Nitric Oxide

Nitric Oxide is an international journal publishing original research articles, methodological advances, state-of-the-art protocols, and invited reviews focused on the chemistry, redox biology, and signaling of nitric oxide and related small signaling molecules, including hydrogen sulfide and carbon monoxide. The journal highlights advances in the enzymatic and non-enzymatic production of these molecules, their chemical interactions, the activation and function of second messengers (such as cGMP, cAMP, and non-canonical cyclic nucleotides), and post-translational modifications involved in the regulation of physiological processes and their implications for human health and disease.

We welcome interdisciplinary studies spanning biological chemistry, physiology, pharmacology, enzymology, and pathophysiology, as well as clinical investigations. Submissions elucidating novel mechanisms, translational relevance, and therapeutic potential are particularly encouraged. The journal also supports research in microbial and plant systems that provide mechanistic or comparative insights into small molecule signaling.

In addition to traditional research articles, we actively encourage the submission of negative results, hypothesis papers, and policy or clinical guideline manuscripts that advance the field or promote rigorous, transparent science.

Nitric Oxide is the official journal of the Nitric Oxide Society.