Save up to 30% on Elsevier print and eBooks with free shipping. No promo code needed.
Save up to 30% on print and eBooks.
Translational Sports Medicine
1st Edition - August 14, 2023
Editors: Adam Eltorai, Jeffrey A. Bakal, Steve DeFroda, Brett D. Owens
Language: English
Paperback ISBN:9780323912594
9 7 8 - 0 - 3 2 3 - 9 1 2 5 9 - 4
eBook ISBN:9780323913348
9 7 8 - 0 - 3 2 3 - 9 1 3 3 4 - 8
Translational Sports Medicine covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. This title is an indisp…Read more
Purchase options
LIMITED OFFER
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
Translational Sports Medicine covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. This title is an indispensable tool in grant writing and funding efforts with its practical, straightforward approach that will help aspiring investigators navigate challenging considerations in study design and implementation. It provides valuable discussions of the critical appraisal of published studies in translational sports medicine, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care.
In short, this practical guidebook will be of interest to every medical researcher or sports medicine clinician who has ever had a good clinical idea but not the knowledge of how to test it. Readers will come to fully understand important concepts, including case-control study, prospective cohort study, randomized trial and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in translational sports medicine, and know what is needed in collaboration.
Focuses on the principles of evidence-based medicine and applies these principles to translational investigations within sports medicine
Details discussions of the critical appraisal of published studies in translational sports medicine, supporting evaluation with respect to measuring outcomes and making effective use of all types of evidence in patient care
Written by experts in the sports medicine field
Clinicians in sports medicine, basic scientists interested in translating their research into clinical practice, Graduate level programs in clinical investigation
Cover image
Title page
Table of Contents
Handbook for Designing and Conducting Clinical and Translational Research
Copyright
List of contributors
Preface
Part I. Introduction
Part I Introduction
Chapter 1. Introduction
Chapter 2. The translational process
Key points
Why it matters
Translational research
Get started
Pitfalls to avoid
Real-world examples
Chapter 3. Scientific method
Key points
Why it matters?
Making an observation
Formulating a question
Generating a hypothesis
Making predictions
Experimentation and data gathering
Analysis and drawing conclusions
Summary
Get started
Potential pitfalls
Example case
Chapter 4. Basic research
Key points
Why it matters?
Reductionist approach
Reductionist versus applied research
Objectives
Disciplines
Common lab methods/techniques
Major areas of current investigation
Get started
Pitfalls to avoid
Real-world examples
Part II. Pre-clinical
Part II Pre-clinical
Chapter 5. Overview of preclinical research
Key points
Why it matters
Get started
The process for preclinical research
Common research techniques for preclinical research
Types of common experimentation methods in preclinical research
Common areas of preclinical sports medicine research
Growth factor study and mechanisms of delivery
Cell-based interventions
Biomechanical testing of proposed surgical procedures using cadaver specimens
Computer modeling for kinematics and implant design
Potential pitfalls to avoid
Translatability
Controls
Reproducibility
Chapter 6. What problem are you solving?
Key points
Defining the problem
Solving the problem
Framing the problem for research
Get started
Pitfalls
Examples
Chapter 7. Types of interventions: drugs, devices, diagnostic, procedural technique, and behavior change
Drugs
Devices
Diagnostic
Procedural technique
Behavior change
Chapter 8. Beyond drugs and surgery: a look at orthobiologics
Key points
Cell therapies
Blood-derived products
Recombinant growth factors
Gene therapies
Small molecules
Fibrosis
Exosomes
Challenges associated with defining the orthobiologics' efficacy
Chapter 9. Drug testing
Key points
Safety and toxicity testing
Good Laboratory Practice
Areas of current investigation
Potential pitfalls
Real-world examples
Get started
Funding considerations
Chapter 10. Device discovery and prototyping
Introduction
Innovation in orthopedics
Needs and market capacity assessments
Prototyping
Cost and budgetary considerations
Conclusion
Chapter 11. Device testing
Key points
Potential pitfalls
Chapter 12. Diagnostic discovery
Introduction
Areas of current investigation
Potential pitfalls to avoid
Get started
Real-world example
Resources and funding sources
Chapter 13. Diagnostic testing
Key points
Introduction
Learning and defining terms
Goals: what does a good diagnostic test look like?
