Nonhuman Primates in Biomedical Research
Diseases
- 2nd Edition, Volume 2 - August 19, 2016
- Editors: Christian R. Abee, Keith Mansfield, Suzette D. Tardif, Timothy Morris
- Language: English
The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedica… Read more
The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject.
- Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research
- Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information
- Includes four color images throughout
Researchers working with nonhuman primates and those dealing with laboratory animal husbandry; Veterinarians in private practice who work with nonhuman primates; Biologists and zoologists who wish to expand their knowledge of nonhuman primates
American College of Laboratory Animal Medicine Series
Preface
Acknowledgments
Reviewers
Contributors
Chapter 1. Viral Diseases of Nonhuman Primates
Introduction
Enveloped DNA Viruses
Nonenveloped DNA-Containing Viruses
Enveloped RNA-Containing Viruses
Nonenveloped RNA-Containing Viruses
Chapter 2. Bacterial and Mycotic Diseases of Nonhuman Primates
Introduction
Bacterial Diseases
Mycotic Diseases
Chapter 3. Tuberculosis Research using Nonhuman Primates
Introduction
Human Tuberculosis
Pathobiology of Human Disease: Natural History of Tuberculosis
Primate Models of Tuberculosis
Pathological Features of Model
Statistical Considerations
Occupational Health and Safety Considerations: Biosafety Level 3 Pathogen
Specific Areas of Research that Benefit from the Nonhuman Primate Model of Tuberculosis
Alternative Animal Models, In Silico Models, and In Vitro Systems
Summary
Acknowledgments
Chapter 4. Parasitic Diseases of Nonhuman Primates
Introduction
Protozoan Parasites
Metazoan Parasites
Acknowledgments
Chapter 5. Nonhuman Primate Models for Human Malaria Research
Introduction
Human Malaria
Life Cycle of Primate Malaria Parasites
Clinical Malaria and Pathology
Nonhuman Primate Models of Human Malaria (Biology, Disease Pathogenesis, Immunity, and Testing of Vaccines or Drugs)
Some Methods and Considerations for Investigations of Malaria Biology and Vaccines
Chapter 6. Neoplasia and Proliferative Disorders of Nonhuman Primates
Introduction
Characterization of Neoplasia
Mechanisms of Cancer Development
System Specific Neoplasia
Treatment and Prognosis
Chapter 7. Hematopoietic, Cardiovascular, Lymphoid and Mononuclear Phagocyte Systems of Nonhuman Primates
Introduction
Hematology
The Heart and Vasculature
Lymphoid and Mononuclear Phagocyte Systems
Chapter 8. Nonhuman Primate Models of Atherosclerosis
Introduction
Pathobiology of Human Atherosclerosis
Advantages of a Nonhuman Primate Model
Introduction to Primate Models
New World Monkeys
Old World Monkeys
Summary Assessment
Acknowledgements
Chapter 9. Respiratory System Diseases of Nonhuman Primates
Introduction
Respiratory System Structure and Function
Approach to the Patient with Respiratory Disease
Upper Airway Diseases
Lower Respiratory Tract Diseases
Disorders of the Diaphragm, Pleura, and Mediastinum
Viral Diseases
Bacterial Diseases and Agents
Mycotic Diseases
Protozoan Diseases
Metazoan Parasites
Acknowledgment
Chapter 10. Urogenital System
Part A. Urinary System
Urinary System
Part B. Genital System: Female
Genital System: Female
Part C. Genital System: Male
Genital System: Male
Chapter 11. Integumentary System Diseases of Nonhuman Primates
Introduction
Structure and Function of the Skin
Definitions and Descriptions of Skin Lesions
Examination of the Skin
Diseases of the Skin
Chapter 12. Digestive System Diseases of Nonhuman Primates
Introduction
Oral Cavity
Stomach and Intestine
Liver
Exocrine Pancreas
Acknowledgments
Chapter 13. Arthritis, Muscle, Adipose Tissue, and Bone Diseases of Nonhuman Primates
Introduction
Arthritis
Connective Tissue Disorders
Skeletal Muscle Diseases
Adipose Tissue Disorders
Bone Diseases
Nutritional Disorders
Musculoskeletal Neoplasia
Acknowledgments
Chapter 14. Diabetes and Obesity Research using Nonhuman Primates
Review of Diabetes in Humans
Review of Diabetes in Nonhuman Primates
Methods for Evaluating Diabetes in Nonhuman Primates
Nonhuman Primate Models of Diabetes
Pathologic Changes in Islets in Diabetic Monkeys
Co-Morbid Conditions in Diabetes
Sex Hormones and Effects on Insulin Resistance and Diabetes
Effects of Stress, Diet, and Caloric Restriction on Insulin Resistance and Diabetes
Pharmacologic Interventions to Treat Diabetes and Obesity
Conclusions and Future Directions
Acknowledgments
Chapter 15. Nervous System Disorders of Nonhuman Primates and Research Models
Clinical and Diagnostic Approaches
Specific Procedures
Naturally Occurring Infectious Diseases
Congenital and Developmental Conditions
Age-Related Changes in the CNS
Nutritional and Metabolic Disorders
Miscellaneous Conditions
Neoplasia of the Nervous System
Important Nonhuman Primate Models of Human Neurologic Diseases
Chapter 16. Nonhuman Primate Models of the Motor System
Introduction
The Rationale for Using Nonhuman Primates in Research Focused on the Motor System
Nonhuman Primate Models and Research on the Motor System
The 3RS and Nonhuman Primate Research on the Motor System
Acknowledgments
Chapter 17. Imaging in Research Using Nonhuman Primates
Introduction
Animal Preparation
Advanced Imaging Techniques
Chapter 18. Nonhuman Primate Models of Drug and Alcohol Addiction
Introduction
The Self-Administration Model
Addiction as a Disease of the Brain
Pharmacokinetic Factors Important for Addiction Research
Behavioral Similarities Important for Addiction Research
Genetic Factors Important for Addiction Research
Conclusions
- Edition: 2
- Volume: 2
- Published: August 19, 2016
- Language: English
CA
Christian R. Abee
Affiliations and expertise
University of Texas, MD Anderson Cancer Center, Michale E. Keeling Center for Comparative, Medicine and Research, Bastrop, Texas, U.S.A.KM
Keith Mansfield
Keith Mansfield is Associate Director for Resource and Collaborative Affairs and Chair, Division of Primate Resources, New England National Primate Research Center, Harvard Medical School, Harvard University, Southborough, US. His research focuses on primarily on the recognition of spontaneously occurring infectious diseases of nonhuman primates and their development into novel animal models to investigate disease pathogenesis.
Affiliations and expertise
Novartis Institutes for Biomedical Research,Cambridge, MA, U.S.A.ST
Suzette D. Tardif
Suzette D. Tardif, Ph.D., is the Associate Director of Research at the Southwest National Primate Research Center. She is an adjunct faculty of The Barshop Institute. The Tardif laboratory's activities center on the development of the marmoset monkey as a disease model. Dr. Tardiff is a past-President of the American Society of Primatologists.
Affiliations and expertise
Barshop Institute for Longevity & Aging Studies, San Antonio, TX USATM
Timothy Morris
Affiliations and expertise
The School of Veterinary Medicine and Science, The University of Nottingham, Leicestershire, UKRead Nonhuman Primates in Biomedical Research on ScienceDirect