Turmeric and Curcumin for Neurodegenerative Diseases
- 1st Edition - January 26, 2021
- Imprint: Academic Press
- Author: Magisetty Obulesu
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 4 4 8 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 4 4 9 - 6
Turmeric and Curcumin for Neurodegenerative Diseases examines protective mechanisms of turmeric products and novel nanotechnological therapeutics and biomaterial design strate… Read more
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Request a sales quoteTurmeric and Curcumin for Neurodegenerative Diseases examines protective mechanisms of turmeric products and novel nanotechnological therapeutics and biomaterial design strategies to circumvent Alzheimer’s Disease, Parkinson’s, and liver diseases. With neurodegenerative and liver diseases posing a serious threat to health care systems worldwide, this book addresses how existing nanotechnology and therapeutic strategies have not been as successful in their treatment. In addition to discussing drawbacks, possible future perspectives to overcome these challenges are also examined. Chapters also focus on therapeutic efficacy and drug delivery systems, providing readers with a full summary of research in this field in one handy reference.
- Summarizes the therapeutic efficacy of turmeric and curcumin for neurodegenerative diseases
- Includes effects on Alzheimer’s, Parkinson’s and liver diseases
- Focuses on different types of drug delivery systems and their challenges
- Examines novel nanotechnological therapeutics and biomaterial design strategies
Graduate students in biological and biomedical sciences, neuroscientists, clinicians, biomedical scientists, post-doctoral fellows, researchers
- Cover image
- Title page
- Table of Contents
- Copyright
- Author biography
- Part One: Alzheimer’s disease
- Chapter One: Health benefits of turmeric: Emphasis on anticancer activity
- Abstract
- Introduction
- Gun puffing
- Curcumin
- Anticancer efficacy of curcumin
- Colorectal cancer
- Renal, bone, and lung cancer
- Blood and other cancers
- Antioxidant and antiinflammatory activity
- Noncurcuminoids
- Turmerones
- Elemenes
- β-Elemene
- Furanodiene, furanodienone, curcumol, and calebin A
- Conclusions and future perspectives
- Chapter Two: Turmeric products in Alzheimer’s disease
- Abstract
- Introduction
- Natural compounds
- Curcumin
- Volatile essential oils of curcumin
- Studies on human subjects
- Metal-chelation by curcumin
- Antiamyloidogenic activity
- Signaling
- Curcumin analogs
- Theracurmin
- Shortcomings in therapeutic efficacy of curcumin
- Conclusions and future perspectives
- Chapter Three: Curcumin in Alzheimer’s disease diagnosis and treatment
- Abstract
- Introduction
- Curcumin’s influence on enzymes
- Curcumin and resveratrol
- Oxidative damage
- Chemistry and metabolism
- Inflammation
- Curcumin in Alzheimer’s disease diagnosis
- Studies on humans
- Amyloid interaction
- Conclusions and future perspectives
- Chapter Four: Curcumin loaded drug delivery systems in the treatment of Alzheimer’s disease
- Abstract
- Introduction
- Curcumin
- Tau inhibition
- Challenges
- Curcumin delivery systems
- Polymeric nanoparticles
- Poly(lactic-co-glycolic acid)
- Surface modification
- Chitosan
- Micelles
- Phytosomes
- Lipid-based nanocarriers
- Liposomes
- Liquid crystalline nanocarriers
- Solid lipid nanoparticles
- Nanostructured lipid carriers
- Magnetic nanoparticles
- Theranostic approach of curcumin
- Conclusions and future perspectives
- Part Two: Parkinson’s disease
- Chapter Five: Turmeric products in Parkinson’s disease treatment
- Abstract
- Introduction
- α-Synuclein
- Therapeutics
- Turmeric
- Turmerone
- Furanodiene
- Curcumin
- α-Synuclein
- Antioxidant activity
- Curcumin against inflammation
- Neuronal apoptosis
- Curcumin analogs
- Conclusions and future perspectives
- Chapter Six: Curcumin in Parkinson’s disease treatment
- Abstract
- Introduction
- Drugs
- Polyphenols
- α-Synuclein
- Curcumin
- Autophagy in Parkinson’s disease
- Curcumin analogs
- Cyclocurcumin
- Tetrahydrocurcumin
- CNB-001
- Conclusions and future perspectives
- Chapter Seven: Curcumin loaded drug delivery systems in Parkinson’s disease
- Abstract
- Introduction
- Blood-brain barrier
- Curcumin
- Challenges in curcumin’s therapeutic efficacy
- Drug delivery systems
- Nanoformulations of curcumin
- Polymeric nanoparticles
- Micelles
- Liposomes
- Solid lipid nanoparticles
- Surface functionalization
- Conclusions and future perspectives
- Part Three: Liver diseases
- Chapter Eight: Turmeric products in liver disease treatment
- Abstract
- Introduction
- Nonalcoholic fatty liver disease
- Oxidative stress in liver diseases
- Drugs
- Natural products
- Turmeric
- Composition
- Therapeutic efficacy of turmeric
- Clinical trials
- Turmeric products
- Curcumin
- Oxidative liver damage
- Elemene
- Conclusions and future perspectives
- Chapter Nine: Curcumin in liver disease treatment
- Abstract
- Introduction
- Drugs and liver
- Curcumin
- Curcumin counters liver damage
- Protective efficacy of curcumin against liver-fibrosis and cirrhosis
- Liver cirrhosis
- Role of curcumin in nonalcoholic steatohepatitis
- Role of curcumin in alcoholic liver disease
- Role of curcumin against oxidative liver damage
- Animal models
- Conclusions and future perspectives
- Chapter Ten: Curcumin loaded drug delivery systems in the treatment of liver diseases
- Abstract
- Introduction
- Challenges in curcumin’s therapeutic efficacy and strategies to overcome
- Drug delivery systems
- Cancer
- Hepatic fibrosis
- Nanoparticles targeted against liver inflammation
- Conclusions and future perspectives
- Index
- Edition: 1
- Published: January 26, 2021
- Imprint: Academic Press
- No. of pages: 186
- Language: English
- Paperback ISBN: 9780128224489
- eBook ISBN: 9780128224496
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Magisetty Obulesu
Magisetty Obulesu is a research associate at the Regional Agricultural Research Station, Acharya N.G. Ranga Agricultural University, Tirupati, India. He has 20 years of research and teaching experience. He is also an editorial board of nanotechnology journals including SciFed Nanotech Research Letters, SciFed Drug Delivery Research, Current Updates in Nanotechnology and Journal of Nanotechnology and Materials Science. His research areas include food science, pathology of neurodegenerative diseases such as Alzheimer’s disease, designing polymer-based biomaterials such as hydrogels, and development of metal chelators to overcome metal induced toxicity. He has researched Alzheimer’s disease and developed an aluminium-induced neurotoxicity rabbit model. Mr. Obulesu’s present research focuses on development of redox-active injectable hydrogels of polyion complex. He has written three books and edited two more; he is also the first and corresponding author for majority of his articles.
Affiliations and expertise
Regional Agricultural Research Station, Acharya N.G. Ranga Agricultural University, Tirupati, IndiaRead Turmeric and Curcumin for Neurodegenerative Diseases on ScienceDirect