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Volpe's Neurology of the Newborn
- 7th Edition - January 8, 2024
- Editors: Joseph J. Volpe, Terrie E. Inder
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 0 5 1 3 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 0 5 4 5 - 6
**Selected for Doody’s Core Titles® 2024 in Neurology**Stay up to date with today’s latest advances in diagnosis and management, as well as the many scientific and technological… Read more
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Stay up to date with today’s latest advances in diagnosis and management, as well as the many scientific and technological advances that are revolutionizing neonatal neurology, with the definitive text in the field. Volpe's Neurology of the Newborn, 7th Edition, shares the knowledge and expertise of world authority Dr. Joseph Volpe, who, along with Dr. Terrie E. Inder of Children’s Hospital of Orange County and other distinguished editors, brings a wealth of insight to this classic text. Known for its clear, engaging writing style, vibrant, full-color illustrations, and authoritative information throughout, this reference is an indispensable resource for those who provide care for neonates with neurological conditions.
Stay up to date with today’s latest advances in diagnosis and management, as well as the many scientific and technological advances that are revolutionizing neonatal neurology, with the definitive text in the field. Volpe's Neurology of the Newborn, 7th Edition, shares the knowledge and expertise of world authority Dr. Joseph Volpe, who, along with Dr. Terrie E. Inder of Children’s Hospital of Orange County and other distinguished editors, brings a wealth of insight to this classic text. Known for its clear, engaging writing style, vibrant, full-color illustrations, and authoritative information throughout, this reference is an indispensable resource for those who provide care for neonates with neurological conditions.
- Provides clear, comprehensive coverage of neonatal neurology in Dr. Joseph Volpe’s own legendary, readable manner—for a masterful, cohesive source of answers to any question that arises in your practice.
- Brings the latest science into the clinical setting, with an emphasis on translating new knowledge to the infant’s bedside.
- Offers comprehensive updates with summary tables and text to reflect major advances in the study of hemorrhage; new insights into molecular genetics and molecular characterization of brain tumors; significant advances in drugs and the developing nervous system; and much more.
- Includes new chapters on fetal neurology which address the importance of understanding and investigating the maternal-fetal origins of neonatal disease, as well as new chapters on neurodevelopmental follow-up, inflammation, and neurology in low-resource settings.
- Contains more than 1,000 illustrations: clinical and pathological specimens, key experimental findings, schematics, algorithms, anatomical drawings, and neuroimaging throughout, as well as numerous tables and boxes that synthesize key points.
