Unlocking Sirtuins
Cellular Biology to Translational Research
- 1st Edition - June 12, 2026
- Latest edition
- Editors: Pranav Kumar Prabhakar, Sumel Ashique
- Language: English
Unlocking Sirtuins: Cellular Biology to Translational Research explores the intricate roles of sirtuins, from basic principles to clinical significance. The book is organi… Read more
Description
Description
The book's content is complemented by case studies, clinical insights, and step-by-step procedures, offering a comprehensive and practical exploration of the subject. Users will find an in-depth overview of sirtuin biology, bridging fundamental science with clinical applications. This comprehensive resource will serve as an essential resource for researchers, clinicians, and advanced students working across cellular and molecular biology, biochemistry, pharmacology, aging, metabolic disorders, translational medicine, and related fields.
Key features
Key features
- Provides an interdisciplinary overview of sirtuin biology, bridging foundational science with translational research
- Facilitates the development of sirtuin-targeted therapies for a variety of diseases, including cancer and neurodegenerative disorders
- Highlights cutting-edge tools and technologies for sirtuin analysis
- Includes case studies and step-by-step procedures to support scientists in their own research
Readership
Readership
Table of contents
Table of contents
1. Sirtuin proteins: structure, functions, and evolutionary insights
2. Nad⁺-dependent enzymatic mechanisms and NAD⁺ precursors (NMN, NR)
Part 2: Sirtuins and aging
3. Sirtuins in senescence, mitochondrial health, and longevity
4. DNA repair and genome maintenance via sirtuin pathways
Part 3: Sirtuins in metabolic regulation
5. Sirtuins and energy homeostasis
6. Role of sirtuins in glucose and lipid metabolism
7. Sirtuins in caloric restriction and fasting responses
Part 4: Sirtuins in disease pathology 8. Sirtuins in neurodegenerative diseases
9. Sirtuins in cardiovascular health
10. The role of sirtuins in cancer progression
11. Sirtuins in inflammation and autoimmunity
Part 5: Therapeutic applications
12. Sirtuin modulators: small molecules and natural compounds
13. Sirtuin-targeted therapies: current challenges, clinical trials, and future directions
14. Translational perspectives in drug discovery
Part 6: Future directions and challenges
15. Emerging trends in sirtuin research
16. Technological advancements in sirtuin analysis
17. Experimental tools for sirtuin modulation: from CRISPR to chemical biology
18. Ethical and clinical implications of sirtuin therapies
Product details
Product details
- Edition: 1
- Latest edition
- Published: June 17, 2026
- Language: English
About the editors
About the editors
PP
Pranav Kumar Prabhakar
Dr. Pranav Kumar Prabhakar is currently working as a Professor and Head at Department of Biotechnology, School of Engineering and Technology, Nagaland University, Meriema, Kohima, Nagaland, India. He is among the World’s Top 2% Scientists (list published by Stanford University, USA, 2021, 2022, 2023, 2024, and 2025). He completed his PhD in Biotechnology from IIT Madras. His research focuses on elucidating molecular mechanisms and strategies for oral insulin delivery and mimicking signaling pathways in metabolic disorders (diabetes) using natural products. Dr. Pranav is a member of the Royal Society of Chemistry and the Asia-Pacific Chemical, Biological & Environmental Engineering Society. He serves as an editorial board member and reviewer for many reputed national and international journals. His honors include a travel grant from IIT Madras and the Council for Scientific and Industrial Research (CSIR) to attend ATTD 2009 in Greece, approved by the Department of Science and Technology (DST). He has published over 160+ research articles, authored/edited 24 books, and 48 book chapters, and delivered 9 oral and poster presentations at scientific meetings.
SA
Sumel Ashique
Dr. Sumel Ashique has been working as an assistant professor at the Department of Pharmaceutical Technology, School of Health and Medical Sciences, Adamas University, West Bengal, India. He has 5 years of teaching experience. He has achieved 100+ publications in international and national accredited reputed journals. He has expertise in drug delivery, nanotechnology, and targeted treatment strategies. Recently, he was honored to be in the World’s Top 2% Scientists by prestigious Stanford University, CA, United States, and Elsevier in 2025.