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Veterinary Immunology
- 11th Edition - September 12, 2024
- Author: Ian R Tizard
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 0 9 7 5 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 1 1 6 1 - 7
Exploring the immunologic concerns of both large and small animals, Veterinary Immunology,11th Edition is the only complete resource on immunology for veterinary practitioners… Read more
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Request a sales quoteExploring the immunologic concerns of both large and small animals, Veterinary Immunology,11th Edition is the only complete resource on immunology for veterinary practitioners. This new edition has been meticulously updated to continue its trend of incorporating the latest advances and topics in the field. It features a straightforward presentation of basic immunologic principles along with thorough and timely information on the most significant immunologic diseases and responses seen in domestic animals. Vibrant images and wealth of clinical examples give you a better understanding of complex topics and concepts and how they come in to play during professional practice.
- NEW! Completely updated content covers the latest advances and topics in veterinary immunology, including cutting-edge information on drugs for the immune system, antibodies, vaccines, cancer immunology, and much more.
- NEW! Enhanced ebook version, included with every new print purchase, features flashcards and enhanced animations, plus access to all the text, figures, and references, with the ability to search, customize content, make notes and highlights, and have content read aloud.
- Comprehensive coverage clearly explains the general principles of immunology and provides information on the most significant immunologic diseases and immunologic responses seen in domestic animals.
- A wealth of clinical examples show how principles are applied in the clinical setting.
- Cover image
- Title page
- Table of Contents
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- Copyright
- Dedication
- Preface
- Acknowledgments
- 1. Surviving in a Microbial World
- ABSTRACT
- Chapter Outline
- THE MICROBIAL WORLD
- THE DEFENDERS
- WHERE TO GO FOR ADDITIONAL INFORMATION
- 2. Innate Immunity: How to Detect Invaders
- Abstract
- Chapter Outline
- HOW INVADERS ARE DETECTED
- PATHOGEN-ASSOCIATED MOLECULAR PATTERNS
- DAMAGE-ASSOCIATED MOLECULAR PATTERNS
- SOLUBLE PATTERN-RECOGNITION MOLECULES
- SENTINEL CELLS
- SPECIES DIFFERENCES
- REFERENCES
- 3. Humoral Innate Immunity: Inflammation
- Abstract
- Chapter Outline
- INFLAMMASOMES
- PRODUCTS OF SENTINEL CELLS
- INFLAMMATORY MEDIATORS
- THE COAGULATION SYSTEM
- REFERENCES
- 4. Humoral Innate Immunity: Antimicrobial Peptides
- Abstract
- Chapter Outline
- DEFENSINS
- CATHELICIDINS
- OTHER PEPTIDES
- SPECIES DIFFERENCES
- REFERENCES
- 5. Humoral Innate Immunity: The Complement System
- Abstract
- Chapter outline
- THE COMPLEMENT SYSTEM
- ACTIVATION PATHWAYS
- REGULATION OF COMPLEMENT
- OTHER CONSEQUENCES
- INTRACELLULAR COMPLEMENT
- COMPLEMENT GENES
- COMPLEMENT DEFICIENCIES
- REFERENCES
- 6. Cellular Innate Immunity: Leukocytes
- Abstract
- Chapter outline
- LEUKOCYTE CLASSIFICATION
- NEUTROPHILS
- EMIGRATION
- PHAGOCYTOSIS
- EXTRACELLULAR TRAPS
- SURFACE RECEPTORS
- FATE
- REFERENCES
- 7. Cellular Innate Immunity: Macrophages and Recovery from Inflammation
- Abstract
- Chapter outline
- MACROPHAGES
- FUNCTIONS
- FATE OF FOREIGN MATERIAL
- RESOLUTION OF INFLAMMATION
- REFERENCES
- 8. Sickness: The Body’s Innate Responses
- Abstract
- Chapter outline
- SICKNESS BEHAVIOR
- FEVERS
- ACUTE-PHASE PROTEINS
- SYSTEMIC INFLAMMATORY RESPONSE SYNDROME
- PROTEIN MISFOLDING DISEASES
- REFERENCES
- 9. How Immune Cells Communicate: Cytokines and Their Receptors
- Abstract
- Chapter outline
- CYTOKINE NOMENCLATURE
- CYTOKINE FUNCTIONS
- CYTOKINE STRUCTURE
- CYTOKINE RECEPTORS
- CYTOKINE REGULATION
- SIGNAL TRANSDUCTION
- GENE TRANSCRIPTION
- REFERENCES
- 10. Antigens: Triggers of Adaptive Immunity
- Abstract
- Chapter Outline
- MICROBIAL ANTIGENS
- NONMICROBIAL ANTIGENS
- WHAT MAKES A GOOD ANTIGEN?
