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Drug Metabolism in Diseases
1st Edition - September 12, 2016
Editor: Wen Xie
Hardback ISBN:9780128029497
9 7 8 - 0 - 1 2 - 8 0 2 9 4 9 - 7
eBook ISBN:9780128029633
9 7 8 - 0 - 1 2 - 8 0 2 9 6 3 - 3
Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains… Read more
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Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states.
Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology.
Written and edited by leaders in drug metabolism from academia and industry
Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more
Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic
Academic researchers involved in drug metabolism, pharmacology, molecular pharmacology, clinical pharmacology and personalized medicine; industry researchers working in drug metabolism, drug toxicity and drug safety evaluation; and regulatory officials in drug safety
Preface
Chapter 1. Introduction of Drug Metabolism and Overview of Disease Effect on Drug Metabolism
Introduction
Overview of Drug Metabolism
Disease Effects on Drug Metabolism
Disease Effects on Absorption Parameters
Changes in Blood Flow to Organs
Changes in Protein Binding
Disease Effects on Transporter Expression
Summary
Chapter 2. Regulation of Drug-Metabolizing Enzymes and Drug Metabolism by Inflammatory Responses
Introduction
The Inflammatory Response
Regulation of DMEs by Inflammatory Mediators
Regulation of P450 Enzymes in Specific Disease States and Models
Disease-Dependent Drug–Drug Interactions
Mechanisms of Regulation
Conclusion
Chapter 3. Regulation of Drug Transporters by Inflammation
Introduction
Acute Inflammation
Models of Acute Inflammation
Effect of Acute Inflammation on Drug Transporters
Chronic Inflammation
Impact of Chronic Inflammation on Drug Transporters
Conclusion
Chapter 4. Drug Metabolism in Kidney Disease
Conventional Drug-Dosing Paradigm in Kidney Disease
Nonrenal Clearance
Influence of Experimental Kidney Disease on Drug Metabolism
Influence of Kidney Disease on Drug Metabolism in Humans
Mechanisms of Altered Drug Metabolism in Kidney Disease
Summary
Chapter 5. Drug and Fatty Acid Cytochrome P450 Metabolism in Critical Care
Introduction
Stroke
Traumatic Brain Injury
Cardiac Arrest
Summary
Chapter 6. Drug Metabolism in Cardiovascular Disease
Introduction
Cardiovascular Diseases
Cytochrome P-450 Expression in Cardiovascular Disease
Pharmacogenomics Related to Cardiovascular Drugs and Disease
Conclusion
Chapter 7. Pharmacogenetic Factors That Affect Drug Metabolism and Efficacy in Type 2 Diabetes Mellitus
Introduction
Sulfonylureas
Meglitinides
Metformin
Thiazolidinediones
α-Glucosidase Inhibitors
DPP-4 Inhibitors
Conclusion
Chapter 8. Hepatic Drug Metabolism in Pediatric Patients
Ontogeny of Hepatic Drug Metabolism
Ontogeny of Intrinsic Hepatic Clearance
Ontogeny of Hepatic Blood Flow
Ontogeny of Plasma Protein Binding
Ontogeny of Hepatic Drug Transporters
Conclusion
Chapter 9. Drug Metabolism in Pregnancy
Introduction
Physiological Adaptations During Pregnancy
Hepatic Phase I Enzymes
Hepatic Phase II Enzymes
Hepatic Transporters
Nuclear Receptors
Hormonal Regulation
Extrahepatic Regulation
Case Example: Bile Acid Metabolism and Transport
Conclusion and Future Directions
Chapter 10. Estrogen-Metabolizing Enzymes in Systemic and Local Liver Injuries: A Case Study of Disease–Drug Interaction
Estrogen Sulfotransferase and Steroid Sulfatase in Estrogen Homeostasis: An Introduction
Estrogen Sulfotransferase and Its Regulation in Sepsis Response
Estrogen Sulfotransferase and Its Regulation in Liver Ischemia and Reperfusion Response
Steroid Sulfatase and Its Regulation in Estrogen Homeostasis and Inflammation in Chronic Liver Disease
Conclusions and Perspectives
Chapter 11. Xenobiotic Receptors in the Crosstalk Between Drug Metabolism and Energy Metabolism
Introduction
Xenobiotic Receptors as Master Regulators of Drug Metabolism
Drug Metabolism can be Affected by Energy Metabolism
Energy Metabolism can be Affected by Drug Metabolism and Xenobiotic Receptors
Conclusion and Perspectives
Index
No. of pages: 294
Language: English
Published: September 12, 2016
Imprint: Academic Press
Hardback ISBN: 9780128029497
eBook ISBN: 9780128029633
WX
Wen Xie
Professor of Pharmaceutical Sciences and Pharmacology, The Joseph Koslow Endowed Chair in Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA; Director of the Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
Affiliations and expertise
Professor of Pharmaceutical Sciences and Pharmacology, The Joseph Koslow Endowed Chair in Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA; Director of the Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA