Transpathology
Molecular Imaging-Based Pathology
- 1st Edition - June 25, 2024
- Editor: Mei Tian
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 2 2 3 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 2 2 4 - 8
Transpathology: Molecular Imaging-Based Pathology is a multidisciplinary reference on molecular imaging and pathology. The book is intended for professionals in the fields of mol… Read more

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Request a sales quoteTranspathology: Molecular Imaging-Based Pathology is a multidisciplinary reference on molecular imaging and pathology. The book is intended for professionals in the fields of molecular imaging, nuclear medicine, radiology, and pathology as well as students and clinical residents. The book describes the importance of non-invasive diagnosis-based precision medicine and presents a detailed description of current transpathological approaches in different aspects essential for the future development of precision medicine. It is molecular imaging approach to experimental research and clinical practice which will drive the field forward and improve research outcomes.
- Introduces a new concept of molecular imaging-guided precise biopsy
- Links in vivo and ex vivo information at various scales by using multi-modality imaging technologies
- Integrates future technologies for the non-invasive cross-validation of underlying mechanisms
Professionals in the fields of pathology, molecular imaging, nuclear medicine, radiology, Medical students, clinical residents, postgraduate students who should aware of the importance of non-invasive diagnosis-based precision medicine and future medicine
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Preface
- Acknowledgment
- Chapter 1. From molecular imaging to transpathology: general principles
- Abstract
- 1.1 Introduction
- 1.2 Recent advances in molecular imaging (instruments and probes)
- 1.3 Progress in pathology
- 1.4 Definition of “transpathology”
- References
- Chapter 2. Positron emission tomography instrumentation and image reconstruction
- Abstract
- 2.1 Introduction
- 2.2 Physics of positron emission tomography imaging
- 2.3 Positron emission tomography scanner
- 2.4 Image reconstruction
- 2.5 Data correction
- 2.6 Future direction
- References
- Chapter 3. PET/SPECT: quantitative imaging and data analysis
- Abstract
- 3.1 Introduction
- 3.2 Compartmental model with plasma input
- 3.3 Compartmental model with reference tissue input
- 3.4 Graphical analysis
- 3.5 Parameter estimation and model fitting
- 3.6 Total-body kinetic modeling
- 3.7 Conclusion
- References
- Chapter 4. Magnetic resonance histology
- Abstract
- 4.1 Introduction
- 4.2 Histology and high-field magnetic resonance imaging
- 4.3 Protocols for magnetic resonance imaging histology preparation
- 4.4 Coregistration of magnetic resonance imaging and histological datasets
- 4.5 The advantage of high-field magnetic resonance
- References
- Chapter 5. Novel biomedical imaging technology for high-resolution histological analysis
- Abstract
- 5.1 Introduction
- 5.2 Dark-field reflectance ultraviolet microscopy for rapid and label-free histological imaging of unprocessed surgical tissues
- 5.3 High-resolution three-dimensional slide-free histopathology with light sheet fluorescence microscopy and tissue clearing
- 5.4 High-frequency ultrasound for vessel structural imaging
- 5.5 High-resolution imaging in magnetic resonance imaging: relating with histology and pathology
- 5.6 High spatial resolution positron emission tomography imaging
- References
- Chapter 6. Photoacoustic imaging
- Abstract
- 6.1 Introduction
- 6.2 Multicontrast and multiscale photoacoustic imaging
- 6.3 Photoacoustic imaging in preclinical research
- 6.4 Photoacoustic imaging in clinical oncology
- 6.5 Summary and outlook
- References
- Chapter 7. Optical imaging technologies and applications
- Abstract
- 7.1 Introduction
- 7.2 Photoacoustic microscopy
- 7.3 Laser scanning fluorescence microscopy
- 7.4 Coherent Raman scattering microscopy
- 7.5 Lens-free computational microscopy
- 7.6 Polarization microscopy