- EPITOPES
- CROSS-REACTIONS
- REFERENCES
- 11. Dendritic Cells, Antigen Processing, and Presentation
- Abstract
- Chapter Outline
- DENDRITIC CELLS
- OTHER ANTIGEN-PROCESSING CELLS
- ANTIGEN PROCESSING
- DENDRITIC CELLS IN DOMESTIC ANIMALS
- HISTIOCYTOSIS AND HISTIOCYTOMAS
- REFERENCES
- 12. The Major Histocompatibility Complex
- Abstract
- Chapter Outline
- MAJOR HISTOCOMPATIBILITY COMPLEX
- MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I MOLECULES
- MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II MOLECULES
- MAJOR HISTOCOMPATIBILITY COMPLEX CLASS III MOLECULES
- MAJOR HISTOCOMPATIBILITY COMPLEX OF DOMESTIC ANIMALS
- MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES AND DISEASE
- MAJOR HISTOCOMPATIBILITY COMPLEX AND BODY ODORS
- REFERENCES
- 13. Lymphoid Organs: Their Structure and Functions
- Abstract
- Chapter Outline
- SOURCES OF LYMPHOCYTES
- PRIMARY LYMPHOID ORGANS
- SECONDARY LYMPHOID ORGANS
- TERTIARY LYMPHOID ORGANS
- REFERENCES
- 14. Lymphocytes
- Abstract
- Chapter Outline
- LYMPHOCYTE STRUCTURE
- LYMPHOCYTE POPULATIONS
- LYMPHOCYTE SURFACE MOLECULES
- SPECIES DIFFERENCES
- LYMPHOCYTE MITOGENS
- REFERENCES
- 15. Helper T Cells: Diverse Responses to Antigens
- Abstract
- Chapter Outline
- THE IMMUNOGLOBULIN SUPERFAMILY
- T-CELL ANTIGEN RECEPTORS
- COSTIMULATORS
- IMMUNOLOGICAL SYNAPSE FORMATION
- SIGNAL TRANSDUCTION
- OVERALL CONSIDERATIONS
- SUPERANTIGENS
- HELPER T-CELL SUBPOPULATIONS
- SPECIES DIFFERENCES
- MEMORY T CELLS
- References
- 16. B Cells and Their Response to Antigens
- Abstract
- Chapter Outline
- B-CELL ANTIGEN RECEPTORS
- ANTIGEN PRESENTATION BY B CELLS
- COSTIMULATION
- B-CELL RESPONSES
- CELLULAR RESPONSES
- PLASMA CELLS
- MEMORY B CELLS
- GERMINAL CENTERS
- MYELOMAS
- MONOCLONAL ANTIBODIES
- REFERENCES
- 17. Antibodies: Soluble Antigen Receptors
- Abstract
- Chapter Outline
- IMMUNOGLOBULINS
- IMMUNOGLOBULIN CLASSES
- THREE-DIMENSIONAL STRUCTURE OF IMMUNOGLOBULINS
- IMMUNOGLOBULIN VARIANTS
- PRODUCTION OF IMMUNOGLOBULIN HEAVY CHAINS
- IMMUNOGLOBULINS OF DOMESTIC MAMMALS
- REFERENCES
- 18. How Antigen-Binding Receptors Are Made
- Abstract
- Chapter Outline
- RECEPTOR-ANTIGEN BINDING
- ANTIGEN RECEPTOR GENES
- IMMUNOGLOBULIN DIVERSITY
- GENE RECOMBINATION
- GENERATION OF JUNCTIONAL DIVERSITY
- SOMATIC MUTATION
- GENE CONVERSION
- RECEPTOR ASSEMBLY