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Neonatologists, Pediatric Neurologists, Neonatal/pediatric nurse practitioners
- Cover image
- Title page
- Table of Contents
- Any screen, Any time, Anywhere
- Copyright
- Dedication
- Contributors
- Preface
- Video Contents
- Chapter 12
- Chapter 37
- Unit I: Human Brain Development
- Chapter 1. Neural Tube Development
- Abstract
- Introduction
- NORMAL DEVELOPMENT OF THE FUNDAMENTAL CENTRAL NEURO-AXIS
- DISORDERS OF CRANIOSPINAL DEVELOPMENT
- KEY REFERENCES
- References
- Chapter 2. Prosencephalic Development
- Abstract
- Normal Prosencephalic Development
- Disorders of Prosencephalic Development
- KEY REFERENCES
- REFERENCES
- Chapter 3. Ventricular Development, Ventriculomegaly, and Hydrocephalus in the Fetus and Newborn
- Abstract
- Introduction
- Fetal Ventriculomegaly
- Fetal Ventriculomegaly and Hydrocephalus
- Management of Fetal Ventriculomegaly and Congenital Hydrocephalus
- Prognosis of Fetal Ventriculomegaly and Congenital Hydrocephalus
- KEY REFERENCES
- REFERENCES
- Chapter 4. Normal and Abnormal Development of the Posterior Fossa Structures
- Abstract
- NORMAL DEVELOPMENT OF THE BRAINSTEM AND CEREBELLUM
- ABNORMAL DEVELOPMENT OF THE POSTERIOR FOSSA STRUCTURES
- KEY REFERENCES
- REFERENCES
- Chapter 5. Neuronal Proliferation
- Abstract
- NEURONAL PROLIFERATION
- Key References
- References
- Chapter 6. Neuronal Migration
- Abstract
- MIGRATION
- KEY REFERENCES
- REFERENCES
- Chapter 7. Organizational Events
- Abstract
- NORMAL DEVELOPMENT
- DISORDERS OF ORGANIZATIONAL EVENTS
- DISORDERS OF MULTIPLE ORGANIZATIONAL EVENTS DELINEATED IN VIVO RELATED TO PREMATURITY-ASSOCIATED FACTORS
- Conclusions
- KEY REFERENCES
- References
- Chapter 8. Myelination Events
- Abstract
- NORMAL DEVELOPMENT
- DISORDERS
- KEY REFERENCES
- REFERENCES
- Unit II: Fetal Neurology
- Chapter 9. Specialized Diagnostic Studies for Assessment of the Fetal Central Nervous System
- Abstract
- INTRODUCTION
- IMAGING THE FETAL BRAIN
- GENETIC EVALUATION OF FETAL BRAIN ANOMALIES
- Conclusions
- KEY REFERENCES
- REFERENCES
- Chapter 10. Placental Conditions With Consequences for the Fetal Brain
- Abstract
- DEVELOPMENT OF NORMAL PLACENTAL STRUCTURE AND FUNCTION
- ABNORMAL PLACENTAL DEVELOPMENT
- KEY REFERENCES
- REFERENCES
- Chapter 11. Maternal and Fetal Conditions With Consequences for the Fetal Brain
- Abstract
- ENDOCRINE DISORDERS IN PREGNANCY AND THE DEVELOPING FETAL BRAIN
- MATERNAL MENTAL HEALTH DISORDERS OF PREGNANCY, FETAL BRAIN DEVELOPMENT, AND LONG-TERM NEUROPSYCHOLOGIC OUTCOME
- FETAL CONDITIONS WITH SECONDARY ADVERSE EFFECTS ON THE FETAL BRAIN: CONGENITAL HEART DISEASE AND FETAL BRAIN DEVELOPMENT
- KEY REFERENCES
- REFERENCES
- Unit III: Neurological Evaluation
- Chapter 12. Neurological Examination: Normal and Abnormal Features
- Abstract
- INTRODUCTION
- NORMAL NEUROLOGICAL EXAMINATION
- ABNORMAL NEUROLOGICAL FEATURES
- VALUE OF THE NEONATAL NEUROLOGICAL EXAMINATION
- KEY REFERENCES
- REFERENCES
- Chapter 13. Specialized Neurological Studies
- Abstract
- CEREBROSPINAL FLUID EXAMINATION
- NEUROPHYSIOLOGICAL STUDIES
- Acknowledgement
- KEY REFERENCES
- REFERENCES
