Transpathology

Molecular Imaging-Based Pathology

1st Edition - June 25, 2024
Editor: Mei Tian
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 2 2 3 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 2 2 4 - 8

Transpathology: Molecular Imaging-Based Pathology is a multidisciplinary reference on molecular imaging and pathology. The book is intended for professionals in the fields of mol… Read more

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Transpathology: Molecular Imaging-Based Pathology is a multidisciplinary reference on molecular imaging and pathology. The book is intended for professionals in the fields of molecular imaging, nuclear medicine, radiology, and pathology as well as students and clinical residents. The book describes the importance of non-invasive diagnosis-based precision medicine and presents a detailed description of current transpathological approaches in different aspects essential for the future development of precision medicine. It is molecular imaging approach to experimental research and clinical practice which will drive the field forward and improve research outcomes.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
Preface
Acknowledgment
Chapter 1. From molecular imaging to transpathology: general principles
Abstract
1.1 Introduction
1.2 Recent advances in molecular imaging (instruments and probes)
1.3 Progress in pathology
1.4 Definition of “transpathology”
References
Chapter 2. Positron emission tomography instrumentation and image reconstruction
Abstract
2.1 Introduction
2.2 Physics of positron emission tomography imaging
2.3 Positron emission tomography scanner
2.4 Image reconstruction
2.5 Data correction
2.6 Future direction
References
Chapter 3. PET/SPECT: quantitative imaging and data analysis
Abstract
3.1 Introduction
3.2 Compartmental model with plasma input
3.3 Compartmental model with reference tissue input
3.4 Graphical analysis
3.5 Parameter estimation and model fitting
3.6 Total-body kinetic modeling
3.7 Conclusion
References
Chapter 4. Magnetic resonance histology
Abstract
4.1 Introduction
4.2 Histology and high-field magnetic resonance imaging
4.3 Protocols for magnetic resonance imaging histology preparation
4.4 Coregistration of magnetic resonance imaging and histological datasets
4.5 The advantage of high-field magnetic resonance
References
Chapter 5. Novel biomedical imaging technology for high-resolution histological analysis
Abstract
5.1 Introduction
5.2 Dark-field reflectance ultraviolet microscopy for rapid and label-free histological imaging of unprocessed surgical tissues
5.3 High-resolution three-dimensional slide-free histopathology with light sheet fluorescence microscopy and tissue clearing
5.4 High-frequency ultrasound for vessel structural imaging
5.5 High-resolution imaging in magnetic resonance imaging: relating with histology and pathology
5.6 High spatial resolution positron emission tomography imaging
References
Chapter 6. Photoacoustic imaging
Abstract
6.1 Introduction
6.2 Multicontrast and multiscale photoacoustic imaging
6.3 Photoacoustic imaging in preclinical research
6.4 Photoacoustic imaging in clinical oncology
6.5 Summary and outlook
References
Chapter 7. Optical imaging technologies and applications
Abstract
7.1 Introduction
7.2 Photoacoustic microscopy
7.3 Laser scanning fluorescence microscopy
7.4 Coherent Raman scattering microscopy
7.5 Lens-free computational microscopy
7.6 Polarization microscopy
7.7 Light sheet fluorescence microscopy
7.8 Optical projection tomography
References
Chapter 8. Stimulated Raman histology
Abstract
8.1 Introduction
8.2 Coherent Raman scattering microscopy
8.3 Stimulated Raman histology
8.4 Future perspective
References
Chapter 9. Imaging of biological processes using positron emission tomography and single-photon emission computed tomography
Abstract
9.1 Introduction
9.2 Radioactive probes
9.3 Nuclear imaging and biological processes
9.4 Conclusions
References
Chapter 10. Imaging of cells: cell injury, death, and adaptation
Abstract
10.1 Introduction
10.2 Cell injury
10.3 Cell death
10.4 Cell adaptation
10.5 Conclusion
References
Chapter 11. Imaging of inflammation and infection
Abstract
11.1 Introduction
11.2 Inflammation caused by various stimuli
11.3 Artificial intelligence in inflammation and infection imaging
11.4 From preclinical to clinical translation
11.5 Summary
References
Chapter 12. Imaging of gastrointestinal endoscopy
Abstract
12.1 Introduction
12.2 Optical imaging
12.3 Ultrasound imaging
12.4 Artificial intelligence in endoscopic diagnosis
References
Chapter 13. Imaging of tissue repair
Abstract
13.1 Introduction
13.2 Tissue repair and affecting factors
13.3 Processes of tissue repair
13.4 Potential biomarkers of tissue repair
