Unlocking Sirtuins
Cellular Biology to Translational Research
- 1st Edition - June 12, 2026
- Latest edition
- Editors: Pranav Kumar Prabhakar, Sumel Ashique
- Language: English
Unlocking Sirtuins: Cellular Biology to Translational Research explores the intricate roles of sirtuins, from basic principles to clinical significance. The book is organi… Read more
Description
Description
The book's content is complemented by case studies, clinical insights, and step-by-step procedures, offering a comprehensive and practical exploration of the subject. Users will find an in-depth overview of sirtuin biology, bridging fundamental science with clinical applications. This comprehensive resource will serve as an essential resource for researchers, clinicians, and advanced students working across cellular and molecular biology, biochemistry, pharmacology, aging, metabolic disorders, translational medicine, and related fields.
Key features
Key features
- Provides an interdisciplinary overview of sirtuin biology, bridging foundational science with translational research
- Facilitates the development of sirtuin-targeted therapies for a variety of diseases, including cancer and neurodegenerative disorders
- Highlights cutting-edge tools and technologies for sirtuin analysis
- Includes case studies and step-by-step procedures to support scientists in their own research
Readership
Readership
Table of contents
Table of contents
1. Sirtuin proteins: structure, functions, and evolutionary insights
2. Nad⁺-dependent enzymatic mechanisms and NAD⁺ precursors (NMN, NR)
Part 2: Sirtuins and aging
3. Sirtuins in senescence, mitochondrial health, and longevity
4. DNA repair and genome maintenance via sirtuin pathways
Part 3: Sirtuins in metabolic regulation
5. Sirtuins and energy homeostasis
6. Role of sirtuins in glucose and lipid metabolism
7. Sirtuins in caloric restriction and fasting responses
Part 4: Sirtuins in disease pathology 8. Sirtuins in neurodegenerative diseases
9. Sirtuins in cardiovascular health
10. The role of sirtuins in cancer progression
11. Sirtuins in inflammation and autoimmunity
Part 5: Therapeutic applications
12. Sirtuin modulators: small molecules and natural compounds
13. Sirtuin-targeted therapies: current challenges, clinical trials, and future directions
14. Translational perspectives in drug discovery
Part 6: Future directions and challenges
15. Emerging trends in sirtuin research
16. Technological advancements in sirtuin analysis
17. Experimental tools for sirtuin modulation: from CRISPR to chemical biology
18. Ethical and clinical implications of sirtuin therapies
Product details
Product details
- Edition: 1
- Latest edition
- Published: June 17, 2026
- Language: English
About the editors
About the editors
Pranav Kumar Prabhakar
Pranav Kumar Prabhakar is Professor and Head of the Department of Biotechnology, School of Engineering and Technology, Nagaland University, Kohima, India. His research focuses on understanding molecular mechanisms involved in metabolic disorders, particularly diabetes, and on developing strategies for oral insulin delivery using natural products and biotechnology-based approaches. He is actively involved in research, academic mentoring, peer review, and editorial activities within the biomedical and biotechnology fields. His professional interests include translational research, signaling pathways associated with metabolic diseases, and the application of biotechnology to improve therapeutic outcomes. He contributes to scientific and academic initiatives that support advancements in biotechnology and healthcare research.
Sumel Ashique
Dr. Sumel Ashique has been working as an assistant professor at the Department of Pharmaceutical Technology, School of Health and Medical Sciences, Adamas University, West Bengal, India. He has 5 years of teaching experience. He has achieved 100+ publications in international and national accredited reputed journals. He has expertise in drug delivery, nanotechnology, and targeted treatment strategies. Recently, he was honored to be in the World’s Top 2% Scientists by prestigious Stanford University, CA, United States, and Elsevier in 2025.