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Yen & Jaffe's Reproductive Endocrinology
Physiology, Pathophysiology, and Clinical Management
- 9th Edition - March 24, 2023
- Editors: Jerome F. Strauss, Robert L. Barbieri, Anuja Dokras, Carmen J Williams, S. Zev Williams
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 1 0 0 7 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 1 0 0 8 - 1
For over 40 years, Yen & Jaffe's Reproductive Endocrinology has been the gold standard text of both basic science and clinical practice of the full range of female and male… Read more
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Request a sales quoteFor over 40 years, Yen & Jaffe's Reproductive Endocrinology has been the gold standard text of both basic science and clinical practice of the full range of female and male reproductive disorders. The fully revised 9th Edition continues this tradition of excellence with complete coverage, including up-to-date information on impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, contraception, and more. An outstanding editorial board and other global experts in the field share their knowledge and expertise to keep you abreast of current science and practice in endocrinology.
Includes new chapters on Meiosis, Fertilization and Embryo Development; Recurrent Pregnancy Loss; Uterus Transplantation; Mitochondrial Transplantation and Gene Editing; and Germs Cells Developed In Vitro.
Provides extensively revised information on contemporary practices in assisted reproduction, fertility preservation, and ovulation induction.
Provides an online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging.
Adds three new members to the exceptional editorial team: Drs. Anuja Dokras, Carmen J. Williams, and Zev Williams.
Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction.
Includes bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section.
Lists Top References at the end of each chapter that distill the most important references for research underpinnings, to complement the complete online reference list.
An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
- Instructions for online access
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Dedication
- Video Contents
- Part 1. The Fundamentals of Reproduction
- 1. Neuroendocrinology of Reproduction
- Central Control of Reproduction
- Neuroendocrinology: The Interface Between Neurobiology and Endocrinology
- 2. The Gonadotropin Hormones and Their Receptors
- Introduction
- Gonadotropins
- Gonadotropin Receptors
- 3. Prolactin in Human Reproduction
- Introduction
- Lactotroph Development
- Prolactin Gene
- Prolactin Synthesis in Pituitary Lactotrophs
- Prolactin Synthesis in the Decidua and Other Tissues
- Prolactin Assays
- Prolactin Secretion
- Regulation of Systemic Prolactin Levels
- Prolactin Actions
- Pathological States of Prolactin Deficiency and Excess
- Prolactin-Secreting Pituitary Adenomas (Prolactinomas)
- Pregnancy and Prolactinomas
- 4. Steroid Hormones and Other Lipid Molecules Involved in Human Reproduction
- Steroid Hormones: Structure and Nomenclature
- Organization of Steroidogenic Organs and Cells
- Acquisition, Storage, and Trafficking of Cholesterol
- Regulation of Cellular Cholesterol Balance
- Overview of Steroidogenesis
- Other Steroid Hormone Metabolic Pathways
- Vitamin D Synthesis and Metabolism
- Regulation of Expression of the Steroidogenic Machinery
- Examples of Extraglandular Steroidogenesis
- Steroid Hormone Metabolism in Skin
- Secretion, Production, and Metabolic Clearance Rates of Steroid Hormones
- Plasma Steroid Hormone-Binding Proteins
- Inhibitors of Enzymes Involved in Synthesis or Metabolism of Sex Steroids
- Eicosanoids: Other Bioactive Lipids Playing a Role in Reproduction