13.5 Imaging tools visualizing tissue repair
13.6 Optical imaging in assessing tissue repair
13.7 Magnetic resonance imaging in assessing tissue repair
13.8 Positron emission tomography in assessing tissue repair
13.9 Other modalities for imaging tissue repair
13.10 Conclusions and future perspectives
References
Chapter 14. Imaging of cardiovascular pathology
Abstract
14.1 Introduction
14.2 Pathological imaging of coronary artery disease
14.3 Pathological imaging of cardiomyopathy
14.4 Pathological imaging of cardiac inflammation
References
Chapter 15. Spatial transcriptomics in transpathology
Abstract
15.1 Introduction
15.2 Spatial transcriptomics technologies
15.3 Next-generation sequencing barcoding-based spatial transcriptomics
15.4 Comparison among different spatial transcriptomics technologies
15.5 Computational approaches
15.6 Challenges and future directions
References
Chapter 16. RNA-interference and molecular imaging: a transpathological analysis
Abstract
16.1 Introduction
16.2 Identifying siRNA-based theranostics in precision medicine
16.3 Identifying miRNA-based theranostics in precision medicine
16.4 Conclusions
References
Chapter 17. Imaging of drug delivery
Abstract
17.1 Introduction
17.2 Magnetic resonance-based monitoring of drug delivery
17.3 Optical-based monitoring of drug delivery
17.4 Ultrasound-based monitoring of drug delivery
17.5 Photoacoustic-based monitoring of drug delivery
17.6 Radionuclide-based monitoring of drug delivery
17.7 Multimode monitoring of drug delivery
17.8 Clinical applications of imaging in drug delivery
17.9 Conclusion
References
Chapter 18. Molecular imaging for neurological diseases
Abstract
18.1 Introduction
18.2 Technology and radiologic imaging
18.3 Radiotracers for positron emission tomography/single-photon emission computed tomography imaging of the brain
18.4 Most frequent clinical applications
18.5 Positron emission tomography/single-photon emission computed tomography database for normal human brain
18.6 Cerebral imaging analysis method
References
Chapter 19. Psychiatric disorders
Abstract
19.1 Introduction
19.2 Multiscale imaging approach in psychiatry
19.3 Important findings of schizophrenia in transpathology
19.4 Future perspectives
References
Chapter 20. Noninvasive molecular imaging for cardiovascular disease
Abstract
20.1 Introduction
20.2 In vivo molecular imaging of vascular disease
20.3 Multimodal noninvasive imaging of pathology in cardiac amyloidosis
20.4 Summary
20.5 Future prospective
References
Chapter 21. Gastrointestinal tract
Abstract
21.1 Introduction
21.2 Technology and radiologic imaging markers
21.3 Application in gastrointestinal diseases
References
Chapter 22. Cancer
Abstract
22.1 Introduction
22.2 Application in liver cancer
22.3 Application in lung cancer
22.4 Application in lymphoma
References
Chapter 23. Digital pathology and artificial intelligence in cancer research
Abstract
23.1 Introduction
23.2 Digital pathology and traditional machine learning methods in cancer research
23.3 Digital pathology and deep learning methods in cancer research
23.4 Opportunities
References
Chapter 24. Endocrine system
Abstract
24.1 Introduction
24.2 Nuclear molecular imaging modalities for endocrine system neoplasms
24.3 The transpathology for endocrine system neoplasms based on molecular imaging
24.4 Conclusion
References
Chapter 25. Female genital system and breast
Abstract
25.1 Introduction
25.2 Breast cancer
25.3 Ovarian malignancy
Chapter 26. Male genital system and lower urinary tract
Abstract
26.1 Introduction
26.2 Prostate cancer
26.3 Breakthroughs in imaging modalities for prostate cancer
26.4 Prostate cancer imaging: unmet needs and knowledge gaps
26.5 Renal cancer
26.6 Bladder cancer
Further reading
Chapter 27. Pediatric positron emission tomography application
Abstract
27.1 Introduction
27.2 Positron emission tomography radiation safety in pediatric patients
27.3 Positron emission tomography imaging protocol in pediatric patients
27.4 Positron emission tomography/computed tomography in pediatric diseases
27.5 Positron emission tomography/magnetic resonance imaging application in pediatric patients
References
Chapter 28. Harnessing artificial intelligence for transpathology advancements
Abstract
28.1 Introduction
28.2 Transparency
28.3 Trans-scale
28.4 Translation
28.5 Limitations of artificial intelligence
28.6 Future perspectives
Credit
References
Chapter 29. The future of transpathology
Abstract
29.1 Introduction
29.2 Molecular imaging-based transpathology
29.3 The integration of artificial intelligence in transpathology
29.4 The goal of transpathology in precision medicine
29.5 Challenges and future opportunities
29.6 Summary
References
Index

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Mei Tian