Update on Non-Alcoholic Steatohepatitis, An Issue of Clinics in Liver Disease

1st Edition, Volume 27-2 - April 11, 2023
Editor: Zobair M. Younossi
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 6 0 5 6 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 6 0 5 7 - 1

In this issue, guest editors bring their considerable expertise to this important… Read more

Update on Non-Alcoholic Steatohepatitis, An Issue of Clinics in Liver Disease

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In this issue, guest editors bring their considerable expertise to this important topic.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Nonalcoholic Fatty Liver Disease: Disease Burden and Disease Awareness
Key points
Introduction
Nonalcoholic fatty liver disease burden
Future projections
Nonalcoholic fatty liver disease awareness
Summary
Clinics care points
Potential competing interests
Funding
Metabolic Syndrome and Its Association with Nonalcoholic Steatohepatitis
Key points
Introduction
Insulin resistance: Basic concepts
Nonalcoholic fatty liver disease and metabolic syndrome: understanding their complex relationship
Nonalcoholic fatty liver disease and metabolic syndrome as biomarkers of insulin resistance
Targeting insulin resistance in clinical practice
Summary
Clinics care points
Disclosures
Hepatic Outcomes of Nonalcoholic Fatty Liver Disease Including Cirrhosis and Hepatocellular Carcinoma
Key points
Introduction
Disease spectrum of nonalcoholic fatty liver disease
Bidirectional evolution of nonalcoholic fatty liver disease
Bidirectional evolution between nonalcoholic fatty liver disease development and resolution from nonalcoholic fatty liver/nonalcoholic fatty liver disease
Bidirectional evolution between nonalcoholic fatty liver and nonalcoholic steatohepatitis
Fibrosis progression and regression in patients with nonalcoholic steatohepatitis
Cirrhosis and its complications
Hepatocellular carcinoma
Summary
Clinics care points
Disclosure
Funding
Changings and Challenges in Liver Transplantation for Nonalcoholic Fatty Liver Disease/Steatohepatitis
Key points
Introduction
Epidemiology of Nonalcoholic Fatty Liver Disease/Steatohepatitis in Candidates for Liver Transplantation
Transplant Evaluation
Dropout and mortality in the waiting list
Immunosuppression
Outcomes after liver transplantation
Therapeutical options after liver transplantation
Hepatocellular carcinoma
De novo malignancies after liver transplantation
Quality of life after liver transplantation
Pediatric population
Summary
Clinics care points
Disclosure
Extrahepatic Outcomes of Nonalcoholic Fatty Liver Disease: Cardiovascular Diseases
Key points
Introduction
Epidemiology of cardiovascular disease in nonalcoholic fatty liver disease individuals
Pathophysiology
Clinical implications and management
Summary
Clinics care points
Extrahepatic Outcomes of Nonalcoholic Fatty Liver Disease: Nonhepatocellular Cancers
Introduction
Summary
Disclosure
Clinics care points
Clinics in Liver Disease: Update on Nonalcoholic Steatohepatitis: Sarcopenia and Nonalcoholic Fatty Liver Disease
Key points
Definition of sarcopenia
An association between sarcopenia and mortality
Treatment
Clinics care points
Nonalcoholic Fatty Liver Disease in Asia, Africa, and Middle East Region
Key points
Introduction
Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Southeast Asia
Nonalcoholic Fatty Liver Disease in South Asia
Nonalcoholic fatty liver disease in the Middle East and North Africa region
Nonalcoholic Fatty Liver Disease in Sub-Saharan Africa
Clinics care points
Disclosure
Nonalcoholic Fatty Liver Disease in Latin America and Australia
Key points
Introduction
Background concepts on Latin America and Caribbean and Australia
Epidemiology of nonalcoholic fatty liver disease in Latin America and Caribbean
Summary and outlook
Clinics care points
Disclosure
Pathogenetic Pathways in Nonalcoholic Fatty Liver Disease: An Incomplete Jigsaw Puzzle
Key points
Introduction
Signaling pathways involved in the pathogenesis of hepatocyte steatosis
Signaling pathways involved in the pathogenesis of nonalcoholic steatohepatitis
Signaling pathways involved in the pathogenesis of liver fibrosis
Summary
Clinics care points
Financial support
Conflicts of interest
Genetic Markers Predisposing to Nonalcoholic Steatohepatitis
Key points
Introduction
Summary
Clinics care points
Disclosure
Role of Liver Biopsy in Clinical Trials and Clinical Management of Nonalcoholic Fatty Liver Disease
Key points
Introduction
FDA guidance on endpoints in nonalcoholic steatohepatitis clinical trials
Liver biopsy in clinical management of nonalcoholic fatty liver disease
Summary
Roles of Radiological Tests in Clinical Trials and the Clinical Management of Nonalcoholic Fatty Liver Disease
Key points
Introduction
Quantifying liver fat for nonalcoholic fatty liver disease diagnosis
Assessing liver fibrosis or fibrotic nonalcoholic steatohepatitis in the context of clinical trial prescreening
Assessing liver fibrosis in the context of a decision tree for referral to hepatology specialists from primary care
Summary
Clinics care points
Conflict of interest
Funding statement
Noninvasive Tests Used in Risk Stratification of Patients with Nonalcoholic Fatty Liver Disease
Key points
Introduction
Summary
Clinics care points
Funding support
Author contributions
Current Treatment Options, Including Diet, Exercise, and Medications: The Impact on Histology
Key points
Introduction
Multidisciplinary lifestyle intervention in nonalcoholic steatohepatitis
Role of macronutrient composition
Repurposed medications for nonalcoholic fatty liver disease/steatohepatitis
Summary
Clinics care points
The Role Bariatric Surgery and Endobariatric Therapies in Nonalcoholic Steatohepatitis
Key points
Introduction
Bariatric surgery
Mechanisms of weight loss and improved metabolic profile after bariatric surgery
Endoscopic bariatric and metabolic therapies
Bariatric surgery in patients with cirrhosis
Summary
Clinics care points
Disclosure
Future Treatment Options and Regimens for Nonalcoholic Fatty Liver Disease
Key points
Introduction
What explains so many failures?
The future of nonalcoholic steatohepatitis therapeutics
Disclosure
Special Population: Lean Nonalcoholic Fatty Liver Disease
Key points
Introduction
Defining adiposity in lean nonalcoholic fatty liver disease
Epidemiology
Pathogenesis
Clinical features and outcomes
Assessment
Treatment
Summary
Clinics care points
Disclosure
Special Population: Pediatric Nonalcoholic Fatty Liver Disease
Key points
Definition
Epidemiology
Pathogenesis/genetics
Comorbidities
Screening
Diagnosis
Natural history of pediatric nonalcoholic fatty liver disease
Therapeutic modalities
Prevention is the key
Summary
Clinics care points
Disclosure
Economic Burden and Patient-Reported Outcomes of Nonalcoholic Fatty Liver Disease
Key points
Health-related quality of life and other patient-reported outcomes in nonalcoholic fatty liver disease
Economic burden of nonalcoholic fatty liver disease
Summary
Conflicts of interest
Funding
Physicians' Use of Digital Health Interventions in the Management of Nonalcoholic Fatty Liver Disease
Key points
Introduction
Methods
Results
Discussion
Summary
Clinics care points
Disclosure
Supplementary data
Research Priorities for Precision Medicine in NAFLD
Key points
Introduction
A public health problem
Research to improve the diagnosis of NAFLD
Challenges in NAFLD clinical trials
Multidisciplinary approaches
Novel approaches in NAFLD management
Summary
Clinics care points
Disclosure

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Update on Non-Alcoholic Steatohepatitis, An Issue of Clinics in Liver Disease

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Save 50% on book bundles

Immediately download your ebook while waiting for your print delivery. No promo code needed.

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Zobair M. Younossi