- Chapter 14. Neurodevelopmental Follow-Up of High-Risk Newborns
- Abstract
- INTRODUCTION
- PRIMARY PURPOSE OF NEURODEVELOPMENTAL FOLLOW-UP
- NEURODEVELOPMENT
- WHICH INFANTS NEED FOLLOW-UP
- MODELS OF NEURODEVELOPMENTAL FOLLOW-UP
- TIMING OF FOLLOW-UP ASSESSMENTS
- NEURODEVELOPMENTAL FOLLOW-UP PROGRAMS
- FUNCTIONAL NEURODEVELOPMENTAL DOMAINS
- CONCLUSIONS
- Acknowledgment
- KEY REFERENCES
- REFERENCES
- Unit IV: Seizures
- Chapter 15. Neonatal Seizures
- ABSTRACT
- INTRODUCTION
- PATHOPHYSIOLOGY
- CLASSIFICATION
- ETIOLOGY
- DIAGNOSIS
- PROGNOSIS
- MANAGEMENT
- KEY REFERENCES
- REFERENCES
- Unit V: Hypoxic-Ischemic and Related Disorders
- Chapter 16. Pathophysiology: General Principles
- Abstract
- DEFINITIONS
- CAUSES OF PATHOLOGICAL HYPOXIA-ISCHEMIA
- THE EVOLUTION OF CEREBRAL INJURY
- PRIMARY MEDIATORS OF HYPOXIC-ISCHEMIC INJURY IN THE NEWBORN BRAIN—PHYSIOLOGICAL AND BIOCHEMICAL
- CONCLUSIONS
- KEY REFERENCES
- REFERENCES
- Chapter 17. Inflammation and the Newborn Brain
- Abstract
- INTRODUCTION
- EPIDEMIOLOGICAL AND CLINICAL EVIDENCE OF THE INPUT OF INFLAMMATION AND NEUROINFLAMMATION IN TERM NEWBORNS
- EPIDEMIOLOGICAL AND CLINICAL EVIDENCE OF THE IMPACT OF INFLAMMATION AND NEUROINFLAMMATION IN PRETERM NEWBORNS
- IMMUNE MEDIATORS
- NEUROINFLAMMATION IN NEONATAL ENCEPHALOPATHY: EXPERIMENTAL STUDIES IN HYPOXIC-ISCHEMIC MODELS
- SYSTEMIC INFLAMMATION, NEUROINFLAMMATION, AND BILATERAL COMMUNICATION IN PRETERM NEWBORNS
- IMPACT OF NEUROINFLAMMATION ON THE PRETERM BRAIN
- THE TERTIARY PHASE OF NEUROINFLAMMATION IN PRETERM INFANTS
- IMPLICATIONS FOR NEUROPROTECTIVE STRATEGIES IN NEWBORNS
- KEY REFERENCES
- REFERENCES
- Chapter 18. Encephalopathy of Prematurity: Neuropathology
- Abstract
- NEUROPATHOLOGICAL FEATURES OF THE ENCEPHALOPATHY OF PREMATURITY
- ENCEPHALOPATHY OF PREMATURITY—NEUROPATHOLOGY IN LIVING INFANTS
- KEY REFERENCES
- REFERENCES
- Chapter 19. Encephalopathy of Prematurity: Pathophysiology
- Abstract
- OVERVIEW OF PATHOGENESIS
- PRETERM CEREBRAL GRAY MATTER INJURY AND DYSMATURATION
- KEY REFERENCES
- REFERENCES
- Chapter 20. Encephalopathy of the Preterm—Clinical Aspects
- Abstract
- INTRODUCTION
- CLINICAL SETTINGS
- NEUROLOGIC SYNDROME
- DIAGNOSIS
- PROGNOSIS AND CLINICOPATHOLOGICAL CORRELATIONS
- MANAGEMENT
- CONCLUSION
- Acknowledgement
- KEY REFERENCES
- REFERENCES
- Chapter 21. Intrauterine and Intrapartum Assessment of the Fetus
- Abstract
- ANTEPARTUM ASSESSMENT
- INTRAPARTUM ASSESSMENT
- KEY REFERENCES
- References
- Chapter 22. Hypoxic-Ischemic Encephalopathy in the Term Infant: Neuropathology
- Abstract
- Neuropathology
- KEY REFERENCES
- References
- Chapter 23. Hypoxic-Ischemic Injury in the Term Infant: Pathophysiology
- Abstract
- Introduction
- PART A
- PART B
- KEY REFERENCES
- References
- Chapter 24. Hypoxic-Ischemic Injury in the Term Infant: Clinical-Neurological Features, Diagnosis, Imaging, Management, and Prognosis
- Abstract
- CLINICAL SETTINGS
- NEUROLOGICAL SYNDROME
- Diagnosis
- COMPUTED TOMOGRAPHY
- MAGNETIC RESONANCE IMAGING
- CLINICOPATHOLOGICAL CORRELATIONS
- Management
- Prognosis
- KEY REFERENCES
- References