Real-world examples
Regulatory considerations
Get started
Potential pitfalls
Chapter 14. Preclinical: discussion of FDA product categories (what the FDA covers, regulated or not)
Chapter 90. CMC and GxP: chemistry, manufacturing, and controls & good practice' guidelines and regulations
Key points
Chemistry, manufacturing, and controls
Good practice' guidelines and regulations
Chapter 91. Non-US regulatory
Key points
Introductory section/Why it matters?
Regulation outside the United States
Chapter 92. Postmarket drug safety monitoring
Chapter 93. Postmarket device safety monitoring
Key points
Introduction
Interim Postmarket Surveillance Report
Final Postmarket Surveillance Report
Evaluation of Postmarket Surveillance Final Report
Failure to comply with postmarket surveillance
Public disclosure of postmarket surveillance plan
Potential pitfall
Get started
Part IX. Clinical implementation
Part IX Clinical implementation
Chapter 94. Implementation research
Key points
Get started
Chapter 95. Design and analysis
Introduction
Overview of implementation objectives and outcomes
Intervention research methods example #1: RE-AIM framework for planning and evaluating outcomes
Intervention research methods example #2: mixed methods
Methodological challenges in implementation research
Study design
Experimental—waitlist randomized controlled trial
Quasi-experimental—multiple baseline trial
Observational study design
Conclusion
Get started
Potential pitfalls
Real-world examples
Resources
Chapter 96. Mixed methods in concussion research
Summary
Why it matters
Defining mixed methods
Types of mixed methods designs
Examples in concussion research
Get started
Pitfalls to avoid
Resources
Chapter 97. Implementation of multimodal concussion research within military medical environments
Key points
Introduction
Resources
Translation example 1. Initial prototype of the Bethesda Eye and Attention Measure
Translational example 2. Initial demonstration of sensitivity in the mTBI clinical population
Translational example 3. Testing an advanced prototype in the military clinical environment
Disclaimer
Chapter 98. Guideline development
Key points
Introduction/why it matters
Get started
Part X. Public health
Part X Public health
Chapter 99. Public health
Key points
Why it matters
Get started
Examples
Resources
Chapter 100. Epidemiology of sports injuries
Key points
Introduction
Sports injuries in adolescents
Demographic data on sports injuries in the United States
International sports injury data
Population level effects of sports injuries
Chapter 101. Factors
Key points
Multifactorial considerations in public health
Get started
Potential pitfalls
Resources
Chapter 102. Good questions—asking the right public health questions
Key points
Why it matters
Examples
Potential pitfalls to avoid
Get started
Chapter 103. Population- and environmental-specific considerations
Key points
Why it matters
Population considerations
Environmental considerations
Potential pitfalls to avoid
Get started
Chapter 104. Law, policy, and ethics
Key points
Why it matters
Overview
Objectives of public health law, policy, and ethics in translational research
Methods
Impact
Challenges
Get started
Potential pitfalls
Chapter 105. Healthcare institutions and systems
Key points
Using translational research to impact policy
Types of healthcare institutions
Interactions between healthcare institutions
Get started
Potential pitfalls
Examples of the influence of healthcare institutions on the translational research process
Resources
Chapter 106. Public health institutions and systems
Key points
Key public health institutions
States and local departments of health
Nongovernmental public health entities
Partnership between translational researchers and public health entities
Social determinants of health
Get started
Potential pitfalls
CMS—Comprehensive Care for Joint Replacement
PCORI
Social determinants of health
Resources
Part XI. Practical resources
Part XI Practical resources
Chapter 107. Presenting data
Chapter 108. Manuscript preparation
Key points
Preface
Abstract
Introduction
Materials and methods
Results
Discussion
Conclusion
References
Get started
Pearls and pitfalls—suggested by Provenzale2
Real-world examples
Resources
Chapter 109. Promoting research
Key points
Introduction
Methods to promote research
Real-world example on how to rewrite abstract components to be more direct and succinct
Real-world example of an effective table that succinctly delivers data
Real-world example of how to create an abstract that is tweetable and easily shared
Author impact metrics
Academic advancement
Risks
Get started
Pitfalls to avoid
Resources
Chapter 110. Quality improvement
Key points
Why it matters?
Introduction
Reporting and disseminating results
Example studies
Personnel
Funding
Potential pitfalls to avoid
Get started
Additional resources
Chapter 111. Team science and building a team
Key points
Why it matters
What is team science?
