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Water and Hydration in Health and Disease Prevention

  • 1st Edition - June 1, 2027
  • Latest edition
  • Editors: Rajkumar Rajendram, Vinood B. Patel, Victor R. Preedy
  • Language: English

Water is one of the most fundamental needs sustaining human life. In the human body, hydration allows for the balance of electrolytes and the functioning of the kidneys,… Read more

Description

Water is one of the most fundamental needs sustaining human life. In the human body, hydration allows for the balance of electrolytes and the functioning of the kidneys, cardiovascular system, the brain, and more. For athletes, water and hydration are crucial in maximizing performance and preventing dehydration. At the same time, not all water is fit for purpose. Consideration must be given to water contaminated with heavy metals or organic chemicals in some communities. Water and Hydration in Health and Disease Prevention compiles the latest research on water in human health and connects otherwise scattered information into one comprehensive resource. Just as water is involved in nearly every aspect of life on earth, its study is vast and interdisciplinary, spanning fields such as environmental sciences, physiology, molecular biology, endocrinology, clinical sciences and other disciplines. Water and Hydration in Health and Disease Prevention will serve as an invaluable resource to researchers, clinicians, and students across all these fields.

Key features

  • Complies interdisciplinary knowledge of water supply, use, nutrition, physiology, and environmental factors
  • Identifies therapeutic benefits of water as a nutraceutical or performance enhancer
  • Covers the most important aspects of water in health and disease

Readership

Researchers, graduate, and post-graduate students interested in beverage science, sports medicine, and nutrition