- Chapter 25. Stroke in the Newborn
- Abstract
- CLASSIFICATION—NOMENCLATURE
- PERINATAL ARTERIAL ISCHEMIC STROKE
- CEREBRAL SINOVENOUS THROMBOSIS
- KEY REFERENCES
- References
- Unit VI: Intracranial Hemorrhage
- Chapter 26. Intracranial Hemorrhage: Subdural, Subarachnoid, Subpial, Intraventricular (Term Infant), Miscellaneous
- Abstract
- Overview
- SUBDURAL HEMORRHAGE
- PRIMARY SUBARACHNOID HEMORRHAGE
- INTRAVENTRICULAR HEMORRHAGE OF THE TERM INFANT
- SUBPIAL HEMORRHAGE
- MISCELLANEOUS EXAMPLES OF NEONATAL INTRACRANIAL HEMORRHAGE
- KEY REFERENCES
- References
- Chapter 27. Cerebellar Hemorrhage
- Abstract
- CEREBELLAR HEMORRHAGE: FETUS
- CEREBELLAR HEMORRHAGE: PRETERM INFANT
- CEREBELLAR HEMORRHAGE: TERM INFANT
- KEY REFERENCES
- References
- Chapter 28. Preterm Intraventricular Hemorrhage/Posthemorrhagic Hydrocephalus
- Abstract
- MAGNITUDE OF THE PROBLEM
- Neuropathology
- Pathogenesis
- CLINICAL FEATURES
- Diagnosis
- Prognosis
- Management
- Conclusions
- KEY REFERENCES
- References
- Unit VII: Metabolic Encephalopathies
- Chapter 29. Glucose
- Abstract
- Introduction
- Definition
- NORMAL METABOLIC ASPECTS
- BIOCHEMICAL ASPECTS OF HYPOGLYCEMIA
- Neuropathology
- CLINICAL ASPECTS
- KEY REFERENCES
- References
- Chapter 30. Bilirubin and Brain Injury
- Abstract
- NORMAL BILIRUBIN STRUCTURE AND METABOLISM
- Pathophysiology
- Neuropathology
- CLINICAL ASPECTS OF ACUTE AND CHRONIC BILIRUBIN ENCEPHALOPATHIES
- KEY REFERENCES
- References
- Chapter 31. Amino Acids
- Abstract
- OVERVIEW OF AMINOACIDOPATHIES WITH NEONATAL NEUROLOGICAL MANIFESTATIONS
- MAPLE SYRUP URINE DISEASE
- NONKETOTIC HYPERGLYCINEMIA
- HYPERAMMONEMIA
- ACQUIRED DISORDERS WITH NEONATAL HYPERAMNONEMIA
- MISCELLANEOUS AMINO ACID DISORDERS
- KEY REFERENCES
- REFERENCES
- Chapter 32. Organic Acids
- Abstract
- OVERVIEW OF MAJOR ORGANIC ACID DISORDERS AND NEONATAL METABOLIC ACIDOSIS
- DISORDERS OF PROPIONATE AND METHYLMALONATE METABOLISM
- DISORDERS OF PYRUVATE AND MITOCHONDRIAL ENERGY METABOLISM
- DISORDERS OF BRANCHED-CHAIN KETOACID METABOLISM
- DISORDERS OF FATTY ACID OXIDATION
- OTHER ORGANIC ACID DISORDERS
- KEY REFERENCES
- REFERENCES
- Unit VIII: Degenerative Disorders
- Chapter 33. Degenerative Disorders of the Newborn
- Abstract
- MAJOR DISORDERS
- DISORDERS PRIMARILY AFFECTING GRAY MATTER
- DISORDERS PRIMARILY AFFECTING WHITE MATTER
- DISORDERS AFFECTING BOTH GRAY AND WHITE MATTER
- KEY REFERENCES
- REFERENCES
- Unit IX: Neuromuscular Disorders
- Chapter 34. Evaluation, Special Studies
- Abstract
- MOTOR SYSTEM
- EVALUATION OF DISORDERS OF THE MOTOR SYSTEM
- KEY REFERENCES
- REFERENCES
- Chapter 35. Arthrogryposis Multiplex Congenita
- Abstract
- CLINICAL FEATURES
- PATHOGENESIS
- CLINICAL CLASSIFICATION
- DIAGNOSIS
- MANAGEMENT
- KEY REFERENCES
- REFERENCES
- Chapter 36. Levels Above Lower Motor Neuron to Neuromuscular Junction
- Abstract
- LEVELS ABOVE THE LOWER MOTOR NEURON
- LEVEL OF THE LOWER MOTOR NEURON
- LEVEL OF THE PERIPHERAL NERVE
- LEVEL OF THE NEUROMUSCULAR JUNCTION
- KEY REFERENCES
- REFERENCES
- Chapter 37. Muscle Involvement and Restricted Disorders
- Abstract
- LEVEL OF THE MUSCLE
- RESTRICTED NEUROMUSCULAR DISORDERS
