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Traumatic Brain Injury Rehabilitation

  • 1st Edition - May 1, 2027
  • Latest edition
  • Editors: Vishal K. Chavda, Creed M. Stary, Bipin Chaurasia, Luis Rafael Moscote Salazar, Harisinh Parmar
  • Language: English

Traumatic Brain Injury Rehabilitation addresses the critical need for an integrated resource spanning traumatic and vascular brain injury models. This reference consolidates divers… Read more

Description

Traumatic Brain Injury Rehabilitation addresses the critical need for an integrated resource spanning traumatic and vascular brain injury models. This reference consolidates diverse experimental platforms from classical rodent systems to advanced human brain organoids and AI-driven simulations, targeting researchers and clinicians navigating the complexities of neurotrauma and stroke. The book responds to the growing demand for translational approaches that link bench-side discoveries with bedside applications to improve therapeutic development. The content is systematically organized into sections covering foundational principles, preclinical models of traumatic brain injury and stroke, pediatric brain injury models, in vitro and ex vivo platforms, clinical biomarkers and neuroimaging, and emerging future directions including personalized medicine and AI modeling. Each chapter offers detailed methodologies, comparative evaluations, and clinical translation insights, supported by extensive visuals such as flowcharts, neuroimaging figures, and infographics to enhance comprehension.

Key features

  • Integrates preclinical and clinical brain injury models across injury types and species
  • Presents emerging technologies such as brain organoids, 3D bioprinting, and AI simulations
  • Emphasizes translational relevance to bridge bench research and clinical practice
  • Organizes content by injury type, modeling approach, and age group for targeted navigation
  • Includes detailed evaluations of model strengths, limitations, and applications

Readership

Neurosurgeons, neurologists, translational neuroscience researchers

Table of contents

SECTION I: FOUNDATIONS IN BRAIN INJURY MODELING

1. The Evolution of Experimental Brain Injury Models

2. Ethical Frameworks and Guidelines in Brain Injury Research

3. Comparative Anatomy and Pathophysiology of the Human Brain vs. Animal Models

4. Translational Gaps in Brain Injury Research: Bridging Preclinical and Clinical Findings

SECTION II: PRECLINICAL MODELS OF TRAUMATIC BRAIN INJURY (TBI)

5. Rodent Models of Focal and Diffuse TBI: Techniques and Relevance

6. Large Animal Models in TBI Research: Pigs, Sheep, and Non-Human Primates

7. Closed Head Injury vs. Open Head Injury Models: Applications and Limitations

8. Blast-Induced Brain Injury Models: Military and Civilian Implications

SECTION III: PRECLINICAL MODELS OF STROKE AND CEREBROVASCULAR INJURY

9. Ischemic Stroke Models: Intraluminal Filament, Embolic, and Photothrombotic Approaches

10. Hemorrhagic Stroke Models: Intracerebral Hemorrhage and Subarachnoid Hemorrhage

11. Comorbidities in Stroke Models: Aging, Hypertension, Diabetes, and Obesity

12. Microvascular Dysfunction in Stroke and TBI: Insights from Preclinical Models

SECTION IV: PRECLINICAL MODELS OF PEDIATRIC AND DEVELOPMENTAL BRAIN INJURY

13. Models of Neonatal Hypoxic-Ischemic Encephalopathy (HIE)

14. Pediatric TBI Models: Unique Pathophysiological Insights

15. Perinatal and Early-Life Brain Injury: Translational Challenges

SECTION V: CLINICALLY RELEVANT IN VITRO AND EX VIVO MODELS

16. Human Brain Organoids and iPSC-derived Neural Systems for Brain Injury Research

17. 3D Bioprinted Brain Tissue Models: New Frontiers in Experimental Neuropathology

