Electrocardiography of Laboratory Animals
- 1st Edition - December 6, 2013
- Authors: Jeffrey W. Richig, Meg M. Sleeper
- Language: English
Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countr… Read more
Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. Electrocardiography of Laboratory Animals will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research.
- Covers safety electrocardiography of large laboratory animals
- Offers comprehensive analysis of ECGs for practical laboratory use
- Includes a self-evaluation section for testing of ECG reading and analysis
Primary Audience: Researchers working with primates, dogs and mini-pigs in academia, pharma, or contract research organization across the biological and medical sciences. Secondary Audience: Vets working with primates, dogs and mini-pigs; Zoologists working with primates, dogs and mini-pigs; and Veterinary professors and students teaching/taking cardiology and ECG course for accreditation
Dedication
Preface
Foreword
Acknowledgements
Chapter 1. Electrocardiography in Preclinical Safety
Introduction
Regulatory Guidance versus Good Science versus Rationale Drug Development
Safety Pharmacology versus Toxicology
Safety Pharmacology Studies: Core-Battery and Second-Tier Testing for Cardiotoxicity
Cardiotoxicity Endpoints in Toxicology
The ECG and Drug Safety
Chapter 2. Principles of Electrocardiography
Recording the ECG
Cardiac Conduction and Waveform Genesis
Evaluation of the Electrocardiogram
Transmembrane Action Potentials
Evaluation of Waveforms
Mean Electrical Axis
Equipment Considerations
Cardiac Effects of Systemic Potassium and Calcium Abnormalities
Chapter 3. Canine Electrocardiography
Introduction
Etiology, Pathophysiology, and Gross Pathology
Rhythm Diagnosis
Chapter 4. Handling and Restraint of Nonhuman Primates
Cynomolgus and Rhesus
Machine Setup and Configuration
Lead Placement
Obtaining the Tracing
Chemical Restraint
Tracing Handling and Storage
Chapter 5. Electrocardiography of Nonhuman Primates
Fundamental Principles of Electrocardiography
Electrocardiography of Cynomolgus and Rhesus Monkeys
Cardiac Arrhythmias
Chimpanzee Electrocardiography
Chapter 6. Electrocardiography of Minipigs
Normal Values
Normal Variants in Order of Occurrence (Commonality)
Lead Placement
Fundamental Principles of Electrocardiography
Electrocardiography of Minipigs (Sus scrofa)
Cardiac Arrhythmias
Sinoatrial Arrhythmias
Supraventricular Arrhythmias
Ventricular Arrhythmias
Abnormalities of Impulse Conduction
Miscellaneous Disturbances
Normal Variants
Chapter 7. Telemetry in Preclinical Safety Studies
Chapter 8. PR (PQ), QRS, QT, and Other Issues
The PR (PQ) Interval
QRS Complex Duration
QT Interval Duration
Chapter 9. Self-Test
Canine ECG Examples
Answers
References
Index
- Edition: 1
- Published: December 6, 2013
- Language: English
JR
Jeffrey W. Richig
Jeffrey W. Richig, DVM is CEO of ECGVET, LLC and Special Government Employee consultant to the FDA for the cardiovascular and renal drugs division. He has over twenty-five years of experience in electrocardiography for pre-clinical safety evaluation studies and is known as a leading expert in the field.
Affiliations and expertise
CEO of ECGVET, LLC and Special Government Employee consultant to the FDA's cardiovascular and renal drugs division, USAMS
Meg M. Sleeper
Meg Sleeper, VMD, graduated cum laude from the University of Pennsylvania veterinary school in 1993. She is an associate professor of cardiology and served as section chief from 2001 to 2011. Dr. Sleeper has published over 70 peer-reviewed original papers, more than 50 review papers or case reports, and authored 4 books. She has lectured at numerous prestigious conferences, including the American Heart Association and the American College of Veterinary Internal Medicine Forum, and has coordinated the small animal cardiology section at the AVMA conference since 2009. Dr. Sleeper has trained 18 veterinary cardiologists and joined the University of Florida veterinary school faculty in 2015. She serves on the editorial or review boards of 11 journals and has contributed to the Great Ape Heart Project since 2011, focusing on improving cardiac health in ape species.
Affiliations and expertise
Clinical Professor, Cardiology, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, University of Florida, Gainsville, FL, USARead Electrocardiography of Laboratory Animals on ScienceDirect