Risk Assessment for Human Metal Exposures

Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA –TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations.

This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication—the classic risk assessment paradigm—with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment.

"Risk Assessment for Human Metal Exposures is a timely publication that covers all aspects of risk assessment of metals, and provides a clear description of recent developments, novel approaches, and their application in evaluating risks of exposure to metals, be they essential trace metals purely toxic ones. New approaches covered include toxicokinetic/toxicodynamic models, biomonitoring strategies, Mode of Action (MoA) assessment, and Adverse Outcome Pathways (AOP) approaches, as well as mechanism of action considerations and specific approaches to the use of human data, particularly from epidemiological studies. It is an excellent piece of work, and a recommended read for risk assessment professionals."—Prof. Dr. Maged Younes, Former Director at WHO and UNEP

"This book is an application of the combination of scientific information over time and the rich experience by the authors of risk assessment of metals for the health of humans. I would like to recommend to students, teachers, researchers and scientists working in toxicology and environmental epidemiology"—Taiyi Jin, MD, PhD, Professor and former Chair of the Department of Occupational Health and Toxicology, School of Public Health , Fudan University, Shanghai, China

"It is my pleasure to recommend the book, Risk Assessment for Human Metal Exposure: Mode of Action and Kinetic Approaches by Gunnar F. Nordberg and Bruce A. Fowler. The book is useful for both beginner and the advanced toxicologists. It presents information on the toxicology of metals in relation to human exposure, risk assessment, and health effects of the most widespread metal in occupational settings in a very concise way

...It will be an asset for toxicologists, occupational hygienists, physicians, pharmaceutists, and students who want to broaden their knowledge further, as well as for those experienced readers who need to have access to the most current guidelines and methods of risk assessment.The authors, who are recognized experts in the field of metal toxicology, guarantee up-to-date information and current knowledge."—Natalia Pawlas, MD, PhD, Associate Professor, Medical University of Silesia, Poland, Scientific Committee on Toxicology of Metals, ICOH