Edition
    • Stéphane Manzo-Silberman
    • English
    Acute Myocardial Infarction in Young Women: Understanding its Mechanisms and Management serves as a seminal reference for understanding the current landscape of cardiovascular health in young women, highlighting clinical areas that require focused attention. By customizing the information to their unique physiological and clinical differences, more precise and effective interventions will lead to improved outcomes. The information is meticulously updated to address the specific cardiovascular health issues encountered by young women with myocardial infarction. This ensures that each stage of care—from cardiovascular risk assessment and symptom-recognition to the acute myocardial infarction (AMI) pathway, and rehabilitation follow-up—is optimized.Ultimately... this book equips health professionals with the most current and evidence-based information, enabling them to deliver the highest standard of care for young women with myocardial infarction. It will enhance quality of care, and contribute to improved health outcomes for young women across all stages of the cardiovascular healthcare continuum.

  • Computational and Experimental Approaches in Protein Engineering and Design

    • 1st Edition
    • Aditya Kumar Padhi + 1 more
    • English
    Computational and Experimental Approaches in Protein Engineering and Design offers a one-stop resource for students, researchers, and practitioners. Cutting-edge techniques in AI and machine learning applications are expertly covered in the book, empowering readers with the tools they need to tackle modern challenges in biotechnology and therapeutics. Step-by-step protocols provide readers with actionable guidance to transition smoothly from computational modelling to laboratory implementation. The inclusion of real-world case studies makes the theoretical concepts relatable and actionable and immediately applicable to solving complex problems, such as producing protein-based vaccines for immunotherapy.The book’s focus on synthetic biology positions it at the forefront of innovation, appealing to a broad audience, from those involved in tissue engineering to those exploring next-generation therapeutics. With its forward-looking approach, emphasizing machine-learning-dri... protein design and nanobody engineering, this book is an indispensable resource for researchers preparing to navigate the future of biotechnology.

  • Dizziness and Vertigo in the Era of Digital Medicine, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 44-4
    • Anand K. Bery + 2 more
    • English
    In this issue of Neurologic Clinics, guest editors Drs. David E. Newman-Toker, Daniel Gold, Ali Tehrani, and Anand Bery bring their considerable expertise to the topic of Dizziness & Vertigo in the Era of Digital Medicine. Top experts discuss the digital imperative for neuro-otology; video eye movement engineering fundamentals; novel digital tools for basic research: video-ocular counter roll and beyond; novel digital tools for clinical research: vestibular simulation; and much more.

  • Fundamentals and Functional Advancements of Fungal Enzymes in Biorefinery and Bioproducts Development

    Volume 1
    • 1st Edition
    • Manikant Tripathi + 1 more
    • English
    Fundamental and Functional Advancements of Fungal Enzymes in Biorefinery and Bioproducts Development offers highlights the fundamental aspects of fungal enzymes which include their structure, function, chemical composition, and their functional importance for biorefinery and bioproducts development. This is the first of two volumes that provides a comprehensive overview of the utilization of fungal enzymes for biorefinery and bioproduct development. Volume 1 introduces various types of fungal enzymes and offers a better understanding of the basic science of fungal enzymes, their structure, their fundamental functions and limitations in biochemical development. This book also explores the processes involved in improving the enhanced production, efficiency, and efficacy of fungal enzymes for application. It also examines biofuel and bioproducts production using fungal enzymes. In combination with Volume 2, this book offers a holistic view of the potential and challenges of engineered fungal enzymes for researchers, scientists, and industry professionals seeking to deepen their knowledge of fungal enzymes and their role in biochemical advances.

  • The Hormonal Treatment of Endometriosis and Adenomyosis

    A Comprehensive Review of the Role of Hormonal Treatments in the Management of Pain and Infertility in Patients with Endometriosis and Adenomyosis
    • 1st Edition
    • Antonio Simone Laganà + 1 more
    • English
    The Hormonal Treatment of Endometriosis and Adenomyosis: A Comprehensive Review of the Role of Hormonal Treatments in the Management of Pain and Infertility in Patients with Endometriosis and Adenomyosis is a comprehensive and practical reference on the effects of various hormonal treatments on endometriosis and adenomyosis lesions. The book summarizes the latest evidence regarding the safety and efficacy of these treatments in managing pain associated with these conditions. Additionally, the book explores the evidence-based benefits of hormonal therapies in improving fertility chances for patients, both through natural conception and assisted reproductive technologies.The book helps readers grasp the generalizability of current research findings and identifies existing research gaps, shedding light on new perspectives for future investigation. Through this comprehensive approach, the book serves as an invaluable resource for healthcare professionals, researchers, and patients alike.