- DISTINGUISHING FEATURES OF DISORDERS OF THE MOTOR SYSTEM
- KEY REFERENCES
- REFERENCES
- Unit X: Intracranial Infections
- Chapter 38. Viral, Protozoan, and Related Intracranial Infections
- Abstract
- DESTRUCTIVE VERSUS TERATOGENIC EFFECTS
- TORCH INFECTIONS
- OTHER VIRUSES
- KEY REFERENCES
- References
- Chapter 39. Bacterial and Fungal Intracranial Infections
- Abstract
- BACTERIAL MENINGITIS
- BRAIN ABSCESS
- DISSEMINATED FUNGAL INFECTION
- TETANUS NEONATORUM
- Acknowledgment
- KEY REFERENCES
- REFERENCES
- Unit XI: Perinatal Trauma
- Chapter 40. Injuries of Extracranial, Cranial, Intracranial, Spinal Cord, and Peripheral Nervous System Structures
- Abstract
- INTRODUCTION
- MAJOR VARIETIES OF PERINATAL TRAUMA
- INJURY TO EXTRACRANIAL, CRANIAL, AND CENTRAL NERVOUS SYSTEM STRUCTURES
- INJURY TO PERIPHERAL NERVOUS SYSTEM STRUCTURES
- KEY REFERENCES
- REFERENCES
- Unit XII: Intracranial Mass Lesions
- Chapter 41. Brain Tumors and Vein of Galen Malformations
- Abstract
- BRAIN TUMORS
- VEIN OF GALEN MALFORMATION
- ARACHNOID CYSTS
- KEY REFERENCES
- References
- Unit XIII: Drugs and the Developing Nervous System
- Chapter 42. Passive Addiction and Teratogenic Effects
- Abstract
- MAJOR FACTORS INVOLVED IN NEUROLOGIC DISTURBANCES ASSOCIATED WITH INTRAUTERINE DRUG EXPOSURE
- DEVELOPMENTAL CONSEQUENCES FOR THE INFANT
- Alcohol
- ANTIEPILEPTIC DRUGS
- Stimulants
- Opioids
- Antidepressants
- Sedatives
- Anesthetics
- Marijuana
- DRUG USE AND THE PRETERM INFANT
- Conclusions
- KEY REFERENCES
- References
- Unit XIV: Neurology in Low Resource Settings
- Chapter 43. Neonatal Neurology in the Low-Resource Setting for the Term and Preterm Newborn
- Abstract
- Introduction
- HIE/NE IN THE TERM-BORN NEWBORN
- PREMATURE INFANTS IN THE LRS—IVH
- KEY REFERENCES
- References
- Index
- Confidence is ClinicalKey
- No. of pages: 1240
- Language: English
- Edition: 7
- Published: January 8, 2024
- Imprint: Elsevier
- Hardback ISBN: 9780443105135
- eBook ISBN: 9780443105456
JV
Joseph J. Volpe
Joseph Volpe is generally considered to have founded the field of neonatal neurology.
Affiliations and expertise
Bronson Crothers Professor of Neurology, Emeritus, Harvard Medical School, Neurologist-in-Chief, Emeritus, Boston Children’s Hospital, Department of Pediatric Newborn Medicine, Harvard Institutes of Medicine, Boston, MassachusettsTI
Terrie E. Inder
Dr. Inder is a dual-boarded neonatologist and child neurologist and is the current Chair of the Department of Pediatric Newborn Medicine. A native of New Zealand, she previously worked at the University of Melbourne, and Washington University in St. Louis before joining Brigham and Women’s Hospital in 2013. She has a passion for improving long-term outcomes of high-risk infants including premature infants and at-risk term born infants. Dr. Inder is the Mary Ellen Avery Professor of Pediatrics in the Field of Newborn Medicine at Harvard Medical School.
Affiliations and expertise
Mary Ellen Avery Professor of Pediatrics, Harvard Medical School, Chair, Department of Pediatric, Newborn Medicine, Brigham and Women’s Hospital, Boston, Massachusetts