Table of contents

Section I. Introductory chapters and setting the scene

1. Guidelines for water intake

2. Hydration and metabolic health: a new narrative

3. An overview of the regulation of water balance in the body

Section II. Physiological variables

4. Psychobiology of thirst: an updated narrative

5. The vasopressin system and regulation of water balance

6. Sodium and water balance

7. Preventing dehydration: Aldosterone and regulation of water balance

8. Preventing dehydration: Renin-Angiotensin system and water regulation

9. Overconsumption of hypotonic fluids: Preventing hyponatremia due to exercise

10. Prevention of delayed symptomatic hyponatremia in surgery

Section III. Cellular and molecular variables

11. Vasopressin system and thirst

12. Osmoreceptors and the control of water balance

13. Cellular and molecular processes: Osmolytes

14. Cellular and molecular processes: Baroreceptors

15. Cellular and molecular processes: Aquaporin

Section IV. Regulation of water intake

16. Regulation of water intake by cannabinoids: CB1 receptors and the insular cortex

17. Brain and control of water intake: linking the paraventricular hypothalamic nucleus

18. Vasopressin and regulation of fluid balance in pregnancy

Section V. Thirst, dehydration, and reduced water intake

19. Definitions: dehydration and underhydration in acute and chronic scenarios

20. The inhibitory mechanisms that control thirst and satiety

21. Thirst in heart failure

22. Deliberate dehydration in sports

23. Dehydration in cholera

Section VI. Water as a nutritional vehicle, sports and energy drinks

24. Hydrogen-rich water intake and effects on human biology

25. Energy drinks consumed by adolescents

26. Popular and new isotonic sports drinks

27. Energy drinks consumed with alcohol

28. Isomaltulose in sports drinks

29. Energy drinks and effects on brachial artery: measures of endothelial functions

30. Hydration with sugar-sweetened beverages

Section VII. Mineral Water

31. Contaminants in mineral water

32. Profiles of bottled mineral waters

33. Mineral waters and modulation of intestinal inflammation

34. Bicarbonate-rich mineral water

35. Iron-rich mineral water as an adverse scenario

Section VIII. Tap and drinking water

36. Global warming and impact on water supplies

37. Phthalates in drinking water

38. Lead-in drinking water

39. Adverse scenarios of tap water linked with reduced cognition

40. Fluoride in drinking water and health consequences

Section IX. Drinking water and intake in different scenarios

41. Improving water intake in sports (football)

42. Menopause and water intake wrinkles and beyond

43. Water intake and menstrual distress

44. Water intake and water insecurity

45. Drinking water and intake in pregnancy: health and disease prevention (arsenic)

46. Hypovolemia in the elderly

Section X. Clinical Scenarios
i. Hyponatremic conditions

47. Water loading and acute hyponatremia

48. Hyponatremia and Psychogenic Polydipsia

ii. Hypovolemic conditions

49. Hypovolemic shock in trauma

50. Prediction and diagnosis of hypovolemic

iii. Diuretics

51. Diuretics and hyponatremia

52. Diuretics use in critically ill patients

iv. Water intake

53. Water intake and effects on copeptin in diabetes

54. Water, hydration and cognition

55. Linking water intake and BMI

v. Conditions and disease

56. Fluid balance in diabetes insipidus

57. Polydipsia

58. Fluid balance in chronic kidney disease

59. Fluid balance in polycystic kidney disease

60. Fluid balance in cardiovascular diseases

61. Water, hydration and cognition

Section XI. Risks and effects of contaminations

62. Perfluoroalkyl substances (PFASs) in water and risks of consumption

63. Drinking water and environmental risk: radioactivity

64. Nitrates in drinking water and FOXE1 polymorphisms

65. Risks and effects of contaminations: hormones

66. Risks and effects of contaminations: pharmaceuticals

67. Risks and effects of contaminations: heavy metals

Section XII. Resources

68. Resources in Water and Hydration in Health and Disease Prevention

Product details

  • Edition: 1
  • Latest edition
  • Published: June 1, 2027
  • Language: English

About the editors

Rajkumar Rajendram

Editor

Dr Rajkumar Rajendram is a clinician-scientist with expertise in internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St Thomas’ Medical School, King’s College London, in 2001, where he received several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram completed specialist training in acute and general medicine in Oxford and subsequently held a Consultant appointment in Acute General Medicine at the John Radcliffe Hospital, Oxford. He also trained in anaesthesia and intensive care in London, including advanced training in regional anaesthesia and intensive care, and subsequently held a Consultant appointment in Intensive Care, Anaesthesia and Peri-operative Medicine at the Royal Free London Hospitals.

His postgraduate training has spanned internal medicine, anaesthesia, intensive care and point-of-care ultrasound (POCUS). He was awarded Fellowship of the Royal College of Anaesthetists in 2009, Fellowship of the Faculty of Intensive Care Medicine in 2013, and the European Diploma in Intensive Care Medicine in 2014. He is a Fellow of both the Royal College of Physicians of Edinburgh and the Royal College of Physicians of London.

Dr Rajendram is currently a Consultant at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, and holds a joint appointment as Associate Professor in the Research Unit, Department of Medical Education, at King Saud bin Abdulaziz University for Health Sciences.

His multidisciplinary clinical background has informed his research interests in nutrition, fluid management and fluid balance in health and disease, particularly in acutely and critically ill patients. His research has also addressed POCUS, COVID-19 phenotypes and nutritional support in illness. Dr Rajendram has contributed extensively to medical research and education and has authored more than 400 textbook chapters, review articles, peer-reviewed papers and conference abstracts.

Affiliations and expertise
Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia & Joint Appointment Associate Professor, Research Unit, Department of Medical Education, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

Vinood B. Patel

Editor

Vinood B. Patel, BSc, PhD, FRSC, is Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to health and well being These books include Ancient and traditional foods, plants and herbs and spices in human health; coffee in health and disease prevention, Nuts and seeds in health and disease prevention Handbook of Substance Misuse and Addictions: From Biology to Public Health, tea in health and disease prevention.

Affiliations and expertise
Professor, Clinical Biochemistry, School of Life Sciences University of Westminster, London, UK

Victor R. Preedy

Editor

Victor R. Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, FRSM, is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He also holds an Honorary Professorship at the University of Suffolk and served as the long‑term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy graduated with an Honours Degree in Biology and Physiology with Pharmacology and later obtained his PhD from the University of London. He subsequently received Membership of the Royal College of Pathologists and later earned his second doctorate (DSc) in recognition of his contributions to protein metabolism. He is a Fellow of the Royal Society of Medicine, the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, and the Royal Society of Chemistry. Professor Preedy has conducted research while affiliated with Imperial College London, the School of Pharmacy (now part of University College London), and the MRC Centre at Northwick Park Hospital. He has collaborated widely with international research groups in Finland, Japan, Australia, the USA, and Germany. His longstanding academic interests include health and well‑being. He has published more than 750 works, including peer‑reviewed research articles, abstracts, symposium presentations, reviews, and edited books.

Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK; Visiting Professor, University of Hull, UK