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Elsevier

Wound Healing, Fibrosis, and the Myofibroblast

A Historical and Biological Perspective

  • 1st Edition - September 28, 2021
  • Latest edition
  • Authors: Giulio Gabbiani, Matteo Coen, Fabio Zampieri
  • Language: English

Wound Healing, and the Myofibroblast: A Historical and Biological Perspective is the fruit of an interdisciplinary and international collaboration involving a historian of medici… Read more

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Description

Wound Healing, and the Myofibroblast: A Historical and Biological Perspective is the fruit of an interdisciplinary and international collaboration involving a historian of medicine (Dr. Zampieri), a physician (Dr. Coen), and a researcher (Prof. Gabbiani, world-renowned for his discovery of the myofibroblast). This book aims to draw a concise yet complete description of the conceptual evolution of wound healing, fibrosis and fibrosis-related pathologies from antiquity to present time, as well as commenting on the role of the myofibroblast and the key cell type essential for tissue repair and fibrosis (from its identification in 1971 throughout its 50-years-old history).

By viewing this complex and century-long history from different perspectives, the book's authors aim to draw an exhaustive overview, with the hope of inspiring new and fruitful basic and clinical research.

Key features

  • Interdisciplinary collaboration: complementary views from medical historian, a physician and a researcher
  • A concise but detailed history of fibrosis, readers can discover the major scientific breakthroughs along this history
  • Includes the pathophysiology of various fibrotic diseases
  • Explores the role of myofibroblast in fibrosis development

Readership

Researchers (in the field of tissue repair/fibrosis/cancer), physicians (cardiologists, pathologists, oncologists, gastroenterologists, internal medicine specialists, nephrologists, pneumologists). Historian of medicine

Table of contents

1. Introduction

2. Fibrous Tissue, Fibrosis and the Fibroblast

3. Wound healing and Wound Contraction

4. Fibrotic Diseases

4.1 Hypertrophic Scars and Keloids

4.2 Fibromatoses and Dupuytren Disease

4.3 Scleroderma

4.4 Myocardial Fibrosis

4.5 Kidney Fibrosis

4.6 Pulmonary Fibrosis

4.7 Liver Fibrosis and Cirrhosis

4.8 Stroma Reaction to Epithelial Tumors

5. The Myofibroblast: Role in Fibrosis Development

5.1 Discovery

5.2 Origin

5.3 Biological features

5.4 Heterogeneity

5.5 Factors influencing myofibroblast biology

6. Conclusions and Perspectives

7. Bibliography

Product details

  • Edition: 1
  • Latest edition
  • Published: September 30, 2021
  • Language: English

About the authors

GG

Giulio Gabbiani

Giulio Gabbiani has obtained an MD degree at the University of Pavia (Italy) and a PhD degree at the University of Montreal (Canada). He has been Research Associate at the Department of Pathology of Harvard Medical School, Professor at the Department of Pathology and Immunology of the University of Geneva (Switzerland), where he is now Emeritus Professor. He has been Secretary and President of the European Cytoskeleton Forum, Secretary and Chairman of the European Vascular Biology Association, Secretary of the European Tissue Repair Society. He has received several distinctions including a degree of Doctor Honoris Causa from the University of Gothenburg (Sweden) and from the University of Limoges (France). Giulio Gabbiani’s interests span from the biology of the myofibroblast (which he discovered in 1971), to mechanisms of fibrosis development and to the biology of arterial smooth muscle cell including its involvement in atherosclerosis.
Affiliations and expertise
Emeritus Professor, Pathology, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland

MC

Matteo Coen

Matteo Coen MD, MD-PhD has obtained a doctorate in medicine (MD), followed by a specialization in vascular surgery at the University of Ferrara (Italy) and a doctorate in medical sciences (“MD-PhD”) at the Faculty of Medicine of Geneva. He has then joined the Service of General Internal Medicine of the University Hospitals of Geneva, where he is actually chief resident, and has attained a specialization in internal medicine. Matteo Coen has also a keen interest in medical education. Alongside his clinical work and research activities in internal medicine, he is a member of the Unit of Development and Research in Medical Education (UDREM) of the University of Geneva, where he participates in various teaching and research projects.
Affiliations and expertise
Division of General Internal Medicine, Department of Medicine, Geneva University Hospitals, and Unit of Development and Research in Medical Education, Faculty of Medicine, University of Geneva, Geneva, Switzerland

FZ

Fabio Zampieri

Fabio Zampieri has a PhD in Philosophy of Science from the University of Padova (Italy), and PhD in History of Medicine from the University of Geneva (Switzerland). He is is actually professor of History of Medicine at the University of Padova. He teaches human sciences, history of medicine, and bioethics to medicine students. His fields of research ranges from the history of prehistoric medicine to contemporary biomedical sciences. He is particularly interested in the history of cardiology and pathology, as well as in the impact of Darwian concepts on medical sciences. He is a renowned expert on the figure of Giovanni Battista Morgagni and of Evolutionary Medicine.
Affiliations and expertise
Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, Padova, Italy

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