Unveiling the Proteolytic Networks of Parasites

1st Edition, Volume 126 - October 23, 2024
Editor: Jan Dvorak
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 2 2 3 3 0 - 3
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 2 3 3 1 - 0

Unveiling the Proteolytic Networks of Parasites, Volume 125 presents a cutting-edge exploration of specific proteases across a spectrum of parasitic organisms. Top resear… Read more

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Unveiling the Proteolytic Networks of Parasites, Volume 125 presents a cutting-edge exploration of specific proteases across a spectrum of parasitic organisms. Top researchers in the field conduct multifaceted examinations, shedding light on the distinct roles of these proteases within significant parasite groups, including malaria, trematodes, nematodes, and blood-feeding arthropods. Chapters in this new release include Bioinformatic analysis of proteases across multiple helminth species: a case study using Wormbase, UniProt and Merops databases, Proteasomes of parasites, Proteases of Trematodes as a promising drug targets-tentative title, Astacins, and metalloproteases in nematodes, and Proteases of bloodfeeding arthropods.

Cover image
Title page
Table of Contents
Series Page
Copyright
Contributors
Chapter One: Unveiling the peptidases of parasites from the office chair – The endothelin-converting enzyme case study
Abstract
1 Introduction
2 From raw data to valuable insights without leaving the office chair – the pipeline
3 Endothelin-converting enzyme in Schistosoma mansoni, a case study
4 Concluding remarks
References
Chapter Two: The proteasome as a drug target for treatment of parasitic diseases
Abstract
1 Introduction
2 PIs as anti-parasitic agents
3 Tools to characterize the proteasome
4 Conclusions
Acknowledgements
References
Chapter Three: An update on proteases and protease inhibitors from trematodes
Abstract
1 Introduction
2 Overview of trematode proteases
3 Overview of protease inhibitors from trematodes
4 Overview of chemotherapeutic, vaccination, and diagnostic targets in trematode proteolytic systems
5 Conclusions
Acknowledgements
References
Chapter Four: Astacin metalloproteases in human-parasitic nematodes
Abstract
1 Introduction
2 Astacins comprise a subfamily of metalloproteases
3 Astacin gene families in human-parasitic nematodes
4 The role of astacins during embryonic development in human-parasitic nematodes
5 The role of astacins during molting in human-parasitic nematodes
6 Implications for nematode control
7 Conclusions and future directions
Acknowledgments
References
Chapter Five: Advances in protease inhibition-based chemotherapy: A decade of insights from Malaria research
Abstract
1 Introduction
2 Proteases associated with the apical complex regulating egress and invasion
3 Direct and indirect ways of selective targeting of P. falciparum over the host proteasome
4 Key proteases in the food vacuole of P. falciparum: focus on non-redundant enzymes
5 Conclusions
Acknowledgments
References
Chapter Six: Proteases and protease inhibitors in saliva of hard ticks: Biological role and pharmacological potential
Abstract
1 Introduction
2 Proteases in tick saliva
3 Protease inhibitors in tick saliva
4 Future directions in research on tick salivary proteases and protease inhibitors
5 Conclusion
Funding
References
Chapter Seven: Plasmodium proteases and their role in development of Malaria vaccines
Abstract
1 Introduction
2 Vaccines targeting malaria
3 Plasmodium life cycle
4 Selected Plasmodium proteases as potential vaccine targets
5 Selected Plasmodium protease inhibitors as potential vaccine targets
6 Conclusion and future perspectives
References

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Unveiling the Proteolytic Networks of Parasites

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