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Williams Textbook of Endocrinology
- 14th Edition - November 14, 2019
- Authors: Shlomo Melmed, Ronald Koenig, Clifford J. Rosen, Richard J. Auchus, Allison B. Goldfine
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 5 5 5 9 6 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 1 1 5 5 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 1 1 5 4 - 8
Expertly bridging the gap between basic science and clinical information, Williams Textbook of Endocrinology, 14th Edition, brings together an outstanding collection of wo… Read more
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Request a sales quoteExpertly bridging the gap between basic science and clinical information, Williams Textbook of Endocrinology, 14th Edition, brings together an outstanding collection of world-renowned authors to provide authoritative discussions of the full spectrum of adult and pediatric endocrine system disorders. New chapters and significant revisions throughout keep you up to date with recent advances in medications, therapies, clinical trials, and more. This essential reference is a must-have resource for endocrinologists, endocrine surgeons, gynecologists, internists, pediatricians, and other clinicians who need current, comprehensive coverage of this multifaceted field.
- Up to date with recent advances in medications, therapies, and clinical trials.
- Provides state-of-the-art coverage of diabetes, metabolic syndrome, metabolic bones disorders, obesity, thyroid disease, testicular disorders, newly defined adrenal disorders and much more - all designed to help you provide optimal care to every patient.
- Contains new chapters on Global Burden of Endocrine Disease, Navigation of Endocrine Guidelines, and Transgender Endocrinology.
- Includes significant updates to the Diabetes section, including a new chapter on Physiology of Insulin Secretion and greater coverage of Type 2 Diabetes.
- Presents current information in a highly illustrated, user-friendly format for quick reference.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Endocrinologists and Internists (adult and pediatric), endocrinology fellows
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Section I. Hormones and Hormone Action
- 1. Principles of Endocrinology
- The Evolutionary Perspective
- Endocrine Glands
- Transport of Hormones in Blood
- Target Cells as Active Participants
- Control of Hormone Secretion
- Hormone Measurement
- Endocrine Diseases
- Diagnostic and Therapeutic Uses of Hormones
- Future Perspectives
- 2. Principles of Hormone Action
- Introduction to Hormone Signaling
- Ligands That Act Through Cell Surface Receptors
- Binding Properties of Cell Surface Receptors
- Cell Surface Hormone Receptors
- Coupling of Cell Surface Receptors to Intracellular Signaling
- Disease Caused by Defective Cell Surface Receptors
- Ligands That Act Through Nuclear Receptors
- Nuclear Receptor Signaling Mechanisms
- Receptor Regulation of Gene Transcription
- Nongenomic Actions of Nuclear Receptor Ligands
- 3. Genetics of Endocrinology
- The Role of Genetics in Endocrinology
- Principles of Genetics
- Genetics of Endocrine Diseases
- Considerations for Clinical Use of Genetic Information and Sequencing in Endocrinology
- 4. Laboratory Techniques for Recognition of Endocrine Disorders
- Laboratory Methods
- Analytic Validation
- Quality Control
- Quality Assurance
- Classes of Assays
- Conclusion
- 5. The Global Burden of Endocrine Diseases
- Introduction
- Obesity and Excess Weight
- The Burden of Diabetes
- The Burden of Thyroid Diseases
- Perspectives for the Next Decade
- 6. Navigating Through Clinical Practice Guidelines in Endocrinology
- Introduction