Why team science?
Examples of team science
Is team science right for you?
Building a team
Finding collaborators
Get started
Potential pitfalls to avoid
Additional reading
Chapter 112. Types of intellectual property
Four main types
Recommendations for timing of filing
Example patent template21,22
Budgetary considerations
Chapter 113. Venture pathways
Key points
Main text
Basics of starting a company
Licensing
Venture capital funding
Exit strategies
Get started
Potential pitfalls to avoid
Real-world examples
Resources
Chapter 114. Utilizing National Institutes of Health (NIH) grants to fund translational research: An Overview
Key points
Introduction to the National Institutes of Health grant application process
Initial preparation for the application process and important personnel
Application completion and review process
Award processing
Pitfalls to avoid
Get started
Real world examples
Additional resources
Chapter 115. Sample forms and templates
Key points
IRB protocols
IRB budgets
Grant proposals
Consort diagram
Equator guidelines
Lincoln and guba framework
Real-world examples
Potential pitfalls to avoid
Glossary
Index
No. of pages: 700
Language: English
Edition: 1
Published: August 14, 2023
Imprint: Academic Press
Paperback ISBN: 9780323912594
eBook ISBN: 9780323913348
AE
Adam Eltorai
Adam Eltorai, MD, PhD, completed his graduate studies in Biomedical Engineering and Biotechnology along with his medical degree from Brown University. He has invented several medical technologies (from immunotherapies to medical devices) and developed innovations from in vitro studies and animal work through randomized clinical trials. Dr. Eltorai has published over 200 scientific journal articles, abstracts, books, book chapters.
Affiliations and expertise
Brown University Warren Alpert Medical School, Connecticut, USA
JB
Jeffrey A. Bakal
Jeff Bakal PhD, P.Stat. is the Program Director for Provincial Research Data Services at Alberta Health Services which operates the Alberta Strategy for Patient Oriented Research (SPOR) data platform and Health Service Statistical & Analytics Methods teams. He has over 10 years of experience working with Health Services data and Randomized Clinical Trials. He completed his PhD jointly with the Department of Mathematics and Statistics and the School of Physical Health and Education at Queen's University. He has worked on the methodology and analysis of several international studies in business strategy, ophthalmology, cardiology, geriatric medicine and the analysis of kinematic data resulting in several peer reviewed articles and conference presentations. His current interests are in developing statistical methodology for time-to-event data and the development of classification tools to assist in patient decision making processes.
Affiliations and expertise
Program Director, Provincial Research Data Services, Data Integration Management and Reporting of Alberta Health Services, Edmonton, Alberta, Canada
SD
Steve DeFroda
Steven DeFroda currently works as a sports medicine fellow at Rush University Medical Center. Steven does research in Orthopedic Surgery, with specific interest in athletic injuries of the knee, shoulder, and elbow. Specific interests include clinical and functional outcomes, biomechanics, and patient quality of life.
Affiliations and expertise
Sports Medicine Fellow, Rush University Medical Center, Columbia, MO, USA
BO
Brett D. Owens
Dr. Owens is a fellowship-trained, board certified orthopedic sports medicine surgeon, specializing in arthroscopic repair of sports-related injuries as well as complex knee and shoulder reconstructions. He is Chief of Sports Medicine at the Miriam Hospital in Providence, RI and Director of the Rhode Island Cartilage Repair Center. He is Professor of Orthopaedic Surgery at Brown University Alpert Medical School. He is currently a Team Physician for Brown University and the Providence Bruins. He serves as a consultant for URI Athletics. Dr. Owens was named by fellow orthopedists in Orthopedics This Week as one of the “Top 28 North American Knee Surgeons.” He has published over 200 articles in peer-reviewed medical journals, given over 200 national or international presentations, co-edited three textbooks on orthopedic injuries, and serves as Associate Editor for the American Journal of Sports Medicine. His research has garnered awards from the American Orthopedic Society for Sports Medicine.
Affiliations and expertise
Chief of Sports Medicine at the Miriam Hospital in Providence, RI; Director of the Rhode Island Cartilage Repair Center; Professor of Orthopaedic Surgery at Brown University Alpert Medical School; Team Physician for Brown University and the Providence Bruins