Visceral Leishmaniasis
Therapeutics and Vaccines
- 1st Edition - May 12, 2021
- Imprint: Academic Press
- Author: Awanish Kumar
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 1 2 4 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 1 2 5 - 2
Visceral Leishmaniasis: Therapeutics and Vaccines describes current therapeutics, natural anti-leishmanial molecules, anti-leishmanial screening, and explores vaccine candidate… Read more
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Request a sales quoteVisceral Leishmaniasis: Therapeutics and Vaccines describes current therapeutics, natural anti-leishmanial molecules, anti-leishmanial screening, and explores vaccine candidates and amastigote-based vaccination strategies for Leishmania. The book provides a precise view on VL, Leishmania parasite culture, host immunity and immunomodulation, natural compounds effective against VL, animal models for VL, and methodologies available for anti-leishmanial drug screening procedures against VL, as well as vaccine and vaccination-related information on Leishmaniasis. Readers will find concrete information on past and current hurdles facing vaccine development for Leishmania, along with scientific opportunities and the potential impact of vaccines, including problems encountered.
The book is designed to increase the understanding of vaccines, particularly in VL, for students and researchers. Although vaccines are now available for many diseases, there are still challenges ahead for a vaccine for VL. The ideal vaccine must be safe and able to induce an immune response that is strong and effective. In a nutshell, a combination of chemotherapy (drugs) and immunoprophylaxis (vaccine) would be ideal to win the battle against VL.
- Provides the first dedicated book on Visceral Leishmaniasis (VL) and anti-leishmanial screening
- Covers major aspects of the fatal disease Visceral Leishmaniasis
- Provides plenty of illustrations and figures
- Includes methods of anti-leishmanial drug screening
- Expands the perspective of readers on the complex problem of drug screening
Basic and applied researchers in immunology, microbiology, biochemistry, molecular biology, medicinal chemistry. Specialists in different sub-disciplines in medicine (parasitology, infection biology), and students in related areas
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- 1: Leishmaniasis: An overview
- Abstract
- General account on leishmaniasis
- Key facts about human leishmaniasis
- Classification of leishmaniasis
- An outline of fatal VL
- Burden of VL
- VL coinfection with HIV
- Chemotherapy for VL
- SAG unresposiveness and resistance
- 2: Maintenance of Leishmania parasite
- Abstract
- In vitro maintenance of Leishmania parasite
- Experimental host for in vivo maintenance of Leishmania
- In vivo maintenance of L. donovani
- Primary culture of promastigotes
- Macrophage cell line maintenance
- Suitabitity of L. donovani as experimental parasite
- Cryopreservation of L. donovani promastigotes
- Cultivation of L. donovani parasite
- Assessment of L. donovani infection
- 3: Host immunity and immunomodulation
- Abstract
- Immune response in general
- Host-specific immune response in VL
- Immunomodulation and immunomodulators
- 4: VL and natural products
- Abstract
- VL: A general account
- Natural products as anti-VL agent
- Problems associated with antiparasitic natural product research
- 5: Antileishmanial drug screening
- Abstract
- Screening of antileishmanials
- Drug screening methods for antileishmanial drug discovery
- Other assays for screened molecules
- In vitro screening of the activity of natural compounds
- In vivo screening of the activity of natural compounds
- Drug testing
- 6: Vaccine and vaccination
- Abstract
- Vaccination: History
- Evolution of vaccine development
- How do vaccines work?
- Basic principles for good vaccine design
- How to make vaccines
- Edward Jenner and the development of the first safe vaccine for smallpox
- Koch, Pasteur, and the germ theory of disease
- Bacille Calmette-Guérin (BCG)
- Dendritic cell-based vaccination against tumors and infectious diseases
- Transcutaneous immunization (TCI)
- Vaccines for various infections of human
- Vaccine for VL
- 7: Different vaccination approach for vaccine development
- Abstract
- Types of vaccine
- Inactivated vaccines
- Live attenuated vaccines
- Recombinant or subunit vaccines
- Conjugate vaccine
- Toxiod vaccine
- Recombinant vector vaccines
- Naked DNA vaccines
- 8: Adjuvants
- Abstract
- Adjuvants and leishmaniasis
- Categories of adjuvants
- Selection of adjuvants
- Mode of action of adjuvants
- 9: Vaccine delivery system
- Abstract
- Delivery systems of vaccines
- 10: Routes of vaccination
- Abstract
- Vaccination route
- 11: Animal models for VL
- Abstract
- Introduction
- Animal models in experimental chemotherapy of VL
- 12: Vaccination approaches for VL
- Abstract
- Various vaccination approaches explored in VL
- Drugs or vaccines for control of VL
- 13: Current status of Leishmania vaccine and problems to be solved
- Abstract
- Current status of Leishmania vaccine
- Problems to be solved before a Leishmania vaccine becomes reality
- 14: Amastigote-based vaccine: Silver lining in leishmaniasis
- Abstract
- Amastigote-based vaccine
- Index
- Edition: 1
- Published: May 12, 2021
- No. of pages (Paperback): 158
- No. of pages (eBook): 158
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323911245
- eBook ISBN: 9780323911252
AK
Awanish Kumar
Dr. Awanish Kumar is currently an Associate Professor in the Department of Biotechnology at the National Institute of Technology, Raipur (CG), India. He has more than 13 years of research experience. He received his PhD in Molecular Parasitology from the CSIR-Central Drug Research Institute, Lucknow, India, and Jawaharlal Nehru University, Delhi, India, and completed his postdoctoral studies at McGill University, Montreal, Canada. His research interests are infection biology, drug targeting, and drug discovery. Dr. Kumar has served on various national and international organizations in different academic and research capacities. He has also served on many national committees and scientific advisory panels, as a member of many international professional research societies, and as a reviewer and editorial board member of reputed and refereed journals. He has authored or edited several monographs, books, and book chapters.
Affiliations and expertise
Associate Professor, Department of Biotechnology, National Institute of Technology Raipur, IndiaRead Visceral Leishmaniasis on ScienceDirect