BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.The journal does not favorably review manuscripts identifying a miRNA-target pair without additional insights into the repression mechanism or significant advances in understanding regulatory pathways. In addition, the following elements should be an integral part of the study: •In silico prediction of miRNA targets must be experimentally verified using appropriate luciferase constructs and assays; •To exclude non-functional miRNA/mRNA interactions a reporter system including the whole 3'UTR of the target gene downstream the "luciferase" or GFP should be considered; •Any miRNA modulation should be validated by measuring the expression of the putative proteinPlease see our Guide for Authors for information on article submission. If you require any further information or help, please visit our Support Center
DNA Repair (DNAREP) is a journal focusing on DNA repair and cellular responses to DNA damage. DNA Repair publishes articles on genetic, cellular, biochemical, structural and molecular aspects of DNA repair. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports will also be considered for publication.The journal publishes topics directly pertaining to DNA damage and repair, which include:ApoptosisBio... responses to genomic insultCell cycle regulationCell fate decisionsEpigenetics and chromatinGenomics/bi... diseases: aging, cancer, and neurological dysfunctionImmune responsesMutagenesis & signature mutationsStructural biology and computational modeling
The subject areas of Mutation Research - Reviews in Mutation Research (MRR) encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus, this section will cover:Advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concernGenetic toxicology and environmental mutagenesis (including the factors that modulate the genetic activity of environmental agents) will continue to be prominent topics in this section.MRR supports and follows the general direction proposed by all major societies in the field part of the International Association of Environmental Mutagenesis and Genomics Societies (IAEMGS):Asociacion Latinoamericana de Mutagenesis, Carcinogenesis y Teratogenesis Ambiental (ALAMCTA)Brazilian Association of Mutagenesis and Environmental Genomics (MutaGen-Brasil)Chin... Environmental Mutagen Society (CEMS)European Environmental Mutagenesis and Genomics Society (EEMGS)Environmental Mutagenesis and Genomics Society (EMGS)Environmental Mutagen Society of India (EMS India)Iranian Environmental Mutagen Society (IrEMS)The Japanese Environmental Mutagen Society (JEMS)Korean Environmental Mutagen Society (KEMS)Molecular and Experimental Pathology Society of Australasia (MEPSA)Pan-African Environmental Mutagen Society (PAEMS)Philippines Environmental Mutagen Society (PEMS)Thai Environmental Mutagen Society (TEMS)Other Mutation Research sections: DNA Repair Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis (MR) Mutation Research - Genetic Toxicology and Environmental Mutagenesis (MRGTEM)
