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Treatment Resistant Depression, An Issue of Psychiatric Clinics of North America
- 1st Edition, Volume 46-2 - May 8, 2023
- Editors: Manish K. Jha, Madhukar H. Trivedi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 2 5 2 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 2 5 3 - 2
In this issue of Psychiatric Clinics, guest editors Drs. Manish K. Jha and Madhukar H. Trivedi bring their considerable expertise to the topic of Treatment-Resistant Depression.… Read more
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Request a sales quoteIn this issue of Psychiatric Clinics, guest editors Drs. Manish K. Jha and Madhukar H. Trivedi bring their considerable expertise to the topic of Treatment-Resistant Depression. Treatment-resistant depression (TRD), when patients experience an inadequate response to standard treatment plans, is a relatively common occurrence in clinical practice. In this issue, top experts shed light on this difficult-to-treat disorder, helping healthcare professionals improve outcomes for their patients with TRD.
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Contains 15 practice-oriented topics including overview of TRD; improving depression outcomes through measurement-based care; approach to diagnosis and treatment for difficult-to-treat depression; TRD in children and in the elderly; neuroimaging biomarkers of treatment-resistant depression; the role of psychedelics in TRD; and more.
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Provides in-depth clinical reviews on treatment-resistant depression, offering actionable insights for clinical practice.
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Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Psychiatrists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- The Individual and Societal Burden of Treatment-Resistant Depression: An Overview
- Key points
- Introduction
- Epidemiology
- Cause
- Variation in illness presentations
- Pseudoresistance
- Tracking treatment outcomes
- The burden of depression
- Discussion
- Summary
- Clinics care points
- Declaration of Interests
- Improving Identification and Treatment Outcomes of Treatment-Resistant Depression Through Measurement-Based Care
- Key points
- Introduction
- Benefits of measurement-based care for treatment-resistant depression
- Implementing measurement-based care
- Critical decision points
- Navigating the measurement-based care course ahead
- The World Healthcare Organization Well-Being Index
- Discussion
- Clinics care points
- Disclosure
- Approach to Diagnosis and Management of Treatment-Resistant Depression
- Key points
- Introduction
- Approach to identification of treatment-resistant depression
- Differential diagnosis of treatment-resistant depression
- Comorbidities
- Structured assessment for treatment-resistant disorder
- Management approaches for treatment-resistant disorder
- Summary
- Clinics care points
- Disclosure
- Acknowledgments
- Pharmacotherapy for Treatment-Resistant Depression: Antidepressants and Atypical Antipsychotics
- Key points
- Introduction
- Evidence for antidepressants after initial nonresponse to another antidepressant
- Atypical antipsychotics in the pharmacotherapy of treatment-resistant depression
- Side effects with atypical antipsychotics in patients with major depressive disorder
- Summary
- Clinics care points
- Pharmacotherapy: Ketamine and Esketamine
- Key points
- Introduction/background
- Patient evaluation overview
- Delivery of treatment
- Treatment resistance/complications
- Summary
- Clinics care points
- Disclosure
- Role of Psychedelics in Treatment-Resistant Depression
- Key points
- Introduction
- Summary and future directions
- Clinics care points
- Disclosure
- Noninvasive Brain Stimulation Techniques for Treatment-Resistant Depression: Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation
- Key points
- Introduction
- Neurobiology of Transcranial Magnetic Stimulation
- Clinical evidence of transcranial magnetic stimulation efficacy in treatment-resistant depression
- Clinical application
- Transcranial direct current stimulation
- Future directions
- Clinics care points
- Disclosure statement
- Declaration of interest
- Photobiomodulation: An Emerging Treatment Modality for Depression
- Key points
- Introduction
- Methods
- Results
- Discussion
- Summary
- Clinics care points
- Disclosure
- The Role of Psychotherapy in the Management of Treatment-Resistant Depression
- Key points
- Introduction
- Psychotherapy alone for treatment-resistant depression
- Psychotherapy in combination with other approaches
- Future directions
- Summary
- Clinics care points
- Disclosures
- Funding
- Special Populations: Treatment-Resistant Depression in Children and Adolescents
- Key points
- Introduction
- Definition of treatment-resistant depression
- Risk factors and predictors of poor outcome
- Differential diagnosis
- Staging efforts
- Initial treatment strategies
- Summary
- Clinics care points
- Disclosure
- Treatment-Resistant Late-Life Depression: A Review of Clinical Features, Neuropsychology, Neurobiology, and Treatment
- Key points
- Case presentation
- Background
- Neuropsychological examination findings
- Contributors to treatment resistance
- Treatment
- Clinics care points
- Financial disclosures
- Brain Features of Treatment-Resistant Depression: A Review of Structural and Functional Connectivity Magnetic Resonance Imaging Studies
- Key points
- Introduction
- Structural abnormalities in treatment-resistant depression: retrospective studies
- Structural abnormalities in treatment-resistant depression: prospective studies
- Functional abnormalities in treatment-resistant depression: retrospective studies
- Functional abnormalities in treatment-resistant depression: prospective studies
- Discussion
- Clinics care points
- Funding
- Declaration of Interests
- Immune Dysregulation in Treatment-Resistant Depression: Precision Approaches to Treatment Selection and Development of Novel Treatments
- Key points
- Introduction
- Role of inflammation in the pathophysiology of major depressive disorder
- Role of immune dysfunction to guide precision medicine
- Tools used to understand immune dysregulation
- Novel statistical analysis of immunological data
- Discussion
- Clinics care points
- Summary
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 46-2
- Published: May 8, 2023
- Imprint: Elsevier
- Hardback ISBN: 9780443182525
- eBook ISBN: 9780443182532
MJ
Manish K. Jha
Affiliations and expertise
Peter O’Donnell Jr. Brain Institute and the Department of Psychiatry, University of Texas Southwestern Medical CenterMT
Madhukar H. Trivedi
Affiliations and expertise
Peter O’Donnell Jr. Brain Institute and the Department of Psychiatry, University of Texas Southwestern Medical Center