- Major Products of the COX Pathway: Prostaglandins, Thromboxanes, and Prostacyclin
- Major Products of the Lipoxygenase Pathway: The Leukotrienes and HETEs
- Transport and Metabolism of Eicosanoids
- Pharmacologic Regulation of Eicosanoid Synthesis
- Eicosanoid Receptors
- Eicosanoids and Reproduction
- Other Lipid Mediators: Lysophosphatidic Acid and Sphingosine-1-Phosphate
- 5. Steroid Hormone Action
- Steroid Hormone Receptors Act as Ligand-Dependent Transcription Activators or Repressors
- Steroid Hormone Receptor Structure and the Evolution of Specificity
- Steroid Hormone Receptor Function
- General Factors That Influence Steroid Hormone Action
- Nongenomic Actions of Steroids
- Summary
- 6. Growth Factors and Reproduction
- Ovary Development
- Formation of the Reproductive Tracts
- Growth Factors in Uterine Biology
- Growth Factor Pathways in Male Reproduction
- Conclusion
- 7. Neuroendocrine Control of the Menstrual Cycle
- The Reproductive Axis
- Neuroendocrine Components of the Reproductive Axis
- Gonadotropin-Releasing Hormones
- Gonadotropin-Producing Cells of the Pituitary
- Ovarian Feedback on the Hypothalamus and Pituitary
- The Normal Menstrual Cycle
- 8. The Ovarian Life Cycle
- Introduction
- Primordial Germ Cells
- Ovarian Morphogenesis
- Epigenetic Programming and Germ Cell Development
- The Follicle and Its Surroundings
- Ovarian Stem Cells
- Follicular Life Cycle
- Ovarian Aging and Insufficiency
- Assessment of Ovarian Reserve and Prediction of Reproductive Age
- Endocrine Activity of the Postmenopausal Ovary
- 9. Meiosis, Fertilization, and Preimplantation Embryo Development
- Introduction
- Meiosis Overview
- Meiotic Initiation
- Prophase I
- Oocyte Growth Phase
- Oocyte Meiotic Maturation
- Sperm Transport
- Sperm Capacitation
- Fertilization
- Egg Activation
- Cleavage Stage Development
- Compaction and Blastocyst Development
- 10. Structure, Function, and Evaluation of the Female Reproductive Tract
- Structure and Function
- Menstrual Cycle
- Endometrium in the Cycle of Conception and Pregnancy
- Endometrial Microbiome
- Clinical Evaluation of the Endometrium
- Endometrium in Advancing Age
- 11. Endocrinology of Human Pregnancy and Fetal-Placental Neuroendocrine Development
- Introduction
- Establishment of Pregnancy
- The Placenta as an Endocrine Organ
- Fetal Neuroendocrine Systems
- Fetal Maturation and the Timing of Parturition
- Uterine Stretch
- Evolutionary Perspective
- 12. The Breast
- Introduction
- Estradiol and Testosterone: Dueling Steroids
- Gynecomastia
- Breastfeeding And Amenorrhea
- The Effect of Steroid Contraceptives on Lactation and Breastfeeding
- Suppression of Lactation
- Induction of Lactation
- Breastfeeding Reduces the Risk of Endometriosis
- Breastfeeding Reduces the Risk of Breast Cancer and Ovarian Cancer
- Breastfeeding Reduces the risk of Developing Diabetes or Cardiovascular Disease
- Galactorrhea
- Hormonal Control of Breast Density
- Breast Cancer
- Cyclical Mastalgia
- 13. The Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs
- Physiology of the Male Gonadal Axis
- Testicular Steroidogenesis
- Sex-Steroid Receptors and Sex Hormone-Binding Globulin
- Physiology of Hypothalamo-Pituitary-Testicular Network
- The Testis
- Accessory Organs
- Spermatogenesis
- Regulation of Male Fertility
- Decremental Changes in GnRH-LH-Te Axis in Aging
- 14. Menopause and Aging
- Epidemiology
- Premature Ovarian Insufficiency
- Menopausal Transition (Perimenopause)
- Effects on Various Organ Systems
- Breast Cancer
- Decision to Use Estrogen
- Endometrial Disease Risk and Other Cancers
- Hormone Regimens
- Aging
- 15. Male Reproductive Aging
- Changes in Male Reproductive Function with Age
- Consequences of Decreased Serum Testosterone Concentrations