- 7.7 Light sheet fluorescence microscopy
- 7.8 Optical projection tomography
- References
- Chapter 8. Stimulated Raman histology
- Abstract
- 8.1 Introduction
- 8.2 Coherent Raman scattering microscopy
- 8.3 Stimulated Raman histology
- 8.4 Future perspective
- References
- Chapter 9. Imaging of biological processes using positron emission tomography and single-photon emission computed tomography
- Abstract
- 9.1 Introduction
- 9.2 Radioactive probes
- 9.3 Nuclear imaging and biological processes
- 9.4 Conclusions
- References
- Chapter 10. Imaging of cells: cell injury, death, and adaptation
- Abstract
- 10.1 Introduction
- 10.2 Cell injury
- 10.3 Cell death
- 10.4 Cell adaptation
- 10.5 Conclusion
- References
- Chapter 11. Imaging of inflammation and infection
- Abstract
- 11.1 Introduction
- 11.2 Inflammation caused by various stimuli
- 11.3 Artificial intelligence in inflammation and infection imaging
- 11.4 From preclinical to clinical translation
- 11.5 Summary
- References
- Chapter 12. Imaging of gastrointestinal endoscopy
- Abstract
- 12.1 Introduction
- 12.2 Optical imaging
- 12.3 Ultrasound imaging
- 12.4 Artificial intelligence in endoscopic diagnosis
- References
- Chapter 13. Imaging of tissue repair
- Abstract
- 13.1 Introduction
- 13.2 Tissue repair and affecting factors
- 13.3 Processes of tissue repair
- 13.4 Potential biomarkers of tissue repair
- 13.5 Imaging tools visualizing tissue repair
- 13.6 Optical imaging in assessing tissue repair
- 13.7 Magnetic resonance imaging in assessing tissue repair
- 13.8 Positron emission tomography in assessing tissue repair
- 13.9 Other modalities for imaging tissue repair
- 13.10 Conclusions and future perspectives
- References
- Chapter 14. Imaging of cardiovascular pathology
- Abstract
- 14.1 Introduction
- 14.2 Pathological imaging of coronary artery disease
- 14.3 Pathological imaging of cardiomyopathy
- 14.4 Pathological imaging of cardiac inflammation
- References
- Chapter 15. Spatial transcriptomics in transpathology
- Abstract
- 15.1 Introduction
- 15.2 Spatial transcriptomics technologies
- 15.3 Next-generation sequencing barcoding-based spatial transcriptomics
- 15.4 Comparison among different spatial transcriptomics technologies
- 15.5 Computational approaches
- 15.6 Challenges and future directions
- References
- Chapter 16. RNA-interference and molecular imaging: a transpathological analysis
- Abstract
- 16.1 Introduction
- 16.2 Identifying siRNA-based theranostics in precision medicine
- 16.3 Identifying miRNA-based theranostics in precision medicine
- 16.4 Conclusions
- References
- Chapter 17. Imaging of drug delivery
- Abstract
- 17.1 Introduction
- 17.2 Magnetic resonance-based monitoring of drug delivery
- 17.3 Optical-based monitoring of drug delivery
- 17.4 Ultrasound-based monitoring of drug delivery
- 17.5 Photoacoustic-based monitoring of drug delivery
- 17.6 Radionuclide-based monitoring of drug delivery
- 17.7 Multimode monitoring of drug delivery
- 17.8 Clinical applications of imaging in drug delivery
- 17.9 Conclusion
- References
- Chapter 18. Molecular imaging for neurological diseases
- Abstract
- 18.1 Introduction
- 18.2 Technology and radiologic imaging
- 18.3 Radiotracers for positron emission tomography/single-photon emission computed tomography imaging of the brain
- 18.4 Most frequent clinical applications
- 18.5 Positron emission tomography/single-photon emission computed tomography database for normal human brain
- 18.6 Cerebral imaging analysis method
- References
- Chapter 19. Psychiatric disorders
- Abstract
- 19.1 Introduction
- 19.2 Multiscale imaging approach in psychiatry
- 19.3 Important findings of schizophrenia in transpathology
- 19.4 Future perspectives
- References
- Chapter 20. Noninvasive molecular imaging for cardiovascular disease
- Abstract
- 20.1 Introduction
- 20.2 In vivo molecular imaging of vascular disease
- 20.3 Multimodal noninvasive imaging of pathology in cardiac amyloidosis
- 20.4 Summary
- 20.5 Future prospective
- References
- Chapter 21. Gastrointestinal tract
- Abstract
- 21.1 Introduction
- 21.2 Technology and radiologic imaging markers
