Understanding Cancer

From Basics to Therapeutics

1st Edition - January 13, 2022
Editors: Buddhi Prakash Jain, Shweta Pandey
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 8 8 3 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 3 9 6 - 9

Understanding Cancer: From Basics to Therapeutics presents both basic concepts and research prospects in the field of cancer biology. This book summarizes the fundamental aspects o… Read more

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Understanding Cancer: From Basics to Therapeutics presents both basic concepts and research prospects in the field of cancer biology. This book summarizes the fundamental aspects of cancer and presents a detailed description of molecular aspects as well as treatment and therapeutics for patients.

The book is divided into three parts: the first part deals with the basics of cancer, including etiology and medical diagnosis; the second part explores the molecular mechanisms associated with cancer, focusing on cell cycle and apoptosis, cell metabolism, gene regulation, epigenetics, and stem cells; and the third part is dedicated to therapeutics, discussing chemo and radiotherapies, gene, hormone, herbal, and immunotherapies.

It is a valuable resource for cancer researchers, oncologists, graduate students, and biomedical researchers who need to understand the fundamental topics related to cancer to apply to their research work or clinical setting.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
Editorial Desk
Preface
Chapter 1 A brief tour guide to cancer disease
Abstract
Keywords
1.1 Overview of cancer
1.2 Neoplasm
1.3 Types of tumor
1.4 Stages of tumor development leading to cancer
1.5 Essential hallmarks of cancer
1.6 Metastasis
1.7 Angiogenesis
1.8 Structure of tumor vasculature
1.9 Summary
References
Chapter 2 Malignant tumors – as cancer
Abstract
Keywords
2.1 Introduction
2.2 Tumors arise from normal tissue
2.3 Specialized cells of the body are involved in cancer development
2.4 Cancer incidence
2.5 Common cancers among male and female
2.6 Tumor grading and staging
2.7 Summary
References
Chapter 3 Etiology of cancer
Abstract
Keywords
3.1 Introduction
3.2 Conclusion
References
Chapter 4 Medical diagnosis of cancer
Abstract
Keywords
4.1 Cancer screening
4.2 Tumor markers in aiding cancer diagnosis
4.3 Biopsy
4.4 Imaging screening and diagnostics
4.5 Immunohistochemistry
4.6 Fluorescence in situ hybridization
4.7 MicroRNA as cancer diagnostic tools
4.8 Liver cancer
4.9 Breast cancer
4.10 Lung cancer
4.11 Prostate and cervical cancer
4.12 Other cancer
4.13 Cancer management in older age
4.14 Conclusion
References
Chapter 5 Molecular mechanisms in cancer development
Abstract
Keywords
5.1 Introduction
5.2 Cancer cells versus normal cells
5.3 How cancer develops?
5.4 Molecular changes that occur in cancer cells
5.5 Important genes in cancer development
5.6 Genetic stability loss in the tumor cells
5.7 Chromosomal changes in cancer cells
5.8 Few biomolecules involved in cancer development
5.9 Summary
References
Chapter 6 Cancer and cell cycle
Abstract
Keywords
6.1 Introduction
6.2 Growth factors in cell cycle and cancer
6.3 Cell cycle regulators
6.4 The relevance of cell cycle regulator in carcinogenesis
6.5 DNA damage response and cell cycle regulator in cancer
6.6 DNA damage checkpoints
6.7 The relevance of checkpoint alteration in carcinogenesis
6.8 Targeting cell cycle in cancer therapeutics
6.9 Combination of chemotherapy and cell cycle inhibitor in cancer
6.10 Summary
References
Chapter 7 Cancer and apoptosis
Abstract
Keywords
7.1 Introduction
7.2 Role of caspases in apoptosis
7.3 Apoptosis signaling pathway
7.4 Deregulation of the apoptotic pathway in cancer