- Attempts to Reverse the Consequences of Aging by Testosterone Treatment
- Conclusion
- 16. Immunology and Reproduction
- Introduction
- Basic Immune Principles
- Alloimmunity and Reproduction
- Autoimmunity and Reproduction
- Conclusions
- Part 2. Pathophysiology and Therapy: Pediatric, Adolescent, and Adult
- 17. Differences of Sex Development
- Introduction
- Mechanisms of Human Sex Development
- Sex Chromosome DSD
- 46,XY Differences of Sex Development
- 46,XX Disorders of Sex Development
- General Management for Patients With Differences of Sex Development
- 18. Puberty: Gonadarche and Adrenarche
- Introduction
- Stages of Pubertal Development, Secular Trends, and Racial and Ethnic Differences in the Onset and Tempo of Puberty
- Physiology of Puberty
- Neurobiology of Gonadarche
- Putative Physiological Control Systems Governing the Timing of Gonadarche
- Activation and Timing of Adrenarche
- Genetics and Puberty Genes
- Factors Modulating the Timing of Puberty
- Disorders of Puberty
- Disorders of Early Puberty
- Approach to the Child With Precocious Pubertal Development
- Delayed Puberty
- Constitutional Delay in Growth and Puberty
- Hypothalamic Hypogonadism
- Mutations in Genes Influencing Gonadotropin-Releasing Hormone Neuron Development and Migration
- Mutations in Genes Associated With Hypothalamic Hypogonadism and Neurologic Phenotypes
- Mutations in Genes Influencing Gonadotropin-Releasing Hormone Function
- Other Factors
- Other Syndromes Associated With Delayed Puberty
- Pituitary-Dependent (Pituitary Hypogonadism)
- Gonadotropin-Releasing Hormone-Receptor Gene Mutations
- Follicle-Stimulating Hormone-β Gene Mutations
- Luteinizing Hormone-β Gene Mutations
- Immunoglobulin Superfamily Member 1
- Steroid Receptor Ribonucleic Acid Activator
- Hyperprolactinemia
- Gonadal Causes of Delayed Puberty (Primary Gonadal Failure)
- Klinefelter Syndrome
- Testicular Regression Syndrome
- Autoimmune Ovarian Insufficiency
- Nonimmune Premature Ovarian Insufficiency
- Noonan Syndrome
- Galactosemia
- Down Syndrome
- Defects in Steroidogenesis or Steroid Hormone Action
- Mayer-Rokitansky-Kuster-Hauser Syndrome
- Gynecomastia
- Chemotherapy and Radiation Therapy
- Approach to the Child With Delayed Puberty
- Psychosocial Considerations for Precocious and Delayed Puberty
- Conclusion
- 19. Nutrition and Reproduction
- Introduction
- Nutrition, Body Weight, and Puberty
- How Does Fat Signal the HPO Axis?
- How Does Body Weight Modify Puberty and Adult Reproduction?
- The Effects of Simple Obesity in Boys
- Adult Obesity and Reproduction
- Obesity and Preeclampsia
- The relative hypogonadotropic hypogonadism of obesity
- Men
- Impact of Weight Loss and Bariatric Surgery on Reproductive Function
- Nutrition in the Young Oncology Patient
- Summary
- Conclusions
- 20. Environmental Factors and Reproduction
- Introduction: Reproductive Health and the Environment
- Definition
- Reproductive Health Professional Society Engagement on Environmental Health
- Key Scientific Concepts
- Human Exposure to Environmental Chemicals
- Mechanisms
- Reproductive Health Outcomes Linked to Environmental Chemical Exposures
- Evidence-Based Decision Making in Environmental Health
- Clinical Management
- Healthcare System and Public Policy Solutions
- Conclusion
- 21. Physiological and Pathophysiological Alterations of the Neuroendocrine Components of the Reproductive Axis
- Hypothalamic Dysfunction
- 22. Polycystic Ovary Syndrome and Hyperandrogenic States
- Introduction
- Diagnostic Criteria
- Epidemiology
- Clinical Description
- Fetal Origin of PCOS
- PCOS in Adolescence
- Altered Physiology
- Genetics of PCOS
- Long-Term Consequences
- Differential Diagnosis
- Evaluation
- Treatment
- 23. Female Infertility
- A Statistical Model of Infertility
- Diseases Associated with Infertility
