Translational Research in Cardio-Oncology, An Issue of Heart Failure Clinics

1st Edition, Volume 18-3 - June 21, 2022
Editors: Ragavendra R. Baliga, George A. Mensah
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 7 4 7 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 7 4 8 - 6

In this issue of Heart Failure Clinics, guest editors Drs. Ragavendra R Baliga and George A. Mensah bring their considerable expertise to the topic of Translational Research in Ca… Read more

Translational Research in Cardio-Oncology, An Issue of Heart Failure Clinics

Purchase options

Info / Buy

Limited Offer

Save 50% on book bundles

Immediately download your ebook while waiting for your print delivery. No promo code needed.

Institutional subscription on ScienceDirect

Request a sales quote

In this issue of Heart Failure Clinics, guest editors Drs. Ragavendra R Baliga and George A. Mensah bring their considerable expertise to the topic of Translational Research in Cardio-Oncology. Top experts in the field cover key topics such as radiation-induced cardiac dysfunction; training and career development; cardiovascular imaging; CAR-T cell therapy and cardiovascular disease; and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Modeling Susceptibility to Cardiotoxicity in Cancer Therapy Using Human iPSC-Derived Cardiac Cells and Systems Biology
Key points
Introduction
Genomics
Transcriptomics
Epitranscriptomics
Epigenetics
Future of functional genomics in cardio-oncology modeling using human-induced pluripotent stem cells
Summary
Clinics care points
Therapy-Related Clonal Hematopoiesis: A New Link Between Cancer and Cardiovascular Disease
Key points
Introduction
What is clonal hematopoiesis?
Clonal hematopoiesis is associated with cardiovascular disease
Clonal hematopoiesis is associated with heart failure
Therapy-associated clonal hematopoiesis is prevalent in patients with cancer
Possible links between therapy-associated clonal hematopoiesis and cardiovascular disease
Summary and future directions
Clinics care points
Funding
Disclosure
Myocardial Dysfunction in Patients with Cancer
Key points
Introduction
Prevalence of myocardial dysfunction in patients with cancer
Myocardial dysfunction associated with cancer
Monitoring for and management of CTRCD
Summary
Clinics care points
Disclosure statement
Arrhythmic Complications Associated with Cancer Therapies
Key points
Introduction
Atrial fibrillation and other atrial arrhythmias
Ventricular arrhythmias
Bradyarrhythmias and Autonomic Dysfunction
Autonomic dysfunction in cancer
Summary
Clinics care points
Cardioprotection of High-Risk Individuals
Key points
Introduction
Risk stratification
Cardioprotective strategies of anthracyclines
Cardioprotective strategies with anti–human-epidermal growth factor receptor-2 therapy
Shorter duration of human-epidermal growth factor receptor-2 targeted therapies
Cardioprotective strategies with radiation
Cardioprotective strategies with hematopoietic cell transplantation
Cardioprotective strategies: vascular endothelial growth factor inhibitors
Cardioprotective strategies with fluoropyrimidines
Cardioprotective strategies with BCR-Abl tyrosine kinase inhibitors
Cardioprotective strategies with immune checkpoint inhibitors
Clinics care points
Radiation-Induced Cardiac Dysfunction: Optimizing Radiation Delivery and Postradiation Care
Key points
Introduction
Elements of radiation therapy delivery impacting radiation-induced cardiac dysfunction risk
Other factors impacting radiation-induced cardiac dysfunction risk
Automated electronic medical record tracking and physician notification as a potential strategy to better detect and treat radiation-induced cardiac dysfunction
Discussion and summary
Clinics care points
Understanding Myocardial Metabolism in the Context of Cardio-Oncology
Key points
Introduction
Anthracyclines and myocardial metabolism
Epigenetic regulation in cancer and myocardial metabolism
Current newer agents in cancer therapy affect metabolism, specifically myocardial metabolism
Interaction between tumor and myocardial metabolism
Future directions
Funding support
Intracellular Signaling Pathways Mediating Tyrosine Kinase Inhibitor Cardiotoxicity
Key points
Introduction
Tyrosine kinase inhibitors and mechanism of action
Receptor signaling pathways and cardiomyopathy
Tyrosine kinase inhibitor-induced cardiovascular dysfunction
Tyrosine kinase inhibitors and heart failure
Current and proposed treatments for tyrosine kinase inhibitor -induced toxicity
Summary and future directions
Clinics care points
Funding
T-cell Immunotherapy and Cardiovascular Disease: Chimeric Antigen Receptor T-cell and Bispecific T-cell Engager Therapies
Key points
Introduction
Mechanisms of chimeric antigen receptor T-cell and bispecific T-cell engager therapies
Cytokine release syndrome
Mechanisms of cardiotoxicity
Clinical evidence of cardiotoxicity
Risk factors for cardiotoxicity
Clinical management
Novel cardiovascular targeted chimeric antigen receptor T-cell therapies
Summary
Clinics care points
Disclosures
Cardiovascular Imaging in Cardio-Oncology: The Role of Echocardiography and Cardiac MRI in Modern Cardio-Oncology
Key points
Introduction
Clinics care points
Disclosure
Funding
Cardiac Amyloidosis
Key points
Introduction
Summary
Clinics care points
Funding
Clinical Practice Guidelines in Cardio-Oncology
Key points
Introduction
Discussion
Cardiotoxicity surveillance
Summary
Clinics care points
Training and Career Development in Cardio-Oncology Translational and Implementation Science
Key points
Introduction
Infrastructure for training
Opportunities for training
Career development
Summary
Spectrum of National Institutes of Health-Funded Research in Cardio-Oncology: A Basic, Clinical, and Observational Science Perspective
Key points
Introduction
National Institutes of Health Workshops and funding opportunity announcements
Spectrum of National Institutes of Health -supported research projects
Research training and fellowships
Summary and future directions
Disclosure
Disclaimer

Life sciences

Physical sciences & Engineering

Social sciences & Humanities

Health

Translational Research in Cardio-Oncology, An Issue of Heart Failure Clinics

Purchase options

Save 50% on book bundles

Immediately download your ebook while waiting for your print delivery. No promo code needed.

Institutional subscription on ScienceDirect

Ragavendra R. Baliga

George A. Mensah