- 21.3 Application in gastrointestinal diseases
- References
- Chapter 22. Cancer
- Abstract
- 22.1 Introduction
- 22.2 Application in liver cancer
- 22.3 Application in lung cancer
- 22.4 Application in lymphoma
- References
- Chapter 23. Digital pathology and artificial intelligence in cancer research
- Abstract
- 23.1 Introduction
- 23.2 Digital pathology and traditional machine learning methods in cancer research
- 23.3 Digital pathology and deep learning methods in cancer research
- 23.4 Opportunities
- References
- Chapter 24. Endocrine system
- Abstract
- 24.1 Introduction
- 24.2 Nuclear molecular imaging modalities for endocrine system neoplasms
- 24.3 The transpathology for endocrine system neoplasms based on molecular imaging
- 24.4 Conclusion
- References
- Chapter 25. Female genital system and breast
- Abstract
- 25.1 Introduction
- 25.2 Breast cancer
- 25.3 Ovarian malignancy
- Chapter 26. Male genital system and lower urinary tract
- Abstract
- 26.1 Introduction
- 26.2 Prostate cancer
- 26.3 Breakthroughs in imaging modalities for prostate cancer
- 26.4 Prostate cancer imaging: unmet needs and knowledge gaps
- 26.5 Renal cancer
- 26.6 Bladder cancer
- Further reading
- Chapter 27. Pediatric positron emission tomography application
- Abstract
- 27.1 Introduction
- 27.2 Positron emission tomography radiation safety in pediatric patients
- 27.3 Positron emission tomography imaging protocol in pediatric patients
- 27.4 Positron emission tomography/computed tomography in pediatric diseases
- 27.5 Positron emission tomography/magnetic resonance imaging application in pediatric patients
- References
- Chapter 28. Harnessing artificial intelligence for transpathology advancements
- Abstract
- 28.1 Introduction
- 28.2 Transparency
- 28.3 Trans-scale
- 28.4 Translation
- 28.5 Limitations of artificial intelligence
- 28.6 Future perspectives
- Credit
- References
- Chapter 29. The future of transpathology
- Abstract
- 29.1 Introduction
- 29.2 Molecular imaging-based transpathology
- 29.3 The integration of artificial intelligence in transpathology
- 29.4 The goal of transpathology in precision medicine
- 29.5 Challenges and future opportunities
- 29.6 Summary
- References
- Index
- No. of pages: 406
- Language: English
- Edition: 1
- Published: June 25, 2024
- Imprint: Elsevier
- Paperback ISBN: 9780323952231
- eBook ISBN: 9780323952248
MT
Mei Tian
Prof. Mei Tian MD, PhD is the President-elect of the World Molecular Imaging Society (WMIS), Director of Medical Imaging and Nuclear Medicine Program of Zhejiang University, the Vice President of Zhejiang University Medical Center, the Vice President of Hangzhou Riverside Hospital of Zhejiang University School of Medicine. (Zhejiang University is one of the top-3 university in China). Dr. Tian has 20+ years post-MD training and practice in radiology, nuclear medicine and molecular imaging. She is the Distinguished Professor of Nuclear Medicine and Molecular Imaging granted by the Ministry of Education of China.
Dr. Tian has won scholastic and scientific awards, such as National Distinguished Women Scientist Award, National Distinguished Young Scientist Award, Merit Award (RSNA), International Young Investigator Grant (RSNA), International Development and Education Grant (ASCO), Asian and Oceanian Distinguished Young Investigator Award (JSNM), JSPS fellowship (JSPS) for her extraordinary accomplishments, and selected as the Fellow of the World Molecular Imaging Society (WMIS). She is the Editorial Consultant of the LANCET, associate editors of the official journals of the Society of Nuclear Medicine and Molecular Imaging, European Association of Nuclear Medicine, Japanese Society of Nuclear Medicine, and the Regional Editor of the official journal of the WMIS.
Affiliations and expertise
President-elect of the World Molecular Imaging Society (WMIS), Director of Medical Imaging and Nuclear Medicine Program of Zhejiang University, the Vice President of Zhejiang University Medical Center, the Vice President of Hangzhou Riverside Hospital of Zhejiang University School of Medicine.Read Transpathology on ScienceDirect