- POTENTIAL IMMUNOGLOBULIN DIVERSITY
- SPECIES DIFFERENCES
- T-CELL RECEPTOR DIVERSITY
- GENERATION OF T-CELL RECEPTOR DIVERSITY
- T-CELL DIVERSITY
- EPIGENETICS
- REFERENCES
- 19. T Cells and the Destruction of Intracellular Invaders
- Abstract
- Chapter Outline
- ENDOGENOUS ANTIGENS
- APOPTOSIS
- CELL COOPERATION
- CYTOTOXIC T-CELL RESPONSES
- CYTOTOXIC T-CELL SUBSETS
- Other Mechanisms of Cellular Cytotoxicity
- MACROPHAGE ACTIVATION
- EFFECTOR T-CELL MEMORY
- REFERENCES
- 20. Innate Lymphoid Cells
- Abstract
- Chapter Outline
- INNATE HELPER CELLS
- INNATE CYTOTOXIC CELLS
- Natural Killer T Cells
- REFERENCES
- 21. Regulation of Adaptive Immunity
- Abstract
- Chapter Outline
- TOLERANCE
- T-CELL TOLERANCE
- B-CELL TOLERANCE
- DURATION OF TOLERANCE
- CONTROL OF IMMUNE RESPONSES
- INHIBITORY RECEPTORS
- REGULATORY CELLS
- NEURAL REGULATION OF IMMUNITY
- REFERENCES
- 22. The Microbiota and the Immune System
- Abstract
- Chapter Outline
- THE LOCATIONS OF THE MICROBIOTA
- THE FUNCTIONS OF THE MICROBIOTA
- IMMUNE RESPONSES TO THE MICROBIOTA
- DYSBIOSIS
- ODORS
- THE VIROME
- INFLAMMATORY BOWEL DISEASES
- REFERENCES
- 23. Immunity on Body Surfaces
- Abstract
- Chapter Outline
- IMMUNITY ON BODY SURFACES
- MUCOSAL LYMPHOID TISSUES
- ADAPTIVE PROTECTIVE MECHANISMS
- IMMUNITY TO FOOD
- VACCINATION ON BODY SURFACES
- REFERENCES
- 24. Immunity in the Fetus and Newborn
- Abstract
- Chapter Outline
- DEVELOPMENT OF THE IMMUNE SYSTEM
- IMMUNE RESPONSES OF NEWBORN MAMMALS
- TRANSFER OF IMMUNITY FROM MOTHER TO OFFSPRING
- TRANSFER OF IMMUNOGLOBULINS
- TRANSFER OF CELL-MEDIATED IMMUNITY
- FAILURE OF PASSIVE TRANSFER
- DEVELOPMENT OF ADAPTIVE IMMUNITY
- VACCINATION OF YOUNG ANIMALS
- REFERENCES
- 25. Vaccines and Their Production
- Abstract
- Chapter Outline
- A BRIEF HISTORY
- TYPES OF IMMUNIZATION PROCEDURES
- PASSIVE IMMUNIZATION
- ACTIVE IMMUNIZATION
- MODERN VACCINE TECHNOLOGY
- ADJUVANTS
- FURTHER INFORMATION
- REFERENCES
- 26. The Use of Vaccines
- Abstract
- Chapter Outline
- ADMINISTRATION OF VACCINES
- VACCINATION STRATEGIES
- VACCINE ASSESSMENT
- FAILURES IN VACCINATION
- ADVERSE CONSEQUENCES OF VACCINATION
- ADVERSE EFFECT PRINCIPLES
- PRODUCTION, PRESENTATION, AND CONTROL OF VACCINES
- REFERENCES
- FURTHER INFORMATION
- 27. Immunity to Bacteria and Fungi
- Abstract
- Chapter Outline
- INNATE IMMUNITY
- ADAPTIVE IMMUNITY
