Books in Clinical pharmacology therapeutics

11-20 of 28 results in All results

Nano-Pharmacokinetics and Theranostics

• 1st Edition
• July 28, 2021
• Nanasaheb D. Thorat + 1 more
• English
• Paperback 978-0-323-85050-6

  9 7 8 - 0 - 3 2 3 - 8 5 0 5 0 - 6
• eBook 978-0-323-85982-0

  9 7 8 - 0 - 3 2 3 - 8 5 9 8 2 - 0

Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy addresses from a comprehensive and multidisciplinary approach the translational aspects and clinical perspectives of nano-pharmacokinetics using cancer as a model disease. Nano-pharmacokinetics is emerging as an important sub discipline of nanoscience and medical sciences because of the increasing safety issues of nanosystems on living organisms. This book reports the dynamics of nanosystems in living organisms for better understanding of nanotoxicity, pharmacology, biochemistry, physiology and medicine perspectives. It further examines current progress of state-of-the art pharmacokinetics mechanisms, which will be of great help to develop more clinical-oriented nanosystems with a wide safety margin. The book is divided into three sections: the first section focuses on the concept of pharmacokinetics with state-of-the-art Nano-Pharmacokinetics (NPK). The second section looks at the engineering of nanoparticles and pharmacokinetics clinical development. The final section focuses on Nano-Pharmacokinetics and Theranostics, elaborating the basic question of how pharmacokinetics of nanomaterials relate to their end applications such as cancer therapy. Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy will be useful to researchers in the field of nanoparticle based targeted drug delivery including pharmaceutical scientists, material scientists, chemists, nanotechnologists, biomedical scientists, and clinicians.

Inflammation and Natural Products

• 1st Edition
• January 19, 2021
• Sreeraj Gopi + 3 more
• English
• Paperback 978-0-12-819218-4

  9 7 8 - 0 - 1 2 - 8 1 9 2 1 8 - 4
• eBook 978-0-12-819219-1

  9 7 8 - 0 - 1 2 - 8 1 9 2 1 9 - 1

Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries.

Saffron

• 1st Edition
• January 23, 2020
• Maryam Sarwat + 1 more
• English
• Paperback 978-0-12-818462-2

  9 7 8 - 0 - 1 2 - 8 1 8 4 6 2 - 2
• eBook 978-0-12-818463-9

  9 7 8 - 0 - 1 2 - 8 1 8 4 6 3 - 9

Saffron: The Age-Old Panacea in a New Light is the first book to detail the functions and effect of saffron in medicinal situations. This book explores the medicinal aspects of saffron and the effect saffron imparts on various diseases of the central nervous system, cardiovascular system, digestive system, locomotor system, urogenital system, eye, skin, and immune system, along with their mechanism of action. This perpetual bulb found mainly in Asia and Europe, Iran, India and Mediterranean countries has been shown to reduce seizures, delay convulsions, and as a neuroprotective agent against cerebral ischemia, brain damage, and Alzheimer's and Parkinson's disease. In addition, it also reduces depression, hypnosis and anxiety and enhances learning and memory skills.

Pharmacogenomics

• 2nd Edition
• November 27, 2018
• Yui-Wing Francis Lam + 1 more
• English
• Hardback 978-0-12-812626-4

  9 7 8 - 0 - 1 2 - 8 1 2 6 2 6 - 4
• eBook 978-0-12-812627-1

  9 7 8 - 0 - 1 2 - 8 1 2 6 2 7 - 1

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition, provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as pharmacogenomic data technologies, clinical testing strategies, cost-effectiveness, and pharmacogenomic education and practice guidelines. The importance of ethnicity is also discussed, which highlights phar,acogenomic diversity across Latin American populations.With chapters written by interdisciplinary experts and insights into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation.

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

• 1st Edition
• April 4, 2017
• Surendra Nimesh + 2 more
• English
• Hardback 978-0-08-100557-6

  9 7 8 - 0 - 0 8 - 1 0 0 5 5 7 - 6
• eBook 978-0-08-100563-7

  9 7 8 - 0 - 0 8 - 1 0 0 5 6 3 - 7

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc.

Progress in Medicinal Chemistry

• 1st Edition
• Volume 56
• March 15, 2017
• David R. Witty + 1 more
• English
• Hardback 978-0-444-63939-4

  9 7 8 - 0 - 4 4 4 - 6 3 9 3 9 - 4
• eBook 978-0-444-63943-1

  9 7 8 - 0 - 4 4 4 - 6 3 9 4 3 - 1

Progress in Medicinal Chemistry, Volume 56 provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a potential new era for Chagas Disease drug discovery, and imaging in drug development. Specific chapters cover timely topics, such as the development of LRRK2 inhibitors for the treatment of Parkinson's, and recent discoveries and developments in TRPA1 modulators. Users will find a comprehensive resource on the topic of medicinal chemistry that also discusses avenues for the acceleration of drug discovery programs.

Individualized Drug Therapy for Patients

• 1st Edition
• November 8, 2016
• Roger W Jelliffe + 1 more
• English
• Paperback 978-0-12-803348-7

  9 7 8 - 0 - 1 2 - 8 0 3 3 4 8 - 7
• eBook 978-0-12-803349-4

  9 7 8 - 0 - 1 2 - 8 0 3 3 4 9 - 4

Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient.

Progress in Medicinal Chemistry

• 1st Edition
• Volume 55
• February 1, 2016
• G. Lawton + 1 more
• English
• Hardback 978-0-444-63715-4

  9 7 8 - 0 - 4 4 4 - 6 3 7 1 5 - 4
• eBook 978-0-444-63742-0

  9 7 8 - 0 - 4 4 4 - 6 3 7 4 2 - 0

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development.

Meyler's Side Effects of Drugs

• 16th Edition
• October 15, 2015
• Jeffrey K. Aronson
• English
• eBook 978-0-444-53716-4

  9 7 8 - 0 - 4 4 4 - 5 3 7 1 6 - 4

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Sixteenth Edition, Seven Volume Set builds on the success of the 15 previous editions, providing an extensively reorganized and expanded resource that now comprises more than 1,500 individual drug articles with the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature, making this a must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company. The online version of the book provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking, and fully downloadable and printable full-text, HTML or PDF articles.

Recent Advances in Medicinal Chemistry, Volume 1

• 1st Edition
• June 2, 2015
• Atta-ur Rahman + 2 more
• English
• Paperback 978-0-12-803961-8

  9 7 8 - 0 - 1 2 - 8 0 3 9 6 1 - 8
• eBook 978-0-12-803962-5

  9 7 8 - 0 - 1 2 - 8 0 3 9 6 2 - 5

Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more.