  • Cranial Nerve Compression Syndromes

    A Multidisciplinary Guide to Management
    • 1st Edition
    • Florian Roser + 1 more
    • English
    Cranial Nerve Compression Syndromes: A Multidisciplinary Guide to Management is a comprehensive volume exploring the entire pathophysiology of cranial nerve pathologies, from diagnosis to treatment options. Following a multidisciplinary approach, this volume integrates perspectives from neurosurgery, neurology, radiology, and pain management from experts in the field. An ideal resource for clinicians and researchers, this volume discusses the latest research on multi-modality, collaborative, and cutting-edge treatment options, with advanced surgical techniques, including microvascular decompression and endoscopic procedures with clear guidance.

  • Nano Meets Micro

    Revolutionizing Medicine through Microfluidic Devices
    • 1st Edition
    • Fatemeh Hataminia + 1 more
    • English
    Nano Meets Micro: Revolutionizing Medicine through Microfluidic Devices explores the transformative potential of integrating nanotechnology with microfluidics to revolutionize medical diagnostics, treatment, and personalized medicine. The book provides a detailed examination of how these cutting-edge technologies are making healthcare more precise, efficient, and personalized. Sections highlight nanomedicine and microfluidics, highlighting their importance in healthcare and their intersection with advanced healthcare solutions. It covers traditional and emerging fabrication techniques for microfluidic devices, the design and synthesis of nanoparticles, and the integration of nanomedicine into microfluidic systems. Examples and case studies illustrate how these technologies are used in drug delivery, disease diagnosis, and rapid diagnostics.With a strong focus on future implications, the book discusses emerging trends and potential advances in microfluidics and nanotechnology, including the integration of artificial intelligence and data analytics. It addresses the challenges and future directions in the commercialization of nanomedicine and microfluidic devices, providing a roadmap for translating laboratory innovations into clinical applications.

  • Clinical Imaging of the Spinal Cord: An Update, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 36-4
    • Tarik F. Massoud + 1 more
    • English
    In this issue of Neuroimaging Clinics, guest editors Drs. Tarik F. Massoud and Syed Hashmi bring their considerable expertise to the topic of Clinical Imaging of the Spinal Cord: An Update. Top experts discuss structural MRI of the spinal cord; myelographic imaging of disorders affecting the spinal cord; imaging of spinal cord infections; imaging of spinal cord inflammatory disorders; and more.

  • Advances in Brain Tumor Therapy

    From Molecular Mechanisms to Clinical Practice
    • 1st Edition
    • Arun Kumar Singh + 4 more
    • English
    Advances in Brain Tumor Therapy: From Molecular Mechanisms to Clinical Practice explores the evolving landscape of brain tumor treatment, addressing challenges posed by these rare yet impactful malignancies. The book highlights significant improvements in patient prognoses due to advances in targeted therapies and immunotherapies while also recognizing the limitations of current treatment options. The content examines brain tumor epidemiology, incidence, risk factors, and survival rates followed by an extensive overview of existing therapeutic approaches, including clinical trials, targeted treatments, immunotherapies, and systemic therapies. It also delves into the critical signaling pathways that drive tumor biology and implications for future strategies.This book serves as an essential resource for healthcare professionals, clinical researchers, medical students, and scientists, bridging the gap between basic science and clinical practice. By providing insights into the latest advancements and emerging technologies, it equips readers with the knowledge necessary to navigate the complexities of brain tumor therapy and prepare for future innovations.

  • Real-World Research to Improve Dementia Care

    Embedding Pragmatic Trials of Non-Drug Interventions
    • 1st Edition
    • Jill Harrison + 1 more
    • English
    Real-World Research to Improve Dementia Care: Embedding Pragmatic Trials of Non-Drug Interventions addresses the urgent need for effective care strategies for the over 50 million individuals living with Alzheimer's disease and related dementias. This insightful book introduces embedded, pragmatic trials as a way to bridge the gap between clinical research and everyday practice, emphasizing collaboration among healthcare systems, researchers, and communities. Through a series of chapters, the book explores partnership strategies, ethical considerations, and the selection of meaningful outcome measures, all aimed at enhancing dementia care. The authors present case studies that showcase successful interventions and innovative practices across care settings.By highlighting both the challenges and solutions in dementia care, this book serves as a vital resource for healthcare professionals and researchers. It advocates for a compassionate approach that values the voices of individuals living with dementia, ultimately aiming to improve their quality of life.

