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Books in Toxicology general

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41-50 of 300 results in All results

Toxicology in Antiquity

  • 2nd Edition
  • October 22, 2018
  • Philip Wexler
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 5 3 3 9 - 0
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 5 3 4 0 - 6
Toxicology in Antiquity provides an authoritative and fascinating exploration into the use of toxins and poisons in antiquity. It brings together the two previously published shorter volumes on the topic, as well as adding considerable new information. Part of the History of Toxicology and Environmental Health series, it covers key accomplishments, scientists, and events in the broad field of toxicology, including environmental health and chemical safety. This first volume sets the tone for the series and starts at the very beginning, historically speaking, with a look at toxicology in ancient times. The book explains that before scientific research methods were developed, toxicology thrived as a very practical discipline. People living in ancient civilizations readily learned to distinguish safe substances from hazardous ones, how to avoid these hazardous substances, and how to use them to inflict harm on enemies. It also describes scholars who compiled compendia of toxic agents. New chapters in this edition focus chiefly on evidence for the use of toxic agents derived from religious texts.

The History of Alternative Test Methods in Toxicology

  • 1st Edition
  • October 20, 2018
  • Michael Balls + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 3 6 9 7 - 3
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 3 6 9 8 - 0
The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies.     　 The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.

Advances in Molecular Toxicology

  • 1st Edition
  • Volume 12
  • September 21, 2018
  • James C. Fishbein + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 6 4 1 9 9 - 1
  • eBook
    9 7 8 - 0 - 4 4 4 - 6 4 1 9 8 - 4
Advances in Molecular Toxicology, Volume Twelve, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The work not only documents these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field.

Risk Assessment for Human Metal Exposures

  • 1st Edition
  • August 21, 2018
  • Gunnar F. Nordberg + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 4 2 2 7 - 4
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 4 2 6 8 - 7
Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA –TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication—the classic risk assessment paradigm—with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment.

Emerging Nanotechnologies in Immunology

  • 1st Edition
  • May 17, 2018
  • Ranjita Shegokar + 1 more
  • English
  • Hardback
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  • eBook
    9 7 8 - 0 - 3 2 3 - 4 0 1 1 3 - 5
Emerging Nanotechnologies in Immunology aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanophamaceuticals currently in the pipeline of S&T development for skin, ocular, and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure.The scientific development of manufactured nanomaterials for drug delivery is increasing rapidly. One of the most prominent applications is topical drug delivery, where cutaneous, ocular, and nasal exposure becomes even more relevant. These targets are the first barrier that nanoparticles encounter when in contact with the human body.The contributors addresses a representative set of the broad spectrum of nanopharmaceuticals currently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue engineered skin substitutes. Regulation and risk is also covered, since the safety of these nanophamaceuticals still represents a barrier to their wide innovative use.

Illustrated Toxicology

  • 1st Edition
  • April 4, 2018
  • P.K. Gupta
  • English
  • Paperback
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  • eBook
    9 7 8 - 0 - 1 2 - 8 1 3 2 1 4 - 2
Illustrated Toxicology: With Study Questions is an essential, practical resource for self-study and guidance catering to a broad spectrum of students. This book covers a range of core toxicological areas, including pesticides, radioactive materials and poisonous plants, also presenting a section on veterinary toxicology. Across 16 chapters, the book presents key concepts with the aid of over 250 detailed, full-color illustrations. Each section is supplemented with practical exercises to support active learning. This combination of clear illustrations and sample testing will help readers gain a deeper understanding of toxicology. This book is useful for toxicology, pharmacy, medical and veterinary students, and also serves as a refresher for academics and professionals in the field, including clinical pharmacists, forensic toxicologists, environmentalists and veterinarians.

The Nature and Use of Ecotoxicological Evidence

  • 1st Edition
  • January 20, 2018
  • Michael C. Newman
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 9 6 4 2 - 0
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 9 6 4 5 - 1
The Nature and Use of Ecotoxicological Evidence: Natural Science, Statistics, Psychology, and Sociology examines how toxicologists and environmental professionals come to understand and make decisions about possible harm from pollutants. Drawing on concepts and techniques from the natural, social and mathematical sciences, the book emphasizes how pollutant-related evidence is gathered, assessed, communicated and applied in decision-making. Each chapter begins with a real-world example before exploring fundamental cognitive, social, statistical or natural science concepts to explain the opening example. Methods from other disciplines for recognizing, reducing or removing the influence of impediments in wise decision-making are highlighted in each chapter. Misreading evidence by the scientific community, and miscommunication to regulators and the public, remain major impediments to wise action in pollution issues. Which evidence comes to dominate the dialogue among scientists, regulators and decision makers depends on social and scientific dynamics. Yet psychological and sociological factors that influence the movement of evidence through scientific communities to regulators receive cursory discussion by professionals unfamiliar with the sociology literature. Toxicologists, environmental scientists, psychologists and professionals and students across the sciences will find the book useful for understanding how evidence is generated, assessed and communicated in their own fields.

The Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence

  • 1st Edition
  • December 20, 2017
  • C. W. M. Wilson
  • English
  • eBook
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The Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence is a collection of proceedings presented at the International Symposium on the Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence, held in London on September 1-2, 1966 under the auspices of the Society for the Study of Addiction to Alcohol and Other Drugs. The symposium provided a forum for discussing the pharmacological and epidemiological aspects of drug dependence in adolescents. Comprised of 10 chapters, this volume begins with an overview of the chemistry and pharmacology of narcotic drugs in adolescence, as well as narcotic addiction in young people in the United States. The discussion then turns to pharmacology and clinical observations on stimulant drugs and hallucinogenic drugs; the epidemiology and social pharmacology of drugs of dependence; and features of adolescent drug dependence. Regulations aimed at controlling drugs of dependence are also analyzed in relation to the national incidence of adolescent dependence in certain countries such as Britain, Belgium, Israel, and the Netherlands. The remaining chapters focus on the language, evidence, and patterns of drug abuse, together with research in relation to drugs of dependence. This book will be of interest to pharmacologists, epidemiologists, and policymakers concerned with drug dependence.

Comprehensive Toxicology

  • 3rd Edition
  • December 1, 2017
  • Charlene McQueen
  • English
  • Hardback
    9 7 8 - 0 - 0 8 - 1 0 0 6 0 1 - 6
  • eBook
    9 7 8 - 0 - 0 8 - 1 0 0 6 1 2 - 2
Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology.

In Vitro Toxicology

  • 1st Edition
  • November 13, 2017
  • Alok Dhawan + 1 more
  • English
  • Paperback
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  • eBook
    9 7 8 - 0 - 1 2 - 8 0 4 7 7 1 - 2
In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials.

Related subjects

Toxicology