Translational Models of Parkinson’s Disease and related Movement Disorders
- 1st Edition - September 27, 2024
- Editor: Wael Mohamed
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 6 1 2 8 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 6 1 2 9 - 2
Translational Models of Parkinson’s Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson’s Disease translati… Read more
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Request a sales quoteTranslational Models of Parkinson’s Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson’s Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book also highlights the future possibilities of introducing new models for Parkinson’s Disease and related movements disorders, underscoring current advancements, pre-clinical and clinical developments, and future scope related to numerous models.
- Highlights induction and validation of different available experimental models of Parkinson’s Disease
- Provides a comparative prospect of different experimental models of Parkinson’s Disease
- Discusses the advantages and disadvantages of each model, including associated limitations
Student, Researchers and Clinician in Neuroscience, Neurology and Movement disorders
SECTION-I: PATHO-PHYSIOLOGY, DIAGNOSIS and PHARMACOTHERAPY OF PD AND RELATED MOVEMENT DISORDERS
1. Fundamentals of PD Pathophysiology
2. Neuroinflammation, Glymphatic system and PD
3. Pharmacotherapy of PD and Related Movements disorders and their limitations
4. Diagnosis and Biomarkers of PD and related movement disorders
5. PD Plus and Atypical PD
6. Parkinson’s Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as α-Synucleinopathies
7. OMICS and Bioinformatics in PD and related movements Disorders
8. Modeling Parkinson’s Disease With the Alpha-Synuclein Protein
SECTION-II: BIOCHEMICAL AND CELLULAR MODELS OF PARKINSON’S DISEASE OF PARKINSON’S DISEASE
9. α-Synuclein Seeding Assay and Analysis
10. LRRK2 in Tissues and Cultured Cells
11. Midbrain Dopaminergic Neurons and PINK1-Parkin using Human iPS Cells
12. Models SHH, Nurr1, Pitx3, and EN1
SECTION-III: MAMMALIAN MODELS OF PARKINSON’S DISEASE
13. 6-OHDA, MPTP, and Rotenone Rodent Model of PD
14. α-Synuclein Mouse Models of Parkinson’s Disease
15. Common Marmoset (Callithrix Jacchus) Model of α-Synuclein
16. Stem Cell for PD: Technical Considerations
17. Deep Brain Stimulation Using Animal Models of Parkinson’s Disease
18. Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies
19. The MitoPark Mouse Model
20. The BSSG rat model of Parkinson’s disease
SECTION-IV: INVERTEBRATE MODELS OF PARKINSON’S DISEASE
21. LRRK2 in Caenorhabditis elegans Model
22. SCA1 Zebra Fish Model
23. MPTP model of PD
24. Drosophila PD Model
25. Neurotoxin-induced silkworm model for PD
26. Caenorhabditis elegans models of tauopathy
27. Various ZF models of PD: what is give us Hope?
SECTION-V: ETHICAL AND REGULATIONS RELATED TO PD TRANSLATIONAL PD MODELS
28. Confounding Factors for validation of PD models
29. Neurobehavioral characterization of PD models
30. Imaging usea in PD models: pros and cones
31. Ethical regulations for induction and validation of PD models
32. OMICS and PD models: Hpes or Hypes
1. Fundamentals of PD Pathophysiology
2. Neuroinflammation, Glymphatic system and PD
3. Pharmacotherapy of PD and Related Movements disorders and their limitations
4. Diagnosis and Biomarkers of PD and related movement disorders
5. PD Plus and Atypical PD
6. Parkinson’s Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as α-Synucleinopathies
7. OMICS and Bioinformatics in PD and related movements Disorders
8. Modeling Parkinson’s Disease With the Alpha-Synuclein Protein
SECTION-II: BIOCHEMICAL AND CELLULAR MODELS OF PARKINSON’S DISEASE OF PARKINSON’S DISEASE
9. α-Synuclein Seeding Assay and Analysis
10. LRRK2 in Tissues and Cultured Cells
11. Midbrain Dopaminergic Neurons and PINK1-Parkin using Human iPS Cells
12. Models SHH, Nurr1, Pitx3, and EN1
SECTION-III: MAMMALIAN MODELS OF PARKINSON’S DISEASE
13. 6-OHDA, MPTP, and Rotenone Rodent Model of PD
14. α-Synuclein Mouse Models of Parkinson’s Disease
15. Common Marmoset (Callithrix Jacchus) Model of α-Synuclein
16. Stem Cell for PD: Technical Considerations
17. Deep Brain Stimulation Using Animal Models of Parkinson’s Disease
18. Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies
19. The MitoPark Mouse Model
20. The BSSG rat model of Parkinson’s disease
SECTION-IV: INVERTEBRATE MODELS OF PARKINSON’S DISEASE
21. LRRK2 in Caenorhabditis elegans Model
22. SCA1 Zebra Fish Model
23. MPTP model of PD
24. Drosophila PD Model
25. Neurotoxin-induced silkworm model for PD
26. Caenorhabditis elegans models of tauopathy
27. Various ZF models of PD: what is give us Hope?
SECTION-V: ETHICAL AND REGULATIONS RELATED TO PD TRANSLATIONAL PD MODELS
28. Confounding Factors for validation of PD models
29. Neurobehavioral characterization of PD models
30. Imaging usea in PD models: pros and cones
31. Ethical regulations for induction and validation of PD models
32. OMICS and PD models: Hpes or Hypes
- No. of pages: 480
- Language: English
- Edition: 1
- Published: September 27, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443161285
WM
Wael Mohamed
Dr Mohamed is a Psychiatrist Neuroscientist. He earned his medical degree from Menoufia Medical School, Egypt and his research doctorate degree from the Penn State University, USA. After finishing his training in the neurosurgery department, he started his career as a clinical pharmacologist with psychopharmacology as a subspecialty. Currently, he is an assistant professor in IIUM, Malaysia as well as he is a doctorate student in cognitive psychology, IIUM, Malaysia. His translational brain research targets the investigation and development of novel treatment for AD and PD using rat, mice, and Zebra Fish animal models.
Affiliations and expertise
Assistant Professor, Basic Medical Science Dept., Medical School, International Islamic University Malaysia, Kuantan Campus, Pahang, Malaysia