- Development of Trustworthy Clinical Practice Guidelines
- Clinical Practice Guidelines Recommendations
- Clinical Practice Guidelines in Endocrinology
- Using Clinical Practice Guidelines in Patient Care
- Case Study: Management of Gestational Diabetes Using Clinical Practice Guidelines in Patient Care
- Shortcomings of Clinical Practice Guidelines
- Guidelines as Tools That Support (Not Dictate) Care
- Disease-Specific and Context-Blind Guidelines
- Guideline Focus on Surrogate Outcomes (Not Patient-Important Outcomes)
- Quality and Trustworthiness of Clinical Practice Guidelines
- Conclusions
- Section II. Hypothalamus and Pituitary
- 7. Neuroendocrinology
- Historic Perspective
- Neural Control of Endocrine Secretion
- Hypothalamic-Pituitary Unit
- Circumventricular Organs
- Pineal Gland
- Hypophysiotropic Hormones and Neuroendocrine Axes
- Thermoregulation and Sleep-Wake Cycle
- Neuroendocrine Disease
- 8. Pituitary Physiology and Diagnostic Evaluation
- Anatomy, Development, and Overview of Control of Hormone Secretion
- Physiology and Disorders of Pituitary Hormone Axes
- Developmental, Genetic, and Acquired Causes of Pituitary Failure
- 9. Pituitary Masses and Tumors
- Pituitary Masses
- Parasellar Masses
- Classification of Pituitary Tumors
- Prolactin-Secreting Adenomas
- Nonfunctioning Pituitary Tumors
- Acromegaly
- ACTH-Secreting Tumors (Cushing Disease)
- Thyrotrophic Hormone-Secreting Tumors
- 10. Posterior Pituitary
- Anatomy
- Synthesis and Release of Neurohypophyseal Hormones
- Physiology of Secretion of Vasopressin and Thirst
- Diabetes Insipidus
- The Syndrome of Inappropriate Antidiuresis
- Oxytocin
- Section III. Thyroid
- 11. Thyroid Pathophysiology and Diagnostic Evaluation
- Phylogeny, Embryology, and Ontogeny
- Anatomy and Histology
- Iodine and the Synthesis and Secretion of Thyroid Hormones
- Thyroid Hormones in Peripheral Tissues
- Regulation of Thyroid Function
- Physical Evaluation of the Thyroid Gland
- Laboratory Assessment of Thyroid Status
- Quantitation of Serum Thyroid Hormone Concentrations
- 12. Hyperthyroid Disorders
- Clinical Manifestations of Thyrotoxicosis
- Laboratory Diagnosis
- Graves Disease
- Graves Hyperthyroidism
- Graves Orbitopathy
- Graves Dermopathy
- Pregnancy and the Thyroid
- Inherited Nonimmune Hyperthyroidism
- Toxic Multinodular Goiter
- Toxic Adenoma
- Subclinical Hyperthyroidism
- Iodide-Induced Hyperthyroidism
- Amiodarone-Induced Thyrotoxicosis
- Hyperthyroidism Due to Thyrotropin Secretion
- Tumor Chorionic Gonadotropin-Induced Hyperthyroidism
- Transient Thyrotoxicosis
- Other Causes of Thyrotoxicosis With a Low Radioiodine Uptake
- 13. Hypothyroidism and Thyroiditis
- Hypothyroidism
- Thyroiditis
- 14. Nontoxic Diffuse Goiter, Nodular Thyroid Disorders, and Thyroid Malignancies
- Structural and Functional Imaging of the Thyroid
- Nontoxic Goiter and Thyroid Nodular Disease
- Management Options for Patients With Nontoxic Diffuse Goiter and Nodular Thyroid Disease
- Malignant Thyroid Disorders
- The Surgical Treatment of Thyroid Malignancy
- Postoperative Management of Thyroid Malignancy
- Long-Term Follow-Up of Patients With Thyroid Cancer Following Initial Therapy
- Section IV. Adrenal Cortex and Endocrine Hypertension
- 15. The Adrenal Cortex
- The Adrenal Cortex—Historical Milestones
- Anatomy and Development
- Adrenal Steroids and Steroidogenesis
- Corticosteroid Hormone Action
- Classification and Pathophysiology of Cushing Syndrome
- Glucocorticoid Deficiency
- Congenital Adrenal Hyperplasia
- Adrenal Adenomas, Incidentalomas, and Carcinomas
- 16. Endocrine Hypertension
- Adrenal Medulla and Catecholamines
- Pheochromocytoma and Paraganglioma
- Renin-Angiotensin-Aldosterone System
- Primary Aldosteronism
