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Reproductive and Developmental Toxicology
- 1st Edition - April 4, 2011
- Author: Ramesh C Gupta
- Editor: Ramesh C. Gupta
- Language: English
- eBook ISBN:9 7 8 - 0 - 1 2 - 3 8 2 0 3 3 - 4
Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Devel… Read more
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Request a sales quoteReproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.
- Provides a complete, integrated source of information on the key risk stages during reproduction and development
- Includes coverage of emerging science such as stem cell application, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory considerations, and risk assessment
- Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis
Biologists, pharmacologists, toxicologists, and teratologists from academia, industry, and governmental agencies; domestic, wildlife, and aquatic specialists; environmentalists; regulatory agencies
Dedication
Foreword
List of Contributors
Chapter 1. Introduction
Chapter 2. Reproductive anatomy and physiology
Chapter 3. Bio-communication between mother and offspring
Chapter 4. Pharmacokinetics in pregnancy
Chapter 5. PBPK models in reproductive and developmental toxicology
Chapter 6. Transfer of drugs and xenobiotics through milk
Chapter 7. Postmarket surveillance and regulatory considerations in reproductive and developmental toxicology
Chapter 8. Reproductive and developmental safety evaluation of new pharmaceutical compounds
Chapter 9. Relevance of animal testing and sensitivity of endpoints in reproductive and developmental toxicity
Chapter 10. OECD guidelines and validated methods for in vivo testing of reproductive toxicity
Chapter 11. Mechanism-based models in reproductive and developmental toxicology
Chapter 12. In vitro embryotoxicity testing
Chapter 13. In vitro approaches to developmental neurotoxicity
Chapter 14. Reproductive and developmental toxicity models in relation to neurodegenerative diseases
Chapter 15. Using zebrafish to assess developmental neurotoxicity
Chapter 16. Caenorhabditis elegans as a model to assess reproductive and developmental toxicity
Chapter 17. A primate as an animal model for reproductive and developmental toxicity testing
Chapter 18. Developmental immunotoxicity testing
Chapter 19. In vitro biomarkers of developmental neurotoxicity
Chapter 20. In vivo biomarkers and biomonitoring in reproductive and developmental toxicity
Chapter 21. Developmental toxicity of engineered nanoparticles
Chapter 22. Effects of radiation on the reproductive system
Chapter 23. Reproductive and developmental toxicology: toxic solvents and gases
Chapter 24. Cigarette smoking and reproductive and developmental toxicity
Chapter 25. Effects of ethanol and nicotine on human CNS development
Chapter 26. Developmental neurotoxicity of abused drugs
Chapter 27. Caffeine
Chapter 28. Melamine and cyanuric acid
Chapter 29. Ionophores
Chapter 30. Selected herbal supplements and nutraceuticals
Chapter 31. Thalidomide
Chapter 32. Aluminum
Chapter 33. Arsenic, cadmium and lead
Chapter 34. Manganese
Chapter 35. Mercury
Chapter 36. Selenium
Chapter 37. Organophosphate and carbamate pesticides
Chapter 38. Chlorinated hydrocarbons and pyrethrins/pyrethroids
Chapter 39. Herbicides and fungicides
Chapter 40. Brominated flame retardants
Chapter 41. Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans
Chapter 42. Developmental dioxin exposure and endometriosis
Chapter 43. Reproductive toxicity of polycyclic aromatic hydrocarbons
Chapter 44. Developmental toxicity of polycyclic aromatic hydrocarbons
Chapter 45. Ethylene glycol
Chapter 46. Methyl tert-butyl ether
Chapter 47. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)
Chapter 48. Phthalates
Chapter 49. Organotins (tributyltin and triphenyltin)
Chapter 50. Bisphenol A
Chapter 51. Toxic plants
Chapter 52. Phytoestrogens
Chapter 53. Fumonisins
Chapter 54. Trichothecenes and zearalenone
Chapter 55. Aflatoxins, ochratoxins and citrinin
Chapter 56. Zootoxins
Chapter 57. HIV-1 Tat toxin
Chapter 58. Applications of stem cells in developmental toxicology
Chapter 59. Applications of toxicogenomics in reproductive and developmental toxicology
Chapter 60. Epigenetic regulation of gene and genome expression
Chapter 61. Mitochondrial dysfunction in reproductive and developmental toxicity
Chapter 62. Stress: its impact on reproductive and developmental toxicity
Chapter 63. Cell signaling mechanisms in developmental neurotoxicity
Chapter 64. Neuroinflammation and oxidative injury in developmental neurotoxicity
Chapter 65. Disruption of cholesterol homeostasis in developmental neurotoxicity
Chapter 66. Cholinergic Toxicity and the Male Reproductive System
Chapter 67. Endocrine disruptors
Chapter 68. Screening systems for endocrine disruptors
Chapter 69. Developmental and reproductive disorders
Chapter 70. Mutagenicity and carcinogenicity
Chapter 71. Genotoxicities and infertility
Chapter 72. Occupational exposure to chemicals and reproductive health
Chapter 73. Teratogenicity
Chapter 74. Ultrasound and magnetic resonance in prenatal diagnosis of congenital anomalies
Chapter 75. Micro-CT and volumetric imaging in developmental toxicology
Chapter 76. Toxicologic pathology of the reproductive system
Chapter 77. Strategies for investigating hemochorial placentation
Chapter 78. The placental role in fetal programming
Chapter 79. The significance of ABC transporters in human placenta for the exposure of the fetus to xenobiotics
Chapter 80. Placental toxicity
Chapter 81. Placental pathology
chapter 82. Reproductive and developmental toxicity in avian species
Chapter 83. Endocrine disruption in wildlife species
Chapter 84. Teratogeneses in livestock
Chapter 85. Mare reproductive loss syndrome
Chapter 86. Reproductive and developmental toxicity in fishes
Color Plates
Index
- No. of pages: 1220
- Language: English
- Edition: 1
- Published: April 4, 2011
- Imprint: Academic Press
- eBook ISBN: 9780123820334
RG
Ramesh C. Gupta
Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer’s disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including seven major books with Elsevier: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, (6) Biomarkers in Toxicology and (7) Neutraceuticals. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.
Affiliations and expertise
Professor and Head, Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USARG
Ramesh C Gupta
Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer’s disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including seven major books with Elsevier: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, (6) Biomarkers in Toxicology and (7) Neutraceuticals. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.
Affiliations and expertise
Professor and Head, Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USARead Reproductive and Developmental Toxicology on ScienceDirect