7.5 Therapeutic targets of apoptosis in cancer
7.6 Apoptosis assay in cancer
7.7 Summary
References
Chapter 8 Fundamentals of cell metabolism and cancer
Abstract
Keywords
8.1 Introduction
8.2 Importance of understanding the metabolism of cancer cells
8.3 Glucose metabolism
8.4 Pentose phosphate pathway/phosphogluconate pathway/hexose monophosphate shunt
8.5 Amino acid metabolism
8.6 Hexosamine biosynthetic pathway
8.7 Fatty acid metabolism
8.8 Cancer metabolism in histone modifications
8.9 Mitochondria and cancer
8.10 Role of signaling pathways and transcription factors in cancer cell metabolism
8.11 Conclusion
References
Chapter 9 Cancer epigenetics: DNA methylation and histone modifications
Abstract
Keywords
9.1 An introduction to cancer epigenetics
9.2 Chromatin and DNA packaging
9.3 Covalent modifications of DNA
9.4 Histone code hypothesis and histone modifications
9.5 Summary
Acknowledgments
References
Chapter 10 Cancer epigenetics: Chromatin remodeling and other epigenetic mechanisms
Abstract
Keywords
10.1 Chromatin remodelers and cancer
10.2 Chromatin remodeling complexes
10.3 Other epigenetic mechanisms leading to cancer: MicroRNA biogenesis
10.4 Nonmalignant epigenetic disorders
10.5 Diagnostic and therapeutic approaches
10.6 Summary
Acknowledgments
References
Chapter 11 Alteration in major cell signaling pathways in cancer
Abstract
Keywords
11.1 Introduction
11.2 Cancer and tyrosine kinase signaling
11.3 Cancer and mitogen-activated protein kinase pathway
11.4 Cancer and phosphatidylinositol 3-kinase signaling
11.5 Cancer and transforming growth factor-beta signaling pathway
11.6 Cancer and G-protein coupled receptor kinase signaling pathway
11.7 Cancer and WNT signaling
11.8 Cancer and notch pathway
11.9 Cancer and Hedgehog signaling
11.10 Cancer and integrin pathway
11.11 Summary
References
Chapter 12 Cancer stem cells
Abstract
Keywords
12.1 Historical perspective
12.2 Definition of cancer stem cells
12.3 Cancer stem cells in hematopoietic cancers
12.4 Cancer stem cells in solid tumors
12.5 Contributions of cancer stem cells in tumor formation, resistance, and relapse
12.6 Cancer stem cell and miRNA
12.7 Controversies concerning the stem cell theory and the “CSC niche” concept
12.8 Therapeutic approaches to cancer stem cells
12.9 Summary
References
Chapter 13 Cancer and regulation of gene expression
Abstract
Keywords
13.1 Introduction
13.2 Central dogma of molecular biology
13.3 Transcriptional and post-transcriptional events
13.4 Summary
Acknowledgments
References
Chapter 14 Chemotherapy and radiation therapy for cancer
Abstract
Keywords
14.1 Introduction
14.2 History of cancer
14.3 Cancer and its hallmarks
14.4 Processes of carcinogenesis
14.5 Biology of tumor
14.6 Etiological factors
14.7 Cancer management
14.8 Targeting cancer stem cells in combination with chemotherapy and radiotherapy
14.9 Summary
Acknowledgments
References
Chapter 15 Cancer gene therapies progress in pre and postgenomics era
Abstract
Keywords
15.1 Introduction
15.2 Cancer treatment
15.3 Recent techniques used for gene editing
15.4 Summary
References
Chapter 16 Hormone therapy for cancer treatment
Abstract
Keywords
16.1 Hormone therapy
16.2 Types of hormone-sensitive cancer
16.3 Summary
References
Chapter 17 Natural herbal products for cancer therapy
Abstract
Keywords
17.1 Introduction
17.2 Natural products and cancer
17.3 Summary
Acknowledgment
References
Chapter 18 Immunotherapy for cancer treatment
Abstract
Keywords
18.1 Introduction
18.2 Evolutionary background of cancer immunotherapy
18.3 Types of immunotherapies
18.4 Summary
References
Index

Life sciences

Physical sciences & Engineering

Social sciences & Humanities

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