- Other Forms of Mineralocorticoid Excess or Effect
- Other Endocrine Disorders Associated With Hypertension
- Section V. Sexual Development and Function
- Chapter 17. Physiology and Pathology of the Female Reproductive Axis
- Reproductive Physiology
- Reproductive Functions of the Hypothalamus
- Reproductive Functions of the Anterior Pituitary
- Ovary
- Endometrium
- Approach to the Woman With Reproductive Dysfunction
- Disorders of the Female Reproductive System
- Diagnosis and Management of Anovulatory Uterine Bleeding
- Hormone-Dependent Benign Gynecologic Disorders
- Management of Menopause
- Postmenopausal Hormone Therapy
- 18. Hormonal Contraception
- Choosing a Contraceptive Method
- Combined Estrogen and Progestin Contraceptives
- Progestin-Only Contraceptive Methods
- Emergency Contraception
- Clinical Challenges in Contraceptive Care
- 19. Testicular Disorders
- Functional Anatomy and Histology
- Testis Development
- Adult Physiology
- Male Hypogonadism
- 20. Sexual Dysfunction in Men and Women
- Human Sexual Response Cycle
- Physiologic Mechanisms of Human Sexual Response
- Role of Testosterone in Regulating Sexual Function in Men
- Physiology of Physical Sexual Arousal in Women: Genital Congestion
- Physiology of Orgasm
- Revised Definitions of Sexual Dysfunction in Men
- Current Definitions of Sexual Disorders in Women
- Sexual Dysfunction in the Context of Endocrine Disease
- Assessment of Sexual Dysfunction
- Management of Sexual Dysfunction in Men
- Management of Sexual Dysfunction in Women
- 21. Transgender Endocrinology
- Introduction
- Care of Transgender Youth
- Care of Transgender Adults
- Barriers to Care and Priorities for Research for Transgender Youth and Adults
- Endocrinology and the Life Span
- Section VIA. Maternal-Fetal
- 22. Endocrine Changes in Pregnancy
- Placental Development
- Maternal Adaptations to Pregnancy
- Maternal Endocrine Alterations
- Placental Hormone Production
- Endocrinology of Pregnancy and Parturition
- Summary
- 23. Endocrinology of Fetal Development
- Placental Transfer of Hormones
- Ectopic Fetal Hormone Production
- Fetal Endocrine Systems
- Fetal Growth
- Neutralization of Hormone Actions in the Fetus
- Programming of Fetal Endocrine Systems
- Transition to Extrauterine Life
- Maternal and Fetal Medicine
- Section VIB. Childhood
- 24. Disorders of Sex Development
- Development of the Reproductive Systems
- Disorders (Differences) of Sex Development
- Investigation and Management of Disorders of Sex Development
- 25. Normal and Aberrant Growth in Children
- Normal Growth
- Endocrine Regulation of Growth
- Pathologic Basis of Growth Retardation
- Pathologic Basis of Excess Growth
- Evaluation and Treatment of Growth Abnormalities
- 26. Physiology and Disorders of Puberty
- Puberty and Evolution
- Fetal Origins of Adult Disease
- Determinants of the Age of Puberty and Menarche
- Secondary Sexual Characteristics and Physical Changes of Puberty
- Central Nervous System Anatomy, Function, Psychology, and Electroencephalographic Rhythm in Puberty
- Hormonal and Metabolic Changes in Puberty
- Central Nervous System and Puberty
- Adrenal Androgens and Adrenarche
- Disorders of Puberty
- Section VIC. Adult
- 27. Hormones and Athletic Performance
- Effect of Athletic Performance on Hormonal Systems
- Performance-Enhancing (Ab)use of Hormones
- 28. Endocrinology and Aging
- Aging and Physical Frailty
- The Endocrinology of Aging
- Menopause
- Andropause Versus Late-Onset Hypogonadism
- Adrenopause
- Somatopause
- The Concept of Successful Aging
- Section VII. Mineral Metabolism
- 29. Hormones and Disorders of Mineral Metabolism
- Basic Biology of Mineral Metabolism: Roles of the Mineral Ions
- Parathyroid Hormone
- Calcitonin
