Cellular and Molecular Neurophysiology
- 3rd Edition - February 6, 2008
- Author: Constance Hammond
- Language: English
Cellular and Molecular Neurophysiology, Third Edition, is the new, thoroughly revised edition of the only current, established, and authoritative text focusing on the cellular… Read more
Cellular and Molecular Neurophysiology, Third Edition, is the new, thoroughly revised edition of the only current, established, and authoritative text focusing on the cellular and molecular physiology of nerve cells. Previously titled Cellular and Molecular Neurobiology, the new title better reflects this focus. This version contains 80% new or updated material.
Fifteen appendices describing neurobiological techniques are interspersed in the text. Now in full color throughout, the book has over 400 carefully selected and constructed illustrations. It includes an instructor website with all the images in electronic format, plus additional material. The book is hypothesis driven rather than just presenting the facts, and the content is firmly based on numerous experiments performed by the top experts in the field.
While covering the important facts, the book also presents the background for how researchers arrived at this knowledge to provide a context for the field. It promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike.
- 80% new or updated material
- Fifteen appendices describing neurobiological techniques are interspersed in the text
- Now in full color throughout, with more than 400 carefully selected and constructed illustrations
- Provides an instructor website with all the images in electronic format, plus additional material
Neurophysiologists, neurobiologists, neurologists, as well as graduate-level courses on neurophysiology.
Part I – Neurons: Excitable and Secretory Cells that Establish Synapses.Chapter 1: NeuronsChapter 2: Neuron –Glial Cell CooperationChapter 3: Ionic Gradients, Membrane Potential and Ionic CurrentsAppendix 3.1: The active transport of ions by pumps and transporters maintain the unequal distribution of ionsAppendix 3.2: The passive diffusion of ions through an open channelAppendix 3.3: The Nernst equationChapter 4: The Voltage-Gated Channels of Na+ Action PotentialsAppendix 4.1: Current clamp recordingAppendix 4.2: Voltage clamp recordingChapter 5: The Voltage-Gated Channels of Ca+2Action Potentials: GeneralizationAppendix 5.1: Fluorescence measures of intracellular Ca2+ concentrationAppendix 5.2: Tail currentsChapter 6: The Chemical SynapsesAppendix 6.1: Neurotransmitters, agonists and antagonistsAppendix 6.2: Identification and Localization of Neurotransmitters and their ReceptorsChapter 7: Neurotransmitter ReleaseAppendix 7.1: Quantal nature of neurotransmitter releaseAppendix 7.2: The probabilistic nature of neurotransmitter release (the neuromuscular junction as a model)Part 2 – Ionotropic and Metabotropic Receptors in Synaptic Transmission and Sensory Transduction.Chapter 8: The Ionotropic Nicotinic Acetycholine ReceptorsAppendix 8.1: The neuronal nicotinic receptorsChapter 9: The Ionotropic GABAA ReceptorAppendix 9.1: Mean time and mean burst duration of the GABAA single-channel currentAppendix 9.2: Non-invasive measurements of membrane potential and of the reversal potential of the GABAA current using cell-attached recordings of single channelsChapter 10: The Ionotropic Glutamate ReceptorsChapter 11: The Metabotropic GABAB ReceptorsChapter 12: The Metabotropic Glutamate ReceptorsPart 3 – Somato-Dendritic Processing and Plasticity of Postsynaptic Potentials.Chapter 13: Somato-Dendritic Processing of Postsynaptic PotentialsI: Passive Properties of DendritesChapter 14: Subliminal Voltage-Gated Currents of the Somato-Dendritic MembraneChapter 15: Somato-Dendritic Processing of Postsynaptic PotentialsII: Role of Subliminal Depolarizing Voltage-Gated CurrentsChapter 16: Somato-Dendritic Processing of Postsynaptic PotentialsIII: Role of High Voltage-Activated Depolarizing CurrentsChapter 17: Firing Patterns of NeuronsChapter 18: Synaptic PlasticityAppendix 18.1: Depolarization of induced suppression of inhibition (DSI)Part 4 – The Adult Hippocampal Network.Chapter 19: The Adult Hippocampal networkChapter 20: Maturation of the Hippocampal Network
"In its third internationally acclaimed edition, this textbook provides an unrivaled account of the basic foundations of molecular and cellular neurophysiology. For those of us who were inclined to believe that the unprecedented development of neuroscience made neurophysiology disposable, Constance Hammond proves us with conviction and elegance that this is just not the case!" -Dr. Robert Dantzer, Professor of Psychoneuroimmunology, Integrative Immunology and Behavior Program University of Illinois at Urbana-Champaign
