Viral Replication Enzymes and their Inhibitors Part A

Preface

1. CoV-er all the bases: Structural perspectives of SARS-CoV-2 RNA synthesis

2. Mechanisms of inhibition of viral RNA replication by nucleotide analogs

3. HCV RdRp, sofosbuvir and beyond

4. Understanding viral replication and transcription using single-molecule techniques

5. In vitro single-molecule manipulation studies of viral DNA replication

6. Allosteric and dynamic control of RNA-dependent RNA polymerase function and fidelity

7. Single-cell analysis for the study of viral inhibitors

8. Structural basis of viral RNA-dependent RNA polymerase nucleotide addition cycle in picornaviruses

9. Picornaviral 2C proteins: A unique ATPase family critical in virus replication

10. Flavivirus enzymes and their inhibitors

11. Watching the bacterial RNA polymerase transcription reaction by time-dependent soak-trigger-freeze X-Ray crystallography

12. Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs