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Transplant-Related Infections, An Issue of Infectious Disease Clinics of North America
- 1st Edition, Volume 37-3 - August 2, 2023
- Editors: Kimberly E. Hanson, Hannah Imlay
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 3 7 8 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 3 7 9 - 9
In this issue, guest editors bring their considerable expertise to this important… Read more
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Contains 14 practice-oriented topics including COVID-19 prevention in organ transplant recipients; COVID-19 management in organ transplant recipients; updates in molecular diagnostics in organ transplant recipients; updates in immunizations for organ transplant recipients; data that inform “low hanging fruit” antimicrobial stewardship interventions among solid organ transplant recipients; and more.
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Provides in-depth clinical reviews of transplant-related infections, offering actionable insights for clinical practice.
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Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- Immunization of Solid Organ Transplant Candidates and Recipients: A 2022 Update
- Key points
- Introduction
- Live, attenuated measles, mumps, rubella, and varicella virus vaccines
- Herpes zoster vaccine
- Pneumococcal vaccine
- Influenza vaccine
- Meningococcal vaccine
- Human papillomavirus vaccine
- Vaccines on the horizon
- Under-immunization of solid organ transplant candidates and recipients
- Barriers to the immunization of the transplant population
- Mechanisms to increase vaccine utilization in the transplant population
- Minimizing the Risk of Donor-Derived Events and Maximizing Organ Utilization Through Education and Policy Development
- Key points
- Introduction
- Donor-derived disease epidemiology
- Deceased donor evaluation—current policies and areas for improvement
- Factors to consider at organ acceptance and conclusions
- Summary
- Disclosure
- COVID-19 Prevention in Solid Organ Transplant Recipients: Current State of the Evidence
- Key points
- Introduction
- Humoral immune responses
- T-cell responses
- Clinical effectiveness
- Immunosuppression modulation to improve vaccine responses
- Monoclonal antibodies
- Post-exposure prophylaxis
- Centers for Disease Control and Prevention and Food and Drug Administration recommendations (as of January 31, 2023)
- Future directions
- Clinics care points
- Funding source
- Conflict of interest/disclosures
- Coronavirus Disease 2019 Management Strategies in Solid Organ Transplant Recipients
- Key points
- Introduction
- Summary and future directions
- Clinics care points
- Disclosure
- Updates in Molecular Diagnostics in Solid Organ Transplantation Recipients
- Key points
- Introduction
- Overview of sequencing technology
- Metagenomic next-generation sequencing
- Next-generation sequencing of microbial cell-free DNA from plasma
- Microbial cell-free DNA for invasive fungal infections
- Clinical impact of microbial cell-free DNA testing
- Metagenomics for central nervous system infections
- Metagenomics for monitoring DNA viruses
- Evaluating host response in conjunction with unbiased metagenomic next-generation sequencing
- Current consensus for metagenomic next-generation sequencing testing
- Broad-range polymerase chain reaction
- Syndromic panels
- Blood pathogen detection panels
- Meningitis/encephalitis syndromic panel
- Upper respiratory panels
- Lower respiratory panels
- Gastrointestinal multiplex panels
- Summary
- Clinics care points
- Antimicrobial Resistance in Organ Transplant Recipients
- Key points
- Introduction
- Epidemiology
- Approach to prevention and management
- Therapeutic options
- Future directions
- Summary
- Clinics care points
- Disclosures
- Opportunities for Antimicrobial Stewardship Interventions Among Solid Organ Transplant Recipients
- Key points
- Introduction
- Development of antimicrobial stewardship programs metrics
- Diagnostic stewardship opportunities
- Syndromic targets for antimicrobial stewardship
- Systems-based targets for antimicrobial stewardship
- Summary
- Clinics care points
- Disclosures
- Update on Epidemiology and Outcomes of Infection in Pediatric Organ Transplant Recipients
- Key points
- Introduction
- Viral infections
- Fungal infections
- Multidrug-resistant bacteria
- Summary
- Clinics care points
- Disclosure
- Mycobacteria in Organ Transplant Recipients
- Key points
- Mycobacterium tuberculosis
- Non-tuberculous Mycobacteria in Solid Organ Transplantation
- Rapidly growing non-tuberculous mycobacteria
- Slow-growing non-tuberculous mycobacteria
- Clinical manifestations
- Summary
- Clinics care points
- Disclosures
- Emerging Diagnostics and Therapeutics for Invasive Fungal Infections
- Key points
- Introduction
- Recent advances in fungal diagnostics
- Molecular diagnostics
- Panfungal polymerase chain reaction
- Pneumocystis
- Aspergillosis
- Mucormycosis
- New therapeutics for invasive fungal infections
- New drugs, old classes
- First-in-class drugs
- Conclusion and future directions
- Clinics care points
- Disclosure
- Current Concepts in the Diagnosis and Management of Pneumocystis Pneumonia in Solid Organ Transplantation
- Key points
- Introduction
- Features of the pathogen and host-pathogen interaction
- Epidemiology in solid organ transplantation
- Clinical presentations in solid organ transplantation
- Diagnostic methods
- Treatment in solid organ transplantation
- Adjunctive treatment
- Emerging treatments
- Drug resistance
- Prevention and mitigation in solid organ transplantation
- Future directions and unmet needs
- Clinics care points
- Disclosure
- Organ Donors with Human Immunodeficiency Virus and Hepatitis C Virus: Expanding the Donor Pool
- Key points
- Introduction
- HIV Organ Policy Equity Act safeguards and research requirements
- Early outcomes of the HIV Organ Policy Equity Act in kidney transplantation
- Outcomes of the HIV Organ Policy Equity Act in liver transplantation
- HIV false-positive HOPE donors
- HOPE donor clinical, immunologic, and virologic profiles
- Barriers to maximizing the potential of the HIV Organ Policy Equity Act
- Transplant center involvement in the HIV Organ Policy Equity Act
- Outcomes of Hepatitis C Virus D+/R− Transplantation
- Summary
- Clinics care points
- Funding
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 37-3
- Published: August 2, 2023
- Imprint: Elsevier
- Hardback ISBN: 9780443183782
- eBook ISBN: 9780443183799
KH
Kimberly E. Hanson
HI