- Vitamin D
- Fibroblast Growth Factor-23
- Calcium and Phosphate Homeostasis
- Laboratory Assessment of Mineral Metabolism
- Hypercalcemic Disorders
- Hypocalcemic Disorders
- Disorders of Phosphate Metabolism
- Disorders of Magnesium Metabolism
- 30. Osteoporosis: Basic and Clinical Aspects
- Historical Context
- Skeletal Biology
- Bone Remodeling and Its Regulation
- Epidemiology of Osteoporosis and Fractures
- Pathogenesis of Osteoporosis
- Approach to Management of Osteoporosis
- 31. Rickets and Osteomalacia
- Introduction
- Historical Perspective
- Epidemiology and Demographics
- Bone Remodeling and Mineralization
- Pathogenesis of Rickets and Osteomalacia
- Clinical Manifestations of Classical Rickets and Osteomalacia
- Treatment of Nutritional Rickets and Osteomalacia
- Rickets Due to Genetic Disorders of Vitamin D Metabolism
- Tumor-Induced Osteomalacia
- Drug-Induced Osteomalacia
- Conditions That Resemble Rickets and Osteomalacia
- Concluding Remarks
- 32. Kidney Stones
- Epidemiology of Stone Formation
- Pathogenesis of Stone Formation
- Clinical Presentation and Evaluation
- Therapy
- Section VIII. Disorders of Carbohydrate and Fat Metabolism
- 33. Physiology of Insulin Secretion
- Introduction
- Neural Regulation of Beta-Cell Function
- Beta-Cell Mass
- Beta-Cell Insulin Content
- Insulin Secretion Versus Plasma Insulin
- Characteristics of Insulin Secretion In Vivo
- Modes of Beta-Cell Response
- Insulin Secretion in the Fasting State
- Insulin Secretory Response to Intravenous Glucose
- Slow Beta-Cell Response Modes and Adaptation Mechanisms
- Insulin Secretory Response to Oral Stimuli
- Insulin Secretion and Insulin Sensitivity
- Genetic Influences on Insulin Secretion
- Insulin Secretion, Insulin Action, and Glucose Homeostasis
- 34. Pathophysiology of Type 2 Diabetes Mellitus
- Epidemiology
- Pathogenesis
- Insulin Signaling
- Insulin Resistance and the Risk of Type 2 Diabetes Mellitus
- Special Conditions That Induce Insulin Resistance
- 35. Therapeutics of Type 2 Diabetes Mellitus
- Epidemiology
- Glucose-Lowering Pharmacotherapy
- Practical Aspects of Treatment
- Considerations in Personalizing Therapy
- Special Situations in Clinical Management
- Preventing Type 2 Diabetes Mellitus
- Future Directions
- 36. Type 1 Diabetes Mellitus
- Diagnosis
- Animal Models
- Histopathology
- Natural History of T1DM—Historical Concepts
- Genetics
- Environmental Factors
- Natural History of T1DM—Emerging Concepts
- Immunotherapy for the Prevention and Reversal of T1DM
- Pancreas and Islet Cell Transplantation
- Disorders Associated With Immunity to Insulin/Insulin Receptor
- Clinical Presentation
- Treatment
- Acute Diabetic Emergencies
- 37. Complications of Diabetes Mellitus
- Biochemistry and Molecular Cell Biology
- Diabetic Retinopathy and Other Ocular Complications of Diabetes
- Diabetic Nephropathy
- Diabetic Neuropathies
- Diabetic Heart Disease
- The Diabetic Foot
- 38. Hypoglycemia
- Physiology of Defense Against Hypoglycemia
- Clinical Hypoglycemia
- Hypoglycemia in Persons With Diabetes
- Hypoglycemia in Persons Without Diabetes
- Hypoglycemia in Infancy and Childhood
- Disclosures
- 39. Neuroendocrine Control of Energy Stores
- The Biologic Control of Energy Balance
- The Hypothalamic Melanocortin System
- Central Nervous System Control of Thermogenesis
- Control of Glucose Homeostasis by the Brain
- Intersection of Energy Balance and Reward Circuits
- Brainstem Circuits That Regulate Energy Balance
- 40. Obesity
- Definition of Obesity
- Physiology of Energy Balance
- Energy Expenditure
- Pathogenesis of Obesity: Genes and Environment
- Adipose Tissue as an Endocrine and Immune Organ
- Metabolically Normal Obesity
- Adverse Consequences of Obesity
- Summary