- EVASION OF THE IMMUNE RESPONSE
- SOME ANTIBACTERIAL VACCINES
- ADVERSE CONSEQUENCES
- SEROLOGY OF BACTERIAL INFECTIONS
- IMMUNITY TO FUNGAL INFECTIONS
- REFERENCES
- 28. Immunity to Viruses
- Abstract
- Chapter Outline
- VIRUS STRUCTURE AND ANTIGENS
- PATHOGENESIS OF VIRUS INFECTIONS
- INNATE IMMUNITY
- ADAPTIVE IMMUNITY
- EVASION OF THE IMMUNE RESPONSE
- ADVERSE CONSEQUENCES OF IMMUNITY TO VIRUSES
- SOME SELECTED VIRAL DISEASES
- SOME ANTIVIRAL VACCINES
- SEROLOGY OF VIRAL DISEASES
- REFERENCES
- 29. Immunity to Parasites
- Abstract
- Chapter Outline
- IMMUNITY TO PROTOZOA
- IMMUNITY TO HELMINTHS
- EVASION OF THE IMMUNE RESPONSE
- VACCINATION
- IMMUNITY TO ARTHROPODS
- ARTHROPOD VACCINES
- REFERENCES
- 30. Mast Cell– and Eosinophil-Mediated Hypersensitivity
- Abstract
- Chapter Outline
- INDUCTION OF TYPE I HYPERSENSITIVITY
- IMMUNOGLOBULIN E
- MAST CELLS
- MAST CELLS AND ANTIGENS
- BASOPHILS
- EOSINOPHILS
- REFERENCES
- 31. Selected Allergic Diseases
- Abstract
- Chapter Outline
- THE HYGIENE HYPOTHESIS
- SPECIFIC ALLERGIC DISEASES
- DIAGNOSIS OF TYPE I HYPERSENSITIVITY
- TREATMENT OF TYPE I HYPERSENSITIVITY
- REFERENCES
- 32. Red Cell Antigens and Antibody-Mediated Hypersensitivity
- Abstract
- Chapter outline
- BLOOD GROUPS
- BLOOD TRANSFUSIONS
- HEMOLYTIC DISEASE OF THE NEWBORN
- DOMESTIC ANIMALS
- PARENTAGE TESTING
- HEMOPHAGOCYTIC SYNDROME
- TYPE II HYPERSENSITIVITY REACTIONS TO DRUGS
- TYPE II HYPERSENSITIVITY IN INFECTIOUS DISEASES
- REFERENCES
- 33. Immune Complexes and Neutrophil-Mediated Hypersensitivity
- Abstract
- Chapter Outline
- CLASSIFICATION
- LOCAL TYPE III HYPERSENSITIVITY
- IMMUNOTHROMBOSIS
- GENERALIZED TYPE III HYPERSENSITIVITY
- OTHER IMMUNE COMPLEX–MEDIATED LESIONS
- REFERENCES
- 34. T Cell–Mediated Hypersensitivities
- Abstract
- Chapter outline
- THE TUBERCULIN REACTION
- PATHOLOGICAL CONSEQUENCES OF TYPE IV HYPERSENSITIVITY
- MEASUREMENT OF CELL-MEDIATED IMMUNITY
- REFERENCES
- 35. Organ Graft Rejection and Pregnancy
- Abstract
- Chapter outline
- ORGAN GRAFTING
- ALLOGRAFT REJECTION
- RENAL ALLOGRAFTS
- PREVENTION OF ALLOGRAFT REJECTION
- SKIN ALLOGRAFTS
- LIVER ALLOGRAFTS
- CARDIAC ALLOGRAFTS
- CORNEAL ALLOGRAFTS
- BONE ALLOGRAFTS
- BONE MARROW ALLOGRAFTS
- XENOGRAFTS
- ALLOGRAFTS AND PREGNANCY
- REFERENCES
- 36. Tumor Immunology and Immunotherapy
- Abstract
- Chapter outline
- TUMORS AS ALLOGRAFTS?