- Initial Infertility Evaluation
- Abnormalities in Oocyte Production
- Premature Ovarian Insufficiency
- Anatomical Factors in the Female
- Immunological Factors and Recurrent Abortion
- Genetic Causes of Infertility
- Unexplained Infertility
- Environmental Exposures Associated with Infertility
- Contraindications to Infertility Treatment
- Infertility Treatment and Pregnancy Outcomes
- Donor Gametes
- Adoption
- Psychosocial Aspects of Infertility
- Social and Ethical Issues
- 24. Male Infertility
- Introduction
- Significance of Male Infertility
- Evaluation of Male Infertility
- Further Investigations and Complete Evaluation
- Conclusion
- 25. Endocrine Disturbances Affecting Reproduction
- Pituitary Disorders
- Pituitary Disorders that Affect Reproduction
- Adrenal Disorders
- Adrenal Disorders that Affect Reproduction
- Thyroid Disorders
- Thyroid Disorders that Affect Reproduction
- 26. Benign Uterine Diseases and Dysfunction
- Abnormal Uterine Bleeding
- Uterine Leiomyomata (Fibroids)
- Adenomyosis
- Endometrial Polyps
- Intrauterine Adhesions
- Pain with Menstruation (Dysmenorrhea)
- 27. Endometriosis
- Introduction
- Epidemiology
- Pathology
- Mechanism
- Clinical Aspects
- 28. Recurrent Pregnancy Loss
- Introduction
- Evaluation and Management
- Genetic Factors
- Uterine Factors
- Immunologic Factors
- Thrombophilia and Fibrinolytic Factors
- Endocrinology and Metabolic Factors
- Lifestyle Factors
- Male Factor
- Unexplained Recurrent Pregnancy Loss
- Future Pregnancy Prognosis
- Conclusion
- 29. Endocrine Diseases of Pregnancy
- Diabetes Mellitus
- Obesity and Pregnancy
- Hypothalamic-Pituitary Diseases
- Disorders of Thyroid Function
- Disorders of Calcium Metabolism
- Adrenal Diseases
- Ovarian Endocrine Tumors
- Preeclampsia
- Parturition
- 30. Hormone-Responsive Cancers
- Breast Cancer
- Endocrine Treatments
- Chemotherapy Treatment in HR-Positive Breast Cancers
- Prostate Cancer
- Clinical Therapies in Locally Advanced or Metastatic Disease
- Mechanisms of Endocrine Therapy Resistance
- Endometrial Carcinoma
- 31. Transgender Hormonal Treatment
- Introduction
- Part 3. Reproductive Technologies
- 32. Evaluation of Hormonal Status
- Introduction
- Hormone Assays
- Measurement of Specific Reproductive Protein and Peptide Hormones and Steroid Hormones
- Measurement of Antimüllerian Hormone
- Measurement of Inhibins
- Assessment of Ovarian Reserve
- Measurement of Human Chorionic Gonadotropin
- Assessment of Glucose Metabolism, Insulin Activity, and Adipose Mass
- Assessment of Glucose Metabolism and Insulin Activity
- Measurement of Adipose Hormones
- Evaluation of Fat Quantity and Distribution
- Measurement of Growth Hormone and Growth Factors
- Measurement of Calcium-Regulating Hormones and Bone Markers
- Measurement and Blood Levels of Thyroid Hormones
- Evaluation of Glucocorticoid Adrenal Function
- Evaluation of Mineralcorticoid Adrenal Function
- Evaluation of Catecholamine Secretion
- Diagnostic Procedure in Suspected Pituitary Tumors
- Pelvic Evaluation
- 33. Pelvic Imaging in Reproductive Endocrinology
- Ultrasound Examination Technique
- Palm-Coein
- Postmenopausal Bleeding
- Müllerian Anomalies
- Ovarian Assessment
- Assessment of Fallopian Tube Patency
- Evaluation of Deeply Invasive Endometriosis
- Early Pregnancy
- Conclusion
- 34. Medical Approaches to Ovarian Stimulation for Infertility
- Concepts of Ovarian Stimulation
- Classification of Anovulation
- Concepts of Follicle Development Relevant to Ovarian Stimulation
- Preparations Used for Ovarian Stimulation
- Other Selective Estrogen Receptor Modulators (SERMS)
- Aromatase Inhibitors
- Outcomes of Ovarian Stimulation
- Induction of Ovulation in Anovulatory Women
- Preparations for Treating Anovulation
- Antiestrogens