- 41. Disorders of Lipid Metabolism
- Lipid Biochemistry and Metabolism
- Integrative Physiology of Lipid Metabolism
- Overview of Hyperlipidemia, Dyslipidemia, and Atherogenesis
- Hypertriglyceridemia
- Hypercholesterolemia Without Hypertriglyceridemia
- Elevated Triglycerides and Cholesterol
- Hypocholesterolemia
- Treatment of Lipid Disorders
- Section IX. Polyendocrine and Neoplastic Disorders
- 42. Multiple Endocrine Neoplasia
- Introduction to Multiple Endocrine Neoplasia Syndromes
- MEN Type 1
- MEN Types 2 and 3
- MEN Type 4
- Future Directions and Concluding Remarks
- Acknowledgments
- 43. The Immunoendocrinopathy Syndromes
- Autoimmunity Primer
- Natural History of Autoimmune Disorders
- Autoimmune Polyendocrine Syndrome Type I
- Autoimmune Polyendocrine Syndrome Type II
- Other Polyendocrine Deficiency Autoimmune Syndromes
- Conclusion
- 44. Endocrinology of HIV/AIDS
- Adrenal Function
- Gonadal Function
- Thyroid Function
- Fluid Balance and Electrolytes
- Calcium Homeostasis and Bone Changes
- The GH/IGF1 Axis
- Glucose Homeostasis and Pancreatic Function
- Metabolic and Body Composition Changes in HIV-Infected Patients
- CVD in HIV-Infected Patients
- 45. Neuroendocrine Tumors and Related Disorders
- Phylogenesis and Embryology
- Molecular Genetics
- Classification
- Biochemistry
- Clinical Presentation
- Diagnosis
- Treatment
- Prognosis
- Other Flushing Disorders
- 46. Managing Reproductive Disorders in Cancer
- What Is Oncofertility, and Why Is It Important?
- Logistics of Fertility Preservation
- Challenges of Fertility Preservation
- Summary and Next Steps
- Index
- No. of pages: 1792
- Language: English
- Edition: 14
- Published: November 14, 2019
- Imprint: Elsevier
- Hardback ISBN: 9780323555968
- eBook ISBN: 9780323711555
- eBook ISBN: 9780323711548
SM
Shlomo Melmed
Shlomo Melmed, MB, ChB, FRCP, MACP, is Executive VP and Dean of the Medical Faculty at Cedars-Sinai Medical Center. He leads Cedars-Sinai’s research and education programs, recruiting nationally recognized faculty leadership, establishing new educational programs and maintaining the highest academic standards. Dr. Melmed holds the Helene A. and Philip E. Hixon Distinguished Chair in Investigative Medicine. An international authority on pituitary medicine, he has pioneered the discovery and application of novel treatments for endocrine tumors and has authored more than 350 peer-reviewed articles.
Dr. Melmed has been a faculty leader at Cedars-Sinai for nearly 40 years and has been the health system’s chief academic officer since 1998. Dr. Melmed's laboratory consistently has received competitive grant awards from the National Institutes of Health since 1980, and he has trained over 80 physicians, scientists and graduate students who occupy leading positions in academic endocrinology worldwide. He is on the editorial board of the Journal of Clinical Investigation and is also an Associate Dean of the UCLA School of Medicine.
Affiliations and expertise
Professor of Medicine, Dean of the Medical Faculty, Cedars Sinai Health System, USACR
Clifford J. Rosen
Affiliations and expertise
Professor of Medicine, Tufts University School of Medicine, Boston, MassachusettsRA
Richard J. Auchus
Affiliations and expertise
Professor, Departments of Pharmacology and Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Endocrinology Service Chief, Ann Arbor VA Healthcare System, Ann Arbor, MichiganAG
Allison B. Goldfine
Affiliations and expertise
Associate Physician, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital; Lecturer, Part-Time, Harvard Medical School, Boston, Massachusetts, Director, Translational Medicine Cardiometabolic Disease, Novartis Institute of Biomedical Research, Cambridge, Massachusetts