- CELLULAR DEFENSES
- FAILURE OF IMMUNITY TO CANCER CELLS
- TUMOR IMMUNOTHERAPY
- ACTIVE IMMUNIZATION
- SOME SELECTED TUMORS
- VIRUS-INDUCED TUMORS
- LYMPHOID TUMORS
- REFERENCES
- 37. Autoimmune Diseases and the Loss of Tolerance
- Abstract
- Chapter Outline
- INDUCTION OF AUTOIMMUNITY
- ABNORMAL IMMUNE RESPONSES
- PREDISPOSING FACTORS
- MECHANISMS OF TISSUE DAMAGE IN AUTOIMMUNITY
- REFERENCES
- 38. Selected Organ-Specific Autoimmune Diseases
- Abstract
- Chapter outline
- AUTOIMMUNE ENDOCRINE DISEASES
- AUTOIMMUNE REPRODUCTIVE DISEASES
- AUTOIMMUNE EYE DISEASES
- AUTOIMMUNE NEUROLOGICAL DISEASE
- AUTOIMMUNE SKIN DISEASES
- AUTOIMMUNE BLOOD DISEASES
- AUTOIMMUNE MUSCLE DISEASES
- AUTOIMMUNE HEPATITIS
- REFERENCES
- 39. Selected Immune-Mediated Inflammatory Diseases
- Abstract
- Chapter Outline
- SYSTEMIC LUPUS ERYTHEMATOSUS
- DISCOID LUPUS ERYTHEMATOSUS
- SJÖGREN’S SYNDROME
- IMMUNE-MEDIATED POLYARTHRITIS
- Villonodular Synovitis
- IMMUNE VASCULITIS
- REFERENCES
- 40. Primary Immunodeficiency Diseases
- Abstract
- Chapter Outline
- INHERITED DEFECTS IN INNATE IMMUNITY
- INHERITED DEFECTS IN THE ADAPTIVE IMMUNE SYSTEM
- IMMUNODEFICIENCIES OF HORSES
- IMMUNODEFICIENCIES OF CATTLE
- IMMUNODEFICIENCIES OF PIGS
- IMMUNODEFICIENCIES OF DOGS
- IMMUNODEFICIENCIES OF CATS
- IMMUNODEFICIENCIES OF MICE
- IMMUNODEFICIENCIES OF HUMANS
- REFERENCES
- 41. Secondary Immunological Defects
- Abstract
- Chapter outline
- VIRUS-INDUCED IMMUNOSUPPRESSION
- CAT RETROVIRUSES
- OTHER SECONDARY IMMUNODEFICIENCIES
- OLD AGE
- OTHER IMMUNODEFICIENCIES
- REFERENCES
- 42. Drugs and Other Agents That Affect the Immune System
- Abstract
- Chapter Outline
- SUPPRESSION OF THE IMMUNE SYSTEM
- NONSPECIFIC IMMUNOSUPPRESSION
- GLUCOCORTICOSTEROIDS
- CYTOTOXIC DRUGS
- SELECTIVE IMMUNOSUPPRESSANTS
- ITCH INHIBITORS
- STIMULATION OF THE IMMUNE SYSTEM
- CYTOKINES AND MONOCLONAL ANTIBODIES
- REFERENCES
- 43. Immunodiagnostic Methods
- Abstract
- Chapter outline
- REAGENTS USED IN SEROLOGICAL TESTS
- PRIMARY BINDING TESTS
- ANTIBODY LABELS
- FLOW CYTOMETRY
- SECONDARY BINDING TESTS
- ASSAYS IN LIVING SYSTEMS
- MOLECULAR METHODS
- DIAGNOSTIC APPLICATIONS
- REFERENCES
- Appendix 1. Selected CD Molecules
- Appendix 2. Some Selected Cytokines
- Appendix 3. Some Important Abbreviations
- Glossary
- Index
- Greek Letters
- Language: English
- Edition: 11
- Published: September 12, 2024
- Imprint: Saunders
- Paperback ISBN: 9780443109751
- eBook ISBN: 9780443111617
IT
Ian R Tizard
Ian R. Tizard, BVMS, BSc, PhD, DSc (Hons), DACVM, is a Diplomate of the American College of Veterinary Microbiologists and a University Distinguished Professor Emeritus of Immunology, Department of Veterinary Pathobiology, The Texas Veterinary Medical Center at Texas A &M University (TAMU), College Station, Texas, USA. Dr. Tizard earned his Bachelor of Veterinary Medicine and Surgery from the University of Edinburgh, Scotland, in 1965. He then completed a Bachelor of Science in Pathology and a PhD in Immunology. After completing his studies, Dr. Tizard became a Post-Doctoral Fellow at the University of Guelph, where he remained as a professor until 1982 when he moved to TAMU. Dr. Tizard wrote the first standardized textbook on Veterinary Immunology in 1977. This text, now in its 11th edition, is used worldwide, and has played a major role in establishing Immunology among the key disciplines.
Affiliations and expertise
University Distinguished Professor of Immunology Emeritus, Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, USA