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Books in Neurochemistry

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31-39 of 39 results in All results

Peptide Receptors, Part II

  • 1st Edition
  • Volume 20
  • December 13, 2002
  • A. Bjorklund + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 8 5 7 - 0
Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complementwith chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry.Data derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-receptor complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.

Neurosteroids and Brain Function

  • 1st Edition
  • Volume 46
  • September 27, 2001
  • Giovanni Biggio + 4 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 3 6 6 8 4 6 - 2
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 4 4 2 3 - 6
International Review of Neurobiology, Volume 46 presents in-depth reviews on such ground-breaking topics as assembly and intracellular trafficking of GABA A receptors, D-1 dopamine receptors, and Alzheimer's disease. This series offers the most comprehensive and up-to-date information available and is a must for anyone in the field.

Glutamate

  • 1st Edition
  • Volume 18
  • November 3, 2000
  • J. Storm-Mathisen + 1 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 2 5 7 - 8
The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment. Particular emphasis is on the localizations of the molecular constituents of the synaptic machinery. Immunogold and other high-resolution methods are used extensively. Each chapter presents new data that have not previously been reviewed. The material presented forms the basis for work directed to understanding the functional properties of excitatory synapses in greater depth, to discover mechanisms of neurological and psychiatric disorders and novel methods for treatment. Chapter 1 deals with the transmitter molecule itself, mechanisms of release and pathways for glutamate synthesis. The anatomy of glutamatergic nerve projection pathways in different brain regions is dealt with. In Chapter 2, focus is on aspartate, the enigmatic congener of glutamate, and its possible role in excitatory neurotransmission. Chapters 3 through 6 deal with glutamate receptors. Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors. The localizations of these receptors at the regional and synaptic level are presented in Chapter 5. The ways in which the receptors are brought to the synapse and held in position are the subject of Chapter 6. Chapter 7 deals with the enzymes responsible for formation and catabolism of glutamate. In Chapter 8, the regulation of extracellular glutamate levels by glutamate transporters is discussed. The final two chapters of the volume focus on two "model synapses" that, due to special features, lend themselves particularly well to demonstrating properties of glutamatergic synapses. The hair cell-to-afferent nerve terminal synapses in the inner ear (Chapter 9), with their supporting cells, share essential properties with glutamatergic synapses in the central nervous system. The salient features of the latter are illustrated by the synapses of the giant reticulo-spinal axons of the lamprey, used to unravel molecular mechanisms of the cycling of synaptic vesicles (Chapter 10).

Peptide Receptors, Part I

  • 1st Edition
  • Volume 16
  • June 8, 2000
  • A. Bjorklund + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 8 2 9 7 2 - 6
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 8 5 8 - 7
During the last few years, the pace of research in the field of neuropeptide receptors has increased steadily: new neuropeptides were discovered, and the classification of receptor subtypes has been refined. It thus appeared essential to update the information. Peptide Receptors Part I summarizes current knowledge on ten distinct peptide families.This volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry, and immunocytochemistry images. Application of these classical techniques and of new approaches such as transgenic and knock-out animals has revealed a distinct species and tissue specific variation in receptor subtypes expression and pharmacology in the mammalian central nervous system.The functional role of neuropeptides and their receptors in the CNS has been investigated thanks to the development of potent and selective receptor antagonists and agonists. The development of specific neuropeptide-related molecules will help to get a better understanding of receptor subtype physiology and neuronal distribution and may lead to innovative treatments in a variety of brain disorders.

The Primate Nervous System, Part III

  • 1st Edition
  • Volume 15
  • October 1, 1999
  • Floyd E. Bloom + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 5 0 0 4 3 - 4
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 9 4 9 - 2
This volume is the third and final part of the planned coverage of the neurochemical circuitry of the primate central nervous system. The five chapters included in this volume complement and integrate magnificently with the two prior volumes. Included in the volume are the following: a two-fold exposition on the human forebrain, comprised of a comprehensive overview of the entire human forebrain, and a specific focus on the basal forebrain (a region critical for a wide range of human problems ranging from substance abuse to Alzheimer's disease), a critical synthesis of the primate basal ganglia (a region under intense scrutiny for the organization of motor programs, and for their dysfunctions in Parkinson's disease, Huntington's disease and other malfunctions), the chemical and anatomic details of the primate hippocampal formation in extenso, and lastly, a review of the rapidly growing literature on the mesocortical projection of dopaminergic circuits onto the primate frontal cortex ( a system highly linked to higher order mental abstractions, as well as the dysfunctions of schizophrenia). Scholars will recognize that the laying out of these status reports on our still vastly incomplete examination of the primate brains is an opportunity for progress.

The Glutamate Synapse as a Therapeutic Target

  • 1st Edition
  • Volume 116
  • November 9, 1998
  • O.P. Ottersen + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 8 2 7 5 4 - 8
This volume provides a comprehensive update on basic glutamate research, from a clinical perspective. Thus, emphasis is placed on how the different molecular players at the glutamate synapse interact to produce a postsynaptic response, how synaptic transmission is perturbed in epilepsy and other pathological conditions, and how glutamate may acquire toxic properties and lead to acute or chronic neurodegeneration. Promising targets for therapeutic strategies are discussed.A coherent picture is provided of the glutamate synapse and its molecular organization. The book therefore deals with each step in the signal process, from synthesis and vesicular uptake of glutamate to its clearance following receptor activation.

Molecular & Cellular Mechanisms of Neurotransmitter Release

  • 1st Edition
  • Volume 29
  • July 21, 1998
  • Lennart Stjarne + 5 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 0 3 6 1 2 9 - 8
This volume reviews recent findings on the regulation of exocytotic release of neurotransmitters from nerve terminals. Leading international investigators examine the properties and composition of the vesicles that store neurotransmitters and the molecular and cellular mechanisms that cause a vesicle to release transmitters in response to a nerve impulse.Coverage includes detailed analyses of quantal release of transmitters in the central and peripheral nervous systems. These studies shed new light on the questions of whether different transmitters are released together in fixed amounts and proportions, and whether and why effectors respond to such "transmitter quanta" in a quantal fashion. The book also highlights the relevance of research on neurotransmitter release to the study of various forms of synaptic plasticity, including higher functions such as learning and memory.

Cholinergic Mechanisms: From Molecular Biology to Clinical Significance

  • 1st Edition
  • Volume 109
  • December 18, 1996
  • J. Klein + 1 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 6 2 3 4 - 7
This volume offers a comprehensive update and overview of the field of cholinergic transmission as presented by some thirty distinguished investigators who were recruited for their task from Germany, Great Britain, Canada, USA, Sweden, Israel, France and Italy. Exciting new discoveries, described in this volume, are due to recent methodological breakthroughs. These discoveries throw new light on many areas of cholinergic mechanisms.

Nitric Oxide Synthase: Characterization and Functional Analysis

  • 1st Edition
  • Volume 31
  • August 6, 1996
  • Mahin D. Maines
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 1 8 5 3 0 1 - 3
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 6 3 7 - 8
Although the function of nitric oxide in a regulatory capacity in the central and peripheral nervous system is widely recognized, the full scope of its actions and its interrelationships with other classes of regulatory molecules is just beginning to be comprehended. This volume contains a number of sophisticated and advanced methods essential for exploring the activity of nitric oxide in the brain. It will be a valuable tool for the established investigator and for those just entering the field.