Eukaryotic Transcription Factors
- 3rd Edition - October 13, 1998
- Imprint: Academic Press
- Author: David S. Latchman
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 3 7 1 7 7 - 4
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 3 7 1 7 6 - 7
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 7 3 5 4 - 0
Familiarity with the mechanisms of eukaryotic gene regulation is now essential for scientists and students in both clinical and basic disciplines. However, the vast array of… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteFamiliarity with the mechanisms of eukaryotic gene regulation is now essential for scientists and students in both clinical and basic disciplines. However, the vast array of transcription factors, which are central to such regulation, can prove daunting to students and newcomers to this fascinating field of molecular genetics. The Third Edition of Eukaryotic Transcription Factors provides the reader with a clear and concise understanding not only of transcription factors, but also of their vital role in the regulation of transcription in different cell types during development and in disease.Revised and completely up-to-date, the Third Edition of Eukaryotic Transcription Factors has been extensively rewritten to reflect the rapid advances in the field. These include the emerging roles of specific co-activator molecules such as CBP in the action of a number of different transcription factors emphasizing particularly their ability to modulate chromatin structure. New sections cover current methods for determining DNA binding specificity, regulation by protein degradation and processing, Pax family transcription factors, and novel anti-oncogenic transcription factors, as well as a discussion of transcription factors in human diseases. A special new color section illustrates the various aspects of transcription factor structure.
- Major families of eukaryotic transcription factors
- Mechanisms of gene activation and repression
- Structure-function relationships
- Their roles in inducible and cell type-specific gene expression, development, differentiation, and human diseases including cancer
- Methods of study in vivo and in vitro
AUDIENCE: Advanced level undergraduates/postgraduates and researchers to the fields of molecular biology, biochemistry, cell biology, immunology, molecular genetics, developmental biology and endocrinology.
DNA Sequences, Transcription Factors, and Chromatin Structure.
Methods for Studying Transcription Factors.
Transcription Factors and Constitutive Transcription.
Transcription Factors and Inducible Gene Expression.
Transcription Factors and Cell Type-Specific Transcription.
Transcription Factors and Developmentally Regulated Gene Expression.
Transcription Factors and Human Disease.
DNA Binding by Transcription Factors.
Activation and Repression of Gene Expression by Transcription Factors.
What Regulates the Regulators?
Conclusions and Future Prospects.
Chapter References.
Index.
Methods for Studying Transcription Factors.
Transcription Factors and Constitutive Transcription.
Transcription Factors and Inducible Gene Expression.
Transcription Factors and Cell Type-Specific Transcription.
Transcription Factors and Developmentally Regulated Gene Expression.
Transcription Factors and Human Disease.
DNA Binding by Transcription Factors.
Activation and Repression of Gene Expression by Transcription Factors.
What Regulates the Regulators?
Conclusions and Future Prospects.
Chapter References.
Index.
- Edition: 3
- Published: October 13, 1998
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780124371774
- Hardback ISBN: 9780124371767
- eBook ISBN: 9780080573540
DL
David S. Latchman
Affiliations and expertise
Master of Birkbeck, University of London, Professor of Genetics, Birkbeck and University College London, UK