- Side effects
- Acupuncture
- Ovarian Stimulation in the Empirical Treatment of Unexplained Subfertility (See Chapter 23)
- Preparations for Empirical Ovarian Stimulation
- Alternative and Adjunctive Therapies
- Effect of Weight Loss on Women with Obesity and Unexplained Infertility
- Health Economics of Ovarian Stimulation
- Conclusions and Future Perspective
- 35. Assisted Reproduction: Clinical Practice
- Introduction
- A Brief History of Art
- Pre-IVF Evaluation
- Indications For IVF
- Overview of IVF Statistics
- Patient Counseling for IVF
- Ovarian Stimulation
- Cycle Monitoring in Fresh IVF Cycles
- Oocyte Retrieval
- Indications for In Vitro Oocyte Maturation
- Indications for ICSI
- Embryo Transfer
- Embryo Cryopreservation and FET
- Repeat IVF Cycles
- Recurrent Implantation Failure
- Third-Party Reproduction
- IVF Risks and Their Management
- Obstetric, Neonatal, and Childhood Outcomes Following IVF
- Paternal Contributions to IVF Outcomes
- Environmental Exposures and Lifestyle Factors in ART
- Concluding Remarks
- 36. Gamete and Embryo Manipulation
- Laboratory Environment
- Procedures
- Cryopreservation of Human Oocyte, Embryo, Ovarian Tissue, and Sperm
- 37. Fertility Preservation
- Introduction
- Fertility Preservation in Nononcologic and Oncologic Conditions
- Fertility Preservation Strategies
- Translational Approaches in Fertility Preservation
- Oncofertility Patient Management
- Summary and Future Outlook
- 38. Emerging Technologies: In Vitro-Derived Germ Cells and Gametogenesis
- Introduction
- Spermatogonial Stem Cell Culture
- Testicular Tissue Organ Culture
- In Vitro Maturation of Oocytes
- In Vitro Follicle Maturation: Primordial Follicles to Antral Follicles
- Emerging Technologies in in Vitro Oocyte Maturation Following in Vitro Follicle Growth
- In Vitro Production of PGCLc, Oocyte, and Sperm from Induced Pluripotent Stem Cells
- In Vitro Gonadal Somatic Cells
- Conclusion
- 39. Emerging Technologies: Genetic Interventions in the Human Germ Line: Mitochondrial Replacement and Gene Editing
- Introduction
- Mitochondrial Replacement
- Gene Editing in Human Embryos and the Germ Line
- Conclusions
- Summary
- 40. Emerging Technologies: Uterus Transplantation
- Introduction
- Indication for UTx
- Preclinical and Clinical Research
- Living Versus Deceased Donor in Uterus Transplant
- Preoperative Considerations
- Surgical Technique
- Approach to Vascular Anastomoses in UTx
- Surgical and Psychological Outcomes in Living Donors and Recipients
- Immunosuppression and Rejection
- Achieving Pregnancy in UTx
- Reproductive, Antenatal, and Fetal Outcomes Following UTx
- Ethical Considerations in UTx
- Developing Alternative Treatments for UFI
- 41. Contraception
- Introduction
- Contraceptive Effectiveness Versus Efficacy
- Intrauterine Contraception
- Contraceptive Implant
- Injectable Contraception
- Combined Oral Contraceptive Pills
- Progestin-Only Oral Contraceptive Pills
- Transdermal Contraceptive Patches
- Contraceptive Vaginal Rings
- Postcoital Contraception
- Male Hormonal Contraception
- Pericoital Contraception
- Female and Male Permanent Contraception
- Contraception and Malignancy
- Contraception for Special Populations
- Index
- No. of pages: 1040
- Language: English
- Edition: 9
- Published: March 24, 2023
- Imprint: Elsevier
- Hardback ISBN: 9780323810074
- eBook ISBN: 9780323810081
JS
Jerome F. Strauss
Affiliations and expertise
Executive Vice President for Medical Affairs, VCU Health System; Dean, School of Medicine, Virginia Commonwealth University, Richmond, VirginiaRB
Robert L. Barbieri
Affiliations and expertise
Kate Macy Ladd Professor, Department of of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School; Chief, Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, Massachusetts