18. Organotypic Brain Slice Cultures in Neurotrauma and Stroke Research

SECTION VI: CLINICAL MODELS AND BIOMARKERS IN BRAIN INJURY

19. Biomarkers of Brain Injury: From Discovery to Clinical Implementation

20. Advanced Neuroimaging in Brain Injury Research: fMRI, PET, DTI, and Beyond

21. Neurocritical Care Data Integration: Clinical Registries and Machine Learning Approaches

SECTION VII: EMERGING CONCEPTS AND FUTURE DIRECTIONS

22. Systems Biology Approaches to Brain Injury Research

23. Artificial Intelligence and Predictive Modeling in Brain Injury

24. Personalized Medicine in Neurotrauma and Stroke

25. Next-Generation Translational Models: Toward Precision Neurotherapeutics

Product details

  • Edition: 1
  • Latest edition
  • Published: May 1, 2027
  • Language: English

About the editors

VC

Vishal K. Chavda

Dr. Vishal Chavda is a distinguished neuroscientist and clinician-scientist & Honorary Professor of Neurology, Neurosurgery & Neurogenetics at ChromoMed Institute whose work bridges basic Neuroscience, clinical neurology, cerebrovascular disease and neurosurgical research. His work addresses critical gaps in understanding ischemic brain injury, cerebral trauma, and translational neuroscience. He serves as Editorial Board Member of multiple Reputed Neuroscience, Neurology and Neurosurgery Journals.

Affiliations and expertise
Department of Medicine and Critical Care, Multispeciality, Trauma and ICCU Center, Sardar Hospital, India

CS

Creed M. Stary

Creed M Stary, MD, PhD – Dr. Creed Stary is a clinical anaesthesiologist with a faculty appointment as an Associate Professor of Anaesthesiology, Perioperative and Pain Medicine (MSD) at the Stanford University School of Medicine. His basic neuroscience laboratory studies epigenetic regulation of mitochondrial dysfunction in the brain after stroke.
Affiliations and expertise
Associate Professor, Department of Anaesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, USA

BC

Bipin Chaurasia

Mr. Bipin Chaurasia is a neurosurgeon and Consultant at Neurosurgery Clinic in Birgunj, Nepal, known for his significant contributions to neurosurgical education and practice in low- and middle-income countries. He sits on the editorial board of the Nepalese Journal of Neuroscience and has extensively published on neurosurgery training and healthcare delivery in Nepal. Notable works include "Neurosurgery training in Nepal: Then and now" and "Exploring the scope and output of neurosurgery in Nepal", which analyze workforce development challenges and chart a path forward for surgical education and service expansion. Dr. Chaurasia's work underscores the importance of structuring experimental and clinical models relevant to resource-limited settings a perspective that is invaluable to this volume’s global and translational focus.

Affiliations and expertise
Consultant Neurosurgeon, Neurosurgery Clinic, Birgunj, Nepal

LS

Luis Rafael Moscote Salazar

Dr. Luis Rafael Moscote Salazar is a professor at the University of Cartagena and a renowned clinician-scientist in neurocritical care and neurosurgery. After completing his MD and neurosurgical training in Colombia, he pursued advanced research at Spain's Ramón y Cajal Institute. He has authored influential Spanish-language texts—Neuroemergencias, Neurocirugía Práctica, Fluidoterapia en Neurotrauma, and Trauma Craneoencefálico and is a founding member and elected leader within Latin American neurocritical and trauma research networks Dr. Moscote Salazar’s scholarly work covers neurovascular management, intracranial hemorrhage, and neurocritical protocols, published in outlets such as the Manipal Journal of Medical Sciences. He is deeply engaged in advancing neurovascular care standards across Latin America, contributing to global neurotrauma education and clinical translation.

Affiliations and expertise
Professor, University of Cartagena, Cartagena, Colombia

HP

Harisinh Parmar

Mr. Harisinh Parmar is an Assistant Professor of Neurosurgery at PDU Medical College and Government Hospital, Rajkot, India. He holds an MS in General Surgery and MCh in Neurosurgery, with advanced international training in skull base and vascular microneurosurgery from leading centers in Japan. Dr. Parmar’s surgical expertise focuses on complex skull base lesions, cerebrovascular neurosurgery, and minimally invasive neuro-oncological procedures. He has been an invited participant in high-level neurosurgical cadaver labs and microdissection workshops held in Japan, Indonesia, and Nepal. His contributions to the development of neurosurgical education and microsurgical techniques in India make him a strong advocate for bridging the gap between global standards and local care delivery. As a contributing editor, he brings a deep understanding of neuroanatomical modeling and its surgical relevance to this volume.

Affiliations and expertise
Assistant Professor, Department of Neurosurgery, PDU Medical College and Government Hospital, Rajkot, India