  • Nonthermal Extraction Technologies of Polysaccharides

    Principles, Techniques, Characterization, and Applications
    • 1st Edition
    • Seyed Mohammad Taghi Gharibzahedi
    • English
    Nonthermal Extraction Technologies of Polysaccharides: Principles, Techniques, Characterization, and Applications explores cutting-edge nonthermal extraction technologies, including ultrasound, microwave, high-pressure, pulsed electric field, enzymatic extraction methods, and cold plasma technology and their effects on polysaccharide biofunctionalities, such as antioxidant and antimicrobial properties and potential applications. With an examination of the therapeutic benefits associated with these compounds, including anti-cancer, antioxidant, antimicrobial, anti-inflammatory, and anti-obesity properties, this book aspires to highlight advanced techniques to significantly enhance polysaccharide yield, bioactivity, and purity when compared to traditional approaches.The initial chapters introduce the fundamental structures, sources, and importance of polysaccharides, thus setting the stage for a deeper understanding of their functionality and chemical characterization. By offering both theoretical frameworks and practical guidance, this book equips professionals with the knowledge required to effectively incorporate polysaccharides into health-promoting products for advancing research and applications in the evolving landscape of functional foods and biomedical innovation.

  • Pediatric Substance Exposure

    • 1st Edition
    • Ju Lee Oei
    • English
    Pediatric Substance Exposure is a crucial resource for medical practitioners focusing on the long-term management of children exposed to addictive substances during pregnancy. It provides guidance on supporting families affected by substance abuse, starting with a comprehensive overview of epidemiology and global policy. The book examines various substances and their impact on children, discussing fetal management, infant and child care, and addressing family needs as the child grows. Beyond the basics, the book reviews social aspects, future research, and policy needs. Clinicians and researchers will find it invaluable for evidence-based decision-making and optimal treatment strategies.

  • Challenges and Trends in Food Safety

    Contamination, Public Health, and Control Measures
    • 1st Edition
    • João Miguel Rocha + 3 more
    • English
    Challenges and Trends in Food Safety: Contamination, Public Health, and Control Measures provides a comprehensive review of the most recent available knowledge about microbiological, chemical and physical risks associated with food consumption. The book also provides a useful future outlook of new trends, and advanced and novel technologies for ensuring food safety and food security. Divided into five sections, the title covers the systems leading to food contamination, food science in service of food security and public health in the first section. Biological hazards and threats for food safety and effective control measures are covered in the second section, while the third one discusses the chemical hazards of food and effective control measures. The fourth section covers physical hazards of food and effective control measures and the final section brings practical solutions, future trends and advanced technologies for ensuring food safety. Edited by a team of experts in the field of Food Safety, Microbilogy and Defense, this book is an ultimate reference, serving as a guide to elaborate on food contamination from various aspects.

  • Innovations for Sustainable Agriculture

    From Lab to Farm to Table
    • 1st Edition
    • Katarzyna Chojnacka + 1 more
    • English
    Mixed crop-livestock systems offer promising strategies for sustainable farming. Innovations for Sustainable Agriculture: From Lab to Farm to Table details solutions for mitigating agricultural waste, such as carbon emissions and chemical runoff, and creating a circular economy on mixed farms. In addition to covering potential solutions, the book will analyze the effectiveness of each strategy in protecting the environment from harm. Notable topics covered include manure management, agricultural waste valorization, wastewater and resource recovery, and even dairy cow feed for lowering methane production.While the book is based primarily on the climates and farming systems of Europe, the climactic diversity of the continent will make this a useful resource for many other parts of the world with similar climates, including North America and portions of South America, Asia, and Oceana. Innovations for Sustainable Agriculture: From Lab to Farm to Table offers practical strategies and solutions to readers and will benefit audience members ranging from students and researchers to farmers and agricultural stakeholders.

  • Clinician’s Guide to Headache

    Head, Neck, and Face Pain Syndromes
    • 1st Edition
    • Pravin Thomas
    • English
    Clinician’s Guide to Headache: Head, Neck, and Face Pain Syndromes is a clinically focused, case-based reference for neurologists, headache specialists, pain physicians, trainees, and allied clinicians caring for patients with head, neck, and facial pain. Rather than relying only on conventional disease-based descriptions, it reflects the realities of everyday practice: complex and overlapping syndromes, diagnostic uncertainty, secondary causes, comorbidities, and rapidly changing therapeutic options. Organized around real clinical scenarios, the book covers the full breadth of headache medicine, from classification, anatomy, history taking, examination, and pathophysiology to migraine, trigeminal autonomic cephalalgias, cranial neuralgias, CSF pressure disorders, neurovascular and inflammatory diseases, infections, metabolic causes, epilepsy-related headache, sleep-related disorders, ophthalmic presentations, pediatric headache, neck pain, and facial pain. Foundational sciences, such as anatomy, neuroradiology, pharmacology, and pathophysiology, are presented in a practical, case-oriented manner to support bedside decision-making. The text also addresses the important frontiers in modern headache care, biologics, percutaneous interventions, implantable and noninvasive neuromodulation, and integrative strategies, such as yoga, meditation, and nutrition.With contributions from an international faculty, this volume provides a pragmatic, modern, and multidisciplinary approach to one of the most challenging areas in clinical neuroscience

