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Drug Metabolism in Diseases

1st Edition - September 12, 2016

Editor: Wen Xie

Hardback ISBN:

9 7 8 - 0 - 1 2 - 8 0 2 9 4 9 - 7

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 0 2 9 6 3 - 3

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains… Read more

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Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states.

Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology.

Preface
Chapter 1. Introduction of Drug Metabolism and Overview of Disease Effect on Drug Metabolism
- Introduction
- Overview of Drug Metabolism
- Disease Effects on Drug Metabolism
- Disease Effects on Absorption Parameters
- Changes in Blood Flow to Organs
- Changes in Protein Binding
- Disease Effects on Transporter Expression
- Summary
Chapter 2. Regulation of Drug-Metabolizing Enzymes and Drug Metabolism by Inflammatory Responses
- Introduction
- The Inflammatory Response
- Regulation of DMEs by Inflammatory Mediators
- Regulation of P450 Enzymes in Specific Disease States and Models
- Disease-Dependent Drug–Drug Interactions
- Mechanisms of Regulation
- Conclusion
Chapter 3. Regulation of Drug Transporters by Inflammation
- Introduction
- Acute Inflammation
- Models of Acute Inflammation
- Effect of Acute Inflammation on Drug Transporters
- Chronic Inflammation
- Impact of Chronic Inflammation on Drug Transporters
- Conclusion
Chapter 4. Drug Metabolism in Kidney Disease
- Conventional Drug-Dosing Paradigm in Kidney Disease
- Nonrenal Clearance
- Influence of Experimental Kidney Disease on Drug Metabolism
- Influence of Kidney Disease on Drug Metabolism in Humans
- Mechanisms of Altered Drug Metabolism in Kidney Disease
- Summary
Chapter 5. Drug and Fatty Acid Cytochrome P450 Metabolism in Critical Care
- Introduction
- Stroke
- Traumatic Brain Injury
- Cardiac Arrest
- Summary
Chapter 6. Drug Metabolism in Cardiovascular Disease
- Introduction
- Cardiovascular Diseases
- Cytochrome P-450 Expression in Cardiovascular Disease
- Pharmacogenomics Related to Cardiovascular Drugs and Disease
- Conclusion
Chapter 7. Pharmacogenetic Factors That Affect Drug Metabolism and Efficacy in Type 2 Diabetes Mellitus
- Introduction
- Sulfonylureas
- Meglitinides
- Metformin
- Thiazolidinediones
- α-Glucosidase Inhibitors
- DPP-4 Inhibitors
- Conclusion
Chapter 8. Hepatic Drug Metabolism in Pediatric Patients
- Ontogeny of Hepatic Drug Metabolism
- Ontogeny of Intrinsic Hepatic Clearance
- Ontogeny of Hepatic Blood Flow
- Ontogeny of Plasma Protein Binding
- Ontogeny of Hepatic Drug Transporters
- Conclusion
Chapter 9. Drug Metabolism in Pregnancy
- Introduction
- Physiological Adaptations During Pregnancy
- Hepatic Phase I Enzymes
- Hepatic Phase II Enzymes
- Hepatic Transporters
- Nuclear Receptors
- Hormonal Regulation
- Extrahepatic Regulation
- Case Example: Bile Acid Metabolism and Transport
- Conclusion and Future Directions
Chapter 10. Estrogen-Metabolizing Enzymes in Systemic and Local Liver Injuries: A Case Study of Disease–Drug Interaction
- Estrogen Sulfotransferase and Steroid Sulfatase in Estrogen Homeostasis: An Introduction
- Estrogen Sulfotransferase and Its Regulation in Sepsis Response
- Estrogen Sulfotransferase and Its Regulation in Liver Ischemia and Reperfusion Response
- Steroid Sulfatase and Its Regulation in Estrogen Homeostasis and Inflammation in Chronic Liver Disease
- Conclusions and Perspectives
Chapter 11. Xenobiotic Receptors in the Crosstalk Between Drug Metabolism and Energy Metabolism
- Introduction
- Xenobiotic Receptors as Master Regulators of Drug Metabolism
- Drug Metabolism can be Affected by Energy Metabolism
- Energy Metabolism can be Affected by Drug Metabolism and Xenobiotic Receptors
- Conclusion and Perspectives
Index