"Unlike many other texts, chapters in this book are structured around the known neurophysiological facts. The author states the fact, gives simple explanations for why it is so, and when appropriate follows her discussion by in-depth analyses. Also unlike many other texts, the chapters are not built around the work of other people, and are not overburdened with references to published material. This style makes for a very fluid and self consistent read which should be of interest to neophytes and advanced students alike." -Jean-Marc Fellous, Professor Psychology, Neuroscience, Cognitive Sciences, and Applied Mathematics, University of Arizona, Tucson
"A particularly strong feature of the book is that most of the exposition is driven by data from original experiments, supplying many figures that offer a ready-made basis for lectures (figures are available on the instructor's website). In addition, appendices of many chapters provide further information about techniques or related topics (e.g. patch-clamping, fluorescence measurements, neurotransmitter identification) that is often not essential to understanding the physiology, but is extremely useful to the more interested or advanced student." -Jim Belanger, Department of Biology, West Virginia University
"More than any similar volume that I have come across in recent years, this one has the potential of luring students of neuroscience and even students from other fields to build a career in neurophysiology." -György Buzsáki, M.D., Ph.D., Board of Governors Professor, Center for Molecular and Behavioral Neuroscience, Rutgers University
"Constance Hammond has rewritten and updated most of the chapters, which gives a better homogeneity to the book. The figures are now in color and thereby easier to read. In summary, this book is a very precious and unique tool, ideal for students with a strong interest in neuroscience." -Jean-Francois Perrier, Institute of Neuroscience and Pharmacology, University of Copenhagen, Denmark
"This is an outstanding book that I will definitely recommend to my students." -Peter Somogyi, Oxford University, United Kingdom
"Unlike many other texts, chapters in this book are structured around the known neurophysiological facts. The author states the fact, gives simple explanations for why it is so, and when appropriate follows her discussion by in-depth analyses. Also unlike many other texts, the chapters are not built around the work of other people, and are not overburdened with references to published material. This style makes for a very fluid and self consistent read which should be of interest to neophytes and advanced students alike." -Jean-Marc Fellous, Professor Psychology, Neuroscience, Cognitive Sciences, and Applied Mathematics, University of Arizona, Tucson
"A particularly strong feature of the book is that most of the exposition is driven by data from original experiments, supplying many figures that offer a ready-made basis for lectures (figures are available on the instructor's website). In addition, appendices of many chapters provide further information about techniques or related topics (e.g. patch-clamping, fluorescence measurements, neurotransmitter identification) that is often not essential to understanding the physiology, but is extremely useful to the more interested or advanced student." -Jim Belanger, Department of Biology, West Virginia University
"More than any similar volume that I have come across in recent years, this one has the potential of luring students of neuroscience and even students from other fields to build a career in neurophysiology." -György Buzsáki, M.D., Ph.D., Board of Governors Professor, Center for Molecular and Behavioral Neuroscience, Rutgers University
"Constance Hammond has rewritten and updated most of the chapters, which gives a better homogeneity to the book. The figures are now in color and thereby easier to read. In summary, this book is a very precious and unique tool, ideal for students with a strong interest in neuroscience." -Jean-Francois Perrier, Institute of Neuroscience and Pharmacology, University of Copenhagen, Denmark
"This is an outstanding book that I will definitely recommend to my students." -Peter Somogyi, Oxford University, United Kingdom
- Edition: 3
- Published: February 6, 2008
- Language: English
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Constance Hammond
Constance Hammond is an INSERM director of research at the Mediterranean Institute of Neurobiology. A renowned Parkinson's disease investigator, in 2012 she became a Chevalier of the Légion d'Honneur in recognition for her services to scientific communication. Studying biology at the University of Pierre and Marie Curie and the Ecole Normale Supérieure in Paris she completed her thesis in neurosciences at the Marey Institute in Paris, directed by Prof. D. Albe-Fessard. Guided by her curiosity and her constant desire to learn, she changed lab and research domains several times. With the knowledge of other systems and the mastering of other techniques she finally came back to her first and preferred subject of research; the role of the subthalamic nucleus in the basal ganglia system in health and Parkinson's disease.
Affiliations and expertise
Director of Research INSERM U901, Institut de Neurobiologie de la Méditerranee, Marseilles, France