  • Advanced MR Techniques for Neurodegenerative Diseases

    • 1st Edition
    • Volume 15
    • Kannie Wy Chan + 3 more
    • English
    Advanced MR Techniques for Neurodegenerative Diseases covers state of the art developments in physiologic, metabolic, functional, and microstructural MRI of the brain. It provides an overview of these approaches and includes dynamic contrast enhanced (DCE) MRI, dynamic susceptibility contrast (DSC) MRI, arterial spin labeling (ASL), chemical exchange saturation transfer (CEST) MRI, magnetic resonance spectroscopy (MRS), resting state functional MRI (rsfMRI), microscopic diffusion imaging, and quantitative susceptibility mapping (QSM). Chapters then follow that present the application of these methods to Alzheimer’s Disease and vascular dementia, small vessel disease, Parkinson’s Disease, Lewy body dementia, Huntington’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis.Advanced MR Techniques for Neurodegenerative Diseases is a comprehensive resource on the latest advanced MR techniques and their application to neurodegenerative diseases, suitable for MR engineers and physicists as well as clinicians and neuroscientists who use MR techniques for diagnosis and research.

  • Integrated Food Safety

    • 1st Edition
    • Mohamed Al-Farsi + 5 more
    • English
    Integrated Food Safety addresses the critical scientific, technological, and regulatory aspects of ensuring a safe and secure food supply chain from farm to fork. The book begins with an introduction to food safety principles that is followed by chapters on food sciences, microbiology, and toxicology, offering a solid foundation in understanding foodborne risks. It then covers food testing methods, safety management systems, inspection protocols, and risk analysis techniques. Additional chapters explore food safety regulations, the impact of microplastics, innovative applications of artificial intelligence, sustainable packaging solutions, and trends in food innovation, equipping readers with a holistic view of modern food safety practices.This book serves as an essential resource for students, industry professionals, regulators, and researchers, providing practical guidance and scientific insights needed to enhance food safety systems, foster innovation, and address emerging challenges in the global food industry.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 135
    • English
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Waller's Medical Pharmacology and Therapeutics

    • 7th Edition
    • Derek G. Waller + 3 more
    • English
    Waller's Medical Pharmacology and Therapeutics, 7th Edition, gives medical, biomedical and healthcare students clear, up-to-date guidance on pharmacology and drug prescribing, supporting your studies and preparation for qualifications such as the Prescribing Safety Assessment (PSA). It provides thorough coverage of the pathogenic mechanisms of disease, drug actions, unwanted effects, and the therapeutic principles of drug use—all while taking a helpful, systems-based approach that orders information according to body systems and disease areas rather than by drug class.

  • Targeting DNA Repair Mechanisms, Tumor Genetics, and Signaling Pathways: Synergistic Approaches in Gastrointestinal Cancer Treatment, 12-Month Access, eBook

    • 1st Edition
    • Ganji Purnachandra Nagaraju + 1 more
    • English

  • Chromatin Signaling and Diseases

    • 2nd Edition
    • Olivier Binda + 2 more
    • English
    Chromatin Signaling and Diseases, Second Edition, a volume in the Translational Epigenetics series, covers the molecular mechanisms that regulate gene expression, which governs embryonic development, growth, and human pathologies associated with aging, such as cancer. Although human genome sequencing continues to improve, molecular mechanisms regulating gene expression remain largely misunderstood. The impact of gene expression defects associated with malfunctioning chromatin signaling are considered in this update. In addition, this new edition has addresses developments in the field, from phase separation of membrane-less organelles and local segregation of factors to chromatinization of naked foreign DNA and cancer evolution as regulated by chromatin signaling.Chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these are also considered.

  • Medicines Safety and Pharmacovigilance

    Introduction, Concepts, and Applications
    • 1st Edition
    • Rabia Hussain
    • English
    Medicines Safety and Pharmacovigilance: Introduction, Concepts, and Applications provides a comprehensive guide for pharmaceutical professionals navigating the complex landscape of medicine safety and vigilance. Designed to support strategic decision-making, this reference draws on industry expertise to uphold the highest standards of patient care. The book addresses essential regulatory requirements, reporting obligations, and ethical considerations, offering practical guidance for implementing effective pharmacovigilance systems. Covering the latest technological advancements, it ensures readers are equipped to meet the modern challenges faced by healthcare and pharmaceutical sectors in monitoring the safety and efficacy of medicines for diverse populations worldwide.Beyond the foundational concepts, the book presents detailed insights into signal detection, risk management plans, and the real-world application of pharmacovigilance through case studies from both high- and low-middle-income countries. It examines the pivotal role of pharmacists and the importance of tailored approaches for special populations, while emphasizing effective communication of medicines safety.

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