BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.The journal does not favorably review manuscripts identifying a miRNA-target pair without additional insights into the repression mechanism or significant advances in understanding regulatory pathways. In addition, the following elements should be an integral part of the study: •In silico prediction of miRNA targets must be experimentally verified using appropriate luciferase constructs and assays; •To exclude non-functional miRNA/mRNA interactions a reporter system including the whole 3'UTR of the target gene downstream the "luciferase" or GFP should be considered; •Any miRNA modulation should be validated by measuring the expression of the putative proteinPlease see our Guide for Authors for information on article submission. If you require any further information or help, please visit our Support Center
DNA Repair (DNAREP) is a journal focusing on DNA repair and cellular responses to DNA damage. DNA Repair publishes articles on genetic, cellular, biochemical, structural and molecular aspects of DNA repair. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports will also be considered for publication.The journal publishes topics directly pertaining to DNA damage and repair, which include:ApoptosisBiological responses to genomic insultCell cycle regulationCell fate decisionsEpigenetics and chromatinGenomics/bioinformaticsHuman diseases: aging, cancer, and neurological dysfunctionImmune responsesMutagenesis & signature mutationsStructural biology and computational modeling
