Unified Airway Disease, An Issue of Otolaryngologic Clinics of North America

1st Edition, Volume 56-1 - November 23, 2022
Editors: Devyani Lal, David Jang, Angela Donaldson
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 3 9 1 4 - 0
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 3 9 1 6 - 4

In this issue of Otolaryngologic Clinics, guest editors Drs. Devyani Lal, Angela Donaldson, and David Jang bring their considerable expertise to the topic of Unified Airway… Read more

Unified Airway Disease, An Issue of Otolaryngologic Clinics of North America

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In this issue of Otolaryngologic Clinics, guest editors Drs. Devyani Lal, Angela Donaldson, and David Jang bring their considerable expertise to the topic of Unified Airway Disease. Unified airway disease is a recently defined entity that alludes to inflammation disease processes that involve both upper and lower airway, and co-management of these conditions by otolaryngologists and allergy immunologists often result in improved outcomes. In this issue, experts in the field provide a thorough overview of the pathophysiology, diagnosis, and management of unified airway disease through the perspective of an otolaryngologist co-managing the patient with an allergy-immunology colleague.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Unified Airway Disease: A Contemporary Review and Introduction
Key points
Introduction
Epidemiology
Phenotypes
Endotypes
Pathophysiological mechanisms between upper and lower airways
Diagnosis
Biomarkers
Treatment
Aspects to be addressed when treating the united airways
Treatment effects on the united airways
Summary
Disclosure
Unified Airway Disease: Diagnosis and Subtyping
Key points
Physical examination
Imaging and radiology
Assessment of airway function
Blood and serum-based tests
Urine tests
Tissue diagnosis and pathology
Specific genetic tests
Summary
Clinics care points
Unified Airway Disease: Genetics and Epigenetics
Key points
Introduction
Discussion
Role of genetic studies in early disease identification and prognostication
Future directions
Summary
Clinics care points
Unified Airway Disease: Environmental Factors
Key points
Environmental Allergens
Occupational exposures
Ambient air pollution
Summary
Clinics care points
Disclosure
Sex Differences in Airway Diseases
Key points
Introduction
Discussion
Summary
Clinics care points
Unified Airway Disease: Examining Prevalence and Treatment of Upper Airway Eosinophilic Disease with Comorbid Asthma
Key points
Introduction
Discussion
Summary
Clinics care points
Disclosure
Non-Eosinophilic Granulomatous Disease and the Unified Airway
Key points
Introduction
Granulomatosis with polyangiitis
Sarcoidosis
Summary
Clinics care points
Disclosure
Immunoglobulin Deficiency and the Unified Airway
Key points
Introduction
Classification
Diagnosis
Pathogenesis
Ear, Nose, and Throat (ENT)/upper airway manifestations
Non-ENT manifestations
Treatment
Summary
Clinics care points
Aspirin-Exacerbated Respiratory Disease and the Unified Airway: A Contemporary Review
Key points
Background
Diagnostics
Future directions
Summary
Clinics care points
Unified Airway—Cystic Fibrosis
Key points
Introduction
Pathophysiology of cystic fibrosis transmembrane conductance regulator dysfunction
The unified airway in cystic fibrosis
Clinical management
Cystic fibrosis transmembrane conductance regulator modulators
Cl− secretagogues for acquired cystic fibrosis transmembrane conductance regulator dysfunction in chronic rhinosinusitis
Summary
Clinics care points
Disclosures
Funding support
Pediatric Unified Airway: Chronic Rhinosinusitis and Lower-Airway Disease
Key points
Introduction
Adenoid disease
Asthma
Cystic fibrosis
Primary ciliary dyskinesia
Summary
Clinics care points
Upper Airway Cough Syndrome
Key points
Introduction
Discussion
Summary
Clinics care points
Unified Airway Disease: Medical Management
Key points
Introduction
Intranasal corticosteroids and nasal irrigation
Systemic oral corticosteroids
Antibiotics
Biologics
Future directions
Summary
Summary
Clinics care points
Unified Airway Disease: Surgical Management
Key points
Introduction
Outcome assessments
Discussion
Clinics care points
Unified Airway Disease: Future Directions
Key points
Introduction
Summary
Clinics care points
Disclosure

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Unified Airway Disease, An Issue of Otolaryngologic Clinics of North America

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Devyani Lal

David Jang

Angela Donaldson