Update on Emerging Treatments for Migraine

1st Edition, Volume 255 - September 3, 2020
Imprint: Elsevier
Editors: Shuu-Jiun Wang, Chi Ieong Lau
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 1 0 8 - 3
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 1 0 9 - 0

Update on Emerging Treatments for Migraine, Volume 255, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume… Read more

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Update on Emerging Treatments for Migraine, Volume 255, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1: Update in migraine preventive treatment
Abstract
1: Introduction
2: Preventive medications for migraine
3: Preventive medications for chronic migraine
4: Calcitonin gene-related peptide monoclonal antibodies
5: Special considerations
6: Conclusion
Chapter 2: Therapeutic implications of cortical spreading depression models in migraine
Abstract
1: Migraine
2: Cortical spreading depression
3: Basics on in vivo experimental models of CSD
4: Consequences of CSD
5: Migraine modulators affect CSD susceptibility
6: CSD inhibition reflecting clinical responsiveness
7: CSD inhibitors that inhibit migraine aura but not headache
8: Novel targets for migraine therapeutics
9: Future directions and potentials for CSD models
10: Conclusion
Chapter 3: Electrophysiological basis for antiepileptic drugs in migraine prevention
Abstract
1: Introduction
2: Basic concepts of electrophysiological studies in migraine
3: The visual cortex
4: The somatosensory cortex
5: The motor cortex
6: Effects of antiepileptic drugs in migraine prevention and the associated electrophysiological studies
7: Conclusions
Acknowledgments
Chapter 4: Targeting the 5-HT1B/1D and 5-HT1F receptors for acute migraine treatment
Abstract
1: Introduction
2: Migraine pathophysiology
3: General principles of acute treatments
4: Second-generation 5-HT1B/1D agonists
5: Ditans – 5-HT1F receptor agonists
6: Conclusions
Chapter 5: A new era for migraine: The role of calcitonin gene-related peptide in the trigeminovascular system
Abstract
1: Introduction
2: Theories of migraine pathophysiology
3: The trigeminovascular system and migraine
4: CGRP and CGRP receptors
5: The role of CGRP in migraine and other headaches
6: CGRP and the trigeminovascular system
7: CGRP & its receptors as therapeutic targets for migraine
8: Conclusions
Acknowledgments
Chapter 6: Calcitonin gene-related peptide (CGRP)-targeted therapies as preventive and acute treatments for migraine—The monoclonal antibodies and gepants
Abstract
1: Introduction
2: CGRP monoclonal antibodies
3: Gepants
4: Conclusion
Conflict of interest
Chapter 7: OnabotulinumtoxinA injection in the treatment of chronic migraine
Abstract
1: Early history of botulinum toxin
2: Clinical application of botulinum toxin
3: Botulinum toxin A injection for headache disorders before PREEMPT
4: Double-blind randomized controlled trials for chronic migraine (Table 1)
5: Open-label phase of PREEMPT trials and real-world studies (Table 2)
6: Tolerability and safety (Table 3)
7: OnabotulinumtoxinA and other preventive medications
8: Practical issues
9: Guidelines (Table 5)
10: Concluding remarks
Chapter 8: The visual system as target of non-invasive brain stimulation for migraine treatment: Current insights and future challenges
Abstract
1: Introduction—The role of the visual system in migraine
2: Altered visual processing in migraine
3: Transcranial magnetic stimulation and the visual cortex
4: Targeting the visual cortex with TMS for migraine therapy
5: Transcranial electrical stimulation (TES) and the visual cortex
6: Rationale for using tES in migraine therapy
7: Future directions
8: Conclusion
Chapter 9: Update on noninvasive neuromodulation for migraine treatment—Vagus nerve stimulation
Abstract
1: Introduction
2: nVNS for acute migraine treatment
3: nVNS for migraine prevention
4: Mode of action and physiological effects
5: Conclusion
Conflicts of interest
Chapter 10: Managing migraine in pregnancy and breastfeeding
Abstract
1: Introduction
2: Overview of migraine pathophysiology and the role of estrogen
3: Migraine during pregnancy
4: Impact of migraine on pregnancy
5: Diagnosis of migraine with and without aura during pregnancy
6: Diagnosis and evaluation of secondary headache during pregnancy
7: Neuroimaging
8: Treatment considerations
9: Acute migraine treatment in pregnancy
10: Preventive treatment
11: Emerging therapies
12: Migraine and lactation
13: Acute treatment during lactation
14: Preventive treatment during lactation
15: Conclusion
Chapter 11: Insights into pathophysiology and treatment of visual snow syndrome: A systematic review
Abstract
1: Introduction
2: Methods
3: Results
4: Discussion
5: Conclusion
Chapter 12: Targeting migraine treatment with neuroimaging—Pharmacological neuroimaging in headaches
Abstract
1: Introduction: Neuroimaging in headache disorders
2: Pharmacological neuroimaging
3: Pharmacological imaging studies in headache disorders
4: Acute medication
5: Preventive medication
6: Emerging new treatment options
7: Can pharmacological neuroimaging studies be used to predict treatment response?
8: Limitations and challenges
9: Conclusion
Chapter 13: Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine?
Abstract
1: Introduction
2: Migraine and sleep disorders
3: Pathophysiology of comorbidity between migraine and sleep disorders
4: Melatonin and melatonin receptors and relevant pharmaceuticals
5: Safety and adverse effects of melatonin
6: Melatonin, migraine and sleep disorders
7: Clinical trials of melatonin in treatment of migraine and sleep disorders
8: Conclusions and future directions
Chapter 14: Clinical and biobehavioral perspectives: Is medication overuse headache a behavior of dependence?
Abstract
1: Introduction
2: Nomenclatural perspective
3: Epidemiological and comorbid perspective
4: Personality and psychological perspective
5: Cognitive and decision-making perspective
6: Neuroimaging perspective
7: Genetic perspective
8: Clinical implications
9: Conclusion
Conflict of interest
Funding
Chapter 15: The genetics of migraine and the path to precision medicine
Abstract
1: Introduction
2: Emerging concepts in migraine pathogenesis
3: The role of genetics in migraine susceptibility
4: Familial hemiplegic migraine
5: Searching for Mendelian genes causing typical migraine
6: The role TRESK in migraine mechanisms
7: Migraine genome-wide association studies
8: Migraine polygenic risk
9: Shared genetic mechanisms with migraine and its comorbidities
10: From genome to therapies
11: Approaches to personalizing migraine treatments
12: Conclusion

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Update on Emerging Treatments for Migraine

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Shuu-Jiun